Career Development Symposium - American Neurological Association
Career Development Symposium - American Neurological Association
Career Development Symposium - American Neurological Association
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Category-Related Deficits in TLE<br />
� Our work has shown that presurgical temporal<br />
lobe epilepsy (TLE) patients often exhibit<br />
category-related deficits involving either<br />
naming or recognition.<br />
� TLE patients with a language dominant<br />
seizure focus often exhibit at least mild<br />
category-related naming deficits (for famous<br />
faces, landmarks, and animals).<br />
� TLE patients with a nondominant seizure<br />
focus often exhibit at least mild categoryrelated<br />
recognition deficits (same<br />
categories).<br />
(See articles by Drane and colleagues in Neuropsychologia, 2008<br />
&Cortex, 2009. Also some abstracts)<br />
Category-Related Deficits in TLE<br />
� Many of these TLE patients decline<br />
significantly on these tasks post-surgically.<br />
� Post-surgical TLE patients frequently exhibit<br />
moderate or greater deficits on these measures<br />
in accordance with the previously p y specified p<br />
pattern. .<br />
� Post-operative decline appears to be mediated<br />
by disease-related factors.<br />
○ Age of Onset<br />
○ Extent of Damage (e.g., mesial temporal<br />
sclerosis vs. normal vs. more widespread<br />
damage visualized on MRI)<br />
Famous Faces Naming and Object<br />
Recognition Subtest<br />
9/6/2011<br />
50<br />
4
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