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Inhibitors of protein <strong>synthesis</strong><br />
34<br />
Inhibitors<br />
streptomycin<br />
tetracycline<br />
chloramphenicol<br />
erythromycin<br />
cycloheximide<br />
diphtheria toxin<br />
puromycin<br />
Mechanism of action<br />
binds to 30s ribosomal subunit,<br />
preventing formation of the initiation complex<br />
binds to 30s ribosomal subunit,<br />
inhibits binding of aa-t RNA to A site<br />
inhibits peptidyl transferase activity of 50s<br />
ribosomal subunit<br />
binds to 50s ribosomal subunit,<br />
prevents translocation<br />
inhibits peptidyl transferase in eukaryotes<br />
inhibit translocation of peptidyl-tRNA from A to<br />
P site<br />
prematurely terminates <strong>synthesis</strong>
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