Overview of Gastric Pathology: Non-Neoplastic Diseases

Eosinophilic Gastritis
• Eosinophilic gastritis is typically part of eosinophilic gastroenteritis, which
may take one of three forms:
– Mucosal (bleeding, protein loss, malabsorption)
– Mural (mass lesion)
– Serosal (ascites)
• The mucosal form of allergic gastroenteritis accounts for the majority of
cases, is typically “allergic” in nature, and commonly involves the gastric
antrum
• To establish a diagnosis of eosinophils/allergic gastroenteritis, eosinophils
must be the predominant cell type, and other possible conditions must be
excluded:
– IBD
– Reflux (esophagitis)
– Parasitic infections
– Vasculitis
– Drug reaction
– Chronic granulomatous disease
– . . .