CURRICULUM VITAE Li Li, M.D., Ph.D. - Ochsner Academics

CURRICULUM VITAE
Li Li, M.D., Ph.D.
Office Address:
Director, Laboratory of Translational Cancer Research
Tom & Gayle Benson Cancer Center
Room 1N508
Ochsner Clinic Foundation
1516 Jefferson Highway
New Orleans, LA 70121
U.S.A.
Telephone: 504-842-2428
Fax: 504-842-3381
E-mail: lli@ochsner.org
Education and Training:
1990 Lübeck Medical University, Germany, Ph.D. in Molecular Immunology
1987 Shanghai Second Medical University, China, Master’s Degree in Immunology
1982 Shanghai Second Medical University, China, M.D. in Pediatrics
Fields of Specialization: I. Immunology
II. Molecular Biology
III. Cancer Biology
Current Research Interests:
(1). Identification of human FDC-signaling molecules that stimulate germinal center B cell and B
cell lymphoma cell growth; characterization of FDC-signaling molecules that regulate cancer
progression and their blocking agents.
(2). Identification of cancer stem cells of B cell lymphoma, colorectal, bladder, renal cell, and
esophageal cancers; their specific biomarkers.
(3). Elucidating the cancer-fostering microenvironment support for cancer stem cell in therapy
resistance and disease recurrence.
Research and Professional Experience:
01/12/present Director, Laboratory of Translational Cancer Research, Ochsner Clinic
Foundation, New Orleans, LA U. S. A.
6/09/ present Adjunct Assistant Professor, Louisiana State University Health Sciences Center,
New Orleans
2/03-present Staff Scientist, Hematology and Oncology Department, Ochsner Clinic
Foundation, New Orleans, LA
6/01-present Associate director, Laboratory of Cellular Immunology, Ochsner Clinic
Foundation, New Orleans, LA
4/92-6/01 Staff Scientist, Laboratory of Cellular Immunology, Alton Ochsner Medical
Foundation, New Orleans, LA
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4/90-4/92 Research Associate, Laboratory of Cellular Immunology, Alton Ochsner Medical
Foundation, New Orleans, LA
11/88-4/90 Postgraduate fellowship, Division of Molecular Immunology, Forschungsinstitut
Borstel, Borstel, FR Germany
6/88-11/88 Assistant Professor, Department of Immunology, Shanghai 2nd. Medical
University, Shanghai, PR China
12/82-6/88 Instructor, Department of Immunology, Shanghai 2nd. Medical University,
Shanghai, PR China
3/81-12/82 Intern, Xinhua Hospital, Shanghai 2nd. Medical University, Shanghai, PR China
Scientific Societies:
2003 American Society of Hematology
2002 Children's Oncology Group
2000 American Association for Cancer Research
1996 American Association of Immunologists
1986 Shanghai Immunological Society
Grants Awarded:
Title: Signaling Molecules Required for Follicular Lymphoma Generation in Vivo.
Agency: The Cancer Association of Greater New Orleans, a United way agency, New Orleans,
LA.
Role: PI
Dates: 2000 through 2001
Amounts of grant awards: $15,000.00
Title: Stromal Cell Molecules Required for Malignant-B Cell Tumor Generation in Vivo.
Role: PI
Agency: The Ladies Leukemia League, Metairie, LA.
Dates: 2001 through 2002
Amounts of grant awards: $30,000.00
Title: Stromal Cell Molecules Required for Lymphoma Generation.
Role: PI
Agency: The Department of Health and Human Services, Cancer Immunology Branch, NIH,
Bethesda, Maryland
Dates: 2001 through 2008
Amounts of grant awards: $1,155,880.00
Title: Identification of B Cell Lymphoma Stem Cells and their Microenvironmental Factors
Role: PI
Agency: The Ladies Leukemia League, Metairie, LA.
Dates: 2008 through 2009
Amounts of grant awards: $35,000.00
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Title: Understanding the microenvironment of cancer stem cells in esophageal
adenocarcinoma
Role: PI
Agency: The Ochsner Research, New Orleans, LA
Dates: 2012 through 2013
Amounts or grant awards: $114,149
OCI-CLL-01, Co PI: A trial that obtains, through one blood draw, chronic lymphocytic
leukemia and lymphoma cells to confirm that BAFF (B-cell activation factor) and related
proteins are found in multiple myeloma and B-cell chronic lymphoytic leukemia. The study is
intended to pave the way for treatments that may combat B-cell CLL by impeding the effect of
these proteins.
2003.113.A OCI- Pro00001108, Co PI: A study that collects lymphoma cells and grows the
cells in culture for the purpose of identifying molecules in these cells that contribute to their
development. The study is expected to be valuable in the development of drugs to inhibit the
growth and survival of lymphoma cells.
2009.037.A OCI- Pro00004172, Understanding the microenvironment of stem cells in colon
cancer. Co PI: A study that collects colon rectal cancer biopsy samples in order to identify colon
cancer stem cell biomarkers and the effects of lymph node stromal cells in cancer recurrence;
and collect clinical history of colon cancer patients in order to prospectively and retrospectively
analyze the correlation between cancer stem cell expression and disease outcomes for the
purpose of identifying molecules in these cells that contribute to their development. The study is
expected to be valuable in the development of drugs to inhibit the growth and survival of drug
resistant cancer cells.
2010.108.A OCI- Pro00005560, Colorectal cancer tumor markers and the relationship to
recurrence and outcomes. Co PI: A study that retrospectively look at biomarkers in tissue
samples for patients who have had pathologically stage 2 or 3 colorectal cancer and determine if
there is a correlation to 5 year recurrence rates and outcomes.
2011.043.C OCI- Pro00006486, Understanding the Microenvironment of Cancer Stem Cells in
Bladder Cancer, Co PI: A study that 1) To obtain bladder cancer biopsy samples including fresh
bladder resection specimens, endoscopic biopsies, paraffin embedded biopsy blocks and lymph
nodes from human subjects in order to identify bladder cancer stem cell biomarkers, and 2). To
obtain the clinical history of bladder cancer patients in order to prospectively and retrospectively
analyze the correlation between cancer stem cell marker expression and disease outcomes.
2011.222.A OCI- Pro00007524 Understanding the Microenvironment of Cancer Stem Cells in
Renal Cell Carcinoma. Co PI: A study that 1). to obtain RCC biopsy samples including fresh
kidney resection specimens, endoscopic biopsies, paraffin embedded biopsy blocks and lymph
nodes from human subjects in order to identify RCC stem cell biomarkers, and 2). to obtain the
clinical history of RCC patients in order to prospectively and retrospectively analyze the
correlation between cancer stem cell marker expression and disease outcomes.
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OCI- Pro00008001, Understanding the microenvironment of tumor initiating cells in esophageal
cancer. Co PI: A study that collects esophageal adenocarcinoma tumor tissue to characterize
cancer stem cell and its microenvironment.
Publication:
1. Silinsky, J., C. Grimes, T. Driscoll, H. Green, J. Cordova, N. Davis, L. Li, and D. Margolin.
CD133 + and CXCR4 + colon cancer cells as a marker for lymph node metastasis. Surgery 2012.
(submitted)
2. Lee, CG., B. Das, T. Lin, C. Grimes, X. Zhang, T. Lavezzi, L. Huang, J. Cole, L. Yau, and L. Li.
A rare fraction of drug-resistant follicular lymphoma initiating cells interact with follicular
dendritic cells to maintain tumorigenic potential. British Journal of Haematology 158:79. 2012
3. Margolin, DA., Slinsky, J., Spencer, N., Grimes, C., Acock, M., Green, H., Cordova, J., Davis,
NK., Driscoll, T., and Li, L. Lymph node stromal cells enhance drug resistant colon cancer cell
tumor formation via SDF-1α/CXCR4 paracrine signaling. Neoplasia 13:874, 2011.
4. Yoon SO, Zhang X, Freedman AS, Zahrieh, D, Lossos, IS, Li, L, and Choi, YS. Down-regulation
of CD9 expression and its correlation to tumor progression in B lymphomas. Am J Pathol
177:377 2010.
5. Zhang, X., C. S. Park, S. O. Yoon, L. Li, Y. M. Hsu, C. Ambrose, and Y. S. Choi. BAFF
supports human B cell differentiation in the lymphoid follicles through distinct receptors. Int
Immunol 17:779. 2005.
6. Prakash, O., R. Swamy, X. Peng, Z.-Y. Tang, L. Li, J.E. Larson, J. C. Cohen, J. Gill, G. Farr, S.
Wang, and F. Samaniego. Activation of Src kinase Lyn by the Kaposi sarcoma–associated
herpesvirus K1 protein: implications for lymphomagenesis. Blood 105:3987. 2005.
7. Li, L., S. O. Yoon, D. D. Fu, X. Zhang, and Y. S. Choi. Novel follicular dendritic cell molecule,
8D6, collaborates with CD44 in supporting lymphomagenesis by a Burkitt lymphoma cell line,
L3055. Blood 104:815. 2004.
8. Jung, J., Yi, A-K., Zhang, X., Choe, J., Li, L., Choi, Y.S. Distinct response of human B cell
subpopulations in recognition of an innate immune signal, CpG DNA. J. Immunol. 169:2368-
2373, 2002
9. Li, L., Choi, Y.S. Follicular dendritic cell-signaling molecules required for proliferation and
differentiation of GC-B cells. (Invited review) Seminar in Immunol. 14:259-266, 2002
10. Zhang, X., Li, L., Jung, J., Xiang, S, and Choi, Y.S. A distinct role of a novel follicular dendritic
cell-signaling molecule 8D6 in germinal center-B cell differentiation. J. Immunol. 167:49-56,
2001
11. Jung, J., Choe, J., Li, L., and Choi, Y.S. Regulation of CD27 expression in the course of germinal
center B cell differentiation: the pivotal role of IL-10. Eur. J. Immunol. 30:2437-2443, 2000
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12. Li, L., Zhang, X., Kovacic, S., Long, A.J., Bourque, K., Wood, C.R., and Choi, Y.S.
Identification of a human follicular dendritic cell molecule that stimulates germinal center B cell
growth. J. Exp. Med. 191:1077-1084, 2000
13. Choe, J., Li, L., Zhang, X., Gregory, C.D., and Choi, Y.S. Distinct role of follicular dendritic
cells and T cells in the proliferation, differentiation, and apoptosis of a centroblast cell line,
L3055. J. Immunol. 164:56-63, 2000
14. Li, L., Krajewski, S., Reed, J.C., and Choi, Y.S. Apoptosis and proliferation of SAC-activated B
cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell.
Immunol. 178:33-41, 1997
15. Klyushnenkova, E.K., Li, L., Armitage, R.J., and Choi, Y.S. CD48 delivers an accessory signal
for CD40-mediated activation of human B cells. Cell. Immunol. 174:90-98, 1996.
16. Zhang, X., Li, L., Choe, J., Krajewski, S., Reed, J.C., Thompson, C., and Choi, Y.S. Upregulation
of Bcl-XL expression protects CD40-activated human B cells from the Fas-mediated
apoptosis. Cell. Immunol. 173:149-154, 1996
17. Li, L., Young, D., Wolf, S.F., and Choi, Y.S. Interleukin-12 stimulates B cell growth by inducing
IFN-γ. Cell. Immunol. 168:133-140, 1995
18. Xia, X., Li, L., and Choi, Y.S. Human recombinant IL-3 is a growth factor for normal B cells. J.
Immunol. 148:491-497, 1992
19. Gerdes, J., Li, L., Schlüter, C., Duchrow, M., Wohlenberg, C., Gerlach, C., Stabmer, I., Kloth, S.,
Brandt, E., and Flad, H.-D. Immunobiochemical characterization and partial gene sequence of the
cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am. J
Pathol. 138:867, 1991
20. Li, L., Wang, W.C., Xie, Y.L., Ma, B.L., Zheng, P., and Fu, P.B. An application of immunogoldsilver
staining technique in diagnosing Thromboangiitis Obliterans. J. Chinese Surgery 1988
21. Li, L., Wang, W.C., and Ma, B.L. Colloid gold and its immunopathological application. Abroad
Medicine, Subvolume of Immunol. 1988
22. Li, L., Wang, W.C., Xie, Y.L., and Ma, B.L. The preparation of colloidal gold labelled
immunoglobulin and its preliminary immunohistochemistry application. J. Chinese Microbiol.
Immunol. 1988
23. Li, L., Wang, W.C., Xie, Y.L., Ma, B.L., Yang, H.T., and Zhang, P.L. An Application of
immunogold-silver staining technique in diagnosing Mixed Connective Tissue Disease. J.
Chinese Immunol. 4(2): 109, 1988
24. Lin, Q.D., Bian, J.F., Li, X.Y., Wu, Y.F., Hong, S.Y., Pan, J.R., Wang, W.C., Li, L., Xie, Y.L.,
Shen, X.L., and Ma, B.L. The changes of lymphocyte subpopulations in normal pregnancy and
pregnancy-induced hypertension syndrome. J. Chinese Immunol. 3(2): 86, 1987
25. Wang, W.C., Li, L., Huang, D.S., Ma, B.L., Tang, X.M., Chen, X.L., Shen, X.L., Xie, Y.L.,
Yang, H.T., Zhang, P.L., Wang, J.H., Wu, X.L., Chen, D.L., Gu, J.Z., Shen, Y.J., Liou, S.L., and
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Zhu, M. The immunopathological research of skin in patients with mixed connective tissue
disease. Chinese Med. 65(9): 513, 1985
26. Li, L., Wang, W.C. SPA and its pathological applications. World Med. 2(2): 105, 1984
Patents
Title: Monoclonal Antibodies that Suppress B-Cell Growth and/or Differentiation
Patent number: 6,743,898.
Issue date: June 1, 2004
Abstract:
1. Targeting colon cancer tumor initiating cells by Li Li. The World Congress on
Gastroenterology & Urology, Omaha, Nebraska. 2012
2. Transrectal injection of colon cancer cells in a murine model by Jennifer Silinsky, Li Li,
David Beck, Jaime Bohl, Terry Hicks, Allen Timmcke, Charles Whitlow, Heather Green,
Jose Cordova, Chelsea Grimes, and David Margolin. The 8th Ochsner Research Night.
2011
3. An in vivo model using patient specimens to evaluate the effect of LN stromal cells on
colorectal cancer by Chelsea Grimes, Jennifer Silinsky, Nakia Spencer, Tiffany Driscoll,
Heather Green, Jose Cordova, David A. Margolin, Nancy K Davis, and Li Li. The 8th
Ochsner Research Night. 2011
4. CD133 as a marker for lymph node metastasis by Jennifer Silinsky, Li Li, David Beck,
Jaime Bohl, Terry Hicks, Allen Timmcke, Charles Whitlow, Heather Green, Jose
Cordova, Chelsea Grimes, Tiffany Driscoll, and David Margolin—This abstract win the
first place of the Residents' Research Award contest, sponsored by the Ochsner Alumni
Association. The 8th Ochsner Research Night. 2011
5. Host bone marrow cells participate in tumor vessel formation that supports colon cancer
cell growth by Xin Zhang, Chelsea Grimes, Nakia Spencer, and Li Li. The 8th Ochsner
Research Night. 2011
6. Zhao, D., Acock, M., Spencer, N., Zhang, X., Green, H., Margolin, D., Davis, N., and Li,
L. Lymph Node Stromal Cells Enhance Tumor Formation of Colon Cancer Stem Cells
Isolated from Patient Specimen. The 7th Ochsner Research Night. 2010
7. Lee, IY., Zhang, X., Acock, M., Yoon, SO., and Li, L. Tumor Microenvironment Models
using Enhanced Green Fluorescent Protein (eGFP) Expressing Immunodeficient Mice.
The 7th Ochsner Research Night. 2010
8. Lee, CG., Lee, IY., Li, L. Interaction of Breast Cancer with Follicular Dendritic Cells
Induces the Metastasis to Distant Organs. The 7th Ochsner Research Night. 2010
9. Lavezzi, T., Regn, R., Lee, CG., and Li, L. Follicular dendritic cells support lymophoma
stem cells by producing SDF-1. The 6th Ochsner Research Night. The Ochsner Journal 9
(2):92, 2009
10. Regn, R., Lavezzi, T., and Li, L. Colon cancer stem cells and their microenvironment.
The 6th Ochsner Research Night. The Ochsner Journal 9 (2):92, 2009
11. Lee, CG., Lavezzi, T., Lee, IY., and Li, L. Role of Follicular Dendritic Cells in Breast
Cancer Metastasis by The 6th Ochsner Research Night. The Ochsner Journal 9 (2):91,
2009
12. Velcheti, V., Tamma, S., Larned, ZL, Fuloria, J., Li, L., Rodwig, FR., Cole, JT., Prakash,
O. Protein Kinase C-epsilon: a Potential Therapeutoc Target in the Treatment of B-Cell
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Chronic Lymphocytic Leukemia (B-CLL). The 6th Ochsner Research Night. The
Ochsner Journal 9 (2):90, 2009
13. Lavezzi, T., Zhang, X., Lee, CG., Huang, L., and Li, L. B Cell Lymphoma Stem Cells.
The 5th Ochsner Research Night. The Ochsner Journal 8(2):83, 2008
14. Aiken, ML., Yoon, SO., Lee, CG., Zhang, X., Kim, JR., Li, L. Whole Body Imaging as a
Tool for Cancer Research The 5th Ochsner Research Night. The Ochsner Journal
8(2):79, 2008
15. Lee, CG., Kim, JR., Aiken, M., Li, L. Lymph Node Follicular Dendritic Cells and their
Signaling Molecules for Breast Cancer Cell Growth. The 5th Ochsner Research Night.
The Ochsner Journal 8(2):84, 2008
16. Prakash, O., Rodwig, FR., Cole, JT., Li, L. LYN Kinase is an Important Component of
the Signal Ttansduction Pathway in the Apoptotic Resistance of B-Chronic Lymphocytic
Leukemia (CLL) Cells. The 5th Ochsner Research Night. The Ochsner Journal 8(2):84,
2008.
17. Li, L. Identification of cancer stem cell for B cell lymphoma. Keystone Symposium: Stem
cells and cancer. Keystone, Colorado, 2007
18. Wilkinson, B. Berner, P., Li, L. Identification of cancer stem cell for B cell lymphoma.
The 4th Ochsner Research Night. The Ochsner Journal 7(2):90, 2007
19. Lee, CG., Yoon, SO., Li, L., Choi, YS. Follicular Dendritic Cells Support Breast
Carcinoma Tumor Formation in Xenograft Models. The 4th Ochsner Research Night. The
Ochsner Journal 7(2):90, 2007
20. Prakash, O., Swamy, OR., Gill, J., Li, L. Protein kinase C-ε: a potential target in the
treatment of B cell chronic lymphocytic leukemia (B-CLL). The 4th Ochsner Research
Night. The Ochsner Journal 7(2):93, 2007
21. Fu, DD., Svatos, N., and Li, L. Identification of tumor stem cells for B cell lymphoma.
The 3rd Ochsner Research Night 2006
22. Yoon, SO., Li, L., and Choi, YS. Comparison of gene expression profiles between FDCdependent
and FDC-independent lymphoma cells. The 3rd Ochsner Research Night 2006
23. Prakash, O., Swamy, OR., Peng, X., Fu, DD., Gill, J., Li, L. Protein kinase C-epsilon
activation by the Kaposi sarcoma-associated herpesvirus K1 protein: implications for
lymphomagenesis. The 3rd Ochsner Research Night 2006
24. Li, L. Novel follicular dendritic cell molecule, 8D6, collaborates with CD44 in
supporting lymphomagenesis by a Burkitt lymphoma cell line, L3055. Keystone—the
Role of Microenvironment in Tumor Induction and Progression. Banff, Canada, 2005
25. Wright, B., Yoon, SO., and Li, L. FDC induces neovascularization in early B cell
lymphomagenesis. The 2nd Ochsner Research Night 2005
26. Svatos, N., Fu, DD., and Li, L. Identification of cancer stem cells for lymphomagenesis.
The 2nd Ochsner Research Night 2005
27. Fu, DD., Zhang, X., and Li, L. Preparation and characterization of new monoclonal
antibodies against CD320. The 2nd Ochsner Research Night 2005
28. Park, CS., Li, L., and Choi, YS. How do follicular dendritic cells interact intimately with
B cells in the germinal center? The 2nd Ochsner Research Night 2005
29. Li, L., A novel follicular dendritic cell molecule, 8D6 collaborates with CD44 in
supporting lymphomagenesis by a Burkitt lymphoma cell line L3055. The 1st Ochsner
Research Night 2004
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30. Fu, DD., and Li, L. Effective gene transfer into human follicular dendritic cell-like cell
line, HK, using the AMAXA Nucleofector. The 1st Ochsner Research Night 2004
31. Yoon, SO., Choi, YS., and Li, L. IL-15 and BAFF, FDC derived factors, support Burkitt
lymphoma L3055 cell proliferation in a synergistic manner. The 1st Ochsner Research
Night 2004
32. Li, L., Yoon, S.-OK., Fu, D.D., Choi, Y.S. A novel FDC-signaling molecule-8D6
collaborates with CD44 in supporting lymphomagenesis by a Burkett's lymphoma cell
line L3055. AACR 2003
33. Li, L. The functional role of BAFF/APRIL in survival and proliferation of follicular
lymphoma cell line L3055. NCI Hematologic Malignancies and the Marrow
Microenvironment Workshop 2002
34. Zhang, X., Li, L., Jung, J., and Choi, Y.S. Distinct functions of FDC-signaling molecules
in germinal center B cell differentiation. Experimental Biology 2002
35. Li, L., Zhang, X., Choe, J., and Choi, Y.S. Human B cell Differentiation in Germinal
Center. Immunology Symposium 2001: Autoimmune Diseases, Shanghai, China, 2001
36. Li, L., Werth, D., and Choi, Y.S. Follicular Dendritic Cell-Signaling Molecules Required
for B Cell Lymphomagenesis. The 11 th International Congress of Immunology,
Stockholm, Sweden, 2001
37. Li, L., Zhang, X., Kovacic, S., Long, A.J., Bourque, K., Wood, C.R., and Choi, Y.S.
Identification of a human follicular dendritic cell molecule that stimulates germinal
center B cell growth. The 7 th Workshop and Conference on Human Leucocyte
Differentiation Antigens. Harrogate, UK, 2000
38. Li, L., Zhang, X., Kovacic, S., Long, A.J., Bourque, K., Wood, C.R. and Choi, Y.S. A
novel signaling molecule of follicular dendritic cells for B cell differentiation. The 64 th
Symposium: Signaling & Gene Expression in the Immune System. Cold Spring Harbor,
New York, 1999
39. Li, L., Choe, J., and Choi, Y. S. CD40 ligand and IL-4 are the determining factors for the
differentiation of centroblast cell line L3055. FASEB, Washington, D.C. 1999
40. Li, L., Lee, B.-S., Long, A., Wood, C., and Choi, Y. S. Galectin-3 expressed by a human
FDC cell line, HK, stimulates the proliferation of B cells. FASEB, San Francisco, CA,
1998
41. Li, L., and Choi, Y. S. The growth arrest/apoptosis and proliferation of SAC activated B
cells by IL-10 is regulated through Bcl-xL expression. Keystone, Steamboat Springs,
Colorado 1997
42. Li, L., Zhang, X., and Choi, Y. S. Interleukin 10 induce SAC activated B cells undergo
apoptosis through down-regulation of Bcl-xL expression. FASEB A1066, New Orleans,
Louisiana 1996.
43. Choe, J., Kim, H.-S., Li, L., Zhang, X., and Choi, Y. S. Anti-Ig protects CD40Lstimulated
B cells from Fas-mediated apoptosis and favors the generation of memory B
cells. FASEB A1209, New Orleans, LA 1996
44. Li, L., and Choi, Y.S. Biochemical and functional characterization of a novel human B
cell growth factor. The 9 th International Congrass of Immunology. 1995
45. Klyushnenkova, E.N., Li, L., Olivier, M.M., and Choi, Y.S. Development and initial
characterization of monoclonal antibodies that inhibited T cell-induced proliferation of B
cells. FASEB 8:A1015, Anaheim, CA 1994
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46. Li, L., Xia, X., and Choi, Y.S. Interleukin 10 in human B cell differentiation. FASEB
8:A256, Anaheim, CA 1994
47. Li, L., Clark, S.C., Young, D., and Choi, Y.S. Recombinant human natural killer cell
stimulatory factor stimulates B cell growth by inducing IFN-γ in B cells. J. Cell. Biochem.
suppplement 17B:F425, 1993
48. Li, L., Young, D., Wolf, S. F., and Choi, Y. S. Recombinant human natural killer cell
stimulatory factor stimulates B cell growth by inducing IFN-γ in B cells. UCLA Meeting,
Taos, New Mexico 1993
49. Choi, Y. S., Xia, X., and Li, L. Novel human B cell growth factors: IL-3 and NKSF. The
8 th International Congress of Immunology, Budapest, Hungary 1992
50. Lee, J. H., Li, L., and Choi, Y. S. Plasma membranes from TPA activated human T cells
activate resting B cells. FASEB 6:1124, Anaheim, CA 1992
51. Li, L., Clark, S.C., Young, D., and Choi, Y.S. Recombinant human natural killer cell
stimulating factor is a B cell growth factor. FASEB 5:4174, Atlanta, Georgia 1991
52. Li, S.G., Li, L., and Choi, Y.S.: Characterization of lymphocyte activation inhibitory
factor. FASEB 5:1485, Atlanta, Georgia 1991
53. Xia, X., Li, L., and Choi, Y.S. Human recombinant IL-3 stimulates normal B cell growth
but not differentiation. FASEB 5:3570, Atlanta, Georgia 1991
54. Gerdes, J., Li, L., Gerlach, C., Stahmer, I., Kloth, S., Brandt, E., and Flad, H.-D. Ki-67
antigen I: immunobiochemical characterization. The 10 th Meeting of European Federation
of Immunological Societies, Edinburgh, 1990
55. Duchrow, M., Li, L., Schlüter, C., Stahmer, I., Gerlach, C., Flad, H.-D., and Gerdes, J.
Ki-67 antigen III: production of recombinant Ki-67 antigen material. The 10 th Meeting of
European Federation of Immunological Societies, Edinburgh, 1990
56. Li, L., Wang, W.C., Xie, Y.L., Ma, B.L., Zheng, P., and Fu, P.B. The preliminary
application of immunogold-silver staining technique in diagnosis of thromboangiitis
obliterans. The 7 th International Congress of Immunology. Berlin, Germany, 1989
57. Li, L., Wang, W.C., Xie, Y.L., Ma, B.L., Yang, H.T., and Zhang, P.L. A preliminary
application of immunogold-silver staining technique in diagnosing of mixed connective
tissue disease. Frühjahrstagung der Gesellschaft für Immunologie. Germany, 1989
58. Li, L., Wang, W.C., Xie, Y.L., Ma, B.L., Zheng, P., and Fu, P.B. The immunohistochemistry
research of TAO. Immunology Fast Newspaper 7(4): 10, 1987
Invited Speaker:
1. World Congress on Gastroenterology & Urology, Omaha, Nebraska: Targeting colon
cancer tumor initiating cells. 3/12-14, 2012
2. Ochsner Quarterly Research Forum at Ochsner Clinic Foundation: Colon Cancer Stem
Cell Microenvironment. June 2011
3. Louisiana Cancer Research Consortium retreat 2011at LCRC: Colon cancer stem cell
microenvironment. March 2011
4. Ochsner Basic Science in Clinical Medicine Lecture Series at Ochsner Clinic Foundation:
Lymphoma Stem Cells. Mar. 2009
5. Louisiana Cancer Research Consortium Speaker Series at Louisiana State University: B
Cell Lymphoma Stem Cells. Feb. 2009
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6. Seminar at the Bao Gang Hospital, Shanghai Second Medical University, Shanghai,
China: A Novel Follicular Dendritic Cell-Signaling Molecule, 8D6 is Essential for
Lymphomagenesis by a Burkitt Lymphoma Cell Line L3055. Aug. 2004
7. The 2004 Reunion Conference of Shanghai Institute of Immunology Overseas Alumni at
Shanghai Institute of Immunology, Shanghai, China: A Novel Follicular Dendritic Cell-
Signaling Molecule, 8D6 is Essential for Lymphomagenesis by a Burkitt Lymphoma Cell
Line L3055. Jul. 2004
8. Seminar at Section of Hematology and Medical Oncology in Tulane Medical School:
Human B Cell Differentiation and Lymphomagenesis. March 2003
9. Seminar at the Cancer Center of Tulane University: Human B Cell Differentiation and
Lymphomagenesis. Dec. 2002
10. Basic Science Research Seminar in Research Division at Ochsner: Human B Cell
Differentiation and Lymphomagenesis. Oct. 2002
11. The NCI Hematologic Malignancies and the Marrow Microenvironment Workshop: The
functional role of BAFF/APRIL in survival and proliferation of B cell lymphoma cell line
L3055. Sept. 2002
12. Immunology Symposium 2001 - Autoimmune Diseases, Shanghai, China: Human B Cell
Differentiation in Germinal Center. Nov. 2001
13. Seminar at Department of Molecular Immunology, Forschungszentrum Borstel, Borstel,
Germany: Follicular dendritic cell-signaling molecules required for human B cell
lymphomagenesis. July 2001
14. The 11 th International Congress of Immunology - Stockholm, Sweden: Follicular
dendritic cell-signaling molecules required for human B cell lymphomagenesis. July
2001
15. Seminar at Department of Molecular Immunology, Forschungszentrum Borstel, Borstel,
Germany: Identification of a human follicular dendritic cell molecule that stimulates
germinal center B cell growth. June 2000
16. The 7 th Workshop and Conference on Human Leukocyte Differentiation Antigen -
Harrogate, UK: Identification of a human follicular dendritic cell molecule that stimulates
germinal center B cell growth. Jun. 2000
17. Keystone Symposia on Molecular & Cellular Biology: Recombinant human natural killer
cell stimulatory factor stimulates B cell growth by inducing IFN-γ in B cells. Feb.1993
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