Visualisering av funktionell och morfologisk hjärt-kärl-diagnostik
Visualisering av funktionell och morfologisk hjärt-kärl-diagnostik
Visualisering av funktionell och morfologisk hjärt-kärl-diagnostik
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Visualizing gene expression in clinical medicine<br />
Anders Gabrielsen, MD, DMSc, Dept. of Cardiology and Center for Molecular medicine, CMM L8:03<br />
Background:<br />
During the past years we h<strong>av</strong>e explored the global gene expression (using gene array technology)<br />
patterns of atherosclerosis and the vulnerable carotid atherosclerotic plaque; i.e. the plaque with the<br />
highest risk of developing a thrombosis. We h<strong>av</strong>e identified target genes which identifies “high risk”<br />
patients.<br />
In a similar way we h<strong>av</strong>e identified the important inflammatory molecules and responses to ischemia in<br />
the heart.<br />
Now, we want to translate this into clinical information.<br />
Our main goal is to develop clinical imaging tool(s) to visualize gene expression of target genes in vivo<br />
based on the target genes already identified.<br />
We are working with all state-of-the art technologies of molecular biology, and h<strong>av</strong>e access to all<br />
modern imaging tools. We would prefer to develop a MR-based platform.<br />
Contacts:<br />
Anders Gabrielsen, MD, DMSc,<br />
Dept. of Cardiology and Center for Molecular medicine,<br />
CMM L8:03, 17176 Karolinska Hospital, Stockholm<br />
Tel. 0709 733 886<br />
e-mail: anders.gabrielsen@ki.se<br />
Gabrielle Paulsson Berne, PhD, Ass. Prof.<br />
CMM L8:03, 17176 Karolinska Hospital, Stockholm<br />
e-mail: Gabrielle.berne@ki.se<br />
Ulf Hedin, MD, Prof.<br />
Dept. of Vascular surgery<br />
e-mail: Ulf.Hedin@ki.se
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