18 - World Journal of Gastroenterology

Leal MF et al . Promoter hypermethylation in gastric cancer 2573
necessary to confirm this association.
This is the first study that has evaluated the methylation
status of CDH1, FHIT, MTAP and PLAGL1
promoters and their hypermethylation frequencies in
gastric tissue samples in a population from Northern
Brazil. The methylation status of MTAP promoter has
never been investigated in gastric samples. Our findings
show that hypermethylation is associated with gastric
carcinogenesis. The H pylori infectious agent was present
in 44.9% of samples and this infection may be a part of
the carcinogenesis process through the gene promoter
hypermethylation; especially the MTAP promoter in
diffuse-type. Increased H pylori infection in diffuse-type
may also be due to higher genetic predisposition.
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