a3)595*! ! !
a3)595*! ! !
a3)595*! ! !
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
stu-s Sromebi – TRANSACTIONS OF GTU – ТРУДЫ ГТУ № 2 (484), 2012<br />
sqema 4<br />
warmatebuli Canacvleba molekulas ani-<br />
Webs met stabilurobas, lipofilurobas da<br />
Sewovis unars. uamravi aseTi Camnacvlebeli<br />
ukve dafiqsirebulia, magram maTi Seqmnis<br />
kombinirebuli gzebi mainc rTuli da mravasafexurovania.<br />
ase, rom axali Camnacvleblebis<br />
aRmoCena ufro martivi sinTezis<br />
gziT Zalian mniSvnelovania da saSualebas<br />
iZleva Seswavlil da miRebul iqnes amid-<br />
Semcveli axali molekulebi da axali inhibitorebi<br />
axali fizikur-qimiuri TvisebebiT.<br />
cnobilia, rom 1,2,3-triazoli SesaniSnavi<br />
Camnacvlebelia peptiduri jgufisaTvis, HIV-<br />
1 proteazas inhibirebisaTvis. es naCvenebia<br />
preparat amprenaviris magaliTze, masSi amiduri<br />
jgufis nacvlad Seyvanilia ufro polaruli<br />
triazoli (>5 debai), riTac TiTqos<br />
gaiyo molekulis sibrtye da Seicvala maxasiaTeblebi<br />
[9].<br />
2. ZiriTadi nawili<br />
yovelive zemoTqmulidan gamomdinare,<br />
uaRresad sainteresod gvesaxeboda Cveni samuSao<br />
– migveRo naerTi, romelic Seicavs<br />
dibenzofuranis triciklTan kondensirebul<br />
1,2,3-triazolis cikls.<br />
sawyis naerTebad aRebuli iyo 1,2-, 2,3-,<br />
3,4-diamindibenzofurani, romlebic me-5_6_7<br />
sqemebis mixedviT miiReba:<br />
1-2-diaminis (1) sawyis naerTad SerCeul<br />
iqna dibenzofurani, romlis pirdapiri nitrirebis<br />
Sedegad miiReba 3-nitrodiben-<br />
zofurani. reaqcia mimdinareobs yinulovani<br />
ZmarmJavas areSi mbolavi azotmJavas (d=1,49)<br />
damatebiT 28 0 C temperaturaze (sqema 5). misi<br />
ZmarmJava anhidridis meSveobiT acilirebiT<br />
da Semdgomi nitrirebiT miiReba 2-nitro-3aminoacildibenzofurani,<br />
hidroliziT _ 2nitro-3-aminodibenzofuranis.<br />
miRebuli 2,3diaminodibenzofuranis.<br />
hidroliziT miRebuli<br />
2-nitro-3-aminodibenzofuranis naerTis<br />
deaminirebis Semdeg miiReba 2-nitrodibenzofurani.<br />
hidrazinhidratis da reneis nike-<br />
lis meSveobiT aRdgeniT da Semdgomi benzolirebiT<br />
da nitrirebiT miRebuli 1-amino-<br />
2aminoacildibenzofuranis hidroliziT<br />
miiReba 1,2 – diaminodibenzofurani.<br />
20<br />
sqema 5. 1,2-diaminodibenzofuranis miReba<br />
sqema 6. 2,3-diaminodibenzofuranis miReba<br />
2,3-diaminis (2) misaRebad (sqema 6) sawyisi<br />
naerTi _ dibenzofuranidan miRebuli 2-aminodibenzofurani<br />
gadis igive stadiebs 2nitro-3-aminodibenzofuranis<br />
miRebamde. miRebuli<br />
naerTis reneis nikelisa da hidrazinhidratis<br />
meSveobiT aRdgeniT da Semdgomi<br />
hidroliziT miiReba 2,3-aminodibenzofurani.<br />
sqema 7. 2,3-diaminodibenzofuranis miReba