Ipotesi sulla schizofrenia * - ABCsalute.it
Ipotesi sulla schizofrenia * - ABCsalute.it
Ipotesi sulla schizofrenia * - ABCsalute.it
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disturbo geneticodella sinapsi?GRM3 G72 DAAO CHRNA7 RGS4 PRODH PPP3CC Akt1 NRG1 Dysbindin DISC1Neurotransmission Plastic<strong>it</strong>y SynaptogenesisCOMTCellularneuropathologyDysregulated dopaminergictransmissionCogn<strong>it</strong>ive and othertra<strong>it</strong> featuresPsychoticsymptomsGRM3 = metabotropic glutamate receptor 3; G72; DAAO= d-amino acid oxidase;CHRNA7 = α7 nicotinic receptor; RGS4: regulator of G protein signalling 4; PRODH = prolinedehydrogenase; PPP3CC ; Akt1= protein kinase B; NRG1 = neuroregulin 1;DISC1 = disrupted-in-schizophrenia 1Harrison & Weinberger, Mol. Psychiatry, 2005
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