Ortho-TOLUIDINE ICSC: 0341 - chemical safety section

ortho-TOLUIDINE ICSC: 0341
Date of Peer Review: March 1995
1-Amino-2-methylbenzene
2-Aminotoluene
o-Methylaniline
CAS # 95-53-4 C7H9N / C6H4CH3NH2
RTECS # XU2975000 Molecular mass: 107.2
UN # 1708
EC Annex 1 Index # 612-091-00-X
EC/EINECS # 202-429-0
TYPES OF HAZARD /
EXPOSURE
FIRE
EXPLOSION
EXPOSURE
ACUTE HAZARDS /
SYMPTOMS
Combustible. Gives off irritating
or toxic fumes (or gases) in a fire.
Above 85°C explosive vapour/air
mixtures may be formed.
Inhalation Blue lips or finger nails. Blue skin.
Confusion. Dizziness. Headache.
Shortness of breath. Weakness.
Skin MAY BE ABSORBED! Redness.
Blue lips or fingernails. Blue skin.
(Further see Inhalation).
PREVENTION
NO open flames. NO contact with
nitric acid.
Above 85°C use a closed system,
ventilation.
FIRST AID / FIRE
FIGHTING
Powder. Foam. Carbon dioxide.
In case of fire: keep drums, etc.,
cool by spraying with water.
AVOID ALL CONTACT! IN ALL CASES CONSULT A
DOCTOR!
Ventilation, local exhaust, or
breathing protection.
Protective gloves. Protective
clothing.
Fresh air, rest. Artificial
respiration may be needed. Refer
for medical attention.
Remove contaminated clothes.
Rinse and then wash skin with
water and soap. Refer for medical
attention.
Eyes Redness. Pain. Safety goggles. First rinse with plenty of water for
several minutes (remove contact
lenses if easily possible), then
take to a doctor.
Ingestion Blue lips or fingernails. Blue skin.
Dizziness. Headache. Laboured
breathing. (Further see
Inhalation).
Do not eat, drink, or smoke
during work.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Collect leaking and spilled liquid in sealable containers as far as
possible. Absorb remaining liquid in sand or inert absorbent and
remove to safe place. Personal protection: complete protective
clothing including self-contained breathing apparatus.
EMERGENCY RESPONSE STORAGE
Transport Emergency Card: TEC (R)-61GT1-II
NFPA Code: H3; F2; R0
IPCS
International
Programme on
Chemical Safety
Do not transport with food and feedstuffs. Note: E
EU Classification
Symbol: T, N
R: 45-23/25-36-50
S: 53-45-61
UN Classification
UN Hazard Class: 6.1
UN Pack Group: II
Rinse mouth. Induce vomiting
(ONLY IN CONSCIOUS
PERSONS!). Refer for medical
attention.
Separated from strong oxidants, strong acids, food and feedstuffs.
Cool. Dry. Well closed. Ventilation along the floor.
Prepared in the context of cooperation between the International
Programme on Chemical Safety and the Commission of the
European Communities © IPCS, CEC 2005
SEE IMPORTANT INFORMATION ON BACK

ortho-TOLUIDINE ICSC: 0341
PHYSICAL STATE; APPEARANCE:
COLOURLESS TO YELLOW LIQUID, TURNS REDDISH-BROWN
ON EXPOSURE TO AIR AND LIGHT.
CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic
fumes including nitrogen oxides. Reacts with strong oxidants,
especially nitric acid.
OCCUPATIONAL EXPOSURE LIMITS:
TLV: 2 ppm as TWA; (skin); A3 (confirmed animal carcinogen with
unknown relevance to humans); BEI issued; (ACGIH 2004).
MAK: skin absorption (H); Carcinogen category: 1; Germ cell mutagen
group: 3A (DFG 2006).
Boiling point: 200°C
Melting point: -16°C
Relative density (water = 1): 1.01
Solubility in water: poor
Vapour pressure, kPa at 20°C: 0.2
Relative vapour density (air = 1): 3.7
The substance is harmful to aquatic organisms.
IMPORTANT DATA
PHYSICAL PROPERTIES
ENVIRONMENTAL DATA
NOTES
ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and
through the skin and by ingestion.
INHALATION RISK:
Evaporation at 20°C is negligible; a harmful concentration of airborne
particles can, however, be reached quickly on spraying.
EFFECTS OF SHORT-TERM EXPOSURE:
The substance irritates the eyes and the skin. The substance may
cause effects on the blood, bladder and kidneys , resulting in tissue
lesions, impaired functions and formation of methaemoglobin.
Exposure to high concentrations may result in damage to kidneys and
bladder. The effects may be delayed. Medical observation is
indicated. See Notes.
EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The substance may have effects on the blood , resulting in formation
of methaemoglobin (see Notes). This substance is possibly
carcinogenic to humans.
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 85°C c.c.
Auto-ignition temperature: 482°C
Explosive limits, vol% in air: 1.5-?
Octanol/water partition coefficient as log Pow: 1.32
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with
this substance; the appropriate means with instructions must be available. The odour warning when the exposure limit value is exceeded is
insufficient. Also consult ICSC # 0342, meta-Toluidine and 0343, para-Toluidine. Card has been partly updated in October 2005. See sections
Occupational Exposure Limits, EU classification, Emergency Response. Card has been partly updated in October 2006. See sections
Occupational Exposure Limits.Card has been partially updated in January 2008: see Fire fighting.
ADDITIONAL INFORMATION
LEGAL NOTICE Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use
which might be made of this information
See Also:
Toxicological Abbreviations
© IPCS, CEC 2005