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YaleB. MITCHEL, MD Yale B. Mitchel, MD joined Merck Research Labs in 1991 and has contributed to the clinical development of lovastatin, simvastatin and the novel cholesterol-absorption inhibitor ezetimibe. He currently is an executive director of Clinical Research, Cardiovascular Disease at Merck and leads the Atherosclerosis section of the department. Dr. Mitchel received his Bachelor of Science in biology from Carnegie Mellon University and earned his MD at New York Medical College. He did his internal medicine residency at the Bronx Municipal Hospital, a teaching hospital of the Albert Einstein College of Medicine, and completed his endocrine fellowship under the supervision of Dr. Howard Eder at the Albert Einstein College of Medicine. As a faculty member at Albert Einstein College of Medicine, Dr. Mitchel's research focused on the identification of a hepatic receptor for high-density lipoproteins and apoprotein A-I, and human lipoprotein metabolism. Dr. Mitchel is board certified in internal medicine and endocrinology, and is a fellow of the Arteriosclerosis, Thrombosis and Vascular Biology Council of the American Heart Association and a member of the International Atherosclerosis Society. ____________________________________________________________________________ Marc A. PFEFFER, MD, PHD Dr. Marc A. Pfeffer, a graduate of Rockford College in Rockford, Illinois, received both his doctorate in physiology and biophysics and his medical degree from the University of Oklahoma in Oklahoma City. He completed his internship, residency and clinical fellowship at the Peter Bent Brigham Hospital, Harvard Medical School in Boston. Dr. Pfeffer is currently the Dzau Professor of Medicine at Harvard Medical School and physician in the Cardiology Division at Brigham and Women's Hospital. Dr. Pfeffer also serves as medical director of Partners Research and Education Program (PREP). Dr. Pfeffer has distinguished himself as a translational investigator. Along with his late wife, Dr. Janice Pfeffer, and Eugene Braunwald, M.D., their studies in an experimental model of myocardial infarction first introduced the concept of an insidious deleterious structural remodeling of the impaired ventricle. They demonstrated in both animals and man that angiotensin converting enzyme (ACE) inhibitors could attenuate these adverse structural and functional changes providing the rationale for the use of these agents in patients experiencing a myocardial infarction. Pfeffer led the first definitive clinical trial demonstrating that this use could prolong survival and prevent the development of heart failure, which has improved the prognosis of untold numbers of survivors of myocardial infarction. From his major initial discovery, Dr. Pfeffer's career trajectory has been to lead a number of other key practice-changing, randomized controlled clinical trials. Indeed, a common theme for his substantial contributions has been in the utilization of the randomized controlled trial to enhance the academic mission. Dr. Pfeffer has had a principal role in several practice-changing clinical trials such as SAVE, CARE, HEART, VALIANT, CHARM and PEACE. He is currently a leading investigator in ARISE, TOPCAT and TREAT. He is generally considered as a team builder and takes pride in academic advancement of trainees and junior faculty collaborating on the trials, and embedding important mechanistic substudies within the major randomized trials to enhance our understanding of the pathophysiology of the disease processes. Pfeffer's trials have set high standards for relationships with the sponsors whether industry or NHLBI. He is known for his fairness in data sharing and assisting others in developing meaningful scholarly works from study databases. His studies have improved medical practice and patient prognosis. The influence of a scientist's work in their field can be assessed by how often their publications are cited by other scientists. In 2006, Pfeffer was listed by Science Watch as having the most "Hot Papers" (highly cited) in all of clinical medicine. On a local level, his leadership abilities are well recognized and appreciated at the Brigham and Women's Hospital as Dr. Pfeffer was recently asked to serve as the Interim Chair of the Department of Medicine. Pfeffer also effectively uses the vehicle of randomized controlled clinical trials to promote physician satisfaction and education for those less academically oriented. As the leader of Partners Research and Education Program (PREP), he has developed networks of community-based physicians who enjoy making meaningful contributions to clinical investigation.
Bertram PITT M.D. Education 1945-49 Forrest Hills High School, Forest Hills, NY 1949-53 Cornell University, New York, New York, B.A 1953-59 University of Basel, Switzerland, M.D. Postdoctoral training 1959-60 Intern, Beth Israel Hospital, New York, NY 1960-62 Assistant Resident, Beth Israel Hospital, Boston, MA 1961-62 Teaching Fellow in Medicine, Harvard University, Boston, MA 1962-63 Chief Resident, Medicine, Beth Israel Hospital, Boston, MA 1962-63 Assistant in Medicine, Harvard University Teaching Fellow in Medicine, Tufts University, Boston, MA 1966-67 National Heart Institute Special Fellow, Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD Academic appointments 1967-68 Instructor in Medicine, Johns Hopkins University 1968-72 Assistant Professor Medicine, Johns Hopkins University 1972-77 Associate Professor of Medicine, Johns Hopkins University 1977-91 Professor of Internal Medicine, Director, Division of Cardiology, University of Michigan School of Medicine 1991-99 Professor of Internal Medicine, Associate Chairman for Academic and Industrial Programs, Department of Internal Medicine, University of Michigan School of Medicine 1999- Professor if Internal Medicine, University of Michigan School of Medicine Certification and licensure Medical Licensure 1960 Connecticut 1960 New York 1963 Massachusetts 1967 Maryland 1978 Michigan Board Certification 1973 American Board of Internal Medicine 1973 American Board of Cardiology Honors and awards 1976-66 Bronze Award, American Heart Association - Maryland Affiliate 1977 Haille Selassie Lecturer, British Heart Foundation 1978 Outstanding Cardiology Staff - University of Michigan 2000 Johns Hopkins University Society of Scholars 2001 Forest Dewey Dodrill Award for Excellence-American Heart Association 2002 Paul Dekruif Lifetime Achievement Award - University of Michigan Membership and offices in professional societies American Physiological Society - Circulation Group ; American Federation for Clinical Research ; American Heart Association Council on Circulation: 1982-83 Chairman Council on Radiology 1987 Fellow, Council on Clinical Cardiology, American Society for Clinical Investigation - Emeritus 2003 Membership, International Society for Heart Research 1994 Fellow, American College of Cardiology, Trustee 1993 American Society of Nuclear Cardiology, Founding Member 1990-93 President, Michigan Chapter of American College of Cardiology 1988-92 Cardiovascular Norms Committee, Member, American College of Cardiology Michigan Heart Association of University Cardiologists American College of Physicians 1988-91Cardiovascular Norms Committee, American College of Cardiology 1985-90 American Journal of Noninvasive Cardiology Consultant, Society for Cardiac Angiography 1985-87 Chairman, Young Investigator's Award Committee, American College of Cardiology 1985 Vice Chairman of the Cardiovascular Council, Central Society for Clinical Research 1982 Association of American Physicians ; Society of Nuclear Medicine ; Fellow, American College of Chest Physicians
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Page 5 and 6: STAGNITTO Maria Director Office of
Page 7 and 8: Jeffrey S. BORER,M.D Biographical S
Page 9 and 10: Gad COTTER, MD, FACC EDUCATION/TRAI
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Page 27 and 28: Hans WEDEL I have been professor in

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