toradoli - GPC
toradoli - GPC
toradoli - GPC
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iski. am reaqciebisadmi ufro metad mgrZnobiarenni arian da ufro cudad itanenxandazmuli da dauZlurebulo pacientebi; swored am jgufSi aRiniSneba kuW-nawlavistraqtis reaqciebis yvelaze meti ricxvi letaluri dasasruliT.iseve rogorc sxva asas mkurnalobisas, gverdiTi movlenebis sixSire da simZimis xarisximatulobs <strong>toradoli</strong>s dozisa da Terapiis xangrZlivobis matebasTan erTad. kuW-nawlavistraqtidan mZime sisxldenebis riski damokidebulia dozaze da izrdeba xandazmuli asakispacientebSi, romlebic dReRameSi <strong>toradoli</strong>s 60 mg-ze mets Rebuloben. anamnezSiwylulovani daavadebis arseboba zrdis kuW-nawlavis mxriv mZime garTulebebisganviTarebis albaTobas.zegavlena Tirkmlebze<strong>toradoli</strong>s, iseve rogorc sxva asas, daniSvna anamnezSi Tirkmlis funqciis darRvevebismqone avadmyofebisaTvis unda ganxorcieldes sifrTxiliT, vinaidan igi prostaglandinebissinTezis Zlieri inhibitoria. sifrTxilis dacvaa agreTve saWiro mocirkulire sisxlisSemcirebuli moculobis da/an Tirkmlis Semcirebuli sisxlmomaragaebis mqone pacientebSi<strong>toradoli</strong>s daniSvnisas, rameTu TirkmlebSi warmoqmnili prostaglandinebi xels uwyobenTirkmlis perfuziis SenarCunebas. am pacientebSi asas gamoyenebam SeiZleba gamoiwviosTirkmlebSi prostaglandinebis warmoqmnis dozaze damokidebuli Semcireba da migviyvanosTirkmlis manifestirebul ukmarisobamde. amis riski yvelaze metadaa gamoxatulimocirkulire sisxlis moculobis Semcirebis, gulis ukmarisobis da RviZlis funqciisdarRvevebis mqone pacientebSi, agreTve xandazmuli asakis pirebSi da avadmyofebSi,romlebic diuretikebs Rebuloben. asas miRebis Sewyvetis Semdeg avadmyofis mdgomareoba,Cveulebriv, sawyiss ubrundeba.anafilaqsiuri (anafilaqtoiduri) reaqciebiavadmyofebs, romelTac anamnezSi aReniSnebaT asTma da bronqospazmi, cxviris polipozi,angionevrozuli SeSupebebi, toradols uniSnaven sifrTxiliT.sisxlis sistema<strong>toradoli</strong> Trgunavs Trombocitebis agregacias, amcirebs Tromboqsanis koncentracias dazrdis sisxldenis xangrZlivobas. aspirinisgan gansxvavebiT toradol xanmokle droiTmoqmedebs Trombocitebis funqciaze, romelic normalizdeba preparatis gauqmebidan 24-48saaTSi.avadmyofebs Sededebis darRvevebiT <strong>toradoli</strong> gansakuTrebuli sifrTxiliT iniSneba, maTimdgomareoba saguldagulo kontrolis fonze. Tumca klinikuri kvlevebiT ar gamovlindamniSvnelovani urTierTqmedeba toradolsa da varfarins an heparins Soris, <strong>toradoli</strong>sa dahemostazze moqmedi preparatebis, maT Soris antikoagulantebis (varfarini,heparinoprofilaqtika dabal dozebSi – 2500-5000 erTeuli 2-jer dRe-RameSi) dadeqstranebis, erTdroulma gamoyenebam SeiZleba gazardos sisxldenebis riski. <strong>toradoli</strong>sdaniSvna msgavs situaciebSi unda ganxorcieldes gansakuTrebuli sifrTxiliT,avadmyofebis saguldagulo kontrolis fonze.aRwerilia postoperaciuli hematomebis da operaciuli Wrilobis sxva garTulbebisganviTarebis SemTxvevebi <strong>toradoli</strong>s parenterulad perioperaciuli gamoyenebisas.sifrTxilis gamoCenaa saWiro <strong>toradoli</strong>s daniSvnisas postoperaciul avadmyofebSi,romlebic gansakuTrebulad saguldagolo hemostazs saWiroeben, magaliTad winamdebarejirkvlis rezeqciis, tonzileqtomiisa an kosmetikuri operaciis Semdeg.xandazmuli asakis avadmyofebies avadmyofebi ufro mgrZnobiarenni arian gverdiTi movlenebisadmi, vidre axalgazrdebi.riskis gazrda asakis parakelurad yvela asas aris damaxiasaTebeli. xandazmuli asakispacientebSi naxevradgamoyofis periodi izrdeba, xolo ketorolakis plazmuri klirensiSeiZleba Semcirdes.siTxis Sekaveba da SeSupebebi<strong>toradoli</strong>s gamoyenebisas aRwerilia siTxis Sekavebisa da SeSupebebis SemTxvevebi, amitompreparatis daniSvnisas sifrTxilis gamoCenaa saWiro gulis dekompensirebuli ukmarisobis,arteriuli hipertenziisa da analogiuri mdgomareobebebis mqone avadmyofebSi.sifrTxilea saWiro <strong>toradoli</strong>sa da probenecidis erTdrouli daniSvnisas, vinaidan amukanasknelma SeiZleba Secvalos ketorolakis farmakokinetika.sifrTxiles moiTxovs <strong>toradoli</strong>s da metotreqsatis erTdrouli gamoyeneba, vinaidanprostaglandinebis inhibitorebi metotreqsatis klirens amcireben da amiT zrdian misSesaZlo toqsiurobas.transportis marTva da manqana-danadgarebTan muSaoba<strong>toradoli</strong>T mkurnalobisas zogierT avadmyofs SeiZleba ganuviTardes Zilianoba,Tavbrusxveva, uZiloba an depresia. aseT SemTxvevebSi gansakuTrebuli sifrTxilea saWiroim saxis samuSaos Sesrulebisas, romelic yuradRebis srul daZabvas moiTxovs.orsuloba da ZuZuTi kveba
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