A Critique of Pure (Genetic) Information

and regeneration, 162–63
and resistant hepatocytes, 167–70
retinoblastoma, 144–45
somatic mutation hypothesis,
117–18, 130–33, 135–36, 144–45,
156, 159–60
SOS system of, 193
and transgenic mouse experiments,
148
tumor suppressor genes, 142–46,
149–52, 154–55, 157–58
virally induced, 133–37
Cartesian vs. Newtonian matter, 8
Celera, 201n.3
Cell, 174
Cell-adhesion molecules, 161, 177,
181
Cell culture model of cancer, 170–72,
181
Cell fusion, 142–44, 146–48
Cell theory
and cancer theory, 124
and the genesis of genes, 18–19
modern, 124–26
Omnis cellula a cellula (cells come
only from cells), 126
Center vs. periphery, 31
Chargaff, Erwin, 65
Cherry, R. J., 94
Child, C. M., 36
Chromatin/chromosome marking,
xix, 76, 77, 111–14, 200n.8
Chromosomes, 19–21, 30–31, 33,
113, 202n.4. See also DNA; Genes,
genesis of
Chunk-of-anlagen, xvi
Circular causality, 9–10
Cirrhosis of the liver, and cancer, 167
Classical medicine, 118
Clockworks, as dynamical processes,
60–61
Cloning, 42, 136, 200–201n.14
Code-script. See Hereditary
code-script
Coding problem, 65–66
Cohnheim, Julius, 127–28, 129
Index 219
Colon cancer, 145, 153–54, 160
Colorectal cancer, 174–81, 182
Compartmentalization of cells,
membrane-based, 77–98
amphipathic substances/boundaries,
78–79, 87
archaea, 78
Band 3 molecules, 93–94
blebbing of membranes, 90
cellular membranes, composition of,
78
cytoskeletal interaction with
membrane proteins, 90, 93
endoplasmic reticulum, 82–83
and equilibrium thermodynamics,
76, 84–85, 91, 94–95, 98–99
eubacteria, 78
eukaryotes, 78, 80
fluid-mosaic model, 87
FRAP, 88–90
glycocalyx, 85–86
Golgi complex, 81
guanosine triphosphate molecules,
84
membrane/genome organization as
mutually dependent, 79–80, 95–98
metazoan ontogeny, 96–98
nuclear envelope, 80–81
nuclear pores, 80–81
Paramecium, 96
phospholipid membranes, 79, 87
protein differentiation, 79, 81–83,
85–86, 104
protein movement, 79, 83–84,
86–94
red blood cells, 92–93
SNAPs, 84
SNARES, 83–84
Tetrahymena, 96
Teutophrys, 96
vector relationship between
membranous stacks, 80–81
water molecules on a hydrophobic
surface, 79
Complexity. See Modularity and
complexity