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qimiuri teqnologiisa da<br />
metalurgiis seqcia<br />
uak 66.098<br />
benzo[b]furo-[3,2-f]-benzimidazolonidan manixis reaqciiT miRebuli<br />
zogierTi warmoebuli<br />
m. maisuraZe*, n. gaxokiZe, s. cqvitaia<br />
qimiuri da biologiuri teqnologiebis departamenti, saqarTvelos teqnikuri universiteti,<br />
saqarTvelo, 0175, Tbilisi, kostavas 77<br />
E‐mail: m_maisuradze@gtu.ge<br />
reziume: ganxilulia axali heterocikluri<br />
kondensirebuli sistemis benzo[b]furo-[3,2f]-benzimidazolonis<br />
da mis bazaze mosalodneli<br />
biologiuri aqtiurobis mqone warmoebulebis3(N,N-dieTilaminomeTil)-benzo[b]furo[3,2‐f]benzimidazolini,3(N-morfolino)-benzo[b]furo[3,2‐f]benzimidazolini3-(N-piperazino)-benzo[b]furo-[3,2-f]-benzimidazolonis<br />
manixis reaqciiT miReba.<br />
sakvanZo sityvebi: dibenzofurani; benzimidazoloni;<br />
manixis reaqcia.<br />
1. Sesavali<br />
cnobilia, rom axali samkurnalo saSualebebis<br />
SeqmnisaTvis sxva meTodebs Soris<br />
erT-erTi mniSvnelovania cnobili, fiziologiurad<br />
aqtiuri molekulis qimiuri modifikacia.<br />
qimiuri modifikacia aseve gulisxmobs<br />
biologiuri aqtiurobis mqone molekulebis<br />
erT molekulaSi gaerTianebas,<br />
rasac, umetes SemTxvevaSi, mivyavarT biologiurad<br />
aqtiuri intensiurobis an speqtris<br />
cvlilebasTan. nivTierebebi, romlebic heterociklur<br />
fragmentebs Seicavs ricxobrivad<br />
pirvel adgils ikavebs samkurnalo preparatebis<br />
arsenalSi (60%-ze meti), xolo gayidvebis<br />
mixedviT 25 wamyvan samkurnalo preparats<br />
Soris 2000 wels 72% Seadgina [1].<br />
Cveni kvlevis sagania benzofurobenzimidazolebi,<br />
romlebic SegviZlia warmovidginoT,<br />
rogorc erT molekulaSi gaerTianebuli<br />
furanisa da imidazolis fragmentebi.<br />
farmakologiurad aqtiuri furanis nawarmebSi<br />
Sedis vitamini C, antibaqteriuli<br />
nitrofuranebis ojaxi da Tanamedrove far-<br />
Tod gamoyenebuli wylulis sawinaaRmdego<br />
preparatebi. imidazolis birTvi xSirad<br />
gvxvdeba sinTetikur samkurnalo preparatebsa<br />
da biogenul nivTierebebSi. Caunacvlebeli<br />
imidazoli inhibirebas uwevs ferment<br />
tromboqsans, romelsac, Tavis mxriv,<br />
mivyavarT prostaciklinis koncentraciis<br />
zrdasTan da Sedegad sisxlis Sededebis<br />
SewyvetasTan. histamini biogenuri aminia da<br />
organizmSi neiromediatoris rols asrulebs.<br />
dihidroqloridis saxiT is gamoiyeneba<br />
poliarTritis, revmatizmisa da alergiuli<br />
daavadebebis samkurnalod. imidazolis warmoebul<br />
dazoqsibens maRali antiTrombuli<br />
aqtiuroba axasiaTebs. samedicino praqtikaSi<br />
triqomonozis sawinaaRmdegod gamoiyeneba 5<br />
nitroimidazolis nawarmi. maT Soris aRsaniSnavia<br />
iseTi parazitsawinaaRmdego agentebi,<br />
rogoricaa metronidazoli da Tinidazoli.<br />
naxevar saukuneze metia glaukomis sawinaaRmdegod<br />
_ Tvalis Siga wnevis dasaregulireblad<br />
gamoiyeneba alkaloidi pilokarpini,<br />
romelic erTdroulad furanisa da<br />
imidazolis cikls Seicavs [1].<br />
CamoTvlili mcire nawilia samedicino<br />
praqtikaSi gamoyenebuli preparatebisa, romlebic<br />
Seicavs furanisa da imidazolis<br />
ciklebs. zemoTqmulidan gamomdinare, sainteresoa<br />
furanisa da imidazolis fragmentebis<br />
Semcveli kondensirebuli sistemebis da maTi<br />
warmoebulebis sinTezi Semdgomi biologiuri<br />
aqtiurobis Sewavlis perspeqtiviT.<br />
2. ZiriTadi nawili<br />
benzimidazolonis misaRebad sawyis naer-<br />
Tad aRebul iqna 2,3-diaminodibenzofurani.<br />
rogorc cnobilia, qlorhidratirebuli fenilendiaminis<br />
SardovanasTan gacxelebis Sedegad<br />
warmoiqmneba 2-benzimidazoloni [2].<br />
Cven SemTxvevaSi reaqcias vatarebdiT 2,3diaminodibenzofuranis<br />
qlorhidratis Sar-<br />
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