BAB I - USU Institutional Repository - Universitas Sumatera Utara

THE RELATION OF BLOOD GLUCOSE RATE CONTROL WITH ASYMMETRICAL
DIMETHYLARGININE (ADMA) IN TYPE-2 DM PATIENTS
Ameliana Purba, Dharma Lindarto
Department of Internal Medicine - Division of Endocrinology and Metabolic H.
Adam Malik Hospital/ Medical Faculty of Universitas Sumatera Utara
ABSTRACT
Background
Increasing life expectacy is ussualy in line with increasing prevalence of metabolic
diseases, especially diabetes mellitus (DM). Cardiovascular disease is the main cause
of morbidity and mortality in diabetic patient. Endothelial dysfunction will carry out in
plaque establishment, progression and rupture. The mechanism of endothelial hindrance
is interceded by inhibitor molecule of endogene nitric oxide sinthase (NOS), which is
known ASYMMETRICAL DIMETHYLARGININE (ADMA).
Risk factor of disturbance endothelial vasodilator function is due to the accumulation of
ADMA. By blockading NO generation, ADMA can begins the process of atherogenesis,
plaque progression and rupture. Datas so far about ADMA in type-2 DM patients in
Indonesia were not greatly published yet, which is still interesting to be analyzed.
OBJECTIVE
To find out the difference of ADMA rate in controlled and uncontrolled blood glucose rate
patients and the relation between HbA1c with ADMA.
METHOD
The research had been done since January 2009 until June 2009 with cross sectional
method. The amount of participant examined 44 which randomly chosen from type-2
controlled blood glucose rate DM outpatient from division of Endocrinology and
Metabolic clinic in Adam Malik General Hospital.
Of all patients were performed anamneses, physical diagnostic, blood glucose
examination, HbA1c, and ADMA. Controlled blood glucose was established if HbA1c
less equal than 7%.
RESULT
Of 44 samples the average age (58.70 ± 9.,059) yo , average ad random blood glucose
rate (194.89 ± 79.310) mg/dl, average HbA1c (8.395 ± 2.5134) %, and average ADMA
(0.9161 ± 0.399) µmol/L.
There were 20 (45.45%) controlled blood glucose samples. Positive relation discovered
between age and ADMA in uncontrolled blood glucose group (r = 0.,535 ; p= 0.007). The
mean ADMA in uncontrolled group was higher than the controlled one (1.03 ± 0.507 vs
0.779 ± 0.1166) µmol/L. Discovered unsignificant relation between ad random blood
glucose rate and HbA1c with ADMA in controlled blood glucose group (respectively p =
0.94 ; p= 0.442) and uncontrolled (respectively p = 0.925; p = 0.933).
Universitas Sumatera Utara