Summer 2010 - McLean Hospital - Harvard University

The Northern New EnglanderClinical Trials Network NewsletterFinal Issue of Northern New Englander!Volume 9, Issue 2Summer 2010Node News!As of September 1 st , the Northern New England Node (RRTC: McLean/Harvard) and the New EnglandNode (RRTC: Yale University) have become the newly merged New England Consortium Nodeunder the direction of Roger D. Weiss, M.D., and Kathy M. Carroll, Ph.D. The combination of thesetwo nodes enhances the strengths of each node by providing broader and deeper scientific expertiseand greater diversity of community treatment programs (CTPs). As such, this will be the last issue ofthe Northern New Englander newsletter!Current Protocol UpdatesIN THIS ISSUEThe CTN-0044 study, “Web-delivery of Evidence-based, Psychosocial Treatmentfor Substance Abuse Disorders” lead by the Long Island Regional Node is beingconducted locally at Stanley Street Treatment & Resources, Inc. (SSTAR) in FallRiver, Massachusetts under the direction of Genie Bailey, M.D.. The primary objectiveof this study is to evaluate the effectiveness of including an interactive, webbasedversion of the Community Reinforcement Approach (CRA) intervention plus incentives targetingdrug abstinence and treatment participation as part of community-based, outpatient substanceabuse treatment. As of August 29 th , SSTAR has randomized 5 participants into the study.The CTN-0030 POATS Long-Term Follow-up Project is being conducted byresearch staff at McLean Hospital. The goal of this exploratory, naturalisticstudy is to describe the substance use trajectories of CTN 0030 participantsand identify factors associated with long-term recovery from opioid analgesicdependence. Participants in the follow-up extension project are assessed via telephone calls at 18,30, and 42 months post-Phase 1 randomization in the CTN-0030 main trial. As of August 31 st , 243month-18, 161 month-30, and 29 month-42 assessments have been completed.Node NewsProtocol Updates1New Faces 2Publications,Presentations andUpcomingMeetings3Future ProtocolsTwo sites affiliated with the node were being considered as part of Wave 2 implementation for theupcoming CTN-0047 protocol, “Screening, Motivational Assessment, Referral, and Treatment inEmergency Departments (SMART-ED).” The two sites under consideration included the MassachusettsGeneral Hospital (MGH) Emergency Department and the Brigham and Women’s Hospital(BWH) Emergency Department. The Lead Node investigators from the CTN Southwest Node(University of New Mexico) visited the sites on August 26 th .

The Northern New EnglanderNew Faces at SSTARRita Chapdelaine, graduated from UMass Dartmouth in 2008 with a B.A. in Sociology. She iscurrently pursuing an MSW at Boston University. In March 2010, she began working atSSTAR. Her professional interests are addictions counseling and research.Autumn Froias, graduated from Boston University in January of 2010 with a B.A. in Psychologyand Sociology. She has been working as a research assistant at STARR since March2010. Her professional interests include dual diagnosis treatment and research.New Faces at McLean HospitalJacob Augenstern, graduated from Harvard University in May 2010 with a B.A. in Psychology. He hasworked at McLean Hospital, as a research assistant in ADATP, since June 2010. His professional interests includemood disorders, aggression, anxiety and substance abuse.Kate Frost, graduated from Wellesley College in the spring of 2010, with a B.A. in Psychology and ReligiousStudies. She has worked at McLean Hospital, as a research assistant in ADATP, since June 2010. Her professionalinterests include the neuroscience of child and adolescent psychopathology, specifically including OCDand childhood schizophrenia.Jessica Dreifuss, Ph.D. , recently joined the staff as a Postdoctoral Research Fellow after completing her doctoratein Clinical Psychology at the University of Georgia. Jessie is very excited about joining the research teamin the Division of Alcohol and Drug Abuse. She is particularly looking forward to increasing her knowledge andproficiency with substance use disorders and their treatment, expanding and refining her research skills, and immersingherself in the NIDA Clinical Trials Network.CTN Research in the NewsMain outcome findings from the NIDA CTN-0010 study examining treatments for opioid-addicted adolescentswere summarized in the recent issue of NIDA Notes [Vol. 23 (1), pages. 8-9]. The aim of the studywas to determine if a 12-week course of outpatient buprenorphine/naloxone (Bup/Nal) plus psychosocialtreatment resulted in fewer opioid positive urine tests at 3 monthly evaluation points among opioid dependentadolescents and young adults (ages 14-21) than the usual treatment, which was detoxification plus psychosocialtreatment alone. Mercy Hospital Recovery Center (Westbrook, ME) was a participating CommunityTreatment Program in the CTN-0010 study from the Northern New England Node. A PDF version ofNIDA Notes is available at: http://www.drugabuse.gov/nida_notes/nnv23index.html. Main outcome resultsfrom the full study were published in the Journal of the American Medical Association (JAMA) 2008; 300(17):2003-2011.2

The Northern New EnglanderPRESENTATIONS: Connery, HS. “Buprenorphone: the “Clozapine” for Patients With Opioid Dependence”, lecture presented at the McLeanHospital forum, March 4, 2010.CTN-0030 Results Presentations:PUBLICATIONS:Weiss, RD. “Results of the Prescription Opioid Addiction Treatment Study: A Multi-site Trial of the NIDA Clinical Trials Network.”163rd Annual Meeting of the American Psychiatric Association, New Orleans, LA, May 22-26, 2010.Weiss RD, Potter JS, Jacobs P, Ling W. “The Multi-site NIDA Clinical Trials Network Prescription Opioid Addiction TreatmentStudy: Outcomes and Implications.” Symposium at the College on Problems of Drug Dependence (CPDD) annualmeeting, June 17, 2010, Scottsdale, AZ. Potter, JS, Ling W. “The Emerging Scientific Basis for Treatment of Pain Patients with Co-Occurring Chronic Pain and PrescriptionOpioid Addiction.” American Pain Society (APS) 29th Annual Scientific Meeting, May 6, 2010, Baltimore, MD.Upcoming CTN-0030 Results Presentations:Weiss, RD. Potter JS. “Prescription Opioid Addiction Treatment Study: Outcomes NS Clinical Implications” AmericanAssociation for the Treatment of Opioid Dependence, Inc. (AATOD) National Conference, October 25, 2010, Chicago, IL.Weiss RD, Potter JS. “Symposium II: Prescription Opioid Dependence: New Evidence on Treatment” American Academyof Addiction Psychiatry 21st Annual Meeting and Symposium, December 2—5, 2010 Boca Raton, FA.Provost SE, Potter JS, Weiss RD. “A community-based, two-phase randomized controlled trial of buprenorphine with andwithout individual drug counseling for the treatment of opioid analgesic addiction”, poster presentation scheduled for the2010 American Public Health Association (APHA) 138th Annual Meeting and Exposition, November 9, 2010, Denver, CO.CTN-0029- Winhusen TM, Somoza EC, Brigham GS, Liu DS, Green CA, Covey LS, Croghan IT, Adler LA, Weiss RD, LeimbergerJD, Lewis DF, Dorer EM. Impact of attention-deficit/hyperactivity disorder (ADHD) treatment on smoking cessationintervention in ADHD smokers: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2010 May 18. [Epubahead of print] PMID: 20492837Gender Special Interest Group- Brooks A, Meade CS, Potter JS, Lokhnygina Y, Calsyn DA, Greenfield SF. Gender Differencesin the Rates and Correlates of HIV Risk Behaviors Among Drug Abusers. Subst Use Misuse. 2010 Jun 10. [Epubahead of print] PMID: 20536356 CTN-0030 Imaging– Upadhyay J, Maleki N, Potter J, Elman I, Rudrauf D, Knudsen J, Wallin D, Pendse G, McDonald L,Griffin M, Anderson J, Nutile L, Renshaw P, Weiss R, Becerra L, Borsook D. Alterations in brain structure and functionalconnectivity in prescription opioid-dependent patients. Brain. 2010 Jul; 133 (Pt &): 2098-114. Epub 2010 Jun 16. PMID:20558415Upcoming Meetings/Conferences:NIDA CTN Steering Committee meeting, Sept. 21-23, 2010 at the Bethesda North Marriott Hotel and Conference Center,Bethesda, MD. Registration details: http://seisservices.com/NIDA/CTN/Meetings/1025039/index.asp2010 Addiction Health Services Research Conference, October 25-27, 2010 at the Hilton Hotel in downtown Lexington, KYhttp://www.cecentral.com/live/2283Addictions 2010: The New Frontier in Addiction Treatment: Evidence-Based Policy and Practice, Oct. 28-31, 2010 inArlington, VAAssociation for Medical Education & Research in Substance Abuse, Nov. 4-6, 2010 in Bethesda, MDAmerican Public Health Association, Nov. 6-10, 2010, in Denver, CO3