Radioaktiv märkning

X
Biomedical Radiation Sciences
SnMe 3
O
C
O
O N
O
O
C
O
O
N
O
NH 2
oxidant
acid.cond.
protein
pH 9.1
Labeling methods
Halogen labelling
N-succinimidyl-halobenzoate
X
X = *I, *Br, 211 At
X
X
O
C
O N
O
C
O
O
H
N
protein
“+” 1. Mild labelling conditions
2. Higher yield compared
to Bolton- Hunter
3. Rapid excretion of
radiocatabolites
“-” 1. Yield is lower compared
to direct labelling.
2. Dehalogenation plays a
minor role in cell
excretion of
radioactivity