Foundational Protocol for Autism and Chronic Illness - Klinghardt ...

• "Addi'onally, brain changes of various types have been
documented to exist during postnatal period, including increasing
brain volume, persistent immune ac'va'on, and diminu'on of cell
size, with the laFer two con'nuing substan'ally into the lifespan.
• The mitochondrial dysfunc'on and altered redox signal
transduc'on pathways found in au'sm would conspire to ac'vate
both astroglia and microglia. These ac'vated cells can then ini'ate
a broad-­‐spectrum proinflammatory gene response. Beyond the
direct effects of ROS on neuronal func'on, receptors on neurons
that bind the inflammatory mediators may serve to inhibit
neuronal signaling to protect them from excitotoxic damage during
various pathologic insults (e.g., infec'on). In au'sm, over-­‐zealous
neuroinflammatory responses could not only influence neural
developmental processes, but may more significantly impair neural
signaling involved in cogni'on in an ongoing fashion. This model
makes specific predic'ons in pa'ents and experimental animal
models and suggests a number of targets sites of interven'on. Our
model of poten'ally reversible pathophysiological mechanisms in
au'sm mo'vates our hope that effec've therapies may soon
appear on the horizon.
Saturday, 11 September 2010