PEUTZ-JEGHERS SENDROMU - Adnan Menderes Üniversitesi Tıp ...

Peutz - Jeghers Sendromu: Bir olgu sunumu
yaþýndaki erkek hastada polipler operasyon sýrasýnda
görülmüþtür. Bu hastanýn aile taramasýnda 4
asemptomatik bireyde intestinal polipozis
bulunmuþtur.
PJS'lu hastalarda kronik kan kaybýna baðlý
anemi sýktýr. Hastamýz da melana þikayeti ile
baþvurmuþ ve demir eksikliði anemisi teþhis
edilmiþtir. Hem anemi ve hem de olabilecek
komplikasyonlar yönünden izleme alýnmýþtýr.
PJS'lu hastalarýn ailelerinde de LKB1
mutasyonlarýnýn bulunmasý, morbidite ve mortalitenin
de artmýþ olmasý bu hastalýðýn benign bir hastalýk
olmadýðýný göstermektedir.
Sonuç olarak malignite riski yüksek olduðundan
genç yaþtaki hastalarýn bu açýdan tetkiki ve izlemi
uygun olur. Ayrýca PJS'lu hastalarda aile araþtýrmasý
yapýlmasý da gereklidir.
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KAYNAKLAR
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Identification of a novel mRNA species of the
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of Peutz-Jeghers syndrome. Cell Mol Life Sci
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YAZIÞMA ADRESÝ
Gülten ÝNAN
Adnan Menderes Üniversitesi Týp Fakültesi
Çocuk Saðlýðý ve Hastalýklarý Anabilim Dalý AYDIN
E-Mail : fginan@yahoo.com
Tel : 0 256 212 59 47
Geliþ Tarihi : 05.04.2001
Kabul Tarihi : 01.05.2001