saqarTvelos mecnierebaTa erovnuli akademia

182
nierebaTa erovnuli akademiis macne, biologiis
seria B, t. 8, #3-4, 2010, 6-10, inglisur enaze).
virTagvas Tavis tvinis sinafsuri membranebis
fraqciaSi Seswavlilia neirotransmiterebis (NT):
5-hidroqsitriftaminis (5-HT), noradrenalinisa
(NA) da endogenuri sinaftosomuri faqtoris (SF)
efeqti aniondamokidebul ATPazebze. naCvenebia,
rom sakuTriv NT da SF ainhibirebs Cl-ATPazas,
xolo maTi erToblivi moqmedebiT (SF/NT) inhibiciuri
efeqti ixsneba da gadadis aqtivaciaSi.
sinafsuri faqtoriT neirotransmiterebis
regulacia universaluria im transportuli fermentuli
sistemebisaTvis, romelTa monawileoba
damtkicebulia sinafsuri gadacemis procesSi da
ar vrceldeba sxva membranul fermentebze rogorc
satransporto, ise ,,Ecto” ATPazebze.
2) `neirotransmiterebisa da sinaftosomuri
faqtoris gavlena orvalentiani kaTionebiT aqtivirebul
ATPazur aqtivobebze” (TanaavtorobiT;
saqarTvelos mecnierebaTa erovnuli akademiis macne,
biologiis seria B, t. 8, #3-4, 2010, 17-19, inglisur
enaze).
virTagvas Tavis tvinis sinafsur fraqciaSi
lokalizebuli orvalentiani kaTionebiT aqtivirebuli
ATPazebis (Cu 2+ -, Zn 2+ - da Ni 2+ -ATPaza) Seswavlam
aCvena, rom rogorc cal-calke noradrenalini
da sinaftosomuri faqtori, ise maTi
erTdrouli moqmedeba gavlenas ar axdens aRniSnuli
fermentuli sistemebis muSaobaze. vinaidan
zemoT CamoTvlili ATPazebi ar monawileoben
sinafsur gadacemaSi, savaraudod, amiT aixsneba
maTi aramgrZnobeloba noradrenalinisa da
sinaftosomuri faqtoris mimarT.