CURRICULUM VITAE Date prepared: 2/06 Name - McLean Hospital ...

Name: Dean Francis Salisbury
CURRICULUM VITAE
Date prepared: 2/06
Office Address: Harvard Medical School/McLean Hospital, Cognitive Neuroscience Laboratory,
NBG21, 115 Mill St., Belmont, MA 02478
Office Phone: (617) 855-3786 FAX: (617) 855-3795
e-mail: dean_salisbury@hms.harvard.edu
dsalisbury@mclean.harvard.edu
Date of Birth: August 8, 1963
Place of Birth: Long Island, New York
Education:
1985 B.A. W hittier College, W hittier, California
1984 University of Copenhagen, Copenhagen, Denmark
1989 M.A. State University of New York, Stony Brook, New York (Biological Psychology)
1990 Ph.D. State University of New York, Stony Brook, New York (Biological Psychology)
Postdoctoral training:
1990 - 1992 Fellow, Clinical Research Training Program, Departm ent of Psychiatry,
Harvard Medical School
Academic appointments:
1992 - 1998 Instructor in Psychology, Department of Psychiatry, Harvard Medical School
1997 - 1998 Part-time Instructor, Department of Psychology, Tufts University
1998 - 2003 Assistant Professor, Department of Psychiatry, Harvard Medical School
1999 - 2000 Part-time Assistant Professor, University of Massachusetts - Boston
2002 - 2003 Adjunct Assistant Professor, Brandeis University
2003 - present Associate Professor, Department of Psychiatry, Harvard Medical School
Hospital appointments:
1987 - 1988 Neuropsychology Intern, University Hospital, SUNY Stony Brook
1990 - present Research Electrophysiologist, Brockton VA Medical Center, Brain Imaging Laboratory
1991 - 1992 Research Associate, Massachusetts Mental Health Center, Chief Electrophysiologist,
Brain Imaging Laboratory
1992 - 2004 Associate Director, Cognitive Neuroscience Laboratory, McLean Hospital
2004 - present Director, Cognitive Neuroscience Laboratory, McLean Hospital
Awards and Honors:
1981 New York State Regents Scholarship
1981 - 1984 W hittier College Scholarship
1982 - 1984 Haynes Scholarship in the Social Sciences
1982 - 1986 Sm ith Trust Fund Scholarship

Awards and Honors: (continued)
1985 - 1990 Graduate Assistantship, SUNY Stony Brook
1990 Sigma Xi Grant-in-aid of Research
1992 Sleep Research Society Travel Award
1993 National Institute of Mental Health Young Investigator Award
1993 - 1995 McDonnell-Pew Program in Cognitive Neuroscience Award
1995 - 1997 National Alliance for Research in Schizophrenia and Depression Young Investigator Award
1997 - 1999 National Alliance for Research in Schizophrenia and Depression Young Investigator Award
2001 - 2005 National Institutes of Mental Health RO1 Award
Major Committee Assignments:
1988 - 1989 Grievance committee, Department of Psychology, SUNY Stony Brook
1989 - 1990 Advisory committee, Department of Psychology, SUNY Stony Brook
2000 - present NIMH Behavioral Science Track Award for Rapid Transition (B/START), Ad Hoc Reviewer
2001 - 2006 Human Resources Policy Review and Advisory Committee, McLean Hospital
2002 Member, National Institute of Mental Health Workshop Planning Meeting: First Episode
Schizophrenia
2002 - 2004 Convention Site Committee, Society for Psychophysiological Research
2003 NIMH Center for Scientific Review, Psychophysiological Responses and Cognition, Special
Emphasis Panel
2003 - present Harvard Medical School, Department of Psychiatry, Mysell Award Committee
2003 NIMH Center for Scientific Review, Clinical Neuroplasticity and Neurotransmitters, Special
Emphasis Panel
2003 - present Harvard Medical School, Department of Psychiatry, Research Committee
2004 NIMH Center for Scientific Review, Medical Devices SBIR, Special Emphasis Panel
2004 - present NIMH Center for Scientific Review, Clinical Neurophysiology, Devices, and Neuroprosthetics
Study Section, ZRG1 BDCN-K 10
2005 Chair, NIMH Center for Scientific Review, Bioengineering Research Partnerships Study
Section, BDCN - BRP K-50R
2005 - present Membership Committee, Society for Psychophysiological Research
2006 - Chair, Harvard Medical School, Department of Psychiatry, Mysell Award Committee
Professional Society Involvement:
1990 - present Society for Psychophysiological Research, Member
1993 - 2003 American Psychological Society, Member
2002 - 2004 Convention Site Committee, Society for Psychophysiological Research
2003 - present Society for Biological Psychiatry, Member
2003 - present Cognitive Neuroscience Society, Member
2005 - present Membership Committee, Society for Psychophysiological Research
2005 - present Board Member, Electroencephalography and Clinical Neuroscience Society
Editorial Boards:
Consulting Editor:
1991 - present Sleep
1994 - present Archives of General Psychiatry
1996 - present Psychophysiology
1997 - present Biological Psychiatry
1998 - present Schizophrenia Bulletin
1998 - present Psychiatry Research
1998 - present Schizophrenia Research
1999 - present Psychological Medicine
2001 - present Cognitive Brain Research
2001 - present Psychological Bulletin
2002 - present American Journal of Psychiatry
2002 - present Journal of Abnormal Psychology
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2002 - present Biological Psychology
2002 - present Journal of Psychiatry & Neuroscience
2002 - present Neurophysiologie Clinique
2003 - present Clinical Neurophysiology
2003 - present Journal of Cognitive Neuroscience
2004 - present Brain and Language
2006 - present Progress in Neuro-Psychopharmacology & Biological Psychiatry
Associate Editor
2006 - Psychophysiology
2006 - Psychiatry Research
Report of Research:
Major Research Interests:
1) Human cognitive electrophysiology with special interest in language processing and meaning activation,
and the relationship between cortical structural organization and the electrophysiology of higher-order
cognitive operations.
2) Electrophysiological signs of language and cognitive dysfunction in schizophrenia and psychotic bipolar
disorder.
3) Response mode factors that affect the electrical topography of event-related potentials.
4) Brain electrical activity reflecting stimulus processing during sleep.
Narrative Report of Research:
My research utilizes electrophysiology and multimodal brain imaging. I specialize in event-related
potential macropotential recordings in humans and have collaborated over the last decade with researchers
using MR and fMR imaging methods. Models of normal brain function need to be constrained by an
awareness of differences that arise when the brain is compromised. To that end, I have examined thought
disturbance (cognitive-level) and basic auditory processing abnormalities (sensory-level) in psychosis and well
controls.
Thought disorder is a cardinal symptom of schizophrenia, and is inferred through abnormal language.
Disordered thought has a high genetic penetrance, and is detected in relatives of schizophrenia patients at
a high rate, even when these relatives do not exhibit overt psychosis. Thus, examination of thinking problems
may be especially insightful for understanding schizophrenia. The broad aim of my work is to combine
behavioral measures and brain activity measure to further understand the underlying interplay between
semantic memory neural networks subserving concept storage and verbal working memory systems that allow
adaptive and flexible human behavior in the face of unique current situations. More specifically, the aims are
to understand automatic semantic activation versus controlled verbal working memory inhibition and to relate
these dysfunctions to underlying brain systems, so as to understand the neurophysiology of psychosis.
Autom atic mem ory processes and related brain activity during language processing tasks using lexical
ambiguities (homographs like toast, box, or panel) are contrasted with controlled contextual inhibitory
processes and related brain activity. In addition to homograph processing and expectancy-based priming, we
measure high frequency brain activity (gamma waves) to lexical access to examine semantic memory neural
network structure across the brain. Memories are stored in distributed networks, and gamma activity allows
the distributed brain areas to work in concert. We also examine the effects of recent memory traces and
recent response outcome traces on current behavior, to assess how memory traces benefit or detract from
current performance, especially in patients. The studies will help determine where in the information
processing stream most blame can be laid for thought disorder, early in the automatic semantic memory
system or later in the controlled working memory system. These results, in turn, when related to underlying
brain system s will help to clarify the nature of thought disorder and cognitive dysfunction in schizophrenia with
respect to actual brain structure and function.
Another program of research looks at basic auditory sensory processing in first-episode psychotic
patients and chronically-ill psychotic patients to determine where abnormalities occur in patients in basic
auditory processing relative to controls, and where patients with schizophrenia differ from patients with m ania
and affective psychosis. In addition, MR measures allow us to determine whether the neural substrates of
these brain processes are also affected in the diseases, and to determine whether we can find brain-behavior
relationships between the size of the electrical brain responses we record and the structural measures derived
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from MR. We also can determine the degree to which such brain-behavior relationships are present at first
psychotic episode and how they develop over time with disease duration through our cross-sectional
measures of first-episode patients and chronic patients, and through longitudinal assessments of first episode
patients. Our data to date suggest that patients first hospitalized with schizophrenia show an abnormality that
is lateralized to the auditory processing centers of the left tem poral lobe in the P300 event-related brain
potential, a brainwave associated with goal-directed stim ulus detection. This P300 voltage abnormality is
correlated with the size of abnormal cortical gray matter reductions in the left posterior superior temporal
gyrus, a polymodal, complex tertiary area of temporal-parietal association cortex. Interestingly, patients first
hospitalized with psychotic mania do not show this pattern of brain structural-functional abnormalities.
Furthermore, patients with first-episode schizophrenia do not show abnormalities in an earlier brain potential
termed mismatch negativity that reflects the early sensory memory automatic detection of stimulus deviance.
However, the size of the mism atch negativity voltage is correlated with the size of Heschl’s gyrus gray matter,
which contains primary auditory cortex in patients at first schizophrenic episode, suggesting that mismatch
negativity may be sensitive to the presence of an initial mild reduction of auditory cortical neuropil. Most
importantly, our longitudinal data shows that mismatch negativity, which is in the normal range at first
hospitalization, becomes progressively abnormal in patients along with the duration of their disease. This
suggests that mismatch negativity may serve as a index of progressive disease pathological processes in the
first few years of schizophrenia.
Research Funding Information:
Principal Investigator
1990 Sigma Xi Grant in Aid of Research. An electrophysiological investigation of auditory eventrelated
potentials and the K complex generated during sleep in humans.
1993 - 1995 McDonnell-Pew Cognitive Neuroscience Program. Electrophysiological indices of
language processing and ambiguity.
1995 - 1997 NARSAD Young Investigator Award. Brain activity measures of language processing and
am biguity.
1997 - 1999 NARSAD Young Investigator Award. Brain activity, ambiguity, and semantic activation
in psychosis.
2001 - 2005 National Institutes of Mental Health, RO1 MH58704. Brain activity and language
comprehension in psychosis.
Mentor
2005 Clinical Research Training Program Post-Doctoral Fellowship. PI: Spencer Lynn, PhD.
Co-Investigator
1990 - present National Institutes of Mental Health, RO1 MH40799, PI Robert W. McCarley.
Neurophysiological Studies of Schizophrenia.
1992 - 1996 National Institutes of Mental Health, P01 MH 31154, PI Phillip Holzman, Collaborative
Biological Research in Schizophrenia. Project PI Robert W. McCarley. Electrophysiology
Studies in Schizophrenia.
1992 - present Veterans Administration Merit Review Award. PI Robert W . McCarley. Neurophysiology of
Behavior.
1994 - present National Institutes of Mental Health, RO1 MH 50740, PI Martha E. Shenton. Computerized
Image Analyses of MR Scans in Schizophrenia.
1994 - present National Institutes of Mental Health, RO1 MH 52807, PI Robert W . McCarley. Biological
Basis of Schizotypal Personality Disorder.
1995 - 2000 Veterans Administration Center for Basic and Clinical Neuroscience Studies of
Schizophrenia. PI Robert W. McCarley. The Neuroscience of Schizophrenia.
2001 - 2005 Veterans Administration Merit Review Award. C0-PIs Paul G. Nestor, Margaret Niznikiewicz.
Psychobiology of schizophrenia.
Pending
2006 - 2011 National Institutes of Mental Health, RO1 MH58704. Brain activity and language
com prehension in psychosis. Competitive renewal. Priority Score: 126, percentile: 3.3
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Report of Teaching:
Local Contributions:
Teaching Assistantships
1985 Brain and Behavior, SUNY Stony Brook
100 Undergraduate students, 5 hours/week, 15 weeks
1986 Human Brain Function, SUNY Stony Brook
30 Undergraduate students, 5 hours/week, 15 weeks
1986 Electrophysiology Lab, SUNY Stony Brook
15 Undergraduate students, 5 hours/week, 15 weeks
1987 Sensation and Perception, SUNY Stony Brook
30 Undergraduate students, 5 hours/week, 15 weeks
1987 Brain and Behavior, SUNY Stony Brook
100 Undergraduate students, 5 hours/week, 15 weeks
1988 Advanced Physiological Psychology, SUNY Stony Brook
30 Undergraduate students, 5 hours/week, 15 weeks
1988 Abnormal Psychology, SUNY Stony Brook
100 Undergraduate students, 5 hours/week, 15 weeks
1989 Statistics, SUNY Stony Brook
40 Undergraduate students, 5 hours/week, 15 weeks
Instructor
1989 Abnormal Psychology, SUNY Stony Brook
61 Undergraduate students, 15 hours/week, 5 weeks
1989 Sensation and Perception, SUNY Stony Brook
53 Undergraduate students, 15 hours/week, 5 weeks
1989 Sensation and Perception, SUNY Stony Brook
89 students, 5 hours/week, 15 weeks
1990 Human Brain Function, SUNY Stony Brook
47 Undergraduate students, 5 hours/week, 15 weeks
1997 Cognitive Neuroscience and Psychopathology, Tufts University
3 Graduate, 2 Senior Undergraduate students, 5 hours/week, 15 weeks
1997 Cognitive Neuropsychology, Tufts University,
2 Graduate, 4 Undergraduate students, 5 hours/wk, 15 weeks
1998 Developmental Psychology, Tufts University
24 Undergraduate students, 5 hours/wk, 15 weeks
1998 Cognitive Psychology, Tufts University
12 Undergraduate students, 15 hours/wk, 5 weeks
1999 Cognitive Psychology, University of Massachusetts - Boston
17 Undergraduate students, 5 hours/wk, 15 weeks
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1999 Sensation and Perception, University of Massachusetts - Boston
17 Undergraduate students, 5 hours/wk, 15 weeks
2002 Introduction to Cognitive Neuroscience, Brandeis University, Waltham , MA
41 Undergraduate students, 5 hours/wk, 15 weeks
Independent Student Research Supervision
1991 - present Undergraduate Student Advisor
Full-time research assistants, Undergraduate research assistants, and Stanley Foundation
Summer Fellows: Edward DiMartino, Melissa Freidman, Amy Benavage, Lisa Kaplan, Wendy
Chang, Lola Lee, Evana Goodreau, Stephanie Rose, Andrea Sherwood, Iris Fischer, Em ily
Chase, Paola Mazzoni, Michele Harper, Bret Rutherford, Sara DeLong, Massimo DeSantis,
Ana Garnecho, Jon-Paul Pepper, Deirdre Farrell, Carlye Griggs, Aaron Bonner-Jackson,
Seema Aurora, Andrea Okruch, Lynn Stravinski, Meg Fagan, Nicola Sumorok, Lori Schwatrz,
Rachel Berman, Akanksha Thakur, Courtney Brown, KC Collins, Mukund Sureshbabu, Marcy
Adler, Matthew Chao
1995 - 1997 Resident Research Advisor
1 Medical Doctor
Alexandra Berezovskaya, MD
1997 - 1999 Graduate Student Advisor (Psychology)
2 Graduate students, Tufts University
Students: Juliana Pare-Blagoev, Tatiana Sitnikova
1997 - 1998 Preparation for the Honors Thesis, Harvard University
1 Undergraduate student
5 hours/wk, 30 weeks
2001 High School Student Advisor
1 student, 20 hours/wk, 10 weeks
2002 Internship and Analysis, Brandeis University, Waltham , MA
1 Undergraduate Student
6 hours/wk, 15 weeks
Post-Doctoral Fellow Mentor
2005 - present Spencer K. Lynn, Clinical Research Training Program T32, Affective Neuroscience
Regional, National, and International Contributions:
Invited Presentations:
1990 Auditory event-related potentials evoked during human sleep. Clinical Research Training Program,
Harvard Medical School/Mass. Mental Health Center
1991 Event-related potential measures of attention: The Nd response and the P3 complex. Cognitive
Neuroscience Colloquium, Brockton VAMC
1991 Stimulus configuration effects on the ERPs in schizophrenics and controls: An analysis using signal
detection theory. Clinical Research Training Program, Harvard Medical School
1992 P3 and Stimulus Parameters. Clinical Research Training Program, Harvard Medical School
1993 Stimulus processing awake and asleep: Similarities and differences in electrical CNS responses.
Sleep Onset Mechanisms. Ontario, Canada
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1993 Functional aspects of P3 in schizophrenia. American Meeting on Cognitive ERP Research,
Columbia University, New York
1994 Does P3 topography discriminate schizophrenic psychosis from affective psychosis? Society
for Neuroscience Annual Meeting, Miami Beach, Florida
1995 Asymmetrical P3 topography in first episode schizophrenia-like psychosis. International
Congress of Schizophrenia Research, W arm Springs, Virginia
1995 Thought disorder in schizophrenia: Lack of controlled inhibition of semantic activation.
Biopsychology Proseminar, Department of Psychology, SUNY Stony Brook
1995 P3 topography differs in schizophrenia-like and mania-like first episode psychosis. Biological
Psychiatry Annual Meeting, Miami Beach, Florida
1995 Examining thought disorder in schizophrenia with homographs: Evidence from event-related
potentials. Department of Psychology, W hittier College, W hittier, California
1997 P300 asymmetry in chronic and first episode schizophrenia. Special Joint Conference, Department
of Psychiatry, University of the Ryukyus. Okinawa, Japan
1997 Temporal P300 asymmetry in first episode schizophrenia versus manic psychosis and controls.
International Congress on Schizophrenia Research, Colorado Springs, Colorado
1997 Abnormal ERP activity despite normal performance to homographs in schizophrenia. Biological
Psychiatry, San Diego, California
1997 Left temporal P3 reductions in chronic and first episode schizophrenia. Biological Psychiatry, San
Diego, California
1999 Longitudinal study of P300 topography in first episode psychosis. International Congress on
Schizophrenia Research, Sante Fe, New Mexico
1999 Left posterior superior temporal gyrus: Progressive gray matter volume reduction in schizophrenia.
International Congress on Schizophrenia Research, Sante Fe, New Mexico
1999 Conjoint structural MRI and ERP studies in schizophrenia: Evidence for a “hot spot” of dominant
hemisphere abnormalities that is present at onset and also progresses. Psychophysiology, Grenada,
Spain
2000 A cognitive neuroscience view of schizophrenia: Basic and complex structural and functional
abnormalities. Neuroscience Seminar, McLean Hospital, Belmont, MA.
2000 Using event-related potentials to study cognitive processing: A look inside the “black box”.
Department of Psychology, Gettysburg College, Gettysburg, PA.
2000 Using event-related potentials to study cognitive processing: A look inside the “black box”.
Department of Psychology, Colgate University, Hamilton, NY.
2001 Mismatch negativity in schizophrenia: Does MMN amplitude decline with disease duration? Biological
Psychiatry, New Orleans, LA.
2001 Thought disorder in psychosis: Using language-related ERPs to probe cognitive dysfunction in
schizophrenia. SUNY Stony Brook, Department of Psychology, Stony Brook, NY.
2001 Brain function and structure in schizophrenia: Relationship between cortex, mismatch negativity and
P300. Nathan Kline Institute, Orangeburg, NY.
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2001 Cognitive Neuroscience models of verbal memory in schizophrenia. Psychophysiology, Montreal,
Canada.
2002 Homograph network strength, associative strength, incongruity, and N400. Psychophysiology,
Washington, DC.
2003 Electrophysiology and MRI of automatic and controlled attention mechanisms in first-episode and
chronic schizophrenia. Department of Psychology, Vanderbilt University, Nashville, TN.
2003 Autom atic and controlled attention processes in schizophrenia: Functional and structural indices of
progressive cortical degeneration following first hospitalization. Yale University School of Medicine,
Departm ent of Psychiatry, W est Haven, CT.
2003 Mismatch negativity amplitude and Heschl’s gyrus volume in first-episode schizophrenia. International
Congress of Schizophrenia Research, Colorado Springs, CO.
2003 A Cognitive Neuroscience Approach to Thinking Disturbance in Schizophrenia: From Auditory
Sensory Mem ory to Distributed Verbal Mem ory. Department of Psychology, Kansas University.
2003 Basic electrophysiology and theory of m ism atch negativity. EEG and Clinical Neuroscience Society,
Houston, TX.
2003 Dominant and subordinate homograph meaning selection in schizophrenia. Department of
Psychology, Rice University, Houston, TX.
2003 Verbal working memory and semantic memory in schizophrenia: A model of fronto-temporal
interactions. Psychophysiology, Chicago, IL.
2003 ERP and MRI investigations of echoic memory in schizophrenia via the mismatch paradigm.
Psychophysiology, Chicago, IL.
2003 Basic MRI and EEG correlates of selective attention in chronic and first episode schizophrenia.
Department of Psychology, Whittier College, Whittier, CA.
2003 ERP and MRI investigations of low-level attention in schizophrenia: Evidence of peri-onset
progressive structural and functional impairment. Schizophrenia and Bipolar Disorders Lecture Series,
McLean Hospital, Belmont, MA.
2004 Mismatch negativity as a probe of early cortical processing in schizophrenia: Electrophysiological and
structural MRI indices of progressive cortical reduction near disease onset. Schizophrenia Program
Invited Lecture Series, Massachusetts General Hospital, Boston, MA.
2004 P300 ERP and MRI asymmetry in first episode schizophrenia. International Congress of Biological
Psychiatry, Sydney, Australia.
2004 Mismatch negativity: A possible ERP and fMRI index of post-onset progression of brain changes in
schizophrenia. International Congress of Biological Psychiatry, Sydney, Australia.
2004 ERP and structural MR correlates of automatic and controlled attention in schizophrenia. International
Congress of Biological Psychiatry, Sydney, Australia.
2004 Event-related potential and homograph comprehension measures of semantic memory and verbal
working memory in psychosis. Department of Psychology, Vanderbilt University, Nashville, TN.
2004 EEG and MR evidence of progressive cortical reduction in new onset schizophrenia. Department of
Psychology, SUNY Stony Brook, Stony Brook, NY.
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2004 Evidence for a period of progressive brain reduction near schizophrenia onset. Fourth Annual
Graduate Psychology Association Invited Lecture, Department of Psychology, SUNY New Paltz, New
Paltz, NY.
2004 N400 evidence of lexical hyperpriming at fast word presentation rates in chronic and first episode
schizophrenia. Twelfth World Congress of Psychophysiology, Chalkidiki, Greece.
2005 Neurodevelopmental Models of Schizophrenia. Children's Hospital Developmental Neuroscience
course, Departm ent of Psychiatry.
2005 Autom atic and Controlled Priming in Schizophrenia. NeuroCognition Laboratory, Department of
Psychology, Tufts University.
2005 In vivo neuroim aging data in support of auditory processing abnormalities in schizophrenia. Biological
Psychiatry Annual Meeting, Atlanta, GA.
2005 Progressive MRI and ERP deficits after schizophrenia onset. 8 th World Congress of Biological
Psychiatry, Vienna, Austria.
2005 Exogenous and endogenous gamma activity in chronic and first episode schizophrenia. 2nd Joint
Meeting of Electroencephalography and Clinical Neuroscience Society and International Society for
NeuroImaging in Psychiatry, Munich, Germany.
2005 N400 measures of context utilization and expectancy-based priming in schizophrenia. Annual meeting
of the Society for Psychophysiological Research, Lisbon, Portugal.
Symposia chaired:
2001 Gamma oscillations in schizophrenia. Speaker: K Spencer, PhD, Harvard Medical School. McLean
Hospital, Belmont, MA.
2001 Cognitive neuroscience models of verbal memory in schizophrenia. Speakers: JM Ford, PhD,
Stanford University School of Medicine; DH Mathalon, MD, PhD, Yale University School of Medicine;
CS Carter, MD, University of Pittsburgh, M Niznikiewicz, PhD, Harvard Medical School; D Titone,
PhD, McLean Hospital. Psychophysiology, Montreal, Canada.
2002 From NMDA receptors to sensory processing dysfunction in schizophrenia. Speaker: DC Javitt, MD,
PhD, Nathan Kline Institute for Psychiatric Research, NYU School of Medicine. McLean Hospital,
Belmont, MA.
2002 Interpreting the visual world: Studies of visual perception in the split brain. Speaker: PM Corballis,
PhD, Dartmouth University. McLean Hospital, Belmont, MA.
2003 Introduction to mismatch negativity. Speakers: S Molholm , PhD, Nathan Kline Institute for Psychiatric
Research, NYU School of Medicine; O Korzyukov, PhD, Yale University School of Medicine; RW
McCarley, MD, Harvard Medical School. ECNS Annual Meeting, Houston, TX.
2003 Functional imaging of frontal lobe-mediated processes in schizophrenia. Speakers: JM Ford, PhD,
Stanford University School of Medicine; DH Mathalon, MD, PhD, Yale University School of Medicine;
A Belger, PhD, University of North Carolina at Chapel Hill; D Barch, PhD, Washington University at
St. Louis.
2004 Electrophysiological evidence for hyperexcitation across domains in schizophrenia. Twelfth W orld
Congress of Psychophysiology, Chalkidiki, Greece.
2005 Expectancy priming and the schizophrenia spectrum. Psychophysiology, Lisbon, Portugal
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Original Reports:
1. Salisbury D, Squires NK, Ibel S, Maloney T. (1992). Auditory event-related potentials during Stage 2
NREM sleep in hum ans. Journal of Sleep Research, 1: 251-257.
2. Salisbury D, Squires NK. (1993). Response properties of long-latency event-related potentials evoked
during NREM sleep. Journal of Sleep Research, 2: 232-240.
3. O'Donnell BF, Shenton ME, McCarley RW , Faux SF, Smith RS, Salisbury DF, Nestor PG, Pollak SD,
Kikinis R, Jolesz FA. (1993). The auditory N2 component in schizophrenia: Relationship to MRI
temporal lobe gray matter and to other ERP abnorm alities. Biological Psychiatry, 34: 26-40.
4. Salisbury DF, O'Donnell BF, McCarley RW , Nestor PG, Faux S, Sm ith RS. (1994). Param etric
manipulations of auditory stim uli differentially affect P3 amplitude in schizophrenics and controls.
Psychophysiology, 31: 29-36.
5. O'Donnell BF, Hokama H, McCarley RW, Smith RS, Salisbury DF, Mondrow E, Nestor PG, Shenton ME.
(1994). Auditory ERPs to non-target stimuli in schizophrenia: Relationship to probability, taskdem
ands, and target ERPs. International Journal of Psychophysiology, 17: 219-231.
6. Salisbury DF, O'Donnell BF, McCarley RW, Shenton ME, Benavage A. (1994). The N2 event-related
potential reflects attention deficit in schizophrenia. Biological Psychology, 39: 1-13.
7. O'Donnell BF, Faux SF, McCarley RW , Kim ble MO, Salisbury DF, Nestor PG, Kikinis R, Jolesz FA,
Shenton ME. (1995). Increased rate of P300 slowing with age in schizophrenia: Electrophysiological
evidence for a neurodegenerative disorder. Archives of General Psychiatry, 52: 544-549.
8. Salisbury DF, Voglmaier MM, Seidman LJ, McCarley RW. (1996). Topographic abnormalities of P3 in
schizotypal personality disorder. Biological Psychiatry, 40: 165-172.
9. Voglmaier M, Seidman L, Salisbury DF, McCarley RW . (1997). Neuropsychological dysfunction in
schizotypal personality disorder: A profile analysis. Biological Psychiatry, 41: 530-540.
10. McCarley RW, O'Donnell BF, Niznikiewicz MA, Salisbury DF, Potts GF, Hirayasu Y, Nestor PG, Shenton
ME. (1997). Update on electrophysiology in schizophrenia. International Review of Psychiatry, 9: 373-
386.
11. Salisbury DF, Shenton ME, Sherwood AR, Fischer IA, Yurgelun-Todd DA, Tohen M, McCarley RW.
(1998). First episode schizophrenic psychosis differs from first episode affective psychosis and
controls in P300 amplitude over left temporal lobe. Archives of General Psychiatry, 55: 173-180.
12. Kwon JS, Shenton ME, Hirayasu Y, Salisbury DF, Fischer IA, Dickey CC, Yurgelun-Todd DA, Tohen M,
Kikinis R, Jolesz FA, McCarley RW . (1998). An MRI study of cavum septum pellucidi in
schizophrenia, affective disorder, and schizotypal personality disorder. American Journal of
Psychiatry, 155: 509-515.
13. Hirayasu Y, Shenton ME, Salisbury DF, Dickey CC, Fischer IA, Mazzoni P, Kisler T, Arakaki H, Kwon JS,
Anderson JA, Yurgelun-Todd D, Tohen M, McCarley RW. (1998). Lower left temporal lobe MRI
volumes in patients with first-episode schizophrenia compared with psychotic patients with firstepisode
affective disorder and normal subjects. American Journal of Psychiatry, 155: 1384-1391.
14. Salisbury DF, Shenton ME, McCarley RW. (1999). P300 topography differs in schizophrenia and m anic
psychosis. Biological Psychiatry, 45: 99-106.
15. O'Donnell BF, McCarley RW , Potts GF, Salisbury DF, Nestor PG, Hirayasu Y, Niznikiewicz MA, Barnard
J, Shen ZJ, Weinstein DM, Bookstein F, Shenton ME. (1999). Identification of neural circuits
underlying P300 abnormalities in schizophrenia. Psychophysiology, 36: 388-398.
10

16. Hirayasu Y, Shenton ME, Salisbury DF, Kwon JS, Wible CG, Fischer IA, Yurgelun-Todd D, Zarate C,
Kikinis R, Jolesz FA, McCarley RW. (1999). Subgenual cingulate cortex volume in first-episode
psychosis. American Journal of Psychiatry, 156: 1091-1093.
17. McCarley RW, Niznikiewicz MA, Salisbury DF, Nestor PG, O’Donnell BF, Hirayasu Y, Grunze H, Greene
RW, Shenton ME. (1999). Cognitive dysfunction in schizophrenia: Unifying basic research and clinical
aspects. European Archives of Psychiatry and Clinical Neuroscience, 249: IV/69-IV/82.
18. Salisbury DF, O’Donnell BF, McCarley RW , Nestor PG, Shenton ME. (2000). Event-related potentials
elicited during a context-free homograph task in normal versus schizophrenic subjects.
Psychophysiology, 37: 456-463.
19. Hirayasu Y, McCarley RW , Salisbury DF, Tanaka S, Kwon JS, Frumin M, Snyderman D, Yurgelun-Todd
DA, Kikinis R, Jolesz FA, Shenton ME. (2000). Planum temporale and Heschl’s gyrus volume
reduction in schizophrenia: a magnetic resonance imaging study of first-episode patients. Archives
of General Psychiatry, 57: 692-699.
20. Hirayasu Y, Shenton ME, Salisbury DF, McCarley RW. (2000). Hippocampal and superior temporal gyrus
volum e in first-episode schizophrenia. Archives of General Psychiatry, 57: 618.
21. Salisbury DF, Rutherford B, Shenton ME, McCarley RW. (2001). Button-pressing affects P300 amplitude
and scalp topography. Clinical Neurophysiology, 112:1676-1684.
22. Hirayasu Y, Tanaka S, Shenton ME, Salisbury DF, DeSantis M, Levitt J, Wible C, Yurgelun-Todd D,
Kikinis R, Jolesz F, McCarley RW. (2001). Prefrontal gray matter reduction in first episode
schizophrenia. Cerebral Cortex, 11: 374-381.
23. Wible C, Kubicki M, Yoo S, Kacher D, Salisbury DF, Anderson M, Shenton ME, Hirayasu Y, Kikinis R,
Jolesz F, McCarley RW. (2001). A Functional Magnetic Resonance Imaging Study of Auditory
Mismatch in Schizophrenia. American Journal of Psychiatry,158: 938-943.
24. Nestor PG, Han SD, Niznikiewicz M, Salisbury D, Spencer K, Shenton ME, McCarley RW. (2001).
Semantic disturbance in schizophrenia and its relationship to the cognitive neuroscience of attention.
Biological Psychology, 57: 23-46.
25. Salisbury DF, DeSantis MA, Shenton ME, McCarley RW. (2002). The effect of background noise on
P300 to suprathreshold stimuli. Psychophysiology, 39:111-115.
26. McCarley RW , Salisbury DF, Hirayasu Y, Yurgelun-Todd, DA, Tohen M, Zarate C, Kikinis R, Jolesz FA,
Shenton ME. (2002). Association between smaller left posterior superior temporal gyrus MRI volume
and smaller left temporal P300 amplitude in first episode schizophrenia. Archives of General
Psychiatry, 59: 321-331.
27. Lee CU, Shenton ME, Salisbury DF, Kasai K, Onitsuka T, Dickey CC, Yurgelun-Todd D, Kikinis R, Jolesz
FA, McCarley RW . (2002). Fusiform gyrus volume reduction in first-episode schizophrenia: A
magnetic resonance study. Archives of General Psychiatry, 59: 775-781.
28. Kubicki M, Shenton ME, Salisbury DF, Hirayasu Y, Kikinis, R, Jolesz FA, McCarley RW. (2002). Voxelbased
morphom etric analysis of gray matter in first episode schizophrenia. NeuroImage, 17: 1711-
1719.
29. Salisbury DF, Shenton ME, Griggs CB, Bonner-Jackson A, McCarley RW . (2002). Mismatch negativity
in chronic schizophrenia and first-episode schizophrenia. Archives of General Psychiatry, 59: 686-
694.
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30. Frum in M, Golland P, Kikinis R, Hirayasu Y, Salisbury DF, Hennen J, Dickey CC, Anderson M, Fischer
IA, Yurgelun-Todd D, Jolesz FA, Grimson WE, McCarley RW, Shenton ME. (2002). Shape
Differences in the Corpus Callosum in First Psychotic Episode Schizophrenia and First Psychotic
Episode Affective Disorder. American Journal of Psychiatry, 159: 866-868.
31. Kubicki M, Westin CF, Maier S, Frumin M, Nestor PG, Salisbury DF, Kikinis R, Jolesz FA, McCarley RA,
Shenton ME. (2002). Uncinate Fasiculus Findings in Schizophrenia: A Magnetic Resonance Diffusion
Tensor Imaging Study. American Journal of Psychiatry, 159: 813-820.
32. Sitnikova T, Salisbury DF, Kuperberg G, Holcomb PJ. (2002). Electrophysiological insights into language
processing in schizophrenia. Psychophysiology, 39: 851-860.
33. Salisbury DF, Shenton ME, Nestor PG, McCarley RW. (2002). Semantic bias, homograph
comprehension, and event-related potentials in schizophrenia. Clinical Neurophysiology, 113: 383-
395.
34. Kasai K, Shenton ME, Salisbury DF, Hirayasu Y, Lee CU, Ciszewski AA, Yurgelun-Todd DA, Kikinis R,
Jolesz FA, McCarley RW . (2003). Progressive decrease of left superior temporal gyrus gray matter
volum e in first-episode schizophrenia. American Journal of Psychiatry, 160:156-164.
35. Spencer KM, Nestor PG, Niznikiewicz MA, Salisbury DF, Shenton ME, & McCarley RW. (2003).
Abnorm al neural synchrony in schizophrenia. Journal of Neuroscience, 23:7407-7411.
36. Kasai K, Shenton ME, Salisbury DF, Hirayasu Y, Onitsuka T, Spencer M, Yurgelun-Todd DA, Kikinis R,
Jolesz FA, McCarley RW . (2003). Progressive decrease of left Heschl's gyrus and planum tem porale
gray matter volum e in first-episode schizophrenia: a longitudinal magnetic resonance imaging study.
Archives of General Psychiatry, 60:766-765.
37. Kasai K, Shenton ME, Salisbury DF, Onitsuka T, Toner S, Yurgelun-Todd DA, Kikinis R, Jolesz FA,
McCarley RW . (2003). Differences and similarities in insular and temporal pole MRI gray matter
volume abnormalities in first-episode schizophrenia and affective psychosis. Archives of General
Psychiatry, 60:1069-1077.
38. Salisbury DF. (2004). Semantic memory and verbal working memory correlates of N400 to subordinate
hom ographs. Brain and Cognition, 55:396-399.
39. W iegand LC, W arfield SK, Levitt JJ, Hirayasu Y, Salisbury DF, Dickey CC, Heckers S, Kikinis R, Jolesz
FA, McCarley RW , Shenton ME. (2004). Prefrontal cortical thickness in first episode psychosis: A
magnetic resonance imaging study. Biological Psychiatry, 55:131-140.
40. Park HJ, Levitt JJ, Shenton ME, Salisbury DF, Kubicki M, Kikinis R, Jolesz F, McCarley RW. (2004). An
MRI Study of Spatial Probability Brain Map Differences Between First-Episode Schizophrenia and
Normal Controls, Neuroimage, 22:1231-1246.
41. Titone DA & Salisbury DF. (2004). Contextual modulation of N400 amplitude to lexically ambiguous
words. Brain and Cognition, 55: 470-478.
42. Salisbury DF, Griggs CB, Shenton ME, McCarley, RW. (2004). The NoGo P300 ‘anteriorization’ effect
and response inhibition. Clinical Neurophysiology, 115:1550-1558.
43. Kasai K, McCarley RW , Salisbury DF, Onitsuka T, Demeo S, Yurgelun-Todd D, Kikinis R, Jolesz FA,
Shenton ME. (2004). Cavum Septi Pellucidi in First-Episode Schizophrenia and First-Episode
Affective Psychosis: An MRI Study. Schizophrenia Research, 71:65-76.
44. Dickey CC, Salisbury DF, Nagy AI, Hirayasu Y, Lee CU, McCarley RW, Shenton ME. (2004). Follow-up
MRI study of prefrontal volumes in first-episode psychotic patients. Schizophrenia Research, 71:349-
351.
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45. Wiegand LC, W arfield SK, Levitt JJ, Hirayasu Y, Salisbury DF, Heckers S, Bouix S, Schwartz D, Spencer
M, Dickey CC, Kikinis R, Jolesz FA, McCarley RW, Shenton ME. (2005). An in vivo MRI study of
prefrontal cortical complexity in first-episode psychosis. American Journal of Psychiatry, 162:65-70.
46. Nierenberg J, Salisbury DF, Levitt, JJ, David EA, McCarley RW, Martha E. Shenton. (2005). Reduced
left angular gyrus volume in first-episode schizophrenia. American Journal of Psychiatry, 162:1539-
1541.
47. Gurrera RJ, Salisbury DF, O'Donnell BF, Nestor PG, McCarley RW. (2005). Auditory P3 indexes
personality traits and cognitive function in healthy men and women. Psychiatry Research, 33:215-228.
48. Kuroki N, Kubicki M, Nestor PG, Salisbury DF, Park HJ, Levitt JJ, Woolston S, Frumin M, Niznikiewicz
M, Westin CF, Maier SE, McCarley RW , Shenton ME. Fornix integrity and hippocam pal volum e in
male schizophrenic patients. Biological Psychiatry, (In Press).
49. Kuroki N, Shenton ME, Salisbury DF, Hirayasu Y, Onitsuka T, Ersner-Hershfield H, Yurgelun-Todd D,
Kikinis R, Jolesz FA, McCarley RW . Middle and Inferior Temporal Gyrus Gray Matter Volume in First-
Episode Schizophrenia: An MRI Study. American Journal of Psychiatry (In Press).
Proceedings of Meetings:
1. Salisbury DF. Stimulus processing awake and asleep: Similarities and differences in electrical CNS
responses. In J. Harsh and R. Ogilvie (Eds.), Sleep Onset Mechanisms. American Psychological
Association, 1994.
2. Hirayasu Y, Shenton ME, Salisbury DF, O’Donnell BF, McCarley RW P300 event-related potential
abnormalities and their relationship to MRI brain structure in first episode schizophrenics and affective
psychotics. In Y. Koga, K. Nagata, and H. Hirata (Eds), Brain Topography Today, Elsevier Science
B.V., 1998.
Reviews and Educationally Relevant Publications:
1. Salisbury DF, O’Donnell BF, Nestor PG, Shenton ME, McCarley RW . (1999). Multim odal Im aging in
Psychiatry: The electroencephalogram as a complement to other modalities. CNS Spectrums, 4: 44-
57.
2. Salisbury DF, Krljes S, McCarley RW. Electrophysiology of Schizophrenia. (2003). In D. Weinberger and
Hirsch (Eds), Schizophrenia (2 nd Edition), Blackwell Science LTD., pp.298-309.
3.Niznikiewicz MA, Spencer KM, Salisbury DF, McCarley RW . (2004). Event related potentials. In: Lawrie
SM, Weinberger DR, Johnstone EC, editors. Schizophrenia: from Neuroimaging to Neuroscience.
Oxford: Oxford University Press, pp.293-330.
Abstracts (unpublished data only):
1. Salisbury D, Squires NK. (1991). The auditory odd-ball paradigm in sleep produces separable P300
potentials and K complexes in NREM and a large occipital N600 in REM. Sleep Research, 20: 157.
2. O'Donnell B, Shenton M, McCarley RW , Cuffin B, Faux S, Smith RS, Salisbury D, Kikinis R, Jolesz F.
(1992). Dipole source modeling and validation of the auditory P300 component in schizophrenia.
Biological Psychiatry, 31: 146A.
3. Niznikiewicz M, O'Donnell BF, McCarley RW , Smith L, Hokama H, Salisbury D, Kimble M, Shenton M.
(1993). Habituation in auditory P3 amplitude and alpha power in normal and schizophrenic subjects.
Biological Psychiatry, 118A.
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4. Salisbury D, Voglmaier M, McCarley RW, Seidman L. (1993). Schizotypy: P3 correlates of
psychopathology. APA New Research Abstracts, 186-187.
5. Salisbury D, Voglmaier M, McCarley RW, Seidman L, Smith L. (1993). Alpha (10 Hz) power is reduced
in episodic schizotypes. Harvard Medical School Department of Psychiatry Annual Research Day.
6. O'Donnell BF, Shenton ME, McCarley RW, Faux SF, Kimble M, Salisbury DF, Kikinis R, Jolesz FA. (1994).
MRI and ERP evidence for a neurodegenerative course in schizophrenia. Biological Psychiatry, 35:
705.
7. Salisbury DF, Voglmaier M, McCarley RW, Seidman L, Goodreau E. (1994). Asymmetrical alpha power
in schizotypy. APA New Research Abstracts, 155.
8. Hirayasu Y, Shenton ME, Dickey CC, Salisbury DF, Fischer IA, Sherwood AR, Yurgelun-Todd DA, Tohen
M, McCarley RW . (1996). Brain CSF volume in patients with first-episode psychosis. Biological
Psychiatry, 39: 519.
9. Voglmaier MM, Shenton ME, McCarley RW , Seidman LJ, Salisbury DF, Solinger J. (1996). Thought
disorder index (TDI) in schizotypal personality disorder. Biological Psychiatry, 39: 549.
10. McCarley RW, Shenton ME, Greene R, O’Donnell BF, Nestor PG, W ible C, Salisbury DF, Niznikiewicz
M, Hirayasu Y, Dickey CC, Kwon JS, Arakaki H, Tohen M, Yurgelun-Todd DA, Holinger D, Kikinis R,
Jolesz F. (1997). Schizophrenia: MRI, electrophysiological, and cellular data bearing on some current
issues and controversies. Biological Psychiatry, 41:6S
11. Fischer IA, Shenton ME, McCarley RW, Mazzoni P, Harper M & Salisbury DF. (1997). Abstraction ability,
P300, and psychosis. Psychophysiology, 34: S34.
12. Salisbury DF, Mazzoni P, McCarley RW, Fischer IA, Tohen M, Yurgelun-Todd DA, Shenton ME. (1998).
P300 asymmetry persists at retest in first psychotic episode schizophrenia. Biological Psychiatry, 43:
122S.
13. Salisbury DF, Shenton ME, Fischer IA, Mazzoni P, Farrell DC, Tohen M, Zarate C, McCarley RW . (1999).
Longitudinal study of P300 topography in first-episode psychosis. Schizophrenia Research, 36: 258.
14. Salisbury DF, Shenton ME, Tohen M, Zarate C, McCarley RW . (1999). P300 topography during the early
course of psychosis. Psychophysiology, 36: S100.
15. McCarley RW , Salisbury DF, Hirayasu Y, Wible C, Shenton ME. (1999). Conjoint structural MRI and ERP
studies in schizophrenia: Evidence for a “hot spot” of dominant hemisphere abnormalities that is
present at onset and also progresses. Psychophysiology, 36: S13.
16. Nagy AI, Lee CU, Shenton ME, Salisbury DF, Kricun AA, Dickey CC, McCarley RW. (2000).
Schizophrenia: Progressive prefrontal gray matter changes. APA New Research Abstracts.
17. Hirayasu Y, Shenton ME, Tanaka S, Salisbury DF, Nagy A, Dickey CC, Kricun A, Yurgelun-Todd DA,
Zarate C, McCarley RW. (2000). Specificity of reduced cortical gray matter to first episode
schizophrenic psychosis. Biological Psychiatry, 47: 102S.
18. McCarley RW , Dickey CC, Niznikiewicz MA, Seidman LJ, Voglmaier MM, Salisbury DF, Sutton J,
Shenton ME. (2000). Structural MR imaging findings in schizotypal personality disorder subjects.
Biological Psychiatry, 47: 120S.
19. Kasai K, Shenton ME, Salisbury DF, Lee CU, Dickey CC, Yurgelun-Todd D, McCarley RW . (2001).
Fusiform gyrus volume reduction in first-episode schizophrenia. Biological Psychiatry, 49: 18S-19S.
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20. Levitt JJ, McCarley RW, Ciszewski A, Salisbury DF, Kikinis R, Jolesz FA, Shenton ME. (2001). An MRI
study of caudate nucleus and lateral ventricle volume in first episode schizophrenia. Biological
Psychiatry, 49: 57S.
21. Salisbury DF, Bonner-Jackson A, Griggs CB, Shenton ME, McCarley RW . (2001). Mismatch negativity
in schizophrenia: Does MMN amplitude decline with disease duration? Biological Psychiatry, 49: 85S.
22. Salisbury DF, Shenton ME, McCarley RW. (2002). Age and chronicity effects on P300 amplitude in
schizophrenia and psychotic m ania. Biological Psychiatry, 51: 45S.
23. Levitt JJ, McCarley RW , Ersner-Hershfield H, Salisbury DF, Kikinis R, Jolesz FA, Shenton ME. (2002).
Am MRI study of caudate nucleus and lateral ventricle volume in first episode schizophrenia and
affective psychosis. Biological Psychiatry, 51: 59S.
24. Salisbury DF, Griggs G, Schwartz L, Sumorok N (2002). Homograph network strength, associate
strength, incongruity, and N400. Psychophysiology, 39: S13.
25. Salisbury DF, Shenton ME, McCarley RW. (2002). Reduction of MMN in the first few years of
schizophrenia. Psychophysiology, 39: S73.
26. Salisbury DF, Kasai K, Shenton ME, McCarley RW. (2002). Mismatch negativity amplitude and Heschl’s
gyrus volume in first-episode schizophrenia. Schizophrenia Research, 60: 259.
27. Salisbury DF, Kasai K, Shenton ME, McCarley RW. (2002). Mismatch negativity and Heschl’s gyrus
volum e longitudinally in first episode schizophrenia. Biological Psychiatry, 53: 89S.
28. Gurrera RJ, Salisbury DF, O’Donnell BF, Nestor PG, McCarley RW. (2002). Auditory P3 correlates with
major personality traits and cognitive performance in healthy individuals. Biological Psychiatry, 53:
209S.
29. Salisbury DF, Berman R, Sumorok N. (2003). Verbal working mem ory and sem antic m em ory in
schizophrenia: A model of fronto-tem poral interactions. Psychophysiology, 40: S19.
30. Berman RE, Shenton ME, McCarley RW , Salisbury, DF. (2004). P300 Latency, Cognition, and Symptom
Course Before and After First Hospitalization:Longitudinal Study of a Bipolar Monozygotic Twin Pair.
Twelfth Annual Research Day, Department of Psychiatry, Harvard Medical School.
31. Salisbury DF, Thakur A, Kuroki N, Kasai K, Shenton ME, McCarley RW. (2004). Mismatch Negativity and
Progressive Cortical Reduction in First Hospitalized Schizophrenia. Twelfth Annual Research Day,
Department of Psychiatry, Harvard Medical School.
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