Drug Disposition Overview - Pharmacology and at UCSD
Drug Disposition Overview - Pharmacology and at UCSD
Drug Disposition Overview - Pharmacology and at UCSD
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BIOM/PHAR 255 Winter 2013 Halpert - Jan. 17, 2013<br />
Cytochrome P450 2B6<br />
Substr<strong>at</strong>es Inhibitor<br />
(S)-Mephenytoin<br />
Buproprion<br />
Non-planar (often V-shaped), lipophilic molecules<br />
Cytochrome P450 2C9<br />
Ticlopidine (MBI)<br />
Substr<strong>at</strong>es Inhibitors<br />
Tolbutamide<br />
Diclofenac<br />
Weakly acidic compounds<br />
Tienilic acid (MBI)<br />
Sulfaphenazole<br />
8 of 22<br />
Cytochrome P450 2C8<br />
Large organic anions<br />
Substr<strong>at</strong>e Inhibitor<br />
Taxol (paclitaxel) Trimethoprim<br />
Cytochrome P450 2C19<br />
Neutral or basic compounds<br />
Substr<strong>at</strong>e Inhibitor<br />
(S)-Mephenytoin<br />
(+)-N-3-Benzyl-nirvanol
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