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Analysis Method Reference range Requirement Comments<br />

Hydroxylysineuria 0.1 - 0.6 mg/dl<br />

Hydroxymethylbilan-synthase HPLC 7.3 - 15.8 nmol/sec/l<br />

Hydroxyproline, free<br />

Hydroxyproline, total<br />

1-Hydroxypyrene<br />

P: No serum, plasma only<br />

urine 10 ml<br />

liquor 1 ml<br />

heparin blood 1 ml<br />

LC/MS EDTA-plasma 2 ml<br />

photometry women < 30 mg/d<br />

men < 42 mg/d<br />

infant:<br />

up to 6 month < 1800 mg/g creatinine<br />

up to 1 year < 260 mg/g creatinine<br />

children<br />

2 - 4 years < 170 mg/g creatinine<br />

5 - 16 years < 140 mg/g creatinine<br />

HPLC non-smoker < 0.5 µg/g creatinine<br />

smoker < 1.0 µg/g creatinine<br />

Hypoxanthine HPLC 4.4 - 7.4 µmol/l<br />

Ibuprofen<br />

Imipenem<br />

HPLC therapeutic range 15.0 - 30.0 mg/l<br />

toxic > 100.0 mg/l<br />

HPLC see report<br />

P: No serum, plasma only<br />

liquor 1 ml<br />

urine 10 ml<br />

urine 10 ml<br />

urine 5 ml<br />

liquor 2 ml<br />

serum 2 ml<br />

serum/plasma 2 ml<br />

P: Keep frozen.<br />

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