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- Formaldehit koklanmasıyla oluşan testiküler hasarın,<br />
önceden gül yağı koklatılarak önlendiği ve sıçanlarda<br />
sperm sayısının arttığı belirlendi13.<br />
- 92 bekar kızla yapılan çift kör çaprazlama klinik<br />
deneyde, gül meyvelerinden hazırlanan etanollü<br />
ekstrenin primer dismenore sendromu (PMS)’nda<br />
ağrı yoğunluğunun mefenamik asite benzer şekilde<br />
azalttığı ve hiçbir yan etki görülmediği belirlendi14.<br />
- Gül’ün sulu ekstresiyle gül absolüsünün hayvan<br />
modellerinde antidepresan etkisi gösterildi15,16.<br />
- Gül yağının depresif erkek hastalarda depresyon<br />
semptomlarını ve seksüel yetersizliği giderdiği rapor<br />
edildi17.<br />
Sonuç<br />
Bilimsel çalışmalar gül yağı ve gül suyu koklamanın<br />
kişiye mutluluk ve güven duygusu getirdiğini, hafıza<br />
fonksiyonlarını güçlendirdiğini, seksüel performansı<br />
iyileştirdiğini, afrodizyak etki gösterdiğini ve daha pek<br />
çok özellikleri olduğunu göstermiştir1,19,20.<br />
Orta çağ bilim adamlarının iddialarının modern çalışmalarla<br />
ispatlanıyor olması, Rosa damascena’nın<br />
insanlığa hizmetini, özellikle ihtiyaç duyduğumuz bir<br />
dönemde, mutluluk, sağlık ve neş’e getiren bir bitki<br />
olarak sürdüreceğini göstermektedir.<br />
Kaynaklar<br />
1 KHC Başer, A. Altıntaş, M. Kürkçüoğlu, Turkish Rose: A<br />
Review of the History, Ethnobotany, and Modern Uses<br />
of Rose Petals, Rose Oil, Rose Water, and Other Rose<br />
Products, HerbalGram (96) 40-53 (2012)<br />
2 MH Boskabady, A. Vatanprast , H. Parsee , M. Ghasemzadeh<br />
.Effect of aqueous-ethanolic extract from Rosa damascena<br />
on guinea pig isolated heart. Iranian J Basic Med<br />
Sci. 14:116- 121 (2011).<br />
3 FS Senol, I Orhan, M Kurkcuoglu, MH Khan, A. Altintas, B.<br />
Sener, KHC Baser, An in vitro approach to neuroprotective<br />
activity of Rosa damascena Mill, a medieval age traditional<br />
medicine used for memory enhancement. Planta Med.<br />
77(12):1440-1440 (2011).<br />
4 F.S. Senol, I. Erdogan Orhan, M. Kurkcuoglu, M.T.H.<br />
Khan, A. Altintas, B. Sener, K.H.C. Baser, A mechanistic<br />
investigation on anticholinesterase and antioxidant effects<br />
of rose (Rosa damascena Mill.), Food Res. Int. 53, 502-<br />
509 (2013)<br />
5 Kwon EK, Lee DY, Lee H, et al. Flavonoids from the buds<br />
of Rosa damascena inhibit the activity of 3-Hydroxy-3-methylglutaryl-<br />
coenzyme A reductase and angiotensin I-converting<br />
enzyme. J Agric Food Chem. 58, 882-886 (2010)<br />
6 Ashrafzadeh F, Rakhshandah H, Mahmoudi E. Rosa damascena<br />
oil: an adjunctive therapy for pediatric refractory<br />
seizer. Iranian J Child Neurol. 13-17 (2007)<br />
7 Awalel S, Tohda C, Tezuka Y, Miyazaki M, Kadota S. Protective<br />
effects of Rosa damascena and its active constituent<br />
on Ab(25– 35)-induced neuritic atrophy. eCAM 149, 1-8<br />
(2009)<br />
8 S. Zhu, H-Y Li, J. Dong, W. Yang, T. Liu, Y. Wang, X.<br />
Wang, M. Wang, D. Zhi, Rose essential oil delayed AD-like<br />
symptoms by SKN-1 pathway in C. elegans, J. Agric.<br />
Food Chem. (2017) DOI: 10.1021/acs.jafc.7b03224<br />
9 Esfandiary E, Karimipour M, Mardani M, et al. Novel effects<br />
of Rosa damascena extract on memory and neurogenesis<br />
in a rat model of Alzheimer’s disease., J Neurosci<br />
Res. 92, 517-530 (2014).<br />
10 Jazayeri SB, Amanlou A, Ghanadian N, Pasalar P, Amanlou<br />
M. A preliminary investigation of anticholinesterase activity<br />
of some Iranian medicinal plants commonly used in traditional<br />
medicine. Daru 22, 17 (2014).<br />
11 Mohammadpour T, Hosseini M, Naderi A, et al. Protection<br />
against brain tissues oxidative damage as a possible<br />
mechanism for the beneficial effects of Rosa damascena<br />
hydroalcoholic extract on scopolamine induced memory<br />
impairment in rats. Nutr Neurosci. 18, 329-336 (2014).<br />
12 Gholamhoseinian A, Sharifi-Far F, Shahouzehi B. Inhibitory<br />
activity of some plant methanol extracts on 3-Hydroxy-3-Methylglutaryl<br />
coenzyme a reductase. Int J Pharmacol.<br />
6, 705-711 (2010).<br />
13 Kose E, Sarsılmaz M, Tas¸ U, Kavakli, A., Turk, G., Ozlem<br />
Dabak, D., Sapmaz, H., Ogeturk, M. Rose oil inhalation<br />
protects against formaldehyde-induced testicular damage<br />
in rats. Andrologia 44(1), 342-348 (2012)<br />
14 Bani S, Hasanpour S, Mousavi Z, Mostafa Garehbaghi P,<br />
Gojazadeh M. The effect of Rosa damascena extract on<br />
primary dysmenorrhea: a double-blind crossover clinical<br />
trial. Iran Red Crescent Med J. 16, e14643 (2014).<br />
15 Dolati K, Rakhshandeh H, Shafei MN. Antidepressant-like<br />
effect of aqueous extract from Rosa damascena in mice.<br />
Avicenna J Phytomed. 1, 91-97.(2011).<br />
16 Nazıroglu M, Kozlu S, Yorgancıgil E, Uguz AC, Karakus¸<br />
K. Rose oil (from Rosa damascena Mill.) vapor attenuates<br />
depression-induced oxidative toxicity in rat brain. J Nat<br />
Med. 67, 152-158 (2013).<br />
17 Farnia V, Shirzadifar M, Shakeri J, et al. Rosa damascena oil<br />
improves SSRI induced sexual dysfunction in male patients<br />
suffering from major depressive disorders: results from a<br />
double-blind, randomized, and placebo-controlled clinical<br />
trial. Neuropsychiatr Dis Treat. 11, 625-635 (2015).<br />
18 M. Mahboubi, Rosa damascena, a holy ancient herb with<br />
novel applications, J Trad Complement Med. 6, 10-16<br />
(2016).<br />
19 H. S. Nunes and M. G. Miguel, Rosa damascena essential<br />
oil: a brief review about chemical composition and biological<br />
properties, Trends Phytochem. Res. 1(3) 111-128<br />
(2017).<br />
20 S. Mohebitabar, M. Shirazi, S. Bioos, R. Rahimi, F. Malekshahi,<br />
F. Nejatbakhsh, Therapeutic efficacy of rose oil:<br />
A comprehensive review of clinical evidence, Avicenna J.<br />
Phytomed. 7(3) 206-213 (2017) https://www.ncbi.nlm.<br />
nih.gov/pmc/articles/PMC5511972/ (En son 4.8.2018’de<br />
ziyaret edildi)<br />
www.ispartalilarvakfi.org<br />
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www.ispartalilarvakfi.org
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