Radioaktiv märkning

Biomedical Radiation Sciences
Labeling methods
Radiometal labelling
Direct labelling of proteins with radiometals:
•Labelling of protein with
intrinsic complexing properties
(e.g. in vivo labelling of
transferrin with 67 Ga);
•Labelling with 99m Tc or 188 Re
by reduction of disulfide bridges:
“+”simplicity and rapidity
“-” 1. structure and properties
can be damaged;
2. limited applicability