MIC - UCL
MIC - UCL
MIC - UCL
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Proteïnebinding vertraagt de eliminatie …maar alleen de vrije fractie van de antibioticum is actief !ceftriaxone 1 gtemocilline 2 g100.0totaal10.01.00.1vrij0.010 4 8 12 16 20 24Paradis et al, AAC 1992, 36: 2085-2092Perry & Schentag, Clin Pharmacokinet. 2001, 40:685-694De Jongh et al. J. Antimicrob. Chemother.2008;61:382-38813-10-2010 Opleidingsprogramma Antibioticabeleid - Gent 23