CIPRO

vamtkicebsaqarTvelos Sromis, janmrTelobisa dasocialuri dacvis ministri-------------------------------------- a. gamyreliZe”-----” ----------------------------- 2003 w.gamoyenebis instruqciacipro(CIPRO)wamlis forma:tabletigeneriuli dasaxeleba:ciprofloqsaciniSemadgenloba:1 tableti Seicavs 500 mg ciprofloqsacinis hidroqloridis monohidrats.damxmare nivTierebebi:titanis dioqsidi.farmakologiuri jgufiftorqinolonebis jgufis antibaqteriuli saSualebafarmakologiuri Tvisebebi:cipro warmoadgens farTo speqtris peroralur sinTezur baqteriocidulsaSualebas. misi baqteriociduli efeqtis Sedegs warmoadgens dnm-is enzimhirazasTan urTierTqmedeba, romelic aucilebelia baqteriuli dnm-is sinTezisaTvis.ciprofloqsacinis aqtivoba, rogorc gramdadebiTi, agreTve gramuaryofiTiorganizmebis mimarT dadgenilia in vitro da klinikuri kvlevebiT.cipros specifikuri moqmedebis gamo, garda qinolonebis jgufisa ar axasiaTebsjvaredini rezistentoba sxva antibiotikebis mimarT, ris gamoc preparati ufrometad aqtiuria im baqteriebis mimarT, romlebic rezistentuli arianantibiotikebis: mag. aminoglikozidebis, penicilinebis, tetraciklinebis da sxvaTamimarT.laboratoriuli da klinikuri gamokvlevebiT dadgenilia misi iseTi aqtivoba iseTimikroorganizmebis mimarT, rogoricaa:Acinetobacter, Aeromonas, Branhamella, Brucella, Campylobacter, Chlamydia, Citrobacter,Corynebacterium, Enterobacter, Escherichia coli, haemophilus, hatnia, Klebsiella, legionella,Listeria, Neiseria, Proteus, Edwardsiella, providentia, moraxella, morganella, Pasteurella,plesiomonas,Pseudomonas, salmonella, Serratia, Shigella, Streptococus agalactiae, Streptococus,Staphyloccocus, vibrio, Yersinia.

mis mimarT xangamoSvebiT rezistentobiT xasiaTdebian: Alcaligenes, Flavobacterium,Gardnerella, Mycobacterium fortuitum, mycoplasma hominis, Mycobacterium tuberculosis,Streptococus faecalis, Streptococus pyogenes, Streptococus viridans.SedarebiT mgrZnobierni arian: Nocardia asteroides, Streptococus faecalis, Streptococuspneumonie, Ureaplasma urealiticum.cipro ar avlens Treponoma pallidum-is mimarT.sxva antibaqteriul preparatebTan kombinaciiT, ciprofloqsacins ZiriTadadaxasiaTebs damatebiTi an neitraluri moqmedeba.sinergizms adgili aqvs ciprosa da beta-laqtamuri jgufis saSualebebis kombinaciisdros.igi ar gamoyeneba gacivebis an virusuli daavadebebis dros.farmakokinetika:peroraluri miRebisas ciprofloqsacini swrafad da kargad absorbirdeba kuWnawlavistraqtidan. pirveladi metabolizmis dros bioSeRwevadoba, yovelgvaridanakargebis gareSe Seadgens 70-80%. misi maqsimaluri koncentracia sisxlisplazmaSi aRiniSneba 1-2 sT-is Semdeg. saSualo koncentracia 12 sT-is Semdegpreparatis 250mg da 500mg miRebidan Seadgens Sesabamisad 0.1 an 0.2mkg\ml-s.preparatis naxevrad gamoyofis periodi, (Tirkmelebis normaluri funqciis mqonepirebSi), Seadgens daaxloebiT 4sT-s. preparatis dozis 40-50% gamoiyofaSeucvleli saxiT SardTan erTad. erTjeradi dozis 10-12% organizmidan gamoiyofametabolitebis saxiT. preparatis 90% gamoiyofa Tirkmelebis saSualebiT pirveli24 sT-is ganmavlobaSi.Tirkmelebis ukmarisobiT daavadebuli avadmyofebi, an avadmyofebi, romlebsac aqvTkreatininis klirensi ara umcires 20ml\wT-Si, saWiroeben dozis naxevars anpreparatis miRebebs Soris intervalis gazrdas.xanSiSesuli avadmyofebis mkurnalobis procesSi aucilebelia kreatininis klirensisgansazRvra, vinaidan preparatis naxevrad daSlis periodi sisxlis plazmaSi,SesaZlebelia xangrZlivi aRmoCndes.ciprofloqsacinis miRebisas Wamis dros misi absorbcia ferxdeba daaxlovebiT 2sTiT,rac gavlenas ar axdens preparatis ZiriTad absorbciaze.Cveneba:zeda da qveda sasunTqi gzebis infeqciebi;sasqeso gzebis infeqciebi, gonoreis CaTvliT;saSarde gzebis infeqciebi;kuW-nawlavis traqtis infeqciebi, infeqciuri diareis CaTvliT;peritoniti, zogierTi mZime sistemuri infeqciebi (sefsisi);piris Rrus infeqciebi;Zvlebis, saxsrebis, rbili qsovilebis, kanis da Wrilobebis infeqciebi;Tvalis infeqciebi;preparati agreTve gamoiyeneba infeqciebis profilaqtikisa da daqveiTebuliimunitetis mqone avadmyofebSi, mag. imunodepresantebiTa da citostatikuripreparatebiT mkurnalobis Sedegad.dozirebis reJimi:preparatis dozis da mkurnalobis xangrZlivobis dadgena xdeba eqimis mier.ciprofloqsacins iReben siTxesTan erTad. preparatis miReba uzmoze, aCqarebs misiSewovis unars.

preparatis iReben 2-jer dReSi 12sT-iani intervaliT. Cveulebrivi sadReRamiso dozaSeadgens 500-dan 1500mg-mde.mkurnalobis xangrZlivoba damokidebulia daavadebis mimdinareobaze. mkurnalobisswrafad Sewyveta iwvevs recidivs.saSarde gzebis mwvave infeqciebi (daavadebis siZlieris mixedviT): 250mg-500mgdReRameSi;mwvave gaurTulebeli gonorea mamakacebSi (ureTriti): 250mg erT miRebaze.mkurnalobis saSualo xangrZlivoba Seadgens 1-dan 7-dRemde. sxva infeqciebTanbrZolas SeiZleba dasWirdes 7-dan 14-dRemde.streptokokebiT gamowveuli infeqciebis mkurnaloba grZeldeba minimum 10 dRisganmavlobaSi.gverdiTi movlenebi:gulisreva, diarea, Rebineba, tkivili da diskomforti muclis areSi, Tavis tkivili,agzneba;kuW-nawlavis traqtis mxriv: saWmlis monelebis darRveva, madis dakargva,meteorizmi. mwvave da mdgradi diareis Sedegad ganviTarebuli fsevdomembranulikoliti;gul-sisxlZarRvTa sistemis mxriv: taqikardia, winagulebis cimcimi, ventrikulurieqtopia, hipotenzia, gulis wasvla;c.n.s. mxriv: Tavbrusxveva, uZiloba. iSviaTad: halucinaciebi, Ramis koSmarebi,maniakaluri reaqciebi, gaRizianebadoba, tremori, ataqsia, krunCxvebi, leTargia,Zilianoba, saerTo sisuste, anoreqsia, fobia, depersonalizacia, depresia,paresTezia, mxedvelobis daqveiTeba.kanis reaqciebi: qavili, WinWris cieba, wamoxureba, Semcivneba, kanis kandidozi,hiperpigmentacia, kvanZovani eriTema, peteqiebi, eqsfoliaturi dermatiti,vaskuliti, hemoragiuli buStukebi;agreTve saxsrebisa da kunTebis tkivilebi, intersticiuli nefriti, hepatiti,RviZlis nekrozi.ukuCvenebebi:preparatis, masSi Semavali ingredientebis an ftorqinolonebis jgufis sxvaantimikrobuli preparatebis mimarT momatebuli mgrZnobeloba;orsuloba da laqtacia;bavSvebSi da 18 wlamde asakis mozrdilebSi.orsuloba da laqtacia:orsulebSi preparatis miReba xdeba mxolod absoluturi aucileblobis SemTxvevaSi.mkurnalobis procesSi saWiroa ZuZuTi kveba Sewydes.gansakuTrebuli miTiTebebi:sifrTxiliT gamoiyeneba xandazmul, epilefsiiT, Tavis tvinSi sisxlismimoqcevismoSliT, fsiqiuri daavadebebiT da cns-is sxva daavadebebiT Sepyrobil pacientebSi.preparatiT mkurnalobis procesSi saWiroa mzis gamosxivebisagan Tavis dacva.zogierT pacientebSi viTardeba fotosensibilizacia.mkurnalobis procesSi SesaZlebelia myesebis anTeba da maTi gagleja. im SemTxvevaSi,rodesac mkurnalobis dros adgili aqvs myesebis areSi (gansakuTrebiT fexebSiaqilevsisqusli) mtkivneul SegrZnebas, saWiroa eqimTan konsultacia.mkurnalobis procesSi Zlieri fizikuri datvirTva nebadarTuli ar aris.

adgan preparati aqveiTebs avtomobilis da sxvadasxva danadgarebis marTvisSesaZleblobas, preparati sifrTxiliT eniSnebaT maTTan kontaqtSi myof pirebs.preparatis miRebis dros saWiroa alkoholis miRebisagan Tavis Sekaveba.Warbi dozireba:cipros tabletebis Warbi raodenobiT miRebis SemTxvevaSi saWiroa simptomaturimkurnaloba, xolo anafilaqsiuri reaqciebis ganviTarebisas Sokis sawinaaRmdegoTerapia.sxva wamlebTan urTierTqmedeba:antacidebTan kombinaciisas, romlebic Seicaven magniumis hidroJangs, alumins dakalciums an rkinisa da TuTiis Semcvel preparatebTan, qveiTdeba ciprofloqsacinisbioSeRwevadoba 90%-iT. amitom mizanSewonilia preparatis miReba 2 sT-iT adre an4sT-is Semdeg antacidebis miRebidan.ciprofloqsacinisa da Teofilinis peroraluri daniSvnisas, Teofilinis klirensimcirdeba, rasac SeiZleba mohyves misi raodenobis gazrda sisxlis plazmaSi daaqedan gamomdinare uaryofiTi reaqciebi c.n.s. mxriv.dadgenilia, rom qinolonebis da zogierTi arasteroiduli anTebis sawinaaRmdegopreparatebis (acetilsalicilis mJavas garda) kombinaciam, SeiZleba gamoiwvioskrunCxvebi.zogierT avadmyofebSi ciprofloqsacinisa da ciklosporinis erTdroulma daniSvnam,SeiZleba gamoiwvios sisxlis plazmaSi kreatininis droebiTi momateba. aRniSnulSemTxvevebSi saWiroa sisxlis suraTis sistematuri (kviraSi 2-jer) kontroli.Senaxvis pirobebi da vadapreparati inaxeba araumetes 25 0 C temperaturaze, mSral, sinaTlisa dabavSvebisagan dacul .dgilas.gamoSvebis forma:tableti 500 mg #14 SefuTvaSi.mwarmoebeli firma:”biofarma” (TurqeTi)farmakologiuri komitetisTavmjdomaren. gongaZe