danarTi #

miRebis Semdeg, plazmaSi miiRweva maqsimaluri plazmuri koncentracia 2-4mg/l. 20 mg tenoqsikamis yoveldRuri miRebis Semdeg (erTjer dReSi), 10-12dReSi miiRweva daaxloebiT Tanabari mdgradi plazmuri koncentracia 11mg/l.ganawilebis moculoba Seadgens 0,15l/kg, naxevargamoyofis periodi 60-75saaTs.miRebuli dozis 2/3 gamoiyofa SardiT, 1/3 - fekaliebiT.tenoqsikami advilad aRwevs osteoarTritiT da revmatoiduli arTritiTdaavadebuli pacientebis sinoviur siTxeSi. dasturdeba RviZlSitransformacia araaqtiur metabolitebad. erT-erTi maTgani (5-hidroqsipiridili) gamoiyofa SardiT, danarCeni gamoiyofa naRveliTglukuronis koniugatebis saxiT.gamoyenebis Cvenebebisayrden-mamoZravebeli aparatis anTebiT-degeneraciuli daavadebebi, Tanmxlebitkivilis sindromiT:- saxsrovani sindromi podagris, revmatiuli arTritis, osteoarTrozis,maankilozebeli spondilitis, osteoqondrozis, revmatizmis saxsrovaniformis (periarTriti, tendiniti, bursiti, mioziti) dros, podagra;- tkivili xerxemlSi, nevralgia, mialgia, iSialgia, lumbago;- algodismenorea;- tramvebisas, damwvrobis dros.ukuCvenebebi- momatebuli mgrZnobeloba tenoqsikamis an sxva aass-ebis mimarT;- saWmlis momnelebeli sistemis eroziul-wylulovani dazianebebi;- sisxldena kuW-nawlavis traqtidan;- aspirinuli triada (bronquli asTmis TanxlebiT);- RviZlis da Tirkmelebis gamoxatuli darRvevebi;- Saqriani diabeti;- arteriuli hipertenzia, gulis ukmarisoba, SeSupeba;- orsuloba, laqtaciis periodi;- sisxlis daavadebebi.gverdiTi moqmedebakuW-nawlavis traqtis mxriv: dispefsia, (gulisreva, Rebineba, gulZmarva,diarea, meteorizmi), tkivili da usiamovno SegrZneba mucelSi, stomatiti,anoreqsia; maRal dozebSi xangrZlivi gamoyenebisas kuW-nawlavis eroziulwylulovanigarTulebebi.nervuli sistemis da grZnobaTa organoebis mxriv: Tavis tkivili,Tavbrusxveva, depresia, momatebuli agznebadoba.alergiuli reaqciebi: WinWris cieba, qavili, eriTema, stivens-jonsisa dalailis sindromebi.sxva: Tirkmlebis funqciis darRveva, plazmaSi kreatininis, azotis,Sardovanas, bilirubinis koncentraciis momateba, RviZlis transaminazebisaqtivobis momateba, sisxldenis drois gaxangrZliveba. sanTlebisgamoyenebisas SesaZlebelia adgilobrivi gaRizianea, mtkivneuli defekacia.gamoyenebis wesi da dozebigamoiyeneba reqtalurad. Cveulebriv iniSneba doziT 20 mg erTjer dRe-RameSierTsadaimave dros.mwvave podagruli arTritis dros iniSneba 40 mg erTjer dRe-RameSi 2 dRisganmavlobaSi, Semdeg 20 mg dReSi erTjer 5 dRis ganmavlobaSi.