Drug Disposition Overview - Pharmacology and at UCSD
Drug Disposition Overview - Pharmacology and at UCSD
Drug Disposition Overview - Pharmacology and at UCSD
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BIOM/PHAR 255 Winter 2013 Halpert - Jan. 17, 2013<br />
Clinically significant drug interactions due to<br />
inhibition of Phase II enzymes are rel<strong>at</strong>ively rare<br />
because:<br />
• N-acetyl<strong>at</strong>ion <strong>and</strong> sulf<strong>at</strong>ion represent the primary<br />
clearance mechanism for few drugs.<br />
• UGTs are the primary clearance mechanism for<br />
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