Bo Lu - Caltech Micromachining Laboratory - California Institute of ...

BO LU
1200 E. California Blvd, MC 136-93, Pasadena, CA 91125, USA
Phone: +1-626-802-0898, Email: lubo@mems.caltech.edu, lubomems@gmail.com
AREAS OF INTEREST
� General MEMS, sensors and actuators, microfabrication, nanotechnology and microelectronic packaging
� BioMEMS, biomedical microdevices, implantable devices and medical microsystems
� Microfluidics and lab-on-a-chip
� Life science and cell & tissue applications
� Modeling and simulation
� Material studies and characterizations
CURRENT EMPLOYMENT
� Present: R&D Scientist at Berkeley Lights, Inc. (Supervisor: Dr. Ming C. Wu, Professor of EECS at UC Berkeley)
EDUCATION
o Responsibility: Develop the new generation of phototransistor-based optoelectronic tweezers
� 2007-2012: Ph.D. in Electrical Engineering, California Institute of Technology, USA (Advisor: Dr. Yu-Chong Tai)
� 2003-2007: B.S. in Microelectronics, Peking University, China (Advisor: Dr. Guizhen Yan)
ACADEMIC ACTIVITY
� Reviewers for “Journal of Microelectromechanical Systems”, “Journal of Micromechanics and Microengineering”,
“IOP Nanotechnology”, “Sensors” and “Computer Methods in Biomechanics and Biomedical Engineering”
RESEARCH EXPERIENCE
Biomedical microdevices for the therapy of age-related macular degeneration (AMD) (2010-2012)
� Create the first parylene-C based microdevice as an artificial Bruch’s membrane for the AMD therapy
� Create the first parylene/SU-8 microfluidic implantation tool to facilitate the surgical process
Microfiltration devices for the detection of circulating tumor cells (CTC) for early cancer diagnosis (2008-2012)
� Create various parylene-C based membrane filtration devices with high performance
� Develop the assays of immunefluorescence detection and telomerase activity detection of CTCs
� Develop the first theory of time-related cancer cell membrane damage under mechanical tension during filtration
Parylene-based superhydrophobic films (2010-2011)
� Design and fabricate the first parylene based superhydrophobic thin films for surface microfluidics applications
� The first characterizations of parylene surfaces under various plasma treatments by AFM and SEM
Characterization of thin parylene film (2008-2012)
� The first study of the autofluorescence and optical properties of parylene-C, -D, -N, -HT and -AM
� The first measurement of the permeability of submicron parylene-C
� Study of the mechanical properties of submicron parylene-C film using the Dynamic Mechanical Analysis
Study of various micromachined gyroscopes (2006-2007)
� Contribute to the design and fabrication of several micro-gyroscopes
� Create a new modeling and simulation method to evaluate the performance of micro-gyroscopes under
fabrication imperfections using ANSYS and SIMULINK
� Design a circuit to demodulate the driving and sensing signals during gyroscope operation

PATENTS
1. Y.C. Tai, M.S. Humayun and B. Lu, “A 3D parylene scaffold cage for culturing retinal pigment epithelial cells”
2. Y.C. Tai and B. Lu, “Methods and design of membrane filters”
3. Y.C. Tai and B. Lu, “Ultrathin parylene-C membranes for biomedical applications”
4. A. Goldkorn, Y.C. Tai, T. Xu and B. Lu, “Method for cancer detection, diagnosis and prognosis”
5. S. Zheng, R. Cote, H. Lin, B. Lu and Y.C. Tai, “Method and apparatus for microfiltration to perform cell separation”
SELECTED PUBLICATIONS
Conference
Journal
1. B. Lu, D. Zhu, D. Hinton, M.S. Humayun and Y.C. Tai, “A 3D parylene scaffold cage for culturing retinal pigment
epithelial cells”, Proc. of MEMS 2012, Paris, France, 2012, pp. 741-744.
2. B. Lu, Z. Liu, L. Liu, D. Zhu, D. Hinton, B. Thomas, M.S. Humayun and Y.C. Tai, “Semipermeable parylene
membrane as an artificial Bruch's membrane”, Proc. of Transducers 2011, Beijing, China, 2011, pp. 950-953.
3. B. Lu, J.H.C. Chang and Y.C. Tai, “Time-dependent cell membrane damage under mechanical tension:
experiments and modeling”, Proc. of Transducers 2011, Beijing, China, 2011, pp. 446-449.
4. B. Lu, Z. Liu and Y.C. Tai, “Ultrathin parylene-C semipermeable membranes for biomedical applications”, Proc. of
MEMS 2011, Cancun, Mexico, 2011, pp. 505-508.
5. B. Lu, J.C.H. Lin, Z. Liu, Y.K. Lee and Y.C. Tai, “Highly flexible, transparent and patternable parylene-C
superhydrophobic films with high and low adhesion”, Proc. of MEMS 2011, Cancun, Mexico, 2011, pp.
1143-1146.
6. B. Lu, T. Xu, A. Goldkorn and Y.C. Tai, “The capture and 3-D culture of viable circulating tumor cells using high
open-factor parylene-C/HT membrane filters”, Proc. of Hilton Head 2010, Hilton Head Island, SC, USA, 2010, pp.
439-442
7. B. Lu, T. Xu, S. Zheng, A. Goldkorn and Y.C. Tai, “Parylene membrane slot filter for the capture, analysis and
culture of viable circulating tumor cells”, Proc. of MEMS 2010, Hong Kong, China, 2010, pp. 935-938.
8. B. Lu, S. Zheng, S. Xie and Y.C. Tai, “Live capture of circulating tumor cells from human blood by a splitable 3D
parylene membrane filtration device”, Proc. of µTAS 2009, Jeju, Korea, 2009, pp. 588-590.
9. B. Lu, S. Zheng and Y.C. Tai, "Parylene background fluorescence for BioMEMS applications", Proc. of
Transducers 2009, Denver, CO, USA, 2009, pp. 176-179.
1. B. Lu, D. Zhu, D. Hinton, M.S. Humayun and Y.C. Tai, “Mesh-supported submicron parylene-C membranes for
culturing retinal pigment epithelial cells”, Biomedical Microdevices, DOI: 10.1007/s10544-012-9645-8, 2012.
2. B. Lu*, T. Xu*, Y.C. Tai and A. Goldkorn, “A cancer detection platform which measures telomerase activity from
live circulating tumor cells captured on a microfilter”, Cancer Research, vol. 70, pp. 6420-6426, 2010. (*equal first
authors)
3. B. Lu, S. Zheng, B. Q. Quach and Y. C. Tai, “A study of the autofluorescence of parylene materials for microTAS
applications”, Lab on a Chip, vol. 10, pp. 1826-1834, 2010.
4. B. Lv*, X. Liu, Z. Yang and G. Yan, “Simulation of a novel lateral axis micromachined gyroscope in the presence of
fabrication imperfections”, Microsystem Technologies, vol. 14, pp. 711-718, 2008. (*Lu can also be spelt as Lv)
5. B. Lu, X. Liu, J. Cui, Z. Yang and G. Yan, “A method of simulating the decoupling property of lateral axis micro
gyroscope using finite element tool”, Chinese Journal of Sensors and Actuators, vol. 21, pp. 255-257, 2008.