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Analysis Method Reference range Requirement Comments<br />

Amantadine<br />

Page 8<br />

see report<br />

GC therapeutic range 300 - 600 µg/l<br />

toxic > 1000 µg/l<br />

Ambroxol HPLC therapeutic peak 55 µg/l<br />

Amikacine<br />

Amino acids<br />

Aminoantipyrine<br />

FPIA trough concentration 0.5 - 5.0 mg/l<br />

toxic 10.0 mg/l<br />

peak concentration 15.0 - 25.0 mg/l<br />

toxic 35.0 mg/l<br />

LC/MS see report<br />

see report<br />

see report<br />

detection limit 0.1 mg/kg<br />

HPLC toxic 1.6 - 2.7 mg/l<br />

drinking water 10 ml<br />

serum 2 ml<br />

serum/plasma 1 ml<br />

serum 1 ml<br />

EDTA-plasma 2 ml<br />

P: No serum, plasma only<br />

liquor 1 ml<br />

urine 10 ml<br />

P: Collect urine for 24 hrs. in 5-10 ml<br />

glacial acetic acid, send aliquot.<br />

solid material 10 g<br />

P: After homogenization and<br />

extraction<br />

serum 2 ml<br />

GC/MS urine 20 ml<br />

4-Aminoantipyrine HPLC therapeutic range 1.0 - 12.0 mg/l<br />

5-Aminosalicylic acid HPLC therapeutic range 0.1 - 1.0 mg/l<br />

4-Aminosalicylic acid<br />

HPLC see report<br />

gastric juice 20 ml<br />

serum 2 ml<br />

serum 1 ml<br />

serum 1 ml<br />

EDTA-blood 1 ml<br />

Reference range, 2 hrs. after oral<br />

administration. Biological half life: 9 hrs.<br />

Active metabolite of metamizol<br />

Biological half-life:45 mins.

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