JOURNAL OF IMMUNOLOGY VOL. 170 NO. 3 FEBRUARY 2003

JOURNAL OF IMMUNOLOGY
VOL. 170 NO. 3 FEBRUARY 2003
IN THIS ISSUE 1129
CUTTING EDGE
Cutting Edge: IFN Consensus Sequence Binding Protein/IFN
1131-1135
Regulatory Factor 8 Drives the Development of Type I IFN-Producing
Plasmacytoid Dendritic Cells
Hideki Tsujimura, Tomohiko Tamura, and Keiko Ozato*
Cutting Edge: Profile of Chemokine Receptor Expression on Human
Plasma Cells Accounts for Their Efficient Recruitment to Target
Tissues
Takashi Nakayama, Kunio Hieshima, Dai Izawa, Youichi Tatsumi,
Akihisa Kanamaru, and Osamu Yoshie
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
Transgenic Expression of RasGRP1 Induces the Maturation of Double-
Negative Thymocytes and Enhances the Production of CD8 Single-
Positive Thymocytes
Anne M. Norment, Lisa Y. Bogatzki, Mark Klinger, Ethan W. Ojala,
Michael J. Bevan, and Robert J. Kay
Deregulated MHC Class II Transactivator Expression Leads to a
Strong Th2 Bias in CD4 + T Lymphocytes
Luc A. Otten, Fabienne Tacchini-Cottier, Michael Lohoff, Francesco
Annunziato, Lorenzo Cosmi, Leonardo Scarpellino, Jacques Louis,
Viktor Steimle, Walter Reith, and Hans Acha-Orbea
Comparative Effects of Human Igα and Igβ in Inducing Autoreactive
Antibodies Against B Cells in Mice
Jim J. C. Sheu, Tammy Cheng, Huan Y. Chen, Carmay Lim, and Tse-
Wen Chang
Sustained Depolarization and ADP-Ribose Activate a Common Ionic
Current in Rat Peritoneal Macrophages
Brice Campo, Annmarie Surprenant, and R. Alan North
IFN-αβ Released by Mycobacterium tuberculosis-Infected Human
Dendritic Cells Induces the Expression of CXCL10: Selective
Recruitment of NK and Activated T Cells
Roberto Lande, Elena Giacomini, Tiziana Grassi, Maria Elena Remoli,
Elisabetta Iona, Minja Miettinen, Ilkka Julkunen, and Eliana M. Coccia
Tumor Eradication by Hepatitis B Virus X Antigen-Specific CD8 + T
Cells in Xenografted Nude Mice
Eunyoung Chun, Jihyun Lee, Hong Seok Cheong, and Ki-Young Lee
Cross-Presentation of HLA Class I Epitopes from Exogenous NY-
ESO-1 Polypeptides by Nonprofessional APCs
Sacha Gnjatic, Djordje Atanackovic, Mitsutoshi Matsuo, Elke Jäger,
Sang Yull Lee, Danila Valmori, Yao-Tseng Chen, Gerd Ritter,
Alexander Knuth, and Lloyd J. Old
1136-1140
1141-1149
1150-1157
1158-1166
1167-1173
1174-1182
1183-1190
1191-1196
The Contribution of NKT Cells, NK Cells, and Other -Chain-
1197-1201
Dependent Non-T Non-B Cells to IL-12-Mediated Rejection of
Tumors
Se-Ho Park, Tim Kyin, Albert Bendelac, and Claude Carnaud
Broadening of Epitope Recognition During Immune Rejection of 1202-1208

ErbB-2-Positive Tumor Prevents Growth of ErbB-2-Negative Tumor
Shari A. Pilon, Carmen Kelly, and Wei-Zen Wei
Transfer of TCR Genes into Mature T Cells Is Accompanied by the
Maintenance of Parental T Cell Avidity
Mark P. Rubinstein, Andre N. Kadima, Mohamed L. Salem,
Christophe L. Nguyen, William E. Gillanders, Michael I. Nishimura,
and David J. Cole
Differential Antigen Sensitivity and Costimulatory Requirements in
Human Th1 and Th2 Antigen-Specific CD4 + Cells with Similar TCR
Avidity
Ursula Holzer, William W. Kwok, Gerald T. Nepom, and Jane Hoyt
Buckner
TCR Reserve: A Novel Principle of CD4 T Cell Activation by Weak
Ligands
Lisa K. McNeil and Brian D. Evavold
Preferential Escape of Subdominant CD8 + T Cells During Negative
Selection Results in an Altered Antiviral T Cell Hierarchy
Mark K. Slifka, Joseph N. Blattman, David J. D. Sourdive, Fei Liu,
Donald L. Huffman, Tom Wolfe, Anna Hughes, Michael B. A.
Oldstone, Rafi Ahmed, and Matthias G. von Herrath
Role for IL-10 in Suppression Mediated by Peptide-Induced
Regulatory T Cells In Vivo
Anette Sundstedt, Emma J. O’Neill, Kirsty S. Nicolson, and David C.
Wraith
Critical Role of MHC Class I-Related Chain A and B Expression on
IFN-α-Stimulated Dendritic Cells in NK Cell Activation: Impairment
in Chronic Hepatitis C Virus Infection
Masahisa Jinushi, Tetsuo Takehara, Tatsuya Kanto, Tomohide
Tatsumi, Veronika Groh, Thomas Spies, Takuya Miyagi, Takahiro
Suzuki, Yutaka Sasaki, and Norio Hayashi
Blockade of Programmed Death-1 Ligands on Dendritic Cells
Enhances T Cell Activation and Cytokine Production
Julia A. Brown, David M. Dorfman, Feng-Rong Ma, Elizabeth L.
Sullivan, Oliver Munoz, Clive R. Wood, Edward A. Greenfield, and
Gordon J. Freeman
Enhanced Differentiation of Splenic Plasma Cells but Diminished
Long-Lived High-Affinity Bone Marrow Plasma Cells in Aged Mice
Shuhua Han, Kaiyong Yang, Zeynep Ozen, Weiyi Peng, Ekaterina
Marinova, Garnett Kelsoe, and Biao Zheng
In Vivo Blockade of Macrophage Migration Inhibitory Factor
Ameliorates Acute Experimental Autoimmune Encephalomyelitis by
Impairing the Homing of Encephalitogenic T Cells to the Central
Nervous System
Claudia M. Denkinger, Michael Denkinger, Jens J. Kort, Christine
Metz, and Thomas G. Forsthuber
Ly6C Induces Clustering of LFA-1 (CD11a/CD18) and Is Involved in
Subtype-Specific Adhesion of CD8 T Cells
Ilkka Jaakkola, Marika Merinen, Sirpa Jalkanen, and Arno Hänninen
Induction of Antigen-Specific CTL by Recombinant HIV Trans-
Activating Fusion Protein-Pulsed Human Monocyte-Derived Dendritic
1209-1217
1218-1223
1224-1230
1231-1239
1240-1248
1249-1256
1257-1266
1267-1273
1274-1282
1283-1290
1291-1298

Cells
Yoshiyuki Tanaka, Steven F. Dowdy, David C. Linehan, Timothy J.
Eberlein, and Peter S. Goedegebuure
Entry into the Thymic Microenvironment Triggers Notch Activation in
the Earliest Migrant T Cell Progenitors
Benjamin C. Harman, Eric J. Jenkinson, and Graham Anderson
Inhibitory Feedback Loop Between Tolerogenic Dendritic Cells and
Regulatory T Cells in Transplant Tolerance
Wei-Ping Min, Dejun Zhou, Thomas E. Ichim, Gill H. Strejan,
Xiaoping Xia, Jinming Yang, Xuyan Huang, Bertha Garcia, David
White, Patrick Dutartre, Anthony M. Jevnikar, and Robert Zhong
TGF-β Regulates Airway Responses Via T Cells
Christoph Schramm, Udo Herz, Jürgen Podlech, Martina Protschka,
Susetta Finotto, Matthias J. Reddehase, Heinz Köhler, Peter R. Galle,
Ansgar W. Lohse, and Manfred Blessing
TNF-α Plus IFN-γ Induce Connexin43 Expression and Formation of
Gap Junctions Between Human Monocytes/Macrophages That
Enhance Physiological Responses
Eliseo A. Eugenín, María C. Brañes, Joan W. Berman, and Juan C.
Sáez
MHC Class II-Peptide Complexes and APC Lipid Rafts Accumulate at
the Immunological Synapse
Elizabeth M. Hiltbold, Neil J. Poloso, and Paul A. Roche
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Rules for Gene Usage Inferred from a Comparison of Large-Scale
Gene Expression Profiles of T and B Lymphocyte Development
Reinhard Hoffmann, Ludovica Bruno, Thomas Seidl, Antonius Rolink,
and Fritz Melchers
Block in Development at the Pre-B-II to Immature B Cell Stage in
Mice Without Igκ and Igλ Light Chain
Xiangang Zou, Tony A. Piper, Jennifer A. Smith, Nicholas D. Allen,
Jian Xian, and Marianne Brüggemann
Mimicry of Native Peptide Antigens by the Corresponding Retro-
Inverso Analogs Is Dependent on Their Intrinsic Structure and
Interaction Propensities
Deepak T. Nair, Kanwal J. Kaur, Kavita Singh, Paushali Mukherjee,
Deepa Rajagopal, Anna George, Vineeta Bal, Satyajit Rath, Kanury V.
S. Rao, and Dinakar M. Salunke
Natural Substrates and Inhibitors of Mannan-Binding Lectin-
Associated Serine Protease-1 and -2: A Study on Recombinant
Catalytic Fragments
Géza Ambrus, Péter Gál, Mayumi Kojima, Katalin Szilágyi, Júlia
Balczer, József Antal, László Gráf, Andreas Laich, Beryl E. Moffatt,
Wilhelm Schwaeble, Robert B. Sim, and Péter Závodszky
Suppressor of Cytokine Signaling 1 Inhibits IL-10-Mediated Immune
Responses
Yaozhong Ding, Dongmei Chen, Adel Tarcsafalvi, Ruthie Su, Lihui
Qin, and Jonathan S. Bromberg
1299-1303
1304-1312
1313-1319
1320-1328
1329-1338
1339-1353
1354-1361
1362-1373
1374-1382
1383-1391
HOST DEFENSE
The Shift of Th1 to Th2 Immunodominance Associated with the 1392-1398

Chronicity of Mycobacterium bovis Bacille Calmette-Guérin Infection
Does Not Affect the Memory Response
Xinan Jiao, Richard Lo-Man, Nathalie Winter, Edith Dériaud, Brigitte
Gicquel, and Claude Leclerc
Lipopolysaccharide (LPS)-Binding Protein Mediates LPS
Detoxification by Chylomicrons
Anita C. E. Vreugdenhil, Corine H. Rousseau, Thomas Hartung, Jan
Willem M. Greve, Cornelis van ‘t Veer, and Wim A. Buurman
Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-
Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-
Microbial Interactions in the Gut
Gil Melmed, Lisa S. Thomas, Nahee Lee, Samuel Y. Tesfay, Katie
Lukasek, Kathrin S. Michelsen, Yuehua Zhou, Bing Hu, Moshe Arditi,
and Maria T. Abreu
A Simian Replication-Defective Adenoviral Recombinant Vaccine to
HIV-1 Gag
Julie C. Fitzgerald, Guang-Ping Gao, Arturo Reyes-Sandoval, George
N. Pavlakis, Zhi Q. Xiang, Anthony P. Wlazlo, Wynetta Giles-Davis,
James M. Wilson, and Hildegund C. J. Ertl
Nonspecific Recruitment of Memory CD8 + T Cells to the Lung
Airways During Respiratory Virus Infections
Kenneth H. Ely, Linda S. Cauley, Alan D. Roberts, Jean W. Brennan,
Tres Cookenham, and David L. Woodland
Impaired Clearance of Herpes Simplex Virus Type 1 From Mice
Lacking CD1d or NKT Cells Expressing the Semivariant Vα14-Jα281
TCR
Branka Grubor-Bauk, Anthony Simmons, Graham Mayrhofer, and
Peter G. Speck
A Soluble Chemokine-Binding Protein from Vaccinia Virus Reduces
Virus Virulence and the Inflammatory Response to Infection
Patrick C. Reading, Julian A. Symons, and Geoffrey L. Smith
A Specific Role for B Cells in the Generation of CD8 T Cell Memory
by Recombinant Listeria monocytogenes
Hao Shen, Jason K. Whitmire, Xin Fan, Devon J. Shedlock, Susan M.
Kaech, and Rafi Ahmed
CCL28 Has Dual Roles in Mucosal Immunity as a Chemokine with
Broad-Spectrum Antimicrobial Activity
Kunio Hieshima, Haruo Ohtani, Michiko Shibano, Dai Izawa, Takashi
Nakayama, Yuri Kawasaki, Fumio Shiba, Mitsuru Shiota, Fuminori
Katou, Takuya Saito, and Osamu Yoshie
Differential Expression of the Murine Mannose-Binding Lectins A and
C in Lymphoid and Nonlymphoid Organs and Tissues
Swen Wagner, Nicholas J. Lynch, Wolfgang Walter, Wilhelm J.
Schwaeble, and Michael Loos
1399-1405
1406-1415
1416-1422
1423-1429
1430-1434
1435-1442
1443-1451
1452-1461
1462-1465
INFLAMMATION
The Long Pentraxin Ptx3 Is Synthesized in IgA Glomerulonephritis 1466-1472
and Activates Mesangial Cells
Benedetta Bussolati, Giuseppe Peri, Gennaro Salvidio, Daniela
Verzola, Alberto Mantovani, and Giovanni Camussi
MHC Class II-Associated Invariant Chain Isoforms Regulate 1473-1480

Pulmonary Immune Responses
Qiang Ye, Patricia W. Finn, Ruth Sweeney, Elizabeth K. Bikoff, and
Richard J. Riese
CLINICAL IMMUNOLOGY
Cytochrome P4502D6 193–212: A New Immunodominant Epitope and
Target of Virus/Self Cross-Reactivity in Liver Kidney Microsomal
Autoantibody Type 1-Positive Liver Disease
Nanda Kerkar, Kaushik Choudhuri, Yun Ma, Ayman Mahmoud,
Dimitrios P. Bogdanos, Luigi Muratori, Francesco Bianchi, Roger
Williams, Giorgina Mieli-Vergani, and Diego Vergani
CD4 + Th2 Cell Recognition of HLA-DR-Restricted Epitopes Derived
from CAMEL: A Tumor Antigen Translated in an Alternative Open
Reading Frame
Elisabeth H. Slager, Martina Borghi, Carolien E. van der Minne,
Corlien A. Aarnoudse, Menzo J. E. Havenga, Peter I. Schrier, Susanne
Osanto, and Marieke Griffioen
Induction of Antigen-Specific CTL Responses Using Antigens
Conjugated to Short Peptide Vectors
Fiona H. Day, Yu Zhang, Philippe Clair, Kenneth H. Grabstein,
Martine Mazel, Anthony R. Rees, Michel Kaczorek, and Jamal
Temsamani
Bordetella pertussis Infection in 2-Month-Old Infants Promotes Type 1
T Cell Responses
Françoise Mascart, Virginie Verscheure, Anne Malfroot, Marc
Hainaut, Denis Piérard, Stéphane Temerman, Alexandra Peltier, Anne-
Sophie Debrie, Jack Levy, Giuseppe Del Giudice, and Camille Locht
CD28/B7 Regulation of Anti-CD3-Mediated Immunosuppression In
Vivo
Qizhi Tang, Judy A. Smith, Greg L. Szot, Ping Zhou, Maria-Luisa
Alegre, Kammi J. Henriksen, Craig B. Thompson, and Jeffrey A.
Bluestone
Lack of a Functional Alternative Complement Pathway Ameliorates
Ischemic Acute Renal Failure in Mice
Joshua M. Thurman, Danica Ljubanovic, Charles L. Edelstein, Gary S.
Gilkeson, and V. Michael Holers
A Novel Anti-Inflammatory Role for Simvastatin in Inflammatory
Arthritis
Bernard P. Leung, Naveed Sattar, Anne Crilly, Morag Prach, David W.
McCarey, Helen Payne, Rajan Madhok, Carol Campbell, J. Alastair
Gracie, Foo Y. Liew, and Iain B. McInnes
The In Vitro and In Vivo Effects of Anti-Galactose Antibodies on
Endothelial Cell Activation and Xenograft Rejection
Hui Xu, Dengping Yin, Bashoo Naziruddin, Libing Chen, Aileen
Stark, Yuanyuan Wei, Ying Lei, JiKun Shen, John S. Logan, Guerard
W. Byrne, and Anita S.-F. Chong
1481-1489
1490-1497
1498-1503
1504-1509
1510-1516
1517-1523
1524-1530
1531-1539
Increased Bone Mass Is a Part of the Generalized Lymphoproliferative 1540-1547
Disorder Phenotype in the Mouse
Vedran Katavic, Ivan Kresimir Lukic, Natasa Kovacic, Danka Grcevic,
Joseph A. Lorenzo, and Ana Marusic
Oral Feeding with Ethinyl Estradiol Suppresses and Treats 1548-1555

Experimental Autoimmune Encephalomyelitis in SJL Mice and
Inhibits the Recruitment of Inflammatory Cells into the Central
Nervous System
Sandhya Subramanian, Agata Matejuk, Alex Zamora, Arthur A.
Vandenbark, and Halina Offner
Peptide Nucleic Acid Antisense Prolongs Skin Allograft Survival by
Means of Blockade of CXCR3 Expression Directing T Cells into Graft
Ming Jiankuo, Wang Xingbing, Huang Baojun, Wu Xiongwin, Li
Zhuoya, Xiong Ping, Xu Yong, Liu Anting, Hu Chunsong, Gong Feili,
and Tan Jinquan
Induction of Apoptosis by HIV-1-Infected Monocytic Cells
Kirk Sperber, Prarthana Beuria, Netai Singha, Irwin Gelman, Patricia
Cortes, Houchu Chen, and Thomas Kraus
Normal Tissue Depresses While Tumor Tissue Enhances Human T
Cell Responses In Vivo to a Novel Self/Tumor Melanoma Antigen,
OA1
Christopher E. Touloukian, Wolfgang W. Leitner, Rhonda E. Schnur,
Paul F. Robbins, Yong Li, Scott Southwood, Alessandro Sette, Steven
A. Rosenberg, and Nicholas P. Restifo
Transcutaneous Immunization with Cholera Toxin B Subunit Adjuvant
Suppresses IgE Antibody Responses Via Selective Induction of Th1
Immune Responses
Fabienne Anjuère, Annie George-Chandy, Florence Audant, Déborah
Rousseau, Jan Holmgren, and Cecil Czerkinsky
LETTER OF RETRACTION
SF20/IL-25, a Novel Bone Marrow Stroma-Derived Growth Factor
That Binds to Mouse Thymic Shared Antigen-1 and Supports
Lymphoid Cell Proliferation
Edgardo E. Tulin, Nobuhisa Onoda, Yasuhiko Nakata, Masatsugu
Maeda, Masakazu Hasegawa, Hitoshi Nomura, and Toshio Kitamura
VOL. 170 NO. 6 MARCH; 2003
EDITORIALS
Benefit Versus Risk
Robert R. Rich
1556-1565
1566-1578
1579-1585
1586-1592
1593
2793
IN THIS ISSUE 2795-2796
CUTTING EDGE
Cutting Edge: Impairment of Dendritic Cells and Adaptive Immunity
by Ebola and Lassa Viruses
Siddhartha Mahanty, Karen Hutchinson, Sudhanshu Agarwal, Michael
Mcrae, Pierre E. Rollin, and Bali Pulendran
Cutting Edge: Toll-Like Receptor 9 Expression Is Not Required for
CpG DNA-Aided Cross-Presentation of DNA-Conjugated Antigens
but Essential for Cross-Priming of CD8 T Cells
Antje Heit, Tobias Maurer, Hubertus Hochrein, Stefan Bauer,
Katharina M. Huster, Dirk H. Busch, and Hermann Wagner
2797-2801
2802-2805
Cutting Edge: CD40 Engagement Eliminates the Need for Bruton’s 2806-2810
Tyrosine Kinase in B Cell Receptor Signaling for NF-κB
Takuya Mizuno and Thomas L. Rothstein
Cutting Edge: Mycobacterium tuberculosis Blocks Ca 2+ Signaling and 2811-2815

Phagosome Maturation in Human Macrophages Via Specific Inhibition
of Sphingosine Kinase
Zulfiqar A. Malik, Christopher R. Thompson, Samad Hashimi,
Brandon Porter, Shankar S. Iyer, and David J. Kusner
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
Endogenous Dendritic Cells Are Required for Amplification of T Cell
Responses Induced by Dendritic Cell Vaccines In Vivo
Petra Kleindienst and Thomas Brocker
Unresponsiveness to Lymphoid-Mediated Signals at the Neonatal
Follicular Dendritic Cell Precursor Level Contributes to Delayed
Germinal Center Induction and Limitations of Neonatal Antibody
Responses to T-Dependent Antigens
Maria Pihlgren, Chantal Tougne, Paola Bozzotti, Alma Fulurija,
Michel A. Duchosal, Paul-Henri Lambert, and Claire-Anne Siegrist
IL-1 Receptor-Associated Kinase 1 Regulates Susceptibility to Organ-
Specific Autoimmunity
Caishu Deng, Caius Radu, Asim Diab, May F. Tsen, Rehana Hussain,
John S. Cowdery, Michael K. Racke, and James A. Thomas
Conditional Expression of Murine Flt3 Ligand Leads to Expansion of
Multiple Dendritic Cell Subsets in Peripheral Blood and Tissues of
Transgenic Mice
Denise J. Manfra, Shu-Cheng Chen, Kristian K. Jensen, Jay S. Fine,
Maria T. Wiekowski, and Sergio A. Lira
Low Activation Threshold As a Mechanism for Ligand-Independent
Signaling in Pre-T Cells
Mariëlle C. Haks, Stanley M. Belkowski, Maria Ciofani, Michele
Rhodes, Juliette M. Lefebvre, Sebastién Trop, Patrice Hugo, Juan
Carlos Zúñiga-Pflücker, and David L. Wiest
The Size of the Synaptic Cleft and Distinct Distributions of
Filamentous Actin, Ezrin, CD43, and CD45 at Activating and
Inhibitory Human NK Cell Immune Synapses
Fiona E. McCann, Bruno Vanherberghen, Konstantina Eleme, Leo M.
Carlin, Ray J. Newsam, David Goulding, and Daniel M. Davis
Forced Expression of the Fc Receptor γ-Chain Renders Human T Cells
Hyperresponsive to TCR/CD3 Stimulation
Madhusoodana P. Nambiar, Carolyn U. Fisher, Anil Kumar, Christos
G. Tsokos, Vishal G. Warke, and George C. Tsokos
T Cell Activation In Vivo Targets Diacylglycerol Kinase to the
Membrane: A Novel Mechanism for Ras Attenuation
Miguel A. Sanjuán, Bérengère Pradet-Balade, David R. Jones, Carlos
Martínez-A, James C. Stone, Jose A. Garcia-Sanz, and Isabel Mérida
Detection of Suppressor T Lymphocytes and Estimation of Their
Frequency in Limiting Dilution Assays by Generalized Linear
Regression Modeling
Thierry Bonnefoix, Philippe Bonnefoix, Jian-Qing Mi, Jean-Jacques
Lawrence, Jean-Jacques Sotto, and Dominique Leroux
Vav-1 and the IKK Subunit of IκB Kinase Functionally Associate to
Induce NF-κB Activation in Response to CD28 Engagement
Enza Piccolella, Francesca Spadaro, Carlo Ramoni, Barbara Marinari,
Antonio Costanzo, Massimo Levrero, Lesley Thomson, Robert T.
2817-2823
2824-2832
2833-2842
2843-2852
2853-2861
2862-2870
2871-2876
2877-2883
2884-2894
2895-2903

Abraham, and Loretta Tuosto
Role of the Cytoplasmic Tails of CXCR1 and CXCR2 in Mediating
Leukocyte Migration, Activation, and Regulation
Ricardo M. Richardson, Robin J. Marjoram, Larry S. Barak, and Ralph
Snyderman
Provision of 4-1BB Ligand Enhances Effector and Memory CTL
Responses Generated by Immunization with Dendritic Cells
Expressing a Human Tumor-Associated Antigen
Carsten Wiethe, Kurt Dittmar, Tracy Doan, Werner Lindenmaier, and
Robert Tindle
Acute Alcohol Inhibits TNF-α Processing in Human Monocytes by
Inhibiting TNF/TNF- α -Converting Enzyme Interactions in the Cell
Membrane
Xue-Jun Zhao, Luis Marrero, Kejing Song, Peter Oliver, So Yeon
Chin, Harriet Simon, Jill R. Schurr, Zili Zhang, Deepu Thoppil, Sharon
Lee, Steve Nelson, and Jay K. Kolls
Glucocorticoids Alter the Lipid and Protein Composition of Membrane
Rafts of a Murine T Cell Hybridoma
François Van Laethem, Xiquan Liang, Fabienne Andris, Jacques
Urbain, Michel Vandenbranden, Jean-Marie Ruysschaert, Marilyn D.
Resh, Thomas M. Stulnig, and Oberdan Leo
A Pool of Central Memory-Like CD4 T Cells Contains Effector
Memory Precursors
J. Magarian Blander, Derek B. Sant’Angelo, Daniela Metz, Sang-Won
Kim, Richard A. Flavell, Kim Bottomly, and Charles A. Janeway, Jr.
The Role of the CD134-CD134 Ligand Costimulatory Pathway in
Alloimmune Responses In Vivo
Xueli Yuan, Alan D. Salama, Victor Dong, Isabela Schmitt, Nader
Najafian, Anil Chandraker, Hisaya Akiba, Hideo Yagita, and
Mohamed H. Sayegh
Protein Kinase A Regulates GATA-3-Dependent Activation of IL-5
Gene Expression in Th2 Cells
Stefan Klein-Hessling, Mithilesh Kumar Jha, Brigitte Santner-Nanan,
Friederike Berberich-Siebelt, Thomas Baumruker, Anneliese Schimpl,
and Edgar Serfling
Secretion of IL-2 and IFN-γ, But Not IL-4, by Antigen-Specific T
Cells Requires Extracellular ATP
Heather P. Langston, Yong Ke, Andrew T. Gewirtz, Kenneth E.
Dombrowski, and Judith A. Kapp
The Cyclic Adenosine 5'-Monophosphate Response Element
Modulator Suppresses IL-2 Production in Stimulated T Cells by a
Chromatin-Dependent Mechanism
Klaus Tenbrock, Yuang-Taung Juang, Mate Tolnay, and George C.
Tsokos
2904-2911
2912-2922
2923-2931
2932-2939
2940-2948
2949-2955
2956-2961
2962-2970
2971-2976
Quantifying Recruitment of Cytosolic Peptides for HLA Class I
2977-2984
Presentation: Impact of TAP Transport
Doriana Fruci, Grégoire Lauvau, Loredana Saveanu, Massimo
Amicosante, Richard H. Butler, Axel Polack, Florent Ginhoux,
François Lemonnier, Hüseyin Firat, and Peter M. van Endert
Regulatory T Cells Control Autoimmunity In Vivo by Inducing 2985-2992

Apoptotic Depletion of Activated Pathogenic Lymphocytes
Loui Thomas Madakamutil, Igor Maricic, Eli Sercarz, and Vipin
Kumar
Cu/Zn Superoxide Dismutase Plays Important Role in Immune
Response
Moshe Marikovsky, Vered Ziv, Nava Nevo, Catherine Harris-Cerruti,
and Ori Mahler
CD28 Signal Enhances Apoptosis of CD8 T Cells After Strong TCR
Ligation
Xue-Zhong Yu, Paul J. Martin, and Claudio Anasetti
A Threshold for Central T Cell Tolerance to an Inducible Serum
Protein
Dipica Haribhai, Deborah Engle, Michelle Meyer, David Donermeyer,
J. Michael White, and Calvin B. Williams
Blockade of CD40-Mediated Signaling Is Sufficient for Inducing Islet
But Not Skin Transplantation Tolerance
Nancy E. Phillips, Thomas G. Markees, John P. Mordes, Dale L.
Greiner, and Aldo A. Rossini
Activation of Alloreactive CD8 + T Cells Operates Via CD4-Dependent
and CD4-Independent Mechanisms and Is CD154 Blockade Sensitive
Yuan Zhai, Lingzhong Meng, Ronald W. Busuttil, Mohamed H.
Sayegh, and Jerzy W. Kupiec-Weglinski
Ca2 + Stores and Ca2 + Entry Differentially Contribute to the Release of
IL-1β and IL-1α from Murine Macrophages
David Brough, Rosalind A. Le Feuvre, Rachel D. Wheeler, Natasha
Solovyova, Sabine Hilfiker, Nancy J. Rothwell, and Alex Verkhratsky
Mast Cell-Derived Exosomes Induce Phenotypic and Functional
Maturation of Dendritic Cells and Elicit Specific Immune Responses
In Vivo
Dimitris Skokos, Hany Goubran Botros, Christian Demeure, Joelle
Morin, Roger Peronet, Gerd Birkenmeier, Sarah Boudaly, and
Salaheddine Mécheri
Elimination of Leukemia in the Absence of Lethal Graft-Versus-Host
Disease After Allogenic Bone Marrow Transplantation
William R. Drobyski, Maria Gendelman, Sanja Vodanovic-Jankovic,
and Jack Gorski
IgE-Mediated Activation of NK Cells Through FcγRIII
Noriko Arase, Hisashi Arase, Satoshi Hirano, Tadashi Yokosuka,
Daiju Sakurai, and Takashi Saito
The Roles of Toll-Like Receptor 9, MyD88, and DNA-Dependent
Protein Kinase Catalytic Subunit in the Effects of Two Distinct CpG
DNAs on Dendritic Cell Subsets
Hiroaki Hemmi, Tsuneyasu Kaisho, Kiyoshi Takeda, and Shizuo Akira
Proline-Rich Tyrosine Kinase 2 and Rac Activation by Chemokine and
Integrin Receptors Controls NK Cell Transendothelial Migration
Angela Gismondi, Jordan Jacobelli, Raffaele Strippoli, Fabrizio
Mainiero, Alessandra Soriani, Loredana Cifaldi, Mario Piccoli, Luigi
Frati, and Angela Santoni
2993-3001
3002-3006
3007-3014
3015-3023
3024-3028
3029-3036
3037-3045
3046-3053
3054-3058
3059-3064
3065-3073
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Differential Distribution of HLA-DQ/DR Epitopes in the Two Forms 3074-3080

of Guillain-Barré Syndrome, Acute Motor Axonal Neuropathy and
Acute Inflammatory Demyelinating Polyneuropathy (AIDP):
Identification of DQ Epitopes Associated with Susceptibility to and
Protection from AIDP
Eleni E. Magira, Miltiadis Papaioakim, Irving Nachamkin, Arthur K.
Asbury, Chun Y. Li, Tony W. Ho, John W. Griffin, Guy M. McKhann,
and Dimitri S. Monos
The Four TCR Genes of Teleost Fish: The cDNA and Genomic DNA
Analysis of Japanese Flounder (Paralichthys olivaceus) TCR α-,β -, γ-,
and δ-Chains
Bo-Hye Nam, Ikuo Hirono, and Takashi Aoki
Ikaros Isoform X Is Selectively Expressed in Myeloid Differentiation
Kimberly J. Payne, Grace Huang, Eva Sahakian, Judy Y. Zhu, Natasha
S. Barteneva, Lora W. Barsky, Marvin A. Payne, and Gay M. Crooks
CD40-Mediated Transcriptional Regulation of the IL-6 Gene in B
Lymphocytes: Involvement of NF-B, AP-1, and C/EBP
Mekhine Baccam, So-Youn Woo, Charles Vinson, and Gail A. Bishop
Role of NFATx (NFAT4/NFATc3) in Expression of
Immunoregulatory Genes in Murine Peripheral CD4 + T Cells
Jingtao Chen, Yoshiharu Amasaki, Yumiko Kamogawa, Miho Nagoya,
Naoko Arai, Ken-ichi Arai, and Shoichiro Miyatake
NF-κB Is Required for Surface Ig-Induced Fas Resistance in B Cells
Brian R. Schram and Thomas L. Rothstein
3118-3124Identification of a Functionally Impaired Positive
Regulatory Domain I Binding Factor 1 Transcription Repressor in
Myeloma Cell Lines
Ildikó Györy, György Fejér, Nilanjan Ghosh, Ed Seto, and Kenneth L.
Wright
Human IgG2 Can Form Covalent Dimers
Esther M. Yoo, Letitia A. Wims, Lisa A. Chan, and Sherie L. Morrison
HOST DEFENSE
Inhibition of NF-κB Activity in T and NK Cells Results in Defective
Effector Cell Expansion and Production of IFN-γ Required for
Resistance to Toxoplasma gondii
Cristina M. Tato, Alejandro Villarino, Jorge H. Caamaño, Mark
Boothby, and Christopher A. Hunter
Role of CD1d in Coxsackievirus B3-Induced Myocarditis
Sally Huber, Danielle Sartini, and Mark Exley
Human NKT Cells Express Granulysin and Exhibit Antimycobacterial
Activity
Jennifer L. Gansert, Viviane Kiebler, Matthias Engele, Frederick
Wittke, Martin Röllinghoff, Alan M. Krensky, Steven A. Porcelli,
Robert L. Modlin, and Steffen Stenger
3081-3090
3091-3098
3099-3108
3109-3117
3125-3133
3134-3138
3139-3146
3147-3153
3154-3161
Immunogene Therapy of Tumors with Vaccine Based on Xenogeneic 3162-3170
Epidermal Growth Factor Receptor
You Lu, Yu-quan Wei, Ling Tian, Xia Zhao, Li Yang, Bin Hu, Bin
Kan, Yan-jun Wen, Feng Liu, Hong-xin Deng, Jiong Li, Yong-qiu
Mao, Song Lei, Mei-juan Huang, Feng Peng, Yu Jiang, Hao Zhou, Liqun
Zhou, and Feng Luo
Dendritic Cell (DC)-Based Protection Against an Intracellular 3171-3179

Pathogen Is Dependent Upon DC-Derived IL-12 and Can Be Induced
by Molecularly Defined Antigens
Christof Berberich, José R. Ramírez-Pineda, Christine Hambrecht,
Gottfried Alber, Yasir A. W. Skeiky, and Heidrun Moll
CD40 Ligand Trimer Enhances the Response of CD8 + T Cells to
Mycobacterium tuberculosis
Buka Samten, Benjamin Wizel, Homayoun Shams, Stephen E. Weis,
Peter Klucar, Shiping Wu, Ramakrishna Vankayalapati, Elaine K.
Thomas, Satoshi Okada, Alan M. Krensky, and Peter F. Barnes
CD4 + T Cell-Induced Differentiation of EBV-Transformed
Lymphoblastoid Cells Is Associated with Diminished Recognition by
EBV-Specific CD8 + Cytotoxic T Cells
Aaruni Khanolkar, Zheng Fu, L. Joey Underwood, Kristy L.
Bondurant, Rosemary Rochford, and Martin J. Cannon
The Dendritic Cell-Specific Chemokine, Dendritic Cell-Derived CC
Chemokine 1, Enhances Protective Cell-Mediated Immunity to Murine
Malaria
Oscar Bruna-Romero, John Schmieg, Margarita Del Val, Michael
Buschle, and Moriya Tsuji
Perforin-Mediated Effector Function Within the Central Nervous
System Requires IFN-γ-Mediated MHC Up-Regulation
Cornelia C. Bergmann, Beatriz Parra, David R. Hinton, Ramakrishna
Chandran, Maureen Morrison, and Stephen A. Stohlman
Serum-Resistant Strains of Borrelia burgdorferi Evade Complement-
Mediated Killing by Expressing a CD59-Like Complement Inhibitory
Molecule
Mario Pausa, Valentina Pellis, Marina Cinco, Piero G. Giulianini,
Gianni Presani, Sandra Perticarari, Rossella Murgia, and Francesco
Tedesco
INFLAMMATION
Lupus-Prone Mice Have an Abnormal Response to Thioglycolate and
an Impaired Clearance of Apoptotic Cells
Paul K. Potter, Josefina Cortes-Hernandez, Pierre Quartier, Marina
Botto, and Mark J. Walport
Proinflammatory Activities of S100: Proteins S100A8, S100A9, and
S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion
Carle Ryckman, Karen Vandal, Pascal Rouleau, Mariève Talbot, and
Philippe A. Tessier
Pre-Existing Glomerular Immune Complexes Induce
Polymorphonuclear Cell Recruitment Through an Fc Receptor-
Dependent Respiratory Burst: Potential Role in the Perpetuation of
Immune Nephritis
Yusuke Suzuki, Carmen Gómez-Guerrero, Isao Shirato, Oscar López-
Franco, Julio Gallego-Delgado, Guillermo Sanjuán, Alberto Lázaro,
Purificación Hernández-Vargas, Ko Okumura, Yasuhiko Tomino,
Chisei Ra, and Jesús Egido
Reduced Macrophage Recruitment, Proliferation, and Activation in
Colony-Stimulating Factor-1-Deficient Mice Results in Decreased
Tubular Apoptosis During Renal Inflammation
Deborah M. Lenda, Eriya Kikawada, E. Richard Stanley, and Vicki R.
3180-3186
3187-3194
3195-3203
3204-3213
3214-3222
3223-3232
3233-3242
3243-3253
3254-3262

Kelley
Activation of STAT3 by IL-6 and IL-10 in Primary Human
Macrophages Is Differentially Modulated by Suppressor of Cytokine
Signaling 3
Claudia Niemand, Ariane Nimmesgern, Serge Haan, Patrick Fischer,
Fred Schaper, Rolf Rossaint, Peter C. Heinrich, and Gerhard Müller-
Newen
Monocytes Are Potent Facilitators of Alveolar Neutrophil Emigration
During Lung Inflammation: Role of the CCL2-CCR2 Axis
Ulrich A. Maus, Katharina Waelsch, William A. Kuziel, Tim Delbeck,
Matthias Mack, Timothy S. Blackwell, John W. Christman, Detlef
Schlöndorff, Werner Seeger, and Jürgen Lohmeyer
Secretory Phospholipases A2 Activate Selective Functions in Human
Eosinophils
Massimo Triggiani, Francescopaolo Granata, Barbara Balestrieri,
Angelica Petraroli, Giulia Scalia, Luigi Del Vecchio, and Gianni
Marone
Engineered Recombinant Peanut Protein and Heat-Killed Listeria
monocytogenes Coadministration Protects Against Peanut-Induced
Anaphylaxis in a Murine Model
Xiu-Min Li, Kamal Srivastava, James W. Huleatt, Kim Bottomly, A.
Wesley Burks, and Hugh A. Sampson
A Causative Relationship Exists Between Eosinophils and the
Development of Allergic Pulmonary Pathologies in the Mouse
HuaHao H. Shen, Sergei I. Ochkur, Michael P. McGarry, Jeffrey R.
Crosby, Edie M. Hines, Michael T. Borchers, Huiying Wang, Travis L.
Biechelle, Katie R. O’Neill, Tracy L. Ansay, Dana C. Colbert,
Stephania A. Cormier, J. Paul Justice, Nancy. A. Lee, and James J. Lee
IL-4 Down-Regulates Anaphylatoxin Receptors in Monocytes and
Dendritic Cells and Impairs Anaphylatoxin-Induced Migration In Vivo
Afsaneh Soruri, Ziba Kiafard, Claudia Dettmer, Joachim Riggert, Jörg
Köhl, and Jörg Zwirner
IFN-γ Reverses the Stop Signal Allowing Migration of Antigen-
Specific T Cells into Inflammatory Sites
Szun S. Tay, Ann McCormack, Charlotte Lawson, and Marlene L.
Rose
Redundancy of a Functional Melanocortin 1 Receptor in the Antiinflammatory
Actions of Melanocortin Peptides: Studies in the
Recessive Yellow (e/e) Mouse Suggest an Important Role for
Melanocortin 3 Receptor
Stephen J. Getting, Helen C. Christian, Connie W. Lam, Felicity N. E.
Gavins, Roderick J. Flower, Helgi B. Schiöth, and Mauro Perretti
Neutrophils Promote Mononuclear Cell Infiltration During Viral-
Induced Encephalitis
Jiehao Zhou, Stephen A. Stohlman, David R. Hinton, and Norman W.
Marten
The Cytokine Macrophage Migration Inhibitory Factor Reduces Pro-
Oxidative Stress-Induced Apoptosis
Mai Tuyet Nguyen, Hongqi Lue, Robert Kleemann, Michael Thiele,
Gabriele Tolle, Doris Finkelmeier, Eva Wagner, Andrea Braun, and
3263-3272
3273-3278
3279-3288
3289-3295
3296-3305
3306-3314
3315-3322
3323-3330
3331-3336
3337-3347

Jürgen Bernhagen
CXCR2 Regulates Respiratory Syncytial Virus-Induced Airway
Hyperreactivity and Mucus Overproduction
Allison L. Miller, Robert M. Strieter, Achim D. Gruber, Samuel B. Ho,
and Nicholas W. Lukacs
Down-Regulation of Proinflammatory Capacity During Apoptosis in
Human Polymorphonuclear Leukocytes
Scott D. Kobayashi, Jovanka M. Voyich, Kevin R. Braughton, and
Frank R. DeLeo
IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and
Matrix Metalloproteinases Production and Regulated Angiogenesis
Aihua Li, Seema Dubey, Michelle L. Varney, Bhavana J. Dave, and
Rakesh K. Singh
CLINICAL IMMUNOLOGY
Macrophage Metalloelastase as a Major Factor for Glomerular Injury
in Anti-Glomerular Basement Membrane Nephritis
Yoshikatsu Kaneko, Minoru Sakatsume, Yuansheng Xie, Takeshi
Kuroda, Michiko Igashima, Ichiei Narita, and Fumitake Gejyo
A Broad-Spectrum Caspase Inhibitor Attenuates Allergic Airway
Inflammation in Murine Asthma Model
Akiko Iwata, Kazumi Nishio, Robert K. Winn, Emil Y. Chi, William
R. Henderson, Jr., and John M. Harlan
Role of the Chemokine Stromal Cell-Derived Factor 1 in Autoantibody
Production and Nephritis in Murine Lupus
Karl Balabanian, Jacques Couderc, Laurence Bouchet-Delbos, Ali
Amara, Dominique Berrebi, Arnaud Foussat, Françoise Baleux, Alain
Portier, Ingrid Durand-Gasselin, Robert L. Coffman, Pierre Galanaud,
Michel Peuchmaur, and Dominique Emilie
CTLA-4 Blockade Enhances the Therapeutic Effect of an Attenuated
Poxvirus Vaccine Targeting p53 in an Established Murine Tumor
Model
Jonathan Espenschied, Jeffrey Lamont, Jeff Longmate, Solange
Pendas, Zhongde Wang, Don J. Diamond, and Joshua D. I. Ellenhorn
Prothrombin Binds to the Surface of Apoptotic, But Not Viable, Cells
and Serves as a Target of Lupus Anticoagulant Autoantibodies
Paolo D’Agnillo, Jerrold S. Levine, Rebecca Subang, and Joyce Rauch
Cytokine Polymorphisms Play a Role in Susceptibility to Ultraviolet
B-Induced Modulation of Immune Responses after Hepatitis B
Vaccination
Annemarie Sleijffers, Berran Yucesoy, Michael Kashon, Johan
Garssen, Frank R. De Gruijl, Greet J. Boland, Jan Van Hattum,
Michael I. Luster, and Henk Van Loveren
Accumulation of B Lymphocytes with a Naive, Resting Phenotype in a
Subset of Hepatitis C Patients
Jianhua Ni, Edgardo Hembrador, Adrian M. Di Bisceglie, Ira M.
Jacobson, Andrew H. Talal, David Butera, Charles M. Rice, Thomas J.
Chambers, and Lynn B. Dustin
CLARIFICATION
3348-3356
3357-3368
3369-3376
3377-3385
3386-3391
3392-3400
3401-3407
3408-3422
3423-3428
3429-3439
Rejection of Syngeneic Colon Carcinoma by CTLs Expressing Single- 3440

Chain Antibody Receptors Codelivering CD28 Costimulation
Nicole M. Haynes, Joseph A. Trapani, Michele W. L. Teng, Jacob T.
Jackson, Loretta Cerruti, Stephen M. Jane, Michael H. Kershaw, Mark
J. Smyth, and Phillip K. Darcy