EUCAST Expert Rules in Antimicrobial Susceptibility Testing - eibne.gr

spp. mg/L for Bacteroides spp. but
susceptible to clindamycin, THEN
report resistant to clindamycin.
11.5 Staphylococcus spp. Clindamycin
Quinupristindalfopristin
IF resistant to clindamycin, THEN
report a warning that bactericidal
activity of quinupristin-dalfopristin is
reduced.
spp. is generally due to the production of
a ribosomal Erm methylase conferring the
MLSB phenotype. In the case of inducible
MLSB resistance, resistance to
clindamycin is poorly expressed in vitro
and this agent should not be considered
as active.
Resistance to clindamycin (associated
with resistance to erythromycin) is a
marker of the constitutive macrolidelincosamide-streptogramin
B (MLSB)
resistance phenotype. Cross resistance
to the streptogramin B-type factor leads
to diminished bactericidal activity of the
combination of quinupristin and
dalfopristin. Experimental models of
staphylococcal endocarditis lead to
conflicting results on the in vivo activity of
quinupristin-dalfopristin for the treatment
of animals infected with constitutive MLSB
resistant isolates.
C [61,62,110]