2013 - University College Cork

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RESEARCH PROJECTS 76 Sustainable Bioresources and Green Technologies BEAUFORT MARINE BIODISCOVERY AWARD Research Centre/Department/School: ERI, Microbiology, Biomerit Research Centre Start Year: 2008 End Year: 2015 Funding Body: Marine Institute Researchers: Alan Dobson, Fergal O’Gara, Jonathan Kennedy, Marlies Mooij, Burkhardt Flemer, Stephen Jackson, Lekha Margassery, John Morrissey, Robert Phelan, Teresa Barbosa. Contact PIs: Alan Dobson (a.dobson@ucc.ie); Fergal O’Gara (f.ogara@ucc.ie) Collaborating Partners: NUIG, QUB Web: http://www.biodiscovery.ie This project is employing both culture dependent and metagenomicapproaches to study the microbial biodiversity of marine sponges. The microbial ecology of these sponges is being studied using modern molecular microbial ecology based approaches. Culture dependant approaches arebeingused to culture, and subsequently identify and characterise a variety of different bacteria and fungi from these sponges. The ability of these isolates to produce bioactive compounds with potential antimicrobial, antifungal and anti-biofouling activities is being assessed on an ongoing basis. A primary focus is on Actinomycetesas these are known to be a major source of natural products, including polyketides and nonribosomal peptides. Twenty candidate microorganisms which produce novel bioactivity have been identified to date and their genomes are currently being characterised at the molecular level to gain a better understanding of the biochemical pathways involved in the production of these compounds. Functional metagenomic based strategies are also be employed using novel prokaryotic expression systems, with metagenomic libraries being constructed and screened at high-throughput in a number of different microbial expression hosts including Gram negative Pseudomonas sp and Gram positive Streptomyces sp. to identify bioactive compounds with activity against pathogenic bacteria, fungi and yeast; and which perturb signal transduction pathways in these pathogens fromthe different marine associated microbial ecosystems. These functional screens are also targeting compounds/molecules which display antibiofilm and anti-biofouling activities. KEY PUBLICATIONS & OUTPUTS Selvin J., Kennedy, J., Lejon, D.P.H., Kiran, S. and Dobson, A.D.W. (2012). Isolation identification and biochemical characterization of a novel halo-tolerant lipase from the metagenome of the marine sponge Haliclonasimulans. Microbial Cell Factories 11:72. Phelan, R.W., O’ Halloran, J.A., Kennedy, J., Morrissey, J.P., Dobson, A.D.W., O’Gara, F., and Barbosa, T.M. (2012).Diversity and bioactive potential of endospore-forming bacteria cultured from the marine sponge Haliclonasimulans, isolated from Irish waters and their bioactive potential. J ApplMicrobiol. 112(1), 65-78.Jackson, S.A., Kennedy, J., Morrissey, J.P., O’Gara, F. and Dobson, A.D.W.(2012).Pyrosequencing reveals diverse and distinct sponge-specific microbial communities in sponges from a single geographical location in Irish waters. Microbial Ecology64,105-116.
Research Projects Listing PHARMASEA (INCREASING VALUE AND FLOW IN THE MARINE BIODISCOVERY PIPELINE) Research Centre/Department/School: ERI, Department of Microbiology, Biomerit Research Centre Start Year: 2012 End Year: 2016 Funding Body: FP7 Researchers: Alan Dobson, Fergal O’Gara, Jonathan Kennedy, Marlies Mooij, John Morrissey. Contact PIs: Alan Dobson (a.dobson@ucc.ie); Fergal O’Gara (f.ogara@ucc.ie) Collaborating Partners: A consortium of 23 European academic and industrial partners. The project focuses on obstacles in marine biodiscovery research, development and commercialization and brings together a broad interdisciplinary team of academic and industry researchers to address and overcome these. The partners aim to demonstrate how to widen the bottlenecks and increase the flow of ideas and products derived from the marine microbiome towards a greater number of successes in a larger number of application areas. Despite the tremendous potential of marine biodiscovery, exploitation, particularly at a commercial scale, has been hampered by a number of constraints. These relate to access (physical and legal), genetics of the organisms, compound isolation, structure elucidation, early reliable validation of biological activity and best mechanisms of flow-through into exploitation. PharmaSea will solve these chronic bottlenecks by developing essential actions beyond the state of the art and linking them with best practice and appropriate pragmatic approaches. The robust pipeline structure established within PharmaSea will process a wide genetic basis including marine microbial strain collections held by partners and new strain collections from extreme environments (deep, cold and hot vent habitats) to produce new products with desirable characteristics for development by the SME partners in three accessible market sectors, health (infection, inflammation, CNS diseases), personal care and nutrition. RESEARCH PROJECTS 77
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2013 - University College Cork

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