Research Report - Nikolaus-Fiebiger-Zentrum für Molekulare Medizin

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Publications (2009-2012) Original Articles 2012 Biburger, M., and Nimmerjahn, F. (2012). Low level of FcgammaRIII expression on murine natural killer cells. Immunol Lett 143, 53-59. Bohm, S., Schwab, I., Lux, A., and Nimmerjahn, F. (2012). The role of sialic acid as a modulator of the anti-inflammatory activity of IgG. Semin Immunopathol. Harre, U., Georgess, D., Bang, H., Bozec, A., Axmann, R., Ossipova, E., Jakobsson, P.J., Baum, W., Nimmerjahn, F., Szarka, E., et al. (2012). Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest 122, 1791-1802. Kasperkiewicz, M., Nimmerjahn, F., Wende, S., Hirose, M., Iwata, H., Jonkman, M.F., Samavedam, U., Gupta, Y., Moller, S., Rentz, E., et al. (2012). Genetic identification and functional validation of FcgammaRIV as key molecule in autoantibody-induced tissue injury. J Pathol. Lehmann, B., Schwab, I., Bohm, S., Lux, A., Biburger, M., and Nimmerjahn, F. (2012). FcgammaRIIB: a modulator of cell activation and humoral tolerance. Expert Rev Clin Immunol 8, 243-254. Moldt, B., Shibata-Koyama, M., Rakasz, E.G., Schultz, N., Kanda, Y., Dunlop, D.C., Finstad, S.L., Jin, C., Landucci, G., Alpert, M.D., et al. (2012). A Nonfucosylated Variant of the anti-HIV-1 Monoclonal Antibody b12 Has Enhanced FcgammaRIIIa- Mediated Antiviral Activity In Vitro but Does Not Improve Protection against Mucosal SHIV Challenge in Macaques. J Virol 86, 6189-6196. Ruiz-Heiland, G., Horn, A., Zerr, P., Hofstetter, W., Baum, W., Stock, M., Distler, J.H., Nimmerjahn, F., Schett, G., and Zwerina, J. (2012). Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis. Ann Rheum Dis 71, 400-407. Schwab, I., Biburger, M., Kronke, G., Schett, G., and Nimmerjahn, F. (2012). IVIgmediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1. Eur J Immunol 42, 826-830. Uderhardt, S., Herrmann, M., Oskolkova, O.V., Aschermann, S., Bicker, W., Ipseiz, N., Sarter, K., Frey, B., Rothe, T., Voll, R., et al. (2012). 12/15-lipoxygenase 107
orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity 36, 834-846. 2011 Baerenwaldt, A., Lux, A., Danzer, H., Spriewald, B.M., Ullrich, E., Heidkamp, G., Dudziak, D., and Nimmerjahn, F. (2011). Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Natl Acad Sci U S A 108, 18772-18777. Biburger, M., Aschermann, S., Schwab, I., Lux, A., Albert, H., Danzer, H., Woigk, M., Dudziak, D., and Nimmerjahn, F. (2011). Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo. Immunity 35, 932-944. Lux, A., and Nimmerjahn, F. (2011). Impact of differential glycosylation on IgG activity. Adv Exp Med Biol 780, 113-124. Nimmerjahn, F., and Lunemann, J.D. (2011). Expression and function of the inhibitory Fcgamma-receptor in CIDP. J Peripher Nerv Syst 16 Suppl 1, 41-44. Nimmerjahn, F., and Ravetch, J.V. (2011). FcgammaRs in health and disease. Curr Top Microbiol Immunol 350, 105-125. Santiago-Raber, M.L., Baudino, L., Alvarez, M., van Rooijen, N., Nimmerjahn, F., and Izui, S. (2011). TLR7/9-mediated monocytosis and maturation of Gr-1(hi) inflammatory monocytes towards Gr-1(lo) resting monocytes implicated in murine lupus. J Autoimmun 37, 171-179. 2010 Anthony, R.M., and Nimmerjahn, F. (2010). The role of differential IgG glycosylation in the interaction of antibodies with FcgammaRs in vivo. Curr Opin Organ Transplant. Aschermann, S., Lux, A., Baerenwaldt, A., Biburger, M., and Nimmerjahn, F. (2010). The other side of immunoglobulin G: suppressor of inflammation. Clin Exp Immunol 160, 161-167. Baerenwaldt, A., Biburger, M., and Nimmerjahn, F. (2010). Mechanisms of action of intravenous immunoglobulins. Expert Rev Clin Immunol 6, 425-434. Comabella, M., Montalban, X., Kakalacheva, K., Osman, D., Nimmerjahn, F., Tintore, M., and Lunemann, J.D. (2010). B cell expression of the inhibitory Fc gamma receptor is unchanged in early MS. J Neuroimmunol 223, 135-137. Heidkamp, G.F., Neubert, K., Haertel, E., Nimmerjahn, F., Nussenzweig, M.C., and Dudziak, D. (2010). Efficient generation of a monoclonal antibody against the human 108
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Nikolaus-Fiebiger-Zentrum für Mole
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PREFACE Our present report covers t
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SCIENTIFIC ADVISORY BOARD The scien
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Financial Concept (Running Costs) R
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DEPARTMENT OF EXPERIMENTAL MEDICINE
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Research projects: I. Analyzing the
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osteoclast activity, we cannot rule
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Previously we have shown that cellu
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The proposed studies will provide n
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We recently introduced Ucma (Upper
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Park J, Bauer S, Schlegel KA, Neuka
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Research Hypertension is the primar
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accessory protein of the H+ vacuola
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Searle, J., Mockel, M., Gwosc, S.,
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DEPARTMENT OF EXPERIMENTAL MEDICINE
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Research Our group analyses molecul
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We found that the transcriptional r
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Fig. 1 Dual functional role of Amer
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HIF target gene expression in renal
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2009 Wacker, I., Sachs, M., Knaup,
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Andreas Brandl* Sebastian Dütting*
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microRNAs in lymphocytes in health
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Function of EFhd1 and EFhd2 in B ce
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mainly expressed on phagocytes, fun
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Lang, V. R., Mielenz, D., Neubert,
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TRAINING OF GRADUATE AND MEDICAL ST
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Research Our research focus lies on
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During the last 3 years we had succ
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Adoptive transfer of memory B cells
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Page 65 and 66: Weisel, F.J., U.K. Appelt, A.M. Sch
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Page 69 and 70: Figure 1: Induced pluripotent stem
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Page 73 and 74: INTERDISCILINARY CENTER OF CLINICAL
Page 75 and 76: Research Primary essential hyperten
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Page 79 and 80: its soluble receptor sVEGFR3). This
Page 81 and 82: Fig. 5. Selective blockade of the V
Page 83 and 84: 2011 Slagman MC, Kwakernaak AJ, Yaz
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Page 87 and 88: Research Our group is mainly intere
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Page 91 and 92: Original Articles Publications (200
Page 93 and 94: 13. Krönke G, Uderhardt S, Kim KA,
Page 95 and 96: Reviews 1. Iwamoto N, Distler JH, D
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Page 99 and 100: esidues, or nucleic acids. This sti
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Page 109 and 110: activating or inhibitory Fc recepto
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Page 119 and 120: From the immunopathogenesis of syst
Page 121 and 122: with bortezomib depletes plasma cel
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Page 127 and 128: application of both TSP-1 and OP-1
Page 129 and 130: Books and Reviews Gelse K, Beyer C.
Page 131 and 132: Stefan Fleischer Technicians Marina
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Page 137 and 138: Original Articles Rath SN, Strobel
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Page 143 and 144: Fig. 3 The nuclear receptor PPARβ
Page 145 and 146: Books and Reviews Scholtysek C, Kr
Page 147 and 148: Elke Nolte geb. Löprich, Dipl. Bio
Page 149 and 150: prognosis and metastases of prostat
Page 151 and 152: Grochola LF, Taubert H, Greither T,
Page 153 and 154: DEPARTMENT OF INTERNAL MEDICINE 5 (
Page 155 and 156: Fig. 1 FACS analysis of NK cell sub
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were able to induce the expression
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Figure 5: A. Kidney of a 7 months o
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protein is highly expressed in the
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and LOXL2 are necessary and suffici
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TEACHING ACTIVITIES at the Nikolaus
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G. Riemekasten, Berlin Systemic scl
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