Tobacco use in shisha: Studies on waterpipe smoking
Tobacco use in shisha: Studies on waterpipe smoking
Tobacco use in shisha: Studies on waterpipe smoking
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14. As an example of biomarker-based research strategies that are needed to evaluate possible genotoxic<br />
acti<strong>on</strong>s of substances <str<strong>on</strong>g>in</str<strong>on</strong>g> the <strong>waterpipe</strong> tobacco smoke, ESPRI c<strong>on</strong>ducted a study of micr<strong>on</strong>uclei <str<strong>on</strong>g>in</str<strong>on</strong>g><br />
oral mucosa cells (small DNA structures separated from the ma<str<strong>on</strong>g>in</str<strong>on</strong>g> nucleus of the basal epithelial layers<br />
and exfoliated <str<strong>on</strong>g>in</str<strong>on</strong>g>to the oral cavity). It was found that the mean micr<strong>on</strong>uclei level was significantly<br />
higher (more than twofold) am<strong>on</strong>g the <strong>waterpipe</strong> smokers compared to never smokers. Validati<strong>on</strong> and<br />
standardizati<strong>on</strong> of such tests will permit the quantificati<strong>on</strong> of <strong>waterpipe</strong> tobacco–related exposure<br />
levels and early biological effects.<br />
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