Prof. Dr. Ralf Bartenschlager Department of Molecular ... - hbigs

Prof. Dr. Ralf Bartenschlager
05/29/1958, Mannheim
CURRICULUM VITAE
Department of Molecular Virology
University of Heidelberg
69120 Heidelberg, Germany
Phone: +49-(0)6221-564569
Fax: +49-(0)6221-5654570
E-mail: Ralf_Bartenschlager@med.uni-heidelberg.de
2002 - present Full professor and head of department of Molecular Virology, University of
Heidelberg
2001 Full professor for Molecular Virology, University of Mainz
1999 Habilitation, University of Mainz
1994 - 1998 Assistant, University of Mainz
1992 - 1993 PostDoc, Central Research Unit, Hoffmann-La Roche AG, Basel
1991 PostDoc, Center for Molecular Biology, Heidelberg
1990 PhD in Molecular Biology
1981-87 Studies in Biology (Heidelberg)
COORDINATING FUNCTIONS
2006 – present Coordinator of the Forschungsschwerpunkt ‚Infection strategies of human
pathogenic viruses’ (Landesstiftung Baden-Württemberg)
2005 – present Project coordinator ‘basic research’ in the BMBF-funded network ‘HepNet’
2005 – present Member of steering committee of EU research network ‘Dengue virus
control’
2002 – present Member of steering committee of EU network of excellence ‘virgil: antiviral
drug resistance’
FIELDS OF INTEREST
Virus-host cell interaction, mechanism of host cell infection, live cell imaging and electron
microscopy, virus assembly and involved host cell factors, RNA replication, proteases and
polymerases, RNA structures, mathematical modelling of virus replication, transcriptome
analysis of virus-induced host cell genes, innate immunity, interferon response and viral
counter measures, antiviral therapy and therapy resistance
CURRENTLY FUNDED PROJECTS
SFB 638, Teilprojekt A5; BMBF project on hepatitis C virus and innate immunity; 3 EU
projects on hepatitis C virus and Dengue virus; Marie Curie Fellowship program EI-HCV;
Landesstiftung Baden-Württemberg (2 projects), Bristol-Myers-Squibb Foundation; PhD
graduate program (2 positions) ; industry support.

PUBLICATIONS (10 most important publications):
Pietschmann T, A. Kaul, G. Koutsoudakis, A. Shavinskaya, S. Kallis, E. Steinmann, K. Abid,
F. Negro, M. Dreux F.L. Cosset, and R. Bartenschlager. (2006). Construction and
characterization of infectious intragenotypic and intergenotypic hepatitis C virus
chimeras. Proc Natl Acad Sci U S A. 103:7408-7413.
Miller, S., S. Sparacio, and R. Bartenschlager. (2006). Subcellular localization and
membrane topology of the Dengue virus type 2 non-structural protein 4B. J. Biol.
Chem., 281:8854-63.
Wakita, T.*, T. Pietschmann*, T. Kato, T. Date, M. Miyamoto, Z. Zhao, K. Murthy, A.
Habermann, H.-G. Kräusslich, M. Mizokami, R. Bartenschlager*, and T.J. Liang.
(2005) Production of infectious hepatitis C virus in tissue culture from a cloned viral
genome. Nat. Med., 11:905. * equal contribution.
Meylan, E., J. Curran, K. Hofmann, D. Moradpour, M. Binder, R. Bartenschlager, and J.
Tschopp. (2005). Cardif is a novel adaptor protein in RIG-I mediated antiviral
responses targeted by hepatitis C virus. Nature, 437:1167-1172.
Lohmann, V., S. Hoffmann, U. Herian, F. Penin, and R. Bartenschlager. (2003) Viral and
cellular determinants of hepatitis C virus RNA replication in cell culture. J. Virol.
77:3007-3019.
Frese, M., V. Schwärzle, K. Barth, N. Krieger, V. Lohmann, S. Mihm, O. Haller and R.
Bartenschlager. (2002) Interferon-gamma inhibits replication of subgenomic and
genomic hepatitis C virus RNAs. Hepatology, 35:694-703.
Moradpour, D., E. Bieck, T. Hügle, W. Wels, J. Z. Wu, Z. Hong, H. E. Blum and R.
Bartenschlager. (2002) Functional properties of a monoclonal antibody inhibiting the
hepatitis C virus RNA-dependent RNA polymerase. J. Biol. Chem., 277:593-601.
Bukh, J., T. Pietschmann, V. Lohmann, N. Krieger, K. Faulk, R.E. Engle, S. Govindarajan, M.
Shapiro, M. St. Claire and R. Bartenschlager. (2002) Mutations that permit efficient
replication of hepatitis C virus replicons in Huh-7 cells prevent productive replication
of the full length genome in chimpanzees. Proc. Natl. Acad. Sci. USA, 99:14416-
14421.
Lohmann, V., F. Körner, J.O. Koch, U. Herian, L. Theilmann and R. Bartenschlager. (1999).
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science,
285:110-113.
R. Bartenschlager, and H. Schaller. (1992). Hepadnaviral assembly is initiated by
polymerase binding to the encapsidation signal in the viral RNA genome. EMBO J
11:3413-3420.

EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Coordinator of doctoral study program of the Hygiene Institut
Coordinator of the new Major ‘Infectious Diseases’ as part of the new Master program
‘Molecular Biosciences’
Member of numerous thesis and thesis advisory committees
International reviewer of doctoral theses
Currently direct supervision of 10 doctoral theses
SUPERVISED DISSERTATIONS (last 5 years)
Marc Windisch, PhD (2007) “Etablierung und Charakterisierung von Hepatitis C Virus-
Replikonzelllinien“, University of Heidelberg
Current occupation: Postdoctoral fellow, University of Heidelberg.
Sven Miller, PhD (2006) “Untersuchungen zur Topologie, Funktion und Lokalisation der
Proteine NS4A und NS4B des Dengue-Virus”, University of Heidelberg
Current occupation: Postdoctoral fellow, University of Heidelberg.
Georgios Koutsoudakis, PhD (2006) “Studies of the Early Steps of Hepatitis C Virus
Replication Cycle”, University of Heidelberg
Current occupation: Postdoctoral fellow, University of Heidelberg.
Peter Friebe, PhD (2004) „RNA-Strukturen im Hepatitis C Virus und ihre Bedeutung für
Translation und Replikation”, University of Heidelberg
Current occupation: Postdoctoral fellow, University of Heidelberg.
Nicole Appel, PhD (2004) “Structural and Functional Analysis of the Hepatitis C Virus Non-
Structuralprotein 5A”, University of Heidelberg
Current occupation: Part time consultant, University of Heidelberg.
Jan Krönke, MD (2003) “Inhibition der Replikation des Hepatitis C Virus durch RNA
Interferenz“, University of Heidelberg
Current occupation: medical doctor, unknown place