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FRIDAY, October 16, 2009<br />
4.45<br />
pm<br />
5.15<br />
pm<br />
5.45<br />
pm<br />
6.15<br />
pm<br />
6.45<br />
pm<br />
FRIDAY, October 16, 2009<br />
Sala Bianca – 4.45-7.00 pm<br />
SITOX-<strong>SIF</strong> Symposium<br />
NEW APPROACHES FOR ASSESSING SAFETY OF DRUG<br />
IMPURITIES<br />
Chairpersons: Galli C. L. (Milan), Hrelia P. (Bologna)<br />
DEFINITION OF THE SAFETY DOSE IN RISK CHARACTERIZATION<br />
Galli C. L. (Milan)<br />
APPLICATION OF THE TTC (THRESHOLD OF TOXICOLOGICAL<br />
CONCERN) TO DRUG IMPURITIES EVALUATION<br />
Marinovich M. (Milan)<br />
IN SILICO MODELS FOR GENOTOXICITY: THE APPROACH OF<br />
CAESAR AND OTHER INITIATIVES<br />
Benfenati E. (Milan)<br />
EMEA APPROACH IN THE NON CLINICAL EVALUATION OF<br />
POTENTIALLY GENOTOXIC IMPURITIES IN PHARMACEUTICAL<br />
DRUG SUBSTANCES<br />
Meneguz A. (Rome)<br />
FINAL TEST<br />
138<br />
4.45<br />
pm<br />
5.05<br />
pm<br />
5.25<br />
pm<br />
5.45<br />
pm<br />
6.05<br />
pm<br />
6.25<br />
pm<br />
6.45<br />
pm<br />
FRIDAY, October 16, 2009<br />
Sala Verde – 4.45-7.00 pm<br />
Symposium<br />
HDAC INHIBITORS: EMERGING DRUGS WITH PLEIOTYPIC<br />
THERAPEUTIC POTENTIAL<br />
Chairpersons: Chiarugi A. (Florence), Mascagni P. (Milan)<br />
TARGETING HISTONE DEACETYLASES: VORINOSTAT AND NOVEL<br />
CLASSES OF HDACI<br />
Steinkühler C. (Rome)<br />
HDACS AND APOPTOSIS: IS HDAC4 A GOOD TARGET?<br />
Brancolini C. (Udine)<br />
HDAC INHIBITORS AS NOVEL ANTI-INFLAMMATORY AGENTS<br />
Dinarello C. A. (Denver)<br />
EPIGENETIC BASIS OF MUSCLE REGENERATION IN MUSCULAR<br />
DYSTROPHY<br />
Puri P. L. (Rome)<br />
HISTONE DEACETYLASE INHIBITORS IN CANCER: GIVINOSTAT, A<br />
CASE STUDY<br />
Fossati G. (Milan)<br />
REGULATION OF SELF-RENEWAL IN CANCER STEM CELLS<br />
Pelicci P. G. (Milan)<br />
FINAL TEST<br />
139<br />
FRIDAY, October 16, 2009
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