William R. Jackman - Bowdoin College

Current Position
WILLIAM R. JACKMAN
CURRICULUM VITAE
Assistant Professor of Biology at Bowdoin College, teaching Developmental Biology and other courses
and researching the development and evolution of teeth in fishes.
Contact Information
Bowdoin College
Biology Department
6500 College Station
Brunswick, ME 04011, USA
Phone: 207-798-4396
Email: wjackman@bowdoin.edu
Web: http://www.bowdoin.edu/faculty/w/wjackman
Formal Education
Ph.D. 2000, University of Oregon, Department of Biology, Eugene, OR.
B.S. 1993, Cell and Molecular Biology (Departmental Honors), University of Washington, Seattle, WA.
Area of Scientific Interest
The evolution of the genetic mechanisms of developmental patterning, especially in regard to the
development and evolution of teeth.
Research Experience
2007-Present. Bowdoin College, Brunswick, ME.
2001-2007. Post-doctoral Research Fellow, Department of Ecology and Evolutionary Biology, University
of Colorado, Boulder, CO, with Dr. David W. Stock. Used antisense knockdown and transgenic
methods to study the development and evolution of teeth in teleost fishes.
1994-2000. Graduate Research Fellow, Department of Biology, Institute of Neuroscience, University of
Oregon, Eugene, OR, with Dr. Charles B. Kimmel. Studied the molecular patterning and evolution of
the amphioxus hindbrain and pharynx.
1993-1994. Research Assistant, College of Forest Resources, University of Washington, Seattle, WA, with
Dr. David L. Peterson. Participated in global climate change data collection, processing, and
laboratory management.
1992-1993. University of Washington School of Aquatic and Fishery Sciences, Northwest Fisheries
Science Center, Seattle, WA, with Drs. Penny Swanson and Walton Dickhoff. Cloned and sequenced a
salmon activin gene.
1991. University of Washington College of Forest Resources, Seattle, WA, with Timothy Quinn. Studied
the use of bile acids in wildlife identification.
1990. Beth Israel Hospital, Boston, MA, with Dr. Robert Jackman. Worked as a technician with rat aortal
tissue culture.

Research Awards
Maine INBRE Investigator, “Comparative functional analysis of a vertebrate genomic cis-regulatory
region involved in embryonic organogenesis.” NIH/NCRR/NIGMS, 2009-present.
National Research Service Award Fellowship, “Transgenic Zebrafish as Models for Tooth
Morphogenesis,” NIH/NIDCR, 2003-2006.
IGERT Evolution and Development Training Grant, NSF, 2000-2001.
Developmental Biology Training Grant, NIH, 1997-2000.
Genetic Mechanisms of Evolution Training Grant, NSF, 1995-1997.
Publications (* undergraduate coauthor)
William R. Jackman, Shelby H. Davies*, David B. Lyons*, Caitlin K. Stauder*, Benjamin R. Denton-
Schneider*, Andrea Jowdry, Sharon R. Aigler, Scott A. Vogel*, and David W. Stock. Manipulation of
Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of
multicuspid teeth. Evolution and Development. (accepted)
Pawat Seritrakul*, Eric Samarut, Tenzing TS Lama*, Yann Gibert, Vincent Laudet, and William R
Jackman. (2012) Retinoic acid expands the evolutionarily reduced dentition of zebrafish. The FASEB
Journal. (epub ahead of print) doi: 10.1096/fj.12-209304
William R. Jackman, James J. Yoo*, and David W. Stock. (2010). Hedgehog signaling is required at
multiple stages of zebrafish tooth development. BMC Developmental Biology 10:119.
Yann Gibert, Laure Bernard, Melanie Debiais-Thibaud, Franck Bourrat, Jean-Stephane Joly, Karen Pottin,
Axel Meyer, Sylvie Retaux, David W. Stock, William R. Jackman, Pawat Seritrakul*, Gerrit
Begemann and Vincent Laudet. (2010). Formation of oral and pharyngeal dentition in teleosts
depends on differential recruitment of retinoic acid signaling. The FASEB Journal 24, 3298-3309.
Yoshiyuki Yamamoto, Mardi S. Byerly, William R. Jackman, and William R. Jeffery. (2009) Pleiotropic
functions of embryonic sonic hedgehog expression link jaw and taste bud amplification with eye loss
during cavefish evolution. Developmental Biology 330, 200-211.
William R. Jackman and David W. Stock. (2006). Transgenic analysis of Dlx regulation in fish tooth
development reveals evolutionary retention of enhancer function despite organ loss. Proceedings of
the National Academy of Sciences of the USA 103, 19390-19395.
David W. Stock, William R. Jackman, and Josh Trapani. (2006). Developmental genetic mechanisms of
evolutionary tooth loss in cypriniform fishes. Development 133, 3127-3137.
William R. Jackman, Bruce W. Draper, and David W. Stock. (2004). FGF signaling is required for
zebrafish tooth development. Developmental Biology 274, 139-157.
William R. Jackman, Jolee M. Mougey*, Georgia D. Panopoulou, and Charles B. Kimmel. (2004). crabp
and maf highlight the novelty of the amphioxus club-shaped gland. Acta Zoologica (Stockholm) 85,
91-99.
William R. Jackman and Charles B. Kimmel. (2002). Coincident iterated gene expression in the
amphioxus neural tube. Evolution and Development 4, 366-374.
Lisa Maves, William R. Jackman, and Charles B. Kimmel. (2002). FGF3 and FGF8 mediate a
rhombomere 4 signaling activity in the zebrafish hindbrain. Development 129, 3825-3837.
William R. Jackman, James A. Langeland, and Charles B. Kimmel. (2000). islet reveals segmentation in
the amphioxus hindbrain homolog. Developmental Biology 220, 16-26.
James A. Langeland, Jill M. Tomsa*, William R. Jackman Jr., and Charles B. Kimmel. (1998). An
amphioxus snail gene: Expression in paraxial mesoderm and neural plate suggests a conserved role in
patterning the chordate embryo. Development Genes and Evolution 208, 569–577.
Timothy Quinn and William R. Jackman. (1994). Influence of diet on detection of fecal bile acids by thinlater
chromatography. Journal of Wildlife Management. 58:295-299.
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Manuscripts in Preparation
Hana Littleford*, Andrea Jowdry, and William Jackman. Fluorescence visualization of gene expression
during zebrafish tooth development.
Andrea Jowdry, Hana Littleford*, Sarah Liu*, Elisabeth Carter*, Elizabeth Richards, and William
Jackman. Functional characterization of a tooth enhancer in zebrafish.
Invited Seminars
“Cell signaling in the development and evolution of vertebrate teeth.” University of Maine Farmington,
Farmington, ME, May 2012.
“Saber-toothed minnows and the genetic control of organogenesis.” University of Southern Maine,
Portland, ME, March 2010.
“What creating saber-toothed zebrafish can tell us about the genetic control of organogenesis.” Southern
Maine Community College, Portland, ME, February 2010.
“Transgenic analysis of Fgf signaling in zebrafish tooth development and evolution.” University of
Maine, Orono, ME, September 2007.
Presentations (last 10 years)
Hana Littleford*, Andrea Jowdry, and William Jackman. Functional characterization of a tooth enhancer.
The 10th International Conference on Zebrafish Development and Genetics, Madison, WI, June
20-24, 2012; and NIH, NIGMS Fourth Biennial National IDeA Symposium of Biomedical Research
Excellence (NISBRE), Washington, DC, June 25-27, 2012.
Pawat Seritrakul*, Andrea Jowdry, Tenzing Lama*, Calli Coffee* and William Jackman. Retinoic acid
expands the evolutionarily reduced dentition of zebrafish. 4th Northeast Regional IDeA Meeting,
Newport, RI, August 10-12, 2011.
Pawat Seritrakul, Tenzing Lama, and William Jackman. Functional analysis of retinoic acid signaling in
early zebrafish tooth development. The 9th International Conference on Zebrafish Development and
Genetics, Madison, WI, June 16-20, 2010.
William R. Jackman, Pawat Seritrakul, and Tenzing Lama. Functional analysis of cell signaling regulation
in zebrafish tooth development. Northeast Regional IDeA Meeting, Whitefield, NH, August 6, 2009.
William R. Jackman and David W. Stock. Ectopic expression of Fgf ligands results in supernumerary and
fused teeth in zebrafish larvae. Society for Integrative and Comparative Biology Annual Meeting,
Boston, MA, January 5, 2009.
William R. Jackman. Transgenic gain-of-function analysis of Fgf signaling in zebrafish tooth
development. The 35 th Maine Biological and Medical Sciences Symposium. MDI Biological
Laboratory, Salisbury Cove, ME, April 25, 2008.
William R. Jackman and David W. Stock. Ectopic expression of Fibroblast growth factor (Fgf) ligands
results in supernumerary and fused teeth in zebrafish larvae. The 8 th International Meeting on
Zebrafish Development and Genetics. Madison, WI, June 27, 2008.
William R. Jackman and David W. Stock. The evolution of hedgehog signaling in vertebrate tooth
development. Society for Integrative and Comparative Biology Annual Meeting. Phoenix, AZ,
January 3-7, 2007.
William R. Jackman and David W. Stock. Transgenic analysis of the mechanism of evolutionary tooth
loss in the zebrafish. The 7 th International Conference on Zebrafish Development and Genetics.
Madison, WI, June 16, 2006.
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William R. Jackman and David W. Stock. Transgenic analysis of the mechanism of cypriniform oral tooth
loss. Society for Integrative and Comparative Biology Annual Meeting, Orlando, FL, January 6,
2006.
William R. Jackman and David W. Stock. Transgenic analysis of Dlx involvement in cypriniform oral
tooth loss. Society for Developmental Biology Southwest Regional Meeting, Boulder, CO, October
30, 2005.
William R. Jackman and David W. Stock. Hedgehog signaling is required at multiple stages of zebrafish
tooth development. Society for Developmental Biology 64th Annual Meeting. San Francisco, CA,
July 27-August 1, 2005.
William R. Jackman and David W. Stock. Signaling pathways in zebrafish tooth development. Denver
Area Fish and Amphibian Meeting, Fort Collins, CO, April 26, 2005.
William R. Jackman, Josh Trapani, and David W. Stock. Evolutionary conservation and change in FGF
signaling during teleost tooth development. 6th International Meeting on Zebrafish Development and
Genetics. Madison, WI, July 29-August 2, 2004.
William R. Jackman and David W. Stock. FGF signaling is required for zebrafish pharyngeal tooth
development. Society for Developmental Biology Annual Meeting. Boston, MA, July 30-August 3,
2003.
Teaching Experience
Instructor
Bowdoin College, Biology 109, Introductory Biology. Spring 2009, 2010.
Bowdoin College, Biology 217, Developmental Biology. Fall 2007-09, 2011-12.
Bowdoin College, Biology 307, Evolutionary Developmental Biology. Spring 2008, 2010.
Bowdoin College, Biology/Biochemistry 401-404, Independent Study Research, Fall & Spring 2008-12.
Teaching Assistant
University of Oregon, Biology 355, Vertebrate Evolution and Development. C. Kimmel. Fall 1994.
University of Oregon, Biology 322, Cell Biology. James Weston. Winter 1995.
University of Oregon, Biology 261, Foundations I: Genetics and Evolution. J. Postlethwait. Spring 1995.
Guest Lecturer and Laboratory Instructor
University of Colorado, EPOB 5800, Genes Development and Evolution. 2003, 2005, 2006. D. Stock.
University of Oregon, Biology 410/510 Evolution of Development. Spring 2000. J. Postlethwait.
University of Oregon, Biology 355 Vertebrate Evolution and Development. Fall 1996-2000. C. Kimmel.
University of Oregon, Biology 131 Introduction to Evolution. Summer 1998. H. Jarrard.
Mentoring at Bowdoin College
2012-present. Mentoring Zachary Fox in his honors independent study research investigating cellular
phenotypes in developing tooth germs after hedgehog cell signaling inhibition.
2012-present. Mentoring Sarah Liu in her honors independent study research examining the genomic
regulation of the dlx2b gene during odontogenesis.
2012-present. Mentoring Bess Carter in her independent study research examining transcription factor
binding sites within a tooth enhancer of the zebrafish the dlx2b gene.
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2011-present. Mentoring Jeffery Yu in his independent study research investigating morphological
changes to developing teeth when hedgehog cell signaling is inhibited.
2011-12. Mentoring Calli Coffee in her honors independent study research studying interactions between
the RA, Fgf, and Bmp signaling pathways during tooth development.
2010-12. Mentoring Hana Littleford in her honors independent study research investigating the genomic
regulation of the dlx2b gene during tooth development.
2009-12. Mentoring Christina Pindar in an honors independent study project investigating the function of
dlx2b in zebrafish tooth developmental initiation.
2010-11. Mentored Benjamin Denton-Schneider in his honors research investigating the cellular and
transcriptional effects of fgf10a signaling during tooth development. (work published in Jackman et
al., 2012)
2010-11. Mentored Alexandra McLain during her honors research studying the role of Bmp and Fgf
signaling molecules in zebrafish tooth development.
2008-11. Mentored Pawat Seritrakul in an honors advanced independent study project investigating the
roles of retinoic acid signaling in the tooth development of several fish species. (work published in
Gibert et al., 2010 and Seritrakul et al., 2012)
2008-10. Mentored Shelby Davies in her honors advanced research project developing in our lab a
technique for directed protein over-expression in zebrafish embryos. (work published in Jackman et
al., 2012)
2008-10. Mentored Tenzing Lama in his honors independent study investigating the role of the prdm1a
transcription factor in zebrafish tooth development. (work published in Seritrakul et al., 2012)
2008-10. Mentored Caitlin Stauder in her honors research project studying the tissue-specific effects of
Fgf overexpression on promoting ectopic tooth development in zebrafish embryos. (work published in
Jackman et al., 2012)
2008-09. Mentored James Yoo’s honors research thesis project investigating dental gain of function
phenotypes associated with the hedgehog cell-signaling pathway. (work published in Jackman et al.,
2010)
2008-09. Mentored Catherine Doyle-Capitman during two independent study semesters comparing dental
morphology between fish species in the Danio genus.
Previous Mentoring
2005-06. Mentored CU undergraduate Scott Vogel in his senior honors thesis research project
investigating over-expression of Dlx genes during zebrafish tooth development.
1999-00. Mentored UO undergraduate Jolee Mougey (Munson) during her honors research project
characterizing the developmental expression of the amphioxus crabp gene. (Work published in
Jackman, Mougey, Panopoulou, and Kimmel, 2004)
Professional Responsibilities
2011-present. Bowdoin College Curriculum Implementation Committee.
2011-present. Manager and training instructor for the Bowdoin College Biology Confocal Microscopy
Facility.
2010. Society for Integrative and Comparative Biology DEDB Chair Nominating Committee.
2008-10. Bowdoin College Research Oversight Committee.
2002-07. Manager, technician, and training instructor for the University of Colorado EEB Confocal
Microscopy Facility.
Reviewed grants for the National Science Foundation.
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Reviewed manuscripts for the journals Acta Zoologica, Development, Developmental Biology,
Developmental Dynamics, Evolution and Development, the International Journal of Developmental
Biology, The Journal of Visualized Experiments, The Journal of Dental Research, and Mechanisms of
Development.
Professional Memberships
Society for Developmental Biology
Society for Integrative and Comparative Biology
American Society of Ichthyologists and Herpetologists
North American Native Fishes Association
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