Manual - New England Biolabs

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Licensing Information:
RheoSwitch ® Mammalian Inducible Expression System Notice to Purchaser
This product is the subject of one or more of U.S. Patent Nos. 5,514,578, 6,245,531, including the corresponding foreign patents (Australian Patent No.
752699, Canadian Patent Application No. 2076386, European Patent 0517805) and patent applications, U.S. Patent Nos. 6,258,603 and 5,530,028, and
U.S. Patent Application Nos. 09/965,697, 09/965,703, 10/239,134, 10/468,199, 10/468,193 licensed to New England Biolabs (NEB). The purchase of this
product conveys to the non-commercial purchaser the non-transferable right to use the purchased amount of the product and components of the product
for research use only conducted by the purchaser. For commercial purchasers using this product for research, the purchase of this product conveys
to the purchaser the non-transferable right to use the purchased amount of the product and components of the product for a six (6) month evaluation
period after the date of purchase for research use only. After the six (6) month evaluation period, the purchaser must contact RheoGene, Inc. to obtain a
commercial research license. Purchaser shall promptly inform RheoGene, Inc. in writing within ten (10) days of discovering, inventing, modifying and/or
improving the RheoSwitch ® System (each an “Alteration”). For a period of thirty (30) days following RheoGene’s receipt of such notification, Purchaser
and RheoGene will negotiate the terms of a royalty-free, irrevocable and perpetual worldwide license to RheoGene to such Alteration; provided, however,
that RheoGene will have no right, title or interest in or to improvements to Purchaser’s applications through use of the RheoSwitch ® System that do not
require an Alteration of the RheoSwitch ® System. If a license agreement for the Alteration is not executed before the expiration of such period of time then
the parties shall be deemed to be joint owners of such Alteration. The purchaser cannot sell or otherwise transfer (a) this product (b) its components or
(c) materials made using this product or its components to a third party or otherwise use this product or its components or materials made using this
product or its components for commercial purposes. The purchaser cannot use this product or its components in whole plants, plant cells or humans. The
purchaser may transfer information or materials made through the use of this product to a scientific collaborator, provided that such transfer is not for
the commercial purposes of the purchaser, and that such collaborator agrees in writing (a) not to transfer such materials to any third party, and (b) to use
such transferred materials and/or information solely for research and not for commercial purposes. Commercial purposes means any activity by a party for
consideration and may include, but is not limited to: (1) use of the product or its components in manufacturing; (2) use of the product or its components
to provide a service, information, or data; (3) use of the product or its components for therapeutic, diagnostic or prophylactic purposes; (4) use of the
product or its components to screen for agonists to the RheoSwitch ® system; or (5) resale of the product or its components, whether or not such product
or its components are resold for use in research. If the purchaser is not willing to accept the limitations of the limited use statement, NEB is willing to
accept return of the products with a full refund. For information on commercial use of this product or obtaining a license to this product for purposes other
than research, contact RheoGene, Inc. by calling Dr. Camille Jolly-Tornetta, Director of Intellectual Property (610-650-8734, ext. 104).
pNEBR-X1GLuc Gaussia Luciferase Control Plasmid
Non-Commercial entities: This product is covered by US Patent # 6,232,107 and other patents that are the legal property as assigned to Prolume
Ltd/NanoLight Technologies. This product is licensed only to the purchasing laboratory-research group. Recipient agrees not to transfer this plasmid or
derivatives of this vector to any other laboratory, person or research group, even if within the same institution.
Recipient agrees not to alter or make any changes to the nucleotide coding sequence or secretory coding sequence of the luciferases(s) contained within
without prior written permission from Prolume Ltd/NanoLight Technologies (www.nanolight.com). Recipient agrees not to file for any patent rights or to
any inventions claiming any portion of the luciferase(s) within this material without prior written permission from Prolume Ltd/NanoLight Technologies.
Commercial For-Profit Entities & Non Profit Foundations (herein referred to as Commercial Recipients): Commercial Recipients wishing to derive products,
engage in the sale or license of any products, discover drugs, or make inventions by use of the materials enclosed, fully agree to the terms mentioned
above for Non-Commercial entities; AND ADDITIONALLY agree to and are hereby bound to use the materials FOR EVALUATION PURPOSES ONLY. Commercial
Recipient hereby agrees to destroy and cease use of any materials or derivatives containing any portion of these materials within 180 days from
receipt. Commercial Recipient agrees not to use the materials for any use, other than the 180 day suitability evaluation without prior written permission or
obtaining a valid license from Prolume/NanoLight Technologies.
Any Recipient that does not accept the license terms mentioned above, shall return the unopened package and materials to NEB for a full refund.