LIMB DEVELOPMENT AND REGENERATION - IRCM
LIMB DEVELOPMENT AND REGENERATION - IRCM
LIMB DEVELOPMENT AND REGENERATION - IRCM
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18:00 – 20:00 Dinner – Buffet<br />
20:00 – 21:00 KEYNOTE LECTURE<br />
SCIENTIFIC PROGRAM<br />
12 th International Conference on<br />
<strong>LIMB</strong> <strong>DEVELOPMENT</strong> <strong>AND</strong> <strong>REGENERATION</strong><br />
Le Grand Lodge – Mont-Tremblant Québec<br />
Chair: Jacques Drouin<br />
Cliff Tabin<br />
June 3-7, 2012<br />
DIMANCHE / SUNDAY, JUNE 3 JUIN<br />
The development and evolution of limb morphology<br />
21:00 Welcome Reception<br />
7:00 – 9:00 Petit déjeuner / Breakfast<br />
LUNDI / MONDAY, JUNE 4 JUIN<br />
Salon<br />
Laurentien<br />
9:00 – 12:30 SESSION 1 – Growth and patterning Salon<br />
Laurentien<br />
9:00 – 9:30<br />
9:30 – 9:50<br />
Chair: Laura Lettice<br />
Rolf Zeller<br />
Vertebrate limb organogenesis and diversification in the age of systems<br />
biology<br />
Rushikesh Sheth<br />
De-coupling the Hox-Shh-Fgf interaction reveals multiple inputs of Hox genes<br />
on pathways ensuring limb growth<br />
9:50 – 10:10 Gregg Duester<br />
Retinoic acid acts upstream of limb proximodistal patterning<br />
10:10 – 10:30 Sevan Hopyan<br />
Ectodermal cell rearrangements during early limb bud outgrowth<br />
10:30 – 11:00 Pause / Break<br />
11:00 – 11:30 Steve Vokes<br />
Transcriptional mechanisms underlying hedgehog mediated regulation<br />
11:30 – 11:50 Brian D. Harfe<br />
Regulation and function of SHH in the early vertebrate limb bud<br />
11:50 – 12:10 Yoshihiro Morishita<br />
Anisotropy of local tissue deformation induces limb bud elongation and<br />
determines limb specific morphology<br />
12:30 – 14:00 Déjeuner / Lunch<br />
Mise à jour 2012-05-24 1/4
15 :00 – 17:00 SESSION 2 – Limb initiation and identity Salon<br />
Laurentien<br />
Chair: Chi-Chung Hui<br />
15:00 – 15:20 Qiyan Mao<br />
Coordinated directional cell motility driving vertebrate limb bud initiation<br />
15:20 – 15:40 Takayuki Suzuki<br />
Expression timing of Gdf11 determines hindlimb position in vertebrates<br />
15:40 – 16:00 Satoko Nishimoto<br />
Active repression restricts Tbx5 expression to the forelimb<br />
16:00 – 16:20 Stephen Nemec<br />
Characterizing the Role of Pitx1, Tbx4 and Tbx5 Genes in Regulation of Limb<br />
Growth, Patterning and Identity<br />
16:20 – 16:40 Yasuhiko Kawakami<br />
Islet1 regulates two distinct processes specific to the development of the<br />
hindlimb bud in mice<br />
17:00 – 20:00 POSTER Session A Salon<br />
Hanley<br />
20:00 DÎNER / DINNER<br />
21:30 Drinks at Posters A Salon<br />
Hanley<br />
7:00 – 9:00 Petit déjeuner / Breakfast<br />
MARDI / TUESDAY, JUNE 5 JUIN<br />
9:00 – 12:30 SESSION 3 – Patterning Salon<br />
Laurentien<br />
Chair: Benoit Robert<br />
9:00 – 9:30 Marian Ros<br />
5’ Hox genes regulate digit patterning by controlling the wavelength of a<br />
Turing-type mechanism<br />
9:30 – 9:50 James Sharpe<br />
A computational model of digit patterning reconciles Wolpertian positional<br />
information, with Turing-type self-organisation<br />
9:50 – 10:10 Juan Jose Sanz-Ezquerro<br />
Characterization of digits in the chicken wing: molecular confirmation of<br />
changes in digit identity and extra phalanx induction by Fgf8<br />
10:10 – 10:30 David AF Loebel<br />
Correct anterior-posterior patterning of the mouse forelimb requires Twist1 in<br />
the forelimb anterior mesenchyme<br />
10:30 – 10:50 Pause / Break<br />
10:50 – 11:10 Dagmar Iber<br />
From networks to tissue engineering - Computational models of limb<br />
development<br />
11:10 – 11:30 Danyi Li<br />
Irx3 and Irx5 homeobox genes link the anteroposterior and proximodistal axes<br />
prior to hindlimb formation<br />
Mise à jour 2012-05-24 2/4
11:30 – 12:00 Elazar Zelzer<br />
Skeleton morphology is determined in a modular fashion by two distinct pools<br />
of chondro-progenitor cells<br />
12:00 – 13:30 Déjeuner / Lunch<br />
14:00 – 15:00 Mercédes Benegbi<br />
Thalidomide: 50 years later!<br />
Robert Seegmiller<br />
False positives, mice and human<br />
Trent Stephens<br />
Thalidomide binding and oxidative damage<br />
Neil Vargesson<br />
Thalidomide and angiogenesis<br />
15:15 – 16:45 SESSION 4 – Genetics, human malformations and regeneration Salon<br />
Laurentien<br />
Chair: Sevan Hopyan<br />
15:15 – 15:45 Elly M. Tanaka<br />
The reactivation of P-D position specific properties in limb blastema cells<br />
15:45 – 16:05 Étienne Vincent<br />
Studying BMPs' and Msx1’s role during axolotl epimorphic regeneration<br />
16:05 – 16:25 Licia Selleri<br />
Pre-axial polydactyly in enu-induced mouse mutation resulting from disruption<br />
of the escrtii complex<br />
16:25 – 16:45 Alison Elliott<br />
Two patients with atypical presentations of longitudinal limb deficiency –<br />
molecular implications from SNP array analysis<br />
17:00 – 20:00 POSTER Session B Salon<br />
Hanley<br />
20:00 DÎNER / DINNER<br />
21:30 Drinks at Posters B Salon<br />
Hanley<br />
7:00 – 9:00 Petit déjeuner / Breakfast<br />
MERCREDI / WEDNESDAY, JUNE 6 JUIN<br />
9:00 – 12:30 SESSION 5 – Epigenetics, the genome and development Salon<br />
Laurentien<br />
9:00 – 9:30<br />
Chair: Marie Kmita<br />
Denis Duboule<br />
Regulation of Hox genes during limb development<br />
9:30 – 9:50 Atsushi Kuroiwa<br />
Analysis of the cis-regulatory elements of Fgf10 responsible for the limb<br />
specific expression<br />
9:50 – 10:10 Nayuta Yakushiji-Kaminatsui<br />
Repression of Meis2 by Polycomb group proteins Ring1A/B is required for<br />
proximo-distal limb bud development<br />
10:10 – 10:30 Nadav Ahituv<br />
Dual function of DNA sequences: coding exons function as limb enhancers of<br />
nearby genes<br />
Mise à jour 2012-05-24 3/4
10:30 – 11:00 Pause / Break<br />
11:00 – 11:30 Miguel Torres<br />
HoxA cluster epigenetic regulation underlies cell-autonomous generation of<br />
late limb proximodistal pattern<br />
11:30 – 11:50 H. Scott Stadler<br />
HOTCHON a novel non-coding RNA that is essential for distal autopod<br />
chondrogenesis and patterning<br />
11:50 – 12:10 John Cobb<br />
Characterization of a limb enhancer downstream of the mouse Shox2 gene<br />
and the search for its human SHOX paralog<br />
12:30 – 14:00 Déjeuner / Lunch<br />
15:00 – 17:30 SESSION 6 – Comparative approaches and evolution Salon<br />
Laurentien<br />
15:00 – 15:30<br />
Chair: Gen Yamada<br />
Marie-Andrée Akimenko<br />
The actinodins, a fish-specific gene family lost during the fin-to-limb transition<br />
15:30 – 16:00 Jose Luis Gomez-Skarmeta<br />
Gene regulation during development and evolution<br />
16:00 – 16:30 Pause / Break<br />
16:30 – 16:50 Nicola Illing<br />
The importance of the 5’ Hoxd genes and Meis2 in the evolution of the bat<br />
wing<br />
16:50 – 17:10 Francisca Leal<br />
Comparative analysis of the limb-specific enhancer of the Sonic hedgehog<br />
(Shh) gene and its relation to vertebrate limb evolution<br />
17:10 – 17:30 James P. Noonan<br />
Comparative systems biology of vertebrate limb development<br />
19:00 COCKTAIL <strong>AND</strong> FAREWELL DINNER<br />
7:00 – 10:30 Petit déjeuner / Breakfast<br />
DÉPART / DEPARTURE<br />
JEUDI / THURSDAY, JUNE 7 JUIN<br />
Mise à jour 2012-05-24 4/4
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