Visualisering av funktionell och morfologisk hjärt-kärl-diagnostik

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Quantification before surgical removment of a lob in patient with lung cancer Is it possible to make a soft ware for quantification of perfusion defects? Rimma.Axelsson@ki.se
POLYMER-SHELLED CONTRAST AGENTS FOR ULTRASOUND, SPECT AND MRI. Dr. Dmitry Grishenkov Ultrasound-based imaging technique is probably the most used approach for rapid investigation and monitoring of anatomical and physiological conditions of internal organs and tissues. The ultrasound imaging technique can be greatly improved by the use of contrast agents to enhance the signal from the area of interest relative to the background. Typically ultrasound contrast agent (UCA) is a suspension of the microbubbles consist of a gas core encapsulated within the solid shell. Generally these devices are injected systemically and function to enhance the ultrasound echo. The ideal UCA should be manufactured from the biocompatible material; be easily injected into the cardiovascular system either using bolus or continuous infusion; be stable during the ultrasound examination; do not cause any obstruction of the flow; remain within the blood pool or have well-defined specific tissue distribution; after destruction the residues should be safely processed and removed from the body. Neither material of the shell no encapsulated gas should be harmful or toxic for the organism. From the technical point of view UCA should modify the acoustic properties of the tissue, for instance by increasing ultrasound backscattered efficiency, or introducing harmonic component to the echo, or combination of both. The overall objective of the project is to test novel polymer shelled UCAs as a possible new generation of multifunctional contrast agents not only for Ultrasound technique but also for MRI and SPECT. In recent years, the UCA has moved from being just visualization tool to a new multifunctional and complex device for drug or gene therapy and targeted imaging. The new medical and technological approach of contrast enhanced ultrasound concerns “theranostics”, i.e. combination of therapy and diagnostics. Therapeutic systems are not any longer stand alone approach against a disease. On the contrary, they tent to integrate in to diagnostic techniques such as ultrasound, MRI and CT. With the help of these techniques in combination with novel UCAs local and specific drug delivery become possible. Within the frame of the project the surface of the polymer microballoon has been decorated with the pharmacological agents and the protocol for cavitation mediated release of the drug is established. The cutting-edge result of these integrated functions is the administration of a much lower drug dosage, avoiding the side effects of pharmaceutical overload. The latest trend in contrast enhanced sonography is so called molecular imaging, which is non-invasive imaging technique to visualize and monitor in real time very fine changes on the molecular level. Nowadays, the key modalities for molecular imaging are MRI, SPECT and PET. However, increasing interest is shown in introduction of specific targeted contrast ultrasound technique to the molecular imaging due to its unique features: high temporal resolution, low-cost and wide availability. In conclusion, the proposed polymer-shelled gas-core microbubbles can be considered as a prospective next generation of contrast agents, which allows not only multimodality image enhancement relevant to diagnostics but also localized and specific drug delivery for non-invasive therapy.
Page 1 and 2: Speed Dating CMIV Hjärtkärlvisual
Page 3 and 4: Visualisering av funktionell och mo
Page 5 and 6: Automated Analysis and Classificati
Page 7 and 8: Spatio-spectral maps Hamed Hamid Mu
Page 9 and 10: Jonas Forsslund, 2010-10-25 KTH Sch
Page 11 and 12: jofo02@kth.se Perceptualization Jon
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Page 15 and 16: WIDE INTENSITY RANGE SENSOR FOR MED
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Page 27 and 28: Prototype electronics • Multipurp
Page 29 and 30: Image fusion - hybid imaging (Kenne
Page 31 and 32: Decision making tools in the diagno
Page 33 and 34: X-ray exam VQ scan in patient with
Page 35: SPECT perfusion transversal reconst
Page 39 and 40: 3MICRON (Collaborative EU Project)
Page 41 and 42: Contact information: Prof. Laszlo F
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Page 45 and 46: Affiliation: Professor emeritus at
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Page 51 and 52: Pre- and per-operative mapping of s
Page 53: Techniques • Multipolar contact a
Page 56 and 57: Posterior-anterior and anterior-pos
Page 58 and 59: CTMH Speed Dating, Oct 29th, 2010 F
Page 60 and 61: ��
Page 62 and 63: Medical User Interfaces Advanced in
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Page 66 and 67: Research project - cardiovascular s
Page 68 and 69: Jeannette Hiromi Spühler PhD stude
Page 70 and 71: 2010‐10‐28 2
Page 72 and 73: Presentation at the Centre for Tech
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Page 76: 2D and 3D Dynamic Programming for D
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