Research Report - Nikolaus-Fiebiger-Zentrum für Molekulare Medizin

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2009 Hoffman AC, Danenberg KD, Taubert H, Danenberg PV, Wuerl P. A three-gene signature for outcome in soft tissue sarcoma. Clin Cancer Res. 2009 15(16):5191-8. Bluemke K, Bilkenroth U, Meye A, Fuessel S, Lautenschlaeger C, Goebel S, Melchior A, Heynemann H, Fornara P, Taubert H. Detection of circulating tumor cells in peripheral blood of patients with renal cell carcinoma correlates with prognosis. Cancer Epidemiol Biomarkers Prev 2009; 2009 Aug;18:2190-4. Grochola LF, Vazquez A, Bond EE, Würl P, Taubert H, Müller TH, Levine AJ, Bond GL. Recent Natural Selection Identifies a Genetic Variant in a Regulatory Subunit of Protein Phosphatase 2A that Associates with Altered Cancer Risk and Survival. Clin Cancer Res. 2009;15(19):6301-8. Schmidt H, Taubert H, Lange H, Kriese K, Schmitt WD, Hoffmann S, Bartel F, Hauptmann S.Small polydispersed circular DNA contains strains of mobile genetic elements and occurs more frequently in permanent cell lines of malignant tumors than in normal lymphocytes. Oncol Rep. 2009 Aug;22:393-400. Seifert A, Taubert H, Hombach-Klonisch S, Fischer B, Navarrete Santos A.: TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions. Int J Oncol. 2009;35:417-24. TRAINING OF GRADUATE AND MEDICAL STUDENTS 147
DEPARTMENT OF INTERNAL MEDICINE 5 (Haematology / Oncology) Head: Andreas Mackensen, Prof. Dr. med. <strong>Research</strong> Cellular Immunoregulation Group: Evelyn Ullrich, Prof. Dr. med. Address: Department of Internal Medicine 5 Ulmenweg 6 D-91054 Erlangen Telefone: + 49 (9131) 85 43091 Fax: + 49 (9131) 85 35958 E-mail: evelyn.ullrich@uk-erlangen.de Homepage: http://www.medizin5.uk-erlangen.de Postdoctoral Fellows Ruth Bauer, Dr. rer. nat. Doctoral Students (Biology) Kathrin Meinhardt Johanna Rothamer Doctoral Students (Molecular Medicine) Stephanie Krieg 148
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Nikolaus-Fiebiger-Zentrum für Mole
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PREFACE Our present report covers t
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SCIENTIFIC ADVISORY BOARD The scien
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Financial Concept (Running Costs) R
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DEPARTMENT OF EXPERIMENTAL MEDICINE
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Research projects: I. Analyzing the
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osteoclast activity, we cannot rule
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Previously we have shown that cellu
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The proposed studies will provide n
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We recently introduced Ucma (Upper
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Park J, Bauer S, Schlegel KA, Neuka
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Research Hypertension is the primar
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accessory protein of the H+ vacuola
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Searle, J., Mockel, M., Gwosc, S.,
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DEPARTMENT OF EXPERIMENTAL MEDICINE
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Research Our group analyses molecul
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We found that the transcriptional r
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Fig. 1 Dual functional role of Amer
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HIF target gene expression in renal
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2009 Wacker, I., Sachs, M., Knaup,
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Andreas Brandl* Sebastian Dütting*
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microRNAs in lymphocytes in health
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Function of EFhd1 and EFhd2 in B ce
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mainly expressed on phagocytes, fun
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Lang, V. R., Mielenz, D., Neubert,
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TRAINING OF GRADUATE AND MEDICAL ST
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Research Our research focus lies on
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During the last 3 years we had succ
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Adoptive transfer of memory B cells
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transplantation represents a novel,
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passive immunization for prevention
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Weisel, F.J., U.K. Appelt, A.M. Sch
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IZKF Junior Group III BMBF Research
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Figure 1: Induced pluripotent stem
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oligomerizing mutant (α-syn mut, F
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INTERDISCILINARY CENTER OF CLINICAL
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Research Primary essential hyperten
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hypertonic interstitial fluid accum
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its soluble receptor sVEGFR3). This
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Fig. 5. Selective blockade of the V
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2011 Slagman MC, Kwakernaak AJ, Yaz
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Matrix Biology Group (Dpt. Of Inter
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Research Our group is mainly intere
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accumulation of collagen, dermal th
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Original Articles Publications (200
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13. Krönke G, Uderhardt S, Kim KA,
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Reviews 1. Iwamoto N, Distler JH, D
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* PhD received Doctoral Students (M
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esidues, or nucleic acids. This sti
Page 101 and 102: Targeting antigens under immunizing
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Page 105 and 106: Loschko J, Hackl D, Dudziak D, Rein
Page 107 and 108: Experimental Immunology and Immunot
Page 109 and 110: activating or inhibitory Fc recepto
Page 111 and 112: M and G levels. This was mirrored b
Page 113 and 114: orchestrates the clearance of apopt
Page 115 and 116: Grevers, L.C., van Lent, P.L., Koen
Page 117 and 118: Clinical Research Group (Reinhard V
Page 119 and 120: From the immunopathogenesis of syst
Page 121 and 122: with bortezomib depletes plasma cel
Page 123 and 124: Voll R, Hiepe F. [Depletion of plas
Page 125 and 126: Matthias Koch Franziska Cipa Melani
Page 127 and 128: application of both TSP-1 and OP-1
Page 129 and 130: Books and Reviews Gelse K, Beyer C.
Page 131 and 132: Stefan Fleischer Technicians Marina
Page 133 and 134: plain BCP constructs, constructs pr
Page 135 and 136: a source to establish a reliable pe
Page 137 and 138: Original Articles Rath SN, Strobel
Page 139 and 140: Research Our group is interested in
Page 141 and 142: essential regulatory mediators duri
Page 143 and 144: Fig. 3 The nuclear receptor PPARβ
Page 145 and 146: Books and Reviews Scholtysek C, Kr
Page 147 and 148: Elke Nolte geb. Löprich, Dipl. Bio
Page 149 and 150: prognosis and metastases of prostat
Page 151: Grochola LF, Taubert H, Greither T,
Page 155 and 156: Fig. 1 FACS analysis of NK cell sub
Page 157 and 158: Ullrich E, Bonmort M, Mignot G, Cha
Page 159 and 160: Tilman Jobst-Schwan Sina Grupp * pe
Page 161 and 162: comparison to the control animals.
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Page 165 and 166: Figure 5: A. Kidney of a 7 months o
Page 167 and 168: protein is highly expressed in the
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Page 171 and 172: TEACHING ACTIVITIES at the Nikolaus
Page 173: G. Riemekasten, Berlin Systemic scl
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Research Report - Nikolaus-Fiebiger-Zentrum für Molekulare Medizin

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