CV d'Alfio Marazzi (pdf) - IUMSP

Surname Marazzi
First names Alfio Natale
CURRICULUM VITAE
Professional Address University of Lausanne
Institut universitaire de médecine sociale et préventive (IUMSP)
Rue du Bugnon 17
1005 Lausanne
Switzerland
Tel. (021) 314 72 60
Present position Associate professor of statistics and medical informatics
Head of the Statistics Unit, IUMSP
Education
1963 – 1966: Liceo cantonale, Lugano
1966 – 1971: Eidgenössische Technische Hochschule (Swiss Federal Institute of Technology)
Zürich, mathematics and physics
Degrees
- Matriculation (scientific), Liceo cantonale, Lugano (1966)
- Degree in mathematics, ETH Zürich (1971)
- PhD in mathematics, ETH Zürich (1976)
- Title of “Privat-docent”, University of Lausanne (1985)
- Associate professor, University of Lausanne (1992)
Professional career
1972 – 1976
Assistant to Prof. P.J. Huber, Chair of Statistics, ETH-Zürich.
PhD under Prof. H. Bühlmann. Subject of thesis: Minimax Credibility.
Walter Saxer Versicherungshochschulpreis for this thesis.
1976 – 1978
Scientific collaborator, Chair of Statistics, ETH-Zürich.
Projet coordinator for the project “Statistical Software” (directed by P.J. Huber, Swiss
National Science Foundation, grant No 2.569-0.76).
1977: september–october
Invited lecturer, Dept. of Sciences, Catholic University of Louvain, Belgium.
Februar 1978 - June 1979
Visiting lecturer at the assistant professor level, Dept. of Statistics, Princeton University,
U.S.A.
August 1979 - Februar 1980
Scientific collaborator, Chair of Statistics, ETH Zürich. Completion of the project “Statistical
Software”.
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Current position:
Head of the Statistics Unit, IUMSP, Lausanne (april 1980–); Associate professor of statistics
and medical informatics, University of Lausanne, Medical School (april 1992–)
Other professional activities
- Member of the Institute of Health Economics and Management, University of Lausanne.
- Member of the Royal Statistical Society (and of other professional associations).
- Council member of the International Association for Statistical Computing, a Section of
the International Statistical Institute (1991–1995).
- Committee member of the Swiss Society for Medical Informatics (1985–1995).
- External examiner in mathematics at the Liceo cantonale, Lugano.
- Associate editor of Student, Presses Académiques, Neuchâtel (1996–2002).
- Reviewer for various scientific journals.
Languages
Mother Tongue Italian
Good Working Knowledge French, Spanish, German, English
Teaching
Université catholique de Louvain, Faculté des sciences (1977):
- Statistiques robustes, postgrade students
- Théorie de la crédibilité: chapitres choisis, postgrade students
Princeton University, Department of Statistics (1978–1979):
- Intermediate Statistical Techniques, statistics and sociology students
- Stochastic Processes, postgrade statistics students
- Statistical Planning of Investigations, statistics students
ETH Zürich, Abteilung für Mathematik und Physik (1980–1984):
- Statistical methods, postgrade students
EPF Lausanne, Département de mathématiques (1984–1987):
- Probability and statistics, 2nd year students
Université de Lausanne, Faculté demédecine:
- Biostatistics, 2nd year students (1992–2004)
- Medical statistics, 1st year students (2005–)
- Various applied statistics courses for doctoral students
Université de Lausanne, Faculté des sciences:
- Mathematical statistics and biostatistics, 2nd year biology and 1st year pharmacy students
(1994 –)
Université de Lausanne, continuing education:
- Statistique pour l’analyse des données: la statistique vers les applications médicales,
joint teaching with the statistics chair of EPFL (1994).
- Santéautravail: Statistiques I et II, joint teaching with the Institut universitaire de
médecine et d’hygiène du travail and ETH Zürich (1994–1997).
- Statistiques appliquées et computationelles (1997, 1998).
- Statistique mathématique, Master of advanced studies in health economics and management
(1995–2005)
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- Biostatistique, Ecole doctorale de la Faculté de Biologie et Médecine, (2006–)
Université deNeuchâtel:
- Logiciels de statistique (Diplôme postgrade en statistique, 1989–1993)
- Statistique computationelle (Diplôme postgrade en statistique, 1994)
Thesis supervision
Phd level
Ohmithi K., Approximation des moments par l’utilisation de la théorie des fonction analytiques,
Thèse No 3640 (2006), EPFL
Amiguet, M.. Adaptively weighted maximum likelihood estimation of discrete distributions.
Université de Lausanne, Science de la vie (2011).
Meylan, D., Robust estimation of the generalized log-gamma regression model and application
to the analysis oh hospital cost of stay. Université de Lausanne, Science de la vie,
Work in progress.
Master level
Supervision of various thesis for the Master of advanced studies in health economics and
management, Université de Lausanne, Institut d’économie et management de la santé.
Past research
Development of the Subroutine library ROBETH, a systematic collection of numerical
algorithms written in FORTRAN for the computation of robust statistical procedures.
S interface for ROBETH: integration of ROBETH into the statistical environment S-plus
(www.insightful.com).
This work has been achieved thanks to several grants from the Swiss National Science
Foundation and in collaboration with the Seminar für Statistik, ETH-Zürich. Part of
ROBETH has been included into the NAG library, Numerical Algorithms Group Ltd,
Oxford, UK, (Mark 13 and above) and into the statistical system S-plus.
ROBETH is in public domain. It is available at Statlib S-Archive: http://lib.stat.cmu.edu
and www.iumsp.ch. It is described in the book “Algorithms, Routines, and S Functions
for Robust Statistics” (Marazzi, 1993).
Current research
1 Robust methods for the analysis of hospital length and cost of stay
This project develops methods to estimate the mean length of stay (LOS) and the mean
cost of hospital stays as a function of available administrative and medical data, which
often contain extremely expensive or unusually cheep cases.
Hospital stays are usually grouped according to a given Patient Classification System
(PCS), an important tool of hospital management. The classes are usually called Diagnosis
Related Groups or DRGs. PCSs are used for epidemiological monitoring and for
standardised comparison of hospital activity. The main applications are however hospital
budgeting, funding and reimbursement. For this purpose, a mean cost of each class is
usually estimated with the help of available information on a national basis. The cost
means are then used as a basis for negotiation to fix prospective payment or retrospective
reimbursement rates.
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The analysis of LOS and cost of stay requires appropriate statistical tool to take into
account the following features of data: (a) LOS and cost distributions are asymmetric
and heteroscedastic; (b) LOS and cost distributions contain outliers. A few outliers can
completely distort both the means and the comparisons based on them. As a remedy,
various kinds rules for removing outliers are currently used in practice; unfortunately,
these rules lack of theoretical ground.
Preliminary research (e.g., Marazzi, Paccaud, Ruffieux, and Beguin, 1998) showed that
the conceptual framework of parametric robust statistics is a very attractive basis for the
development of adequate statistical tool. Therefore, as a first step, new robust rules for
trimming atypical values have been developed (Marazzi and Ruffieux 1999; Ruffieux, Paccaud,
and Marazzi 2000 ). As a second step, tool for modeling LOS and cost distributions
with the help of covariates, is being developed (Project 2).
Marazzi, Gardiol and Duong (2007) propose reimbursement schemes based on PCSs that
include adjustments for LOS and exceptional costs and are designed to minimize undesirable
effects of economic incentives. In addition, in this paper, a novel statistical approach
to compare the schemes and the underlying PCSs is proposed.
2 Robust methods for positive asymmetrically distributed responses
Project 1 motivates the development of general robust statistical methods to estimate
the mean of a positive and asymmetrically distributed random variable as a function of
a number of covariates, in the presence of outliers. The following steps have been made
(papers can be downloaded from www.iumsp.ch).
1. Development of M-estimates for the parameters of the Gammma, Weibull, and Lognormal
distributions (Marazzi and Ruffieux, 1996). This kind of estimate is well known in
theory but too complex for applications in hospital management.
2. Development of “truncated means” of asymmetric distributions using parametric models
(Marazzi and Ruffieux 1999). Although the statistical performance of this kind of estimate
is not optimal, it is the method of choice for practitioners in hospital management.
3. Bootstrap tests for robust means of asymmetric distributions (Marazzi 2002). Simple
inference procedures for comparing LOS or cost means using samples of stays.
4. Robust parametric means of asymmetric distributions: estimation and testing (Marazzi
and Barbati 2003). Extension of the methods developed in steps 2–3.
5. Adaptively truncated maximum likelihood regression with asymmetric errors (Marazzi
and Yohai 2004). Extension of the methods developed in steps 2–4 to multiple regression.
6. Development of robust regression methods for asymmetrically distributed responses using
Box-Cox transformations (Marazzi and Yohai 2004; 2006; Marazzi, Villar, Yohai
2009). This is a robust approach to nonlinear regression with asymmetric and heteroscedastic
errors.
7. Extension of robust regression for asymmetrically distributed responses to survival analysis.
These methods are useful for censored data, e.g., incomplete follow up, incomplete
hospital stays. e.g., transfer to a different hospital. (Locatelli, Marazzi, Yohai, 2010). A
package for robust accelerate failure time regression (RobustAFT) has been made available
on The Comprehensive R Archive Network (CRAN) of the statistical environment
R (Marazzi, Muralti, 2011).
8. Robust estimation of the generalized log-gamma regression model. (Marazzi, Yohai,
Agostinelli, 2011). Work in progress.
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3 Maintenance and development of ROBETH
The main purposes of this project are:
- to include the new tool developed under Project 2 into the ROBETH software;
- to maintain ROBETH and its interface to S-plus;
- to implement the methods of ROBETH into the R-software (http://www.r-project.org/).
ROBETH and the associated libraries are available at www.iumsp.ch.
4 Statistical consulting
Statistical consulting for various joint projects (e.g., Cheung S.L.K., Robine J.-M., Paccaud
F., Marazzi A., 2009).
Research grants from the Swiss National Science Foundation
Logiciels d’analyse statistique robuste. Start of the ROBETH project. Swiss National
Science Foundation, Grant 2.317–0.81. Main applicant: A. Marazzi
Nouvelles méthodes statistiques dans l’expérimentation animale et dans ses méthodes de
substitution. Application of robust statistical methods in biological assay. Swiss National
Science Foundation, Grant 4.785–0.84.17. Main applicant: A. Marazzi.
Validation et comparaison de méthodes de substitution à l’aide des statistiques robustes
dans le cadre de l’essai biologique. Application of robust statistical methods in biological
assay. Swiss National Science Foundation, Grant 4.015–0.86.17 Main applicant: A.
Marazzi.
Le calcul numérique des estimateurs de régression et de covariance à point de rupture
élevé etsonintégration dans le progiciel ROBETH. Development of high breakdown point
procedures in ROBETH. Swiss National Science Foundation, Grant 2.145–0.86. Main
applicant: A. Marazzi.
Algorithms and software for robust generalized linear model fitting. Development of robust
regression methods for generalized linear models. Swiss National Science Foundation,
Grant 20–25529.88. Main applicant: A. Marazzi.
Robuste Ausgleichung in der Triangulation. Use of ROBETH in the “Software für Triangulationsausgleichung
des Bundesamtes für Landestopographie” (swiss standard de facto).
Swiss National Science Foundation, Grant 21–27689.89. Main applicant: A. Carosio, Institut
für Geodäsie und Photogrammetrie, ETH Zürich. Joint applicant: A. Marazzi.
Logiciel de modélisation robuste. Interfacing ROBETH with the S-plus environment. Swiss
National Science Foundation, Grant 21–36521.92. Main applicant: A. Marazzi.
Robust modeling of length of stay distributions in diagnosis related groups. Development
of robust statistical methods for asymmetric distributions and application to the analysis of
hospital length of stay. Swiss National Science Foundation, Grant 3200–039614.93/1. Main
applicant: F. Paccaud, Institut universitaire de médecine sociale et préventive, Lausanne.
Joint applicant: A. Marazzi.
Robuste Schätzer mit hohem Bruchpunkt für geodätische Transformationen. Continuation
of the project Robuste Ausgleichung in der Triangulation. Swiss National Science
Foundation, Grant 2100-043441.95. Main applicant: A. Carosio, Institut für Geodäsie und
Photogrammetrie, ETH Zürich. Joint applicant: A. Marazzi.
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Statistical tool for modeling length of stay distributions with the help of covariates: robust
regression for asymmetrically distributed responses. Swiss National Science Foundation,
Grant 2100-054146.98/1. Main applicant: A. Marazzi
Robust regression with asymmetrically distributed responses and application to the analysis
of hospital cost of stay Swiss National Science Foundation, Grant 21-54146.98 and
2053-066895. Main applicant: A. Marazzi.
Robust regression with censored data and application to the analysis of hospital cost of
stay. Part I. Swiss National Science Foundation, Grant 205320-108424. Main applicant:
A. Marazzi.
Robust regression with censored data and application to the analysis of hospital cost of
stay. Part II. Swiss National Science Foundation, Grant 205320-116357. Current project.
Main applicant: A. Marazzi.
Other funded projects
Evaluation de l’efficacité delalégislation sur la privation de liberté à des fins d’assistance.
Swiss National Science Foundation, Grant 1.343–0.86. Main applicant: M. Borghi, Université
de Fribourg. Statistical consultant: A. Marazzi
Research and Development Program on Robust Methods for Analysis of Designed Experiments.
Grant of the US National Science Foundation, Small Business Innovation Research.
Principal investigator: R. Douglas Martin, Statistical Sciences, Inc., Seattle, WA 98109.
Consultant (1992–1993): A. Marazzi .
Distributional analysis using sample data, Distributional Analysis Research Programme.
Suntory-Toyota International Centre for Economics and Related Disciplines, London
School of Economics. Director: Frank Cowell. Project associate (1994–1996): A. Marazzi
Modelli di simulazione per la pianificazione di risorse delle aziende sanitarie. Development
of admission/discharge models for the Regione Toscana, Italy. Director: F. Schoen, Università
di Firenze, Dipartimento di sistemi e informatica. Statistical consultant (1998): A.
Marazzi
Useable Robust Statistical Modeling and Inference. Grant of the US Department of Human
Services, Public Health Servics, Small Business Innovation Research. Principal investigator:
R. Douglas Martin, Mathsoft, Data Analysis Products Division, Seattle, WA 98109.
Consultant (1999–2001): A. Marazzi
Validation du codage des statistiques médicales dans le canton de Vaud. Services de la
Santé publiques des Cantons de Vaud et de Valais (1999 - 2004). Director: A. Marazzi
Méthodological adaptation of DRG groupers for Switzerland. SwissDRG Association
(2004–2005). Statistical consultant and investigator: A. Marazzi
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Publications
1ROBETH
Abbreviations
Cah rech doc IUMSP: Cahiers de recherche et documentation,
Institut universitaire de médecine sociale et préventive,
Bugnon 17, CH-1005 Lausanne
Res rep Stat ETHZ: Research report,
Fachgruppe für Statistik, ETH-Zürich,
ETH-Zentrum, CH-8092 Zürich
Book
Marazzi A. [1993]. Algorithms, Routines and S Functions for Robust Statistics. Pacific
Grove, California: Wadsworth & Brooks/Cole.
Articles
Marazzi A. [1980]. ROBETH: a subroutine library for robust statistical procedures. In:
COMPSTAT 1980 Proceedings in computational statistics, 577-583.
Marazzi A. [1981]. ROBETH: un logiciel pour les procédés statistiques robustes. Méd soc
prév, 26, 288-290.
Marazzi A., Randriamiharisoa A. [1986]. ROBSYS: a package for robust statistical computing.
In: Salamon R., Blum B., Jørgensen M., Eds., MEDINFO 86, Elsevier Sciences
Publishers B.V. (North Holland), 1111-1113.
Marazzi A. [1986]. On the numerical solution of bounded influence regression problems.
In: COMPSTAT 1986 Proceedings in computational statistics, 114-119.
Marazzi A. [1987]. Solving bounded influence regression problems with ROBSYS. In:
Dodge Y., Ed., Statistical data analysis based on the L1 norm and related methods, North
Holland, 145-161.
Marazzi A. [1988]. Algorithms for the computation of weights in bounded influence regression.
Computational statistics and data analysis, 6, 251-276.
Marazzi A., Ruffieux C., Randriamiharisoa A. [1988]. Robust regression in biological
assay: application to the evaluation of alternative experimental techniques. Experientia,
44, 857-873.
Marazzi A. [1988]. Implementing robust regression in ROBSYS. Proceedings of the Third
International Workshop on Statistical Modelling, Vienna, July 4-8, 1988 (invited lecture).
Marazzi A. [1989]. Computing robust covariances with collinear data. In: Dodge Y., Ed.,
Statistical data analysis and inference, North Holland, Amsterdam.
Joss J. and Marazzi A. [1990]. Probabilistic algorithms for Least Median of Squares Regression.
Computational statistics and data analysis, 9, 123-133.
Marazzi A. [1991]. Algorithms and programs for robust linear regression. In: Stahel W.
and Weisberg S., Eds. Directions in Robust Statistics and Diagnostics, PartI.NewYork:
Springer-Verlag 1991: 183-199. (The IMA Volumes in Mathematics and its Applications,
Vol. 33).
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Technical reports
Marazzi A. [1979]. FORTRAN subroutines for M-estimators in the linear model.
Tech rep no 147, Dept of statistics, Princeton University.
Marazzi A. [1980]. Robust linear regression programs in ROBETH.
ROBETH Document no 2, Res rep Stat ETHZ no 23.
Marazzi A. [1980]. Robust affine invariant covariances in ROBETH.
ROBETH Document no 3, Res rep Stat ETHZ no 24.
Marazzi A. , Campbell A. [1981]. Choosing the best regression with ROBETH.
ROBETH Document no 4, Res rep Stat ETHZ no 30.
Marazzi A. [1985]. Subroutines for robust estimation of location and scale in ROBETH.
ROBETH-85 Document no 1, Cah rech doc IUMSP no 3.
Marazzi A. [1985]. Subroutines for robust and bounded influence regression in ROBETH.
ROBETH-85 Document no 2, Cah rech doc IUMSP no 3.
Marazzi A. [1985]. Weights for bounded influence regression in ROBETH.
ROBETH-85 Document no 3, Cah rech doc IUMSP no 3.
Marazzi A. [1985]. Testing in linear models and model selection in ROBETH.
ROBETH-85 Document no 4, Cah rech doc IUMSP no 3.
Marazzi A. [1985]. Robust affine invariant covariances in ROBETH.
ROBETH-85 Document no 6, Cah rech doc IUMSP no 3.
Randriamiharisoa A., Marazzi A. [1985]. ROBETH-ROBSYS: a software for robust statistical
computing. ROBSYS Document no 0, Cah rech doc IUMSP no 3.
Randriamiharisoa A., Marazzi A. [1985]. ROBSYS: basic commands.
ROBSYS Document no 1, Cah rech doc IUMSP no 3.
Randriamiharisoa A., Marazzi A. [1985]. ROBSYS commands for robust linear regression
and robust testing of linear hypotheses. ROBSYS Document no 2, Cah rech doc IUMSP
no 3.
Randriamiharisoa A., Marazzi A., Braoudakis G. [1985]. ROBETH-ROBSYS: implementation
notes. Cah rech doc IUMSP no 3.
Marazzi A., Randriamiharisoa A. [1986]. ROBSYS commands for exploratory data
analysis. ROBSYS Document no 3, Cah rech doc IUMSP no 3.
Randriamiharisoa A., Marazzi A. [1987]. Statistical analysis of the parallel line and slope
ratio assay. ROBSYS Document no 4, Cah rech doc IUMSP no 3.
Marazzi A.,Randriamiharisoa A., van Melle G. [1991]. Algorithms and programs for bounded-influence
estimates in discrete generalized linear models,
ROBETH Document no 7, Cah rech doc IUMSP no 3.
Clarkson D.B., Marazzi A. [1993]. S-plus functions for high breakdown point and high
efficiency regression with test for bias. Statistical Sciences, Inc., Seattle.
Marazzi A., Randriamiharisoa A. [1997]. S-plus functions for M-estimators of the parameters
of the Gaussian and the Lognormal distribution. Technical Report, IUMSP.
www.hospvd.ch/iumsp.
Marazzi A., Randriamiharisoa A. [1997]. S-plus functions for M-estimators of the parameters
of the Gamma distribution. Technical Report, IUMSP. www.hospvd.ch/iumsp.
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Marazzi A., Randriamiharisoa A. [1997]. S-plus functions for M-estimators of the parameters
of the Weibull distribution. Technical Report, IUMSP. www.hospvd.ch/iumsp.
Marazzi A., [1997]. Object oriented S-plus functions for Huber type robust regression.
Technical Report, IUMSP, www.hospvd.ch/iumsp.
Clarkson D.B., Marazzi A. [1997]. Object oriented S-plus functions for high breakdown
point and high efficiency regression with test for bias. Technical Report, IUMSP, (revision
of a report mentioned above). www.hospvd.ch/iumsp.
Marazzi A., [1997]. Object oriented S-plus functions for robust discrete generalized linear
models. Technical Report, IUMSP. www.hospvd.ch/iumsp.
Marazzi A., Randriamiharisoa A., Ruffieux C. [1998]. S-Plus functions for truncated and
weighted means of asymmetric distributions.
Technical Report, IUMSP. www.hospvd.ch/iumsp.
Marazzi A., Randriamiharisoa A. [1999]. S-plus functions for constrained robust mean
estimates and bootstrap tests of robust means.
Technical Report, IUMSP. www.hospvd.ch/iumsp.
Marazzi A., Randriamiharisoa A. [2002]. S-plus functions for the Cox-test for separate
families based on M-estimators of asymmetric models.
Technical Report, IUMSP. www.hospvd.ch/iumsp.
2 Statistics
Marazzi A. [1976]. Minimax Credibility. Dissertation no 5695, ETH-Zürich.
Marazzi A. [1976]. Minimax Credibility. Bulletin de l’association des actuaires suisses, 76,
119-129.
Marazzi A. [1980]. Robust bayesian estimation for the linear model.
Res rep Stat ETHZ no 27.
Marazzi A. [1985]. On constrained minimization of the Bayes risk for the linear model.
Statistics and Decisions, 3, 277-296.
Marazzi A. [1990]. Restricted Minimax Credibility: two special cases. Mitteilungen der
Schweiz. Vereinigung der Versicherungsmathematiker, 1, 101-114.
Marazzi A. [1990]. Restricted Minimax Credibility: two special cases.
In: Festgabe Bühlmann, Stämpfli+Cie AG, Bern, 137-150.
Marazzi A., Ruffieux Ch. [1996]. Implementing M-estimators of the Gamma distribution.
In: Rieder H. (Ed.), Robust Statistics, Data Analysis, and Computer intensive Methods,
Springer Verlag.
Marazzi A., Ruffieux Ch. [1999]. The truncated mean of an asymmetric distribution.
Computational Statistics and Data Analysis, 32, 79-100.
Marazzi A. [2002]. Bootstrap tests for robust means of asymmetric distributions. Computational
Statistics and Data Analysis, 39, 503-528.
Marazzi A., Barbati G. [2003]. Robust parametric means of asymmetric distributions:
estimation and testing. Estadistica, 54 (162-163), 47-72.
Marazzi A., Yohai V.J. [2004]. Adaptively truncated maximum likelihood regression with
asymmetric errors. Journal of Statistical Planning and Inference. 122 (1-2), 271-291.
3

Marazzi A., Yohai V.J. [2004]. Robust Box-Cox transformations for simple regression. in:
Hubert,Pison,Struyf,VanAelst(Eds.),Statistics for Industry and Technology, Theory
and Applications of recent Robust Methods, Birkäuser, Basel, 173-182.
Marazzi A., Yohai V.J. [2006]. Robust Box-Cox transformations based on minimum residual
autocorrelation. Computational Statistics & Data Analysis, 50, 2752-2768.
Marazzi A., Gardiol L., Duong H.D. [2007]. New approaches to reimbursement schemes
based on patient classification systems and their comparison. Health services management
research, 20, 203-210.
Marazzi A., Villar A.J., Yohai V. J. [2009]. Robust Response Transformations Based on
Optimal Prediction. Journal of the American Statistical Association, 104(485), pp. 360-
370. doi:10.1198/jasa.2009.0109.
Marazzi A., Villar A.J., Yohai V. J. [2009]. Supplemental Material for : Robust Response
Transformations Based on Optimal Prediction. Journal of the American Statistical Association,
http://pubs.amstat.org/doi/suppl/10.1198/jasa.2009.0109
Locatelli I., Marazzi A. [2009]. A Note on Estimating A Mean Cost of Hospital Stay with
Incomplete Information. Health Care Costs: Causes, Effects and Control, B.R.Hofmann
(Ed.). Nova Publishers, ISBN: 978-1-60456-976-6.
Marazzi A.[2009]. Robust regression with asymmetric errors. Classification and Data
Analysis 2007. 7th Meeting of the Classification and Data Analysis Group of the Italian
Statistical Society. Book of short papers. S.Ingrassioa and R. Rocci (Ed.). ISBN 978-88-
6129-406-6.
Locatelli I., Marazzi A., Yohai V.J. [2010]. Robust Accelerated Failure Time Regression.
Computational Statistics and Data Analysis, 55, 874-887.
Marazzi A., Yohai V.J. [2010]. Optimal robust estimates based on the Hellinger distance.
Advances in Data Analysis and Classification. Springer-Verlag. DOI 10.1007/s11634-010-
0061-8.
Locatelli I., Marazzi A. [2011]. Robust estimation of the expected cost of a hospital stay.
Draft. Submitted.
Marazzi A., Yohai V.J, Agostinelli C. [2011]. Robust estimation of the generalized loggama
model. Draft.
3 Health econometrics
Ruffieux C., Marazzi A., Paccaud F. [1993]. Exploring models for the length of stay
distribution. Soz Präventivmed, 38, 77-82.
Marazzi A., Ruffieux C., Paccaud F. [1993]. Trimming rules and M-estimates for the
expected length of stay in diagnosis related groups. Proceedings of the 9th International
PCS/E Working Conference, München 15-18 September 1993, Vol I.
Marazzi A., Paccaud F., Ruffieux C., Beguin C. [1998]. Fitting the distributions of length
of stay by parametric models. Medical Care 36, 915-927.
Marazzi A., Ruffieux C. [1998]. Rules for removing outliers and test based on parametric
models for estimating and comparing average length of stay. Proceedings of the 14th
International PCS/E Working Conference, Manchester UK, 1-3 October 1998.
Ruffieux C., Paccaud F., Marazzi A. [2000]. Comparing rules for truncating hospital length
of stay, CASEMIX 2, 1,3-11.
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Najda A., Vader J.-P., Marazzi A. [2000]. Cohérence du codage diagnostique: étude de
contrôle de qualité dansleshôpitaux vaudois et valaisans. Med Hyg, 58, 1422-4.
Marazzi. A., Najda A. [2001]. Validation du codage des diagnostics dans les établissements
médicaux vaudois: données 1999. Rapport. Service cantonal de recherche et d’information
statistique de l’Etat de Vaud.
Gauthier H., Marazzi. A., Randraimiharisoa, A. [2002]. Validation du codage des diagnostics
dans les établissements médicaux vaudois: données 2000. Rapport. Service cantonal
de recherche et d’information statistique de l’Etat de Vaud.
Gauthier H., Marazzi. A., Randraimiharisoa, A. [2003]. Validation du codage des diagnostics
dans les établissements médicaux vaudois: données 2001. Rapport. Service cantonal
de recherche et d’information statistique de l’Etat de Vaud.
Gauthier H., Marazzi. A., Randraimiharisoa, A. [2004]. Validation du codage des diagnosticsetdesinterventionsdanslesétablissements
médicaux vaudois avec analyse de la
variation de la valeur de casemix: données 2003. Rapport. Service cantonal de recherche
et d’information statistique de l’Etat de Vaud.
Bouchard C., Marazzi. A., Randraimiharisoa, A. [2004]. Validation du codage des diagnostics
et des interventions dans les établissements médicaux valaisans avec analyse de la
variation de la valeur de casemix: données 2003. Rapport. Observatoire valaisan de la
santé.
Chalé J.J., Duong H.D., Marazzi A., Meylan D. [2006]. Methodological rules with a view
to helvitise a DRG-grouper. Revue économique et sociale, 64, 95-109.
Marazzi A., Gardiol L., Duong H.D. [2006]. New approaches to reimbursement schemes
based on PCSs and their comparison. Bulletin de la Société d’études économiques et
sociales, Vol 64, 83-94.
4 Joint biomedical research
Guillemin M., Bauer D., Martin B., Marazzi A. [1982]. Human exposure to styrene. Int
Arch Occup Environ Health, 51, 139-150.
Boillat M.A., Djevahirdjian L., Droz P.O., Marazzi A. [1983]. Surveillance médicale de
personnes exposées au perchloréthylène: Etude dans les pressings. Soz Präventivmed 28,
256-257.
Légeret M.J., Darioli R., Grandjean T., Gersbach P., Essinger A., Marazzi A. [1983].
Facteurs de risque de l’artériosclérose coronarienne chez la femme. Schweiz med Wschr,
113, 1850-1853.
Weissbrodt P., Marazzi A., Truhan M., Steiner E., Hofstetter J.R. [1983]. L’enseignement
du patient diabétique et son évaluation par un questionnaire à choix multiple. Schweiz
med Wschr, 113, 1919-1921.
Frenk E., Marazzi A. [1984]. Neurofibromatosis of von Recklinghausen: a quantitative
study of the epidermal keratinocyte and melanocyte populations. The Journal of Investigative
Dermatology, 83/1, 23-25.
Braoudakis G., Marguerat Ph., Marazzi A., Gutzwiller F. [1984]. Etude de la variation
interlaboratoire du test de dépistage prénatal des défauts de fermeture du tube neural.
Soz Präventivmed, 29, 207-208.
5

Burnand B., Marazzi A., Heraief E., Burckhardt P. [1985]. Influence des habitudes alimentaires
sur la morbidité chez 645 patients obèses d’une consultation spécialisée. Schweiz
med Wschr, 115, 1770-1772.
Domenighetti G., Luraschi P., Marazzi A. [1985]. Hysterectomy and sex of the gynecologist.
Letter to the editor, NEnglJMed, 313, 1482.
Gutzwiller F., Marazzi A., Nater B., Howald H., Haller E. [1985]. Validation par ergométrie
d’un questionnaire sur l’activité physique dans 2 villes suisses. Rev Epidém et Sté Publ,
33, 103-107.
Haller E., Marazzi A. [1985]. Toxicomanie dans le canton de Vaud: un regard sur les
données de la Police cantonale. Soz Präventivmed 30, 333-335.
Mevorah B., Marazzi A., Frenk E. [1985]. The prevalence of accentuated palmoplantar
markings and keratosis pilaris in atopic dermatitis, autosomal dominant ichthyosis and
control dermatological patients. British Journal of Dermatology, 112, 679-685.
Bonard C., Darioli R., Petrillo A., Cretin T., Marazzi A. [1986]. Intérêt des bandelettes
colorimétriques pour l’examen urinaire de routine en pratique ambulatoire. Schweiz med
Wschr, 116, 338-341.
Stalder J.-B., De Grandi P., Huguenin M., Wietlisbach V., Gutzwiller F., Marazzi A.
[1986]. Prévalence des facteurs de risques de cancer du sein dans la population féminine
vaudoise: Délimitation des indications au dépistage. Med Hyg, 44, 1526-1532.
Fouda A., Marazzi A., Boillat N., Sonnay M., Guillain H., Atkinson J. [1987]. Changes
in the vascular reactivity of the isolated tail arteries of spontaneous and renovascular
hypertensive rats to endogenous and exogenous noradrenaline. Blood Vessels, 24, 63-75.
Bourgeois R., Darioli R., Grandjean T., Essinger A., Sigwart U., Marazzi A. [1987].
Plasma phospholipids level is the best parameter predicting angiographic coronary stenosis.
Atherosclerosis and cardiovascular diseases, vol. 3, Lenzi S. and Descovich G.C. Eds.,
Bologna.
Patel M.S., Gutzwiller F., Paccaud F., Marazzi A. [1987]. The clinical effectiveness of
acupuncture for the relief of chronic pain. In: Evaluation des technologies médicales,
Gutzwiller F., Glassser J.H., Chrzanowski R., Paccaud F., Patel M., Eds., Cah rech doc
IUMSP no 15.
Patel M.S., Gutzwiller F., Paccaud F., Marazzi A. [1989]. A meta-analysis of acupuncture
for chronic pain. International Journal of Epidemiology, 18, No.4, 900-905.
Patel M.S., Gutzwiller F., Paccaud F., Marazzi A. [1990]. Een meta-analyse van acupunctuur
tegen chronische pijn. Nederlands Tijdschrift voor Integrale Geneeskunde, Jrg.6,nr.
43, 296-302
Berger M.M., Marazzi A., Freeman J., Chiolero R. [1992]. Evaluation of the consistency
of Acute Physiology and Chronic Health Evaluation (APACHE II) scoring in a surgical
intensive care unit. Critical Care Medicine, 20, No. 12, 1681-1687.
Ruffieux C., Marazzi A., Paccaud F. [1992]. The circadian rhythm of perinatal mortality
rate in Switzerland. American Journal of Epidemiology, 135, 936-952.
Paccaud F., Sidoti Pinto C., Marazzi A., Mili J. [1998]. Age at death and rectangularization
of the survival curve: trends in Switzerland, 1969-1994. Journal of Epidemiology and
Community Health 52, 412-415.
6

Halfon P., Eggli Y., Prêtre-Rohrbach I., Meylan D., Marazzi A., Burnand B. [2006]. Validation
of the potentially avoidable hospital readmission rate as a routine indicator of the
quality of hospital care. Medical Care, 44 (11), 972-981.
Katz E., Metzger J.-T., Marazzi A., Kappenberger L. [2006]. Increase of sudden cardiac
deaths in Switzerland during the 2002 FIFA World Cup. International Journal of
Cardiology, 107, 132-133.
Domenighetti G., Tomada A., Marazzi A., Abazi O., Quaglia J. [2009]. Impact of job
insecurity on sexual desire: an exploratory analysis. Swiss Medical Weekly, 139(33-34),
pp. 486-492.
Cheung S.L.K., Robine J.-M., Paccaud F., Marazzi A. [2009]. Dissecting the Compression
of Mortality in Switzerland. Demographic Research, 21, 569-598.
6 Other publications
Articles and technical reports
Huber P., Marazzi A., Stützle W. [1974]. Unsere Zufallszahlengeneratoren. Bulletin des
Rechenzentrums der ETH Zürich.
Marazzi A. [1975]. Testresultate von Zufallszahleneratoren. Res rep Stat ETHZ no 7.
Marazzi A. [1982]. Le département de statistique de l’Institut universitaire de médecine
sociale et préventive, Lausanne. Soz Präventivmed 27, 228-229.
Hampel F., Marazzi A., Ronchetti E., Rousseeuw P., Stahel W., Welsch R.E. [1982]. Handouts
for the Instructional Meeting on Robust Statistical Methods. In connection with the
15th European meeting of statisticians, Palermo, 10-11 Sept. 1982.
Marazzi A. [1984]. L’informatique dans l’analyse statistique de fichiers biomédicaux. (Informatique
et Université). UNI Lausanne, 40, 34-35.
Marazzi A., Gutzwiller F. [1985]. Epidémiologie et biostatistique: une introduction programmée.
WorldHealthForum, 6/no 3, 286 (présentation d’un livre).
Marazzi A. [1987]. Quelques abus de la statistique dans la recherche médicale. Schweiz
med Wschr, 117, 609-618.
Ziegler W.J., Marazzi A. [1989]. Medizinische Informatik: Aus- und Weiterbildung in der
Schweiz. Schweiz. Aerztezeitung, 70, 142-143.
Marazzi A. [2001]. L’Unité de statistique de l’Institut universitaire de médecine sociale et
préventive, Lausanne. Swiss Statistical Society, Bulletin Nr. 40, 18.
Chapters of books
Marazzi A. [1991]. Méthodes statistiques appliquées à l’enquête ED. Contribution. In:
Borghi M., Evaluation de l’efficacité delalégislation sur la privation de liberté à des fins
d’assistence. Weinfelden: Fondation Suisse Pro Mente Sana, pp. 29-39.
Marazzi A., Minder C. [1996]. L’analyse statistique. In: Gutzwiller F., Janneret O., Eds.
Médecine sociale et préventive, Santé publique. Editions Hans Huber, Berne.
Marazzi A., Schindler Ch., Paccaud F. [2009]. Biostatistique. In: Gutzwiller F., Paccaud
F., Eds. Médecine sociale et préventive – Santé publique. 3ème édition. Editions Hans
Huber, Berne.
7

Statistical software
Marazzi A., Muralti J.L. [2011]. RobustAFT, The Comprehensive R Archive Network.
Courses
Marazzi A., van Melle G. [1986]. Tests usuels dans l’analyse de données biomédicales.
Cours de statistiques appliquées, Faculté demédecine, Université de Lausanne.
Marazzi A. [1994]. Introduction àlarégression linéaire. Cours de statistiques appliquées,
Facultés de médecine et Faculté des sciences, Université de Lausanne.
Marazzi A. [2002]. Introduction à la biostatistique. Cours de 2ème année, Faculté de
biologie et médecine, Université de Lausanne. Available at www.iumsp.ch.
Invited lectures
15th European Meeting of Statisticians, Instructional Meeting on Robust Statistical
Methods, Palermo, 10–11 septembre, 1982.
Séminaire de 3ème cycle romand en statistique et probabilités appliquées, Saas Fee,
7–11 mars, 1983.
Convegno sulla robustezza, Istituto di statistica e ricerca sociale C. Gini, Università di
Roma, Roma, 9–10 juin, 1983.
First Oberwolfach Conference on Robust Statistics, Mathematisches Forschungsinstitut
Oberwolfach, 9–15 septembre, 1984.
First International Conference on Statistical Data Analysis Based on the L1-Norm and
Related Methods, Neuchâtel, 1–4 septembre, 1987.
Third International Workshop on Statistical Modelling, Vienna, 4–8 juillet, 1988.
Meeting on Medical Statistics (Statistical Methods in Epidemiology), Mathematical
Research Institute, Oberwolfach, 19–25 février, 1989.
Institute for Mathematics and its Applications, Summer Program on Robustness, Diagnostics,
Computing and Graphics in Statistics, University of Minnesota, Minneapolis, 10
juillet–4 août, 1989.
International Conference on Recent Developments in Statistical Data Analysis and
Inference (in honor of C.R. Rao), Neuchâtel, 21–24 août, 1989.
Biometrisches Seminar der International Biometrische Gesellschaft Region Österreich -
Schweiz, Klagenfurt, 25–29 septembre, 1989.
European Courses on Advanced Statistics, ECAS, Course on Robust Statistics,
Reisenburg, 2–7 octobre, 1989.
Dutch Association of Statisticians, Meeting of the Working Group on Statistical Software,
Utrecht, 23–24 janvier, 1990.
IMSL User Group Europe Conference, Bologna, 26–28 mars, 1990.
Second International Workshop on S Software, Toulouse, 1-11 september 1992.
XXVIe Journées de Statistique, Association pour la statistique et ses utilisations,
Neuchâtel, 24-27 mai 1994.
8

Università di Napoli, Dip. matematica e statistica, Progetto di ricerca sulle procedure
robuste e analisi multivariata in collaborazione con membri dell’Accademia delle scienze
Bulgare. Seminari introduttivi, Napoli 28-29 avril, 1994.
Association Suisse de Statistique, Assemblée générale, Berne, 6 mai 1994.
Universität Bayreuth, Festkolloquium on the occasion of Prof. Peter J. Huber’s 60th
birthday, Bayreuth, 9 juin 1994.
Euro Anesthesia’95, Bern, 27–28 janvier, 1995.
Workshop on “New approximation techniques for statistical inference”, Centro Stefano
Franscini, Ascona, 20 – 24 mars, 1995.
Center for Operation Research and Econometrics, Université catholique de Louvain, Louvain
la Neuve, 7 juin 1995.
Istituto nazionale per lo studio e la cura dei tumori, Divisione di statistica medica e
biometria, Università degli studi, Milano, 23 juin 1995.
Tagung der Region Österreich-Schweiz der Internationalen Biometrischen Gesellshaft, Rapperswil,
26 settembre, 1995.
Centre pour le perfectionnement des professeurs de l’enseignement secondaire, Cours:
Mathématiques et finances, Ecole des hautes études commerciales, Université deLausanne,
29 septembre 1995.
London School of Economics and Political Science, Advisory Group Meeting (Distributional
Analysis using Sample Data), Londre, 20 octobre 1995.
Scuola di specializzazione in igiene e medicina preventiva, Università degli studi di Firenze,
Corso: Programmazione, gestione e valutazione dei servizi sanitari, Firenze, 1–2 décembre
1995.
International society for photogrammetry and remote sensing, Tutorial on recent advances
in numerical cartography, (Exposé: Un software per il calcolo di procedimenti statistici
robusti), Politecnico di Milano, Dipartimento di ingegneria idraulica, ambientale e del
rilevamento, Milano, 29 février 1996.
Zürcher Kolloquium über Anwendungsorientierte Statistik, ETHZ, (Exposé: Beispiele von
Resampling-Prozeduren für Konfidenzintervalle und Tests), Zürich, 2 mai 1996.
Forschungsinstitut für Mathematik de ETH Zürich, (Exposé: Estimating and testing the
means of asymmetric distributions using M-estimators), Zürich, 31 mai 1996.
Ecole Européenne d’Oncologie, Cours: L’Evaluation pluridisciplinaire des stratégies en
cancérologie: Introduction àlarégression logistique, Genève, 9 octobre 1996.
Scuola di specializzazione in igiene e medicina preventiva, Università degli studi di Firenze,
Corso: Strumenti di programmazione e gestione dei servizi sanitari: Modelli matematici e
statistici, Firenze, 10-11 janvier 1997.
Istituto svizzero di pedagogia per la formazione professionale, Sezione di lingua italiana,
Exposé: Applicazione della statistica alla matematica finanziaria, Scuola propedeutica,
Lugano-Trevano, 19 février 1997.
Universidad Nacional de La Plata, Departamento de matematica, Profesor Visitante,
Cours: Aplicaciones de metodos robustos, La Plata, 17 juillet - 17 août 1997.
9

Scuola di specializzazione in igiene e medicina preventiva, Università degli studi di Firenze.
Corso: Strumenti di programmazione e gestione dei servizi sanitari: Modelli matematici e
statistici. Firenze, 26–27 février 1998.
Corso di formazione manageriale per dirigenti dei ruoli sanitario ed amministrativo. Unità
sanitaria locale n. 12. Corso: Modelli matematici per la gestione delle attività sanitarie:
principi di statistica e di ricerca operativa. Viareggio, 6–8 juillet 1998.
Idem. Unità sanitaria locale n. 3. Montecatini, 9–11 juillet 1998.
The Data Analysis Products Division of Mathsoft, Inc., 1700 Westlake Ave N., Suite 500,
Seattle, WA 98109, dans le cadre du mandat Useable Robust Statistical Modeling and
Inference. 18–25 juillet 1999.
Scuola di specializzazione in igiene e medicina preventiva, Universit degli studi di Firenze,
La gestione del sistema sanitario : principi, strumenti, metodi. Elementi di statistica.
Firenze, 11fvrier, 2000.
Robust statistical software. Mathsoft, Data Analysis Products Division, Seattle. Workshop:
17-29 juillet, 2000.
Robust means of asymmetric distributions, Institut fuer Mathematische Statistik und Versicherungslehre,
Universitt Bern, Berne, 19 avril 2002
Analysis of hospital costs: robust methods for aymmetric responses Summer Meeting of
the Swiss Statistical Society, Bern, Berne, 24 mai 2002.
Analisi di costi di degenza: metodi statistici robusti per distribuzioni asimmetriche, Ospedale
Fatebenefratelli, Rome, 31 maggio 2002
Robust means of asymmetric distributions, Département de mathématiques, Université de
Fribourg, Fribourg, 11 juin 2002
Robust modeling of length of stay distributions, International workshop for health care
management, Lido di Camaiore (Lucca), 15 June 2002
Robust statistical procedures for aymmetric distributions and applications to the anylysis
of hospital costs. International Workshop on Computational Management Science,
Economics, Finance and Engeneering, 28-30 March 2003, Limassol, Cyprus.
Robust Box and Cox transformations in regression, International Conference on Robust
Statistics, 13-18 July 2003, Antwerp, Belgium.
Metodi robusti per distribuzioni asimmetriche ed applicazioni all’analisi dei costi ospedalieri.
Facoltà di scienze statistiche, Universtità La Spienza, 26 marzo 2004, Roma.
Robust Box-Cox transformations for multiple regression (with V. Yohai). International
Conference on Robust Statistics (ICORS04) Beijing, 12-16 July 2004.
Robust methods for asymmetric responses and applications to the analysis of hospital
costs. Charles University, Department of Statistics, Prague, 8 December 2004.
Robust response transformations in regression. Facultad de Ciecias Exactas y Naturales,
Universidad de Buenos Aires, 19 mai 2005.
Robust Box-Cox transformations in regression. Université deNeuchâtel,GroupedeStatistique,
Neuchâtel, 21 juin 2005.
International workshop on robust statistics and R. Coordinateur du groupe Econometric
models (with E. Cantoni). Università Ca’ Foscari di Venezia, Treviso, 28-28 octobre 2005.
10

Truncated maximum likelihood regression with censored observations. Facultad de Ciecias
Exactas y Naturales, Universidad de Buenos Aires, 2 mars 2006.
Truncated maximum likelihood regression with censored observations. International Conference
on Robust Statistics (ICORS06), Lisbone, 16-21 July 2006.
Truncated Maximum Likelihood Regression with censored responses and application to
the estimation of the mean hospital cost of stay. Workshop on Robustness and Statistical
Inference in Honor of Victor J. Yohai, Universidad Carlos III de Madrid, 5 octobre 2006.
Robust regression with censored responses and application to the estimation of the mean
hospital cost of stay, 4th International Conference on Computational Management Science
Geneva, April 20-22, 2007.
TML: a library for adaptively truncated maximum likelihood regression with asymmetric
errors, Second International Workshop on Robust Statistics and R, BIRS, Banff, Canada,
October 28 - November 2, 2007.
Regressione robusta “Truncated Maximum Likelihood” per risposte a distribuzione asimmetrica,
Università di Torino, Dipartimento di scienze biomediche e oncologia umana,
Torino, November 30, 2007
Stime robuste “Truncated Maximum Likelihood” per modelli AFT con risposte censurate
ed applicazione alla stima del costo medio delle degenze ospedaliere, Università di Torino,
Dipartimento di scienze biomediche e oncologia umana, Torino, November 30, 2007
Robust estimation of the log-gamma regression model, International Conference on Robust
Statistics (ICORS08), Antalya, September 8 - 12, 2008
Robust response transformations based on optimal prediction. Faculty of Economics and
Social Sciences (HEC), University of Geneva, October 31, 2008.
Robust regression with asymmetric errors. 7th Meeting of the Classification and Data
Analysis Group of the Italian Statistical Society. Catania, September 9-11, 2009.
Robust Accelerated Failure Time Regression. Dpto. de Estatdistica e Investigacin Operativa,
Universidad de Valladolid. July 12, 2010.
Robust Statistics and DRG. Kickoff-Workshops of the project Robust Risk Estimation.
Fraunhofer ITWM, Kaiserslautern, July 15, 2011.
Robust estimates of the generalized loggamma model. 4th International Conference of the
ERCIM Working Group on Computing & Statistics. London, 17-19 December 2011.
11