hrvatski glasnik intelektualnog vlasništva 05/2005 - Državni zavod ...

1978 HR - Patenti. - Hrvatski glasnik intelektualnog vlasništva 12, 2005, 5, 1897 – 2089
opcionalno biti supstituirana; R 5 i -A-R 6 uzeti zajedno s atomom dušika,
na kojeg su vezani mogu također formirati Het 1 ili Het 2 , R 12 je H, -NH 3 , -
NR 5 AR 6 , C 1-6 alkil ili alkil-W-R 14 , gdje navedeni alkil je opcionalno
supstituiran s halogenom, hidroksidom, arilom, heteroarilom, Het 1 , Het 2 ,
ili aminom, gdje navedena amino grupa je mono- ili di-supstituirana s C 1-
4alkilom i R 13 je H, C 1-6 alkil, opcionalno supstituiran s arilom, Het 1 , Het 2 ,
hidroksidom, halogenom, aminom, gdje amino grupa može opcionalno
biti mono- ili di-supstituirana s C 1-4 alkilom.
(51) Int.Cl. C 07 D 239/30 7 (10) HR P20050601 A2
C 07 D 239/47
C 07 D 239/48
C 07 D 239/50
C 07 D 401/12
C 07 D 403/12
C 07 D 403/14
C 07 D 405/12
C 07 D 409/12
C 07 D 411/12
C 07 D 417/12
C 07 D 417/14
A 61 K 31/506
A 61 P 35/02
(21) P20050601A (22) 28. 06.2005.
(43) 31. 10.2005.
(86) PCT/EP03/013443; 28. 11.2003.
(87) WO04/048343; 10. 06.2004.
(31) 02026607.8 (32) 28. 11.2002. (33) EP
(54) PIRIMIDINI KOJI INHIBIRAJU CHK, PDK I AKT, NJIHOVA
PROIZVODNJA I UPOTREBA KAO FARMACEUTSKIH
SREDSTAVA
CHK-, PDK-, AND AKT-INHIBITORY PYRIMIDINES, THEIR
PRODUCTION AND USE AS PHARMARMACEUTICAL AGENTS
(71) Schering AG, Müllerstrasse 178, 13353 Berlin, DE
(72) Judi Bryant, 318 Via Recodo, Mill Valey, CA 94941, US
Monica Kochanny, 590 East J Street, Bencia, CA 94510, US
Shendong Yuan, 708 Forest Run, Hercules, CA 94547, US
Seock-Kyu Khim, 148 Overlook Terrance, Hercules, CA 94547, US
Brad Buckman, 2042 Leimert Blvd., Oakland, CA 94602, US
Damian Arnaiz, 103 Bedford, 94547 Hercules, CA, US
Ulf Bömer, Leipziger Strasse 49, 16548 Glienicke/Nordbahn, DE
Hans Briem, Baumhauser Weg 41a, 28279 Bremen, DE
Peter Esperling, Furastrasse 15c, 12107 Berlin, DE
Christoph Huwe, Sandhauser Strasse 111, 13505 Berlin, DE
Joachim Kuhnke, Schlegelstrasse 2, 14469 Berlin, DE
Martina Schäfer, Ossietzkystrasse 7, 13583 Berlin, DE
Lars Wortmann, Rockenhauser Strasse 11, 13583 Berlin, DE
Dirk Kosemund, Ulan-Baton-Strasse 51, 99091 Erfurt, DE
Emil Eckle, Strudelstrasse 41, 73329 Kuchen, DE
Richard Feldmann, 100 Pompona Avenue, El Cerrito, CA 94530,
US
Gary Phillips, 3043 Shetland Drive, Pleasant Hill, CA 94523, US
(74) Dragutin Sikirić, Zagreb, HR
(57)
Ovaj se izum odnosi na derivate pirimidina opće formule (I) kao inhibitore
kinaza, na njihovu proizvodnju kao i na njihovu upotrebu kao lijekova za
tretiranje raznih bolesti.
(51) Int.Cl. C 07 D 239/46 7 (10) HR P20031042 A2
C 07 D 401/12
A 61 K 31/506
A 61 P 25/28
(21) P20031042A (22) 16. 12.2003.
(43) 31. 10.2005.
(86) PCT/IB02/02261; 17. 06.2002.
(87) WO03/000663; 03. 01.2003.
(31) 60/299,953 (32) 21. 06.2001. (33) US
(54) LIGANDI 5-HT RECEPTORA I NJIHOVE UPOTREBE
5-HT RECEPTOR LIGANDS AND USES THEREOF
(71) Pfizer Products Inc., Eastern Point Road, Groton, CT 06340, US
(72) Yuan-Ching Phoebe Chiang, Pfizer Global Research and
Development, Eastern Point Road, Groton, CT 06340, US
William Albert Novomisle, Pfizer Global Research and
Development, Eastern Point Road, Groton, CT 06340, US
Willard McKowan Welch, Pfizer Global Research and Development,
Eastern Point Road, Groton, CT 06340, US
(74) Hraste & Partneri odvjetničko društvo, Zagreb, HR
(57) U ovoj specifikaciji opisani su spojevi Formule (IA) koji djeluju kao
ligandi 5-HT receptora i njihove upotrebe u liječenju bolesti povezanih s
aktivacijom receptora 5-HT 2 kod životinja.
(51) Int.Cl. C 07 D 239/48 7 (10) HR P20031081 A2
A 61 K 31/505
A 61 K 31/506
A 61 P 35/00
C 07 D 239/47
C 07 D 239/34
C 07 D 239/42
C 07 D 405/12
C 07 D 401/12
C 07 D 403/12
C 07 D 409/12
C 07 D 417/12
(21) P20031081A (22) 23. 12.2003.
(43) 31. 10.2005.
(86) PCT/EP02/05669; 23. 05.2002.
(87) WO02/096888; 05. 12.2002.
(31) DE 101 27 581.1 (32) 29. 05.2001. (33) DE
DE 102 12 098.6 11. 03.2002. DE
(54) CDK INHIBITORNI PIRIMIDINI, NJIHOVA PROIZVODNJA I
PRIMJENA KAO LIJEKOVA
CDK INHIBITING PYRIMIDINES, PRODUCTION THEREOF AND
THEIR USE AS MEDICAMENTS
(71) Schering Aktiengesellschaft, Müllerstrasse 178, 13342 Berlin, DE
(72) Thomas Brumby, Lepsiusstrasse 60, 12163 Berlin, DE
Rolf Jautelat, Driesenerstrasse 1, 10439 Berlin, DE
Olaf Prien, Lützenstrasse 12, 10711 Berlin, DE
Martina Schäfer, Ossietzystrasse 7, 13187 Berlin, DE
Gerhard Siemeister, Reimerswalder Steig 26, 13503 Berlin, DE
Urlich Lücking, Bergstrasse 62, 11115 Berlin, DE
Christoph Huwe, Sandhauser Strasse 111, 13505 Berlin, DE
(74) Dragutin Sikirić, Zagreb, HR
(57) Izum koji se predlaže odnosi se na derivate pirimidina opće formule
(I) gdje se R 1 , R 2 , X, A i B definiraju kako je opisano, a koji se koriste kao
inhibitori o ciklinu ovisnoj kinazi. Izum se dalje odnosi i na proizvodnju
ovih spojeva u svrhu njihove primjene u liječenju raznih bolesti.
(51) Int.Cl. C 07 D 239/91 7 (10) HR P20050520 A2
C 07 D 279/16
C 07 D 413/04
C 07 D 265/38
C 07 D 209/86
C 07 D 215/14
C 07 D 209/08
C 07 D 213/30
C 07 D 207/32
C 07 D 235/06
C 07 D 409/04
C 07 D 261/08
C 07 D 405/04
A 61 K 31/421
A 61 K 31/422
A 61 K 31/47
A 61 K 31/358
A 61 K 31/4439
C 07 C 43/03
A 61 P 3/10
(21) P20050520A (22) 09. 06.2005.
(43) 31. 10.2005.
(86) PCT/IN03/000358; 14. 11.2003.
(87) WO04/046119; 03. 06.2004.
(31) 792/MUM/2003 (32) 12. 08.2003. (33) IN
992/MUM/2002 15. 11.2002. IN
(54) SUPSTITUIRANI AKRILNI DERIVATI
SUBSTITUTED ARALKYL DERIVATIVES
(71) Cadila Healthcare Limited, Zydus Tower, Satellite Cross Roads,
Ahmedabad 380 015 Gujarat, IN
(72) Braj, Bhushan Lohray, Zydus Tower, Satellite Cross Roads,
ISSN 1331-2030