SCIENCE VOL. 305, NO. 5689, SEPTEMBER 3 ; 2004
SCIENCE VOL. 305, NO. 5689, SEPTEMBER 3 ; 2004
SCIENCE VOL. 305, NO. 5689, SEPTEMBER 3 ; 2004
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<strong>SCIENCE</strong><br />
<strong>VOL</strong>. <strong>305</strong>, <strong>NO</strong>. <strong>5689</strong>, <strong>SEPTEMBER</strong> 3 ; <strong>2004</strong><br />
SPECIAL ISSUE<br />
Deconstructing Aging<br />
Lisa Chong, Heather McDonald, and and Evelyn Strauss<br />
News<br />
Coming to Grips With Bone Loss<br />
Jean Marx<br />
Viewpoint<br />
Aging in Rhesus Monkeys: Relevance to Human Health Interventions<br />
George S. Roth, Julie A. Mattison, Mary Ann Ottinger, Mark E.<br />
Chachich, Mark A. Lane, and Donald K. Ingram<br />
Review<br />
What Can Progeroid Syndromes Tell Us About Human Aging?<br />
David Kipling, Terence Davis, Elizabeth L. Ostler, and Richard G. A.<br />
Faragher<br />
RESEARCH<br />
This Week in Science<br />
Plug-In Photonics * Clumps and Bumps in a Dusty Disk * Neat<br />
Nanotube Fibers * Bone Supports Bipedal Contention * Slicer Steps<br />
into the Limelight * Methane Counter-Production * Molecular Beak<br />
Tweaking * Sending a Cell-Death Sentence * A Disarming Approach to<br />
Predation * A Swell Way to Grow * Tiny Star Grains<br />
Editors' Choice: Highlights of the recent literature<br />
ECOLOGY/E<strong>VOL</strong>UTION: Tear-Away Spots * GEOCHEMISTRY: On<br />
the Hot Seat * CHEMISTRY: One Carbene Helps Another *<br />
GEOLOGY: Refreshing Water * CELL BIOLOGY: Moving Supplies to<br />
the Front * CANCER: Inflammation Revisited * STKE: Arousal<br />
Without Anxiety<br />
Brevia<br />
Evolution of Coral Pigments Recreated<br />
Juan A. Ugalde, Belinda S. W. Chang, and Mikhail V. Matz<br />
Research Article<br />
Crystal Structure of Argonaute and Its Implications for RISC Slicer<br />
Activity<br />
Ji-Joon Song, Stephanie K. Smith, Gregory J. Hannon, and Leemor<br />
Joshua-Tor<br />
Argonaute2 Is the Catalytic Engine of Mammalian RNAi<br />
Jidong Liu, Michelle A. Carmell, Fabiola V. Rivas, Carolyn G.<br />
Marsden, J. Michael Thomson, Ji-Joon Song, Scott M. Hammond,<br />
Leemor Joshua-Tor, and Gregory J. Hannon<br />
Reports<br />
Substructure in the Circumstellar Disk Around the Young Star AU<br />
Microscopii<br />
Michael C. Liu<br />
1419<br />
1420-1422<br />
1423-1426<br />
1426-1431<br />
1365<br />
1371<br />
1433<br />
1434-1437<br />
1437-1441<br />
1442-1444
Electrically Driven Single-Cell Photonic Crystal Laser<br />
Hong-Gyu Park, Se-Heon Kim, Soon-Hong Kwon, Young-Gu Ju, Jin-<br />
Kyu Yang, Jong-Hwa Baek, Sung-Bock Kim, and Yong-Hee Lee<br />
Macroscopic, Neat, Single-Walled Carbon Nanotube Fibers<br />
Lars M. Ericson, Hua Fan, Haiqing Peng, Virginia A. Davis, Wei Zhou,<br />
Joseph Sulpizio, Yuhuang Wang, Richard Booker, Juraj Vavro, Csaba<br />
Guthy, A. Nicholas G. Parra-Vasquez, Myung Jong Kim, Sivarajan<br />
Ramesh, Rajesh K. Saini, Carter Kittrell, Gerry Lavin, Howard Schmidt,<br />
W. Wade Adams, W. E. Billups, Matteo Pasquali, Wen-Fang Hwang,<br />
Robert H. Hauge, John E. Fischer, and Richard E. Smalley<br />
External and Internal Morphology of the BAR 1002'00 Orrorin<br />
tugenensis Femur<br />
K. Galik, B. Senut, M. Pickford, D. Gommery, J. Treil, A. J.<br />
Kuperavage, and R. B. Eckhardt<br />
Testing Predator-Driven Evolution with Paleozoic Crinoid Arm<br />
Regeneration<br />
Tomasz K. Baumiller and Forest J. Gahn<br />
Polymorphism in Presolar Al2O3 Grains from Asymptotic Giant Branch<br />
Stars<br />
Rhonda M. Stroud, Larry R. Nittler, and Conel M. O'D. Alexander<br />
Reverse Methanogenesis: Testing the Hypothesis with Environmental<br />
Genomics<br />
Steven J. Hallam, Nik Putnam, Christina M. Preston, John C. Detter,<br />
Daniel Rokhsar, Paul M. Richardson, and Edward F. DeLong<br />
Bmp4 and Morphological Variation of Beaks in Darwin's Finches<br />
Arhat Abzhanov, Meredith Protas, B. Rosemary Grant, Peter R. Grant,<br />
and Clifford J. Tabin<br />
Molecular Shaping of the Beak<br />
Ping Wu, Ting-Xin Jiang, Sanong Suksaweang, Randall Bruce Widelitz,<br />
and Cheng-Ming Chuong<br />
Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix<br />
Loren D. Walensky, Andrew L. Kung, Iris Escher, Thomas J. Malia,<br />
Scott Barbuto, Renee D. Wright, Gerhard Wagner, Gregory L. Verdine,<br />
and Stanley J. Korsmeyer<br />
A Small Molecule Smac Mimic Potentiates TRAIL- and TNF-Mediated<br />
Cell Death<br />
Lin Li, Ranny Mathew Thomas, Hidetaka Suzuki, Jef K. De Brabander,<br />
Xiaodong Wang, and Patrick G. Harran<br />
The Emergence of Competition Between Model Protocells<br />
Irene A. Chen, Richard W. Roberts, and Jack W. Szostak<br />
1444-1447<br />
1447-1450<br />
1450-1453<br />
1453-1455<br />
1455-1457<br />
1457-1462<br />
1462-1465<br />
1465-1466<br />
1466-1470<br />
1471-1474<br />
1474-1476<br />
Technical Comments<br />
Comment on "Inhibition of Hepatitis B Virus Replication by<br />
1403<br />
APOBEC3G"<br />
Christine Rösler, Josef Köck, Michael H. Malim, Hubert E. Blum, and<br />
Fritz von Weizsäcker<br />
Response to Comment on "Inhibition of Hepatitis B Virus Replication 1403
y APOBEC3G"<br />
Priscilla Turelli, Stéphanie Jost, Bastien Mangeat, and Didier Trono<br />
COMMENTARY<br />
Editorial<br />
Longevity, Quality, and the One-Hoss Shay<br />
Donald Kennedy<br />
Letters<br />
Disclosure of Clinical Trials in Children Maurizio Bonati, Chiara<br />
Pandolfini, and Antonio Clavenna ; Antidepressants' Use in Anorexic<br />
Girls Per Södersten and Cecilia Bergh ; SSRIs in Children and Suicide<br />
Donald F. Klein ; Disparities in Cancer Funding Phillip A. Dennis ;<br />
The Case Against Stem Cell Research John T. Durkin ; Problems in<br />
FBI mtDNA Database Hans-Jürgen Bandelt, Antonio Salas, and Claudio<br />
Bravi ; CORRECTIONS AND CLARIFICATIONS<br />
Essays on Science and Society<br />
BEYOND THE IVORY TOWER<br />
A World of Glass<br />
Alan Macfarlane and Gerry Martin<br />
Books et al.<br />
PHILOSOPHY OF <strong>SCIENCE</strong>:<br />
The Embryo of a Dialogue<br />
Günter P. Wagner<br />
HISTORY OF <strong>SCIENCE</strong><br />
The First Lord from Science<br />
John S. Rigden<br />
1369<br />
1401<br />
1407-1408<br />
1405-1406<br />
1406<br />
Books Received 1406<br />
Perspectives<br />
MOLECULAR BIOLOGY<br />
Argonaute Journeys into the Heart of RISC<br />
1409-1410<br />
Erik J. Sontheimer and Richard W. Carthew<br />
PHYSICS<br />
Crystalline Electron Pairs<br />
Marcel Franz<br />
MEDICINE<br />
Targeting Apoptotic Pathways in Cancer Cells<br />
Catherine Denicourt and Steven F. Dowdy<br />
ECOLOGY<br />
Spite Among Siblings<br />
Andy Gardner and Stuart A. West<br />
PLANETARY <strong>SCIENCE</strong><br />
Enhanced: Looking into the Giant Planets<br />
Jonathan J. Fortney<br />
NEWS<br />
News of the Week<br />
EXTRASOLAR PLANETS<br />
Planet Hunting Gets Rocky As Teams Clash Over Small Worlds<br />
1410-1411<br />
1411-1413<br />
1413-1414<br />
1414-1415<br />
1382
Robert Irion<br />
DEVELOPMENTAL BIOLOGY<br />
Bonemaking Protein Shapes Beaks of Darwin's Finches<br />
Elizabeth Pennisi<br />
VIROLOGY<br />
Avian Flu Finds New Mammal Hosts<br />
Martin Enserink and Jocelyn Kaiser<br />
PALEONTOLOGY<br />
400-Million-Year-Old Wounds Reveal a Time When Predators Romped<br />
Erik Stokstad<br />
SCIENTIFIC PUBLISHING<br />
Zerhouni Plans a Nudge Toward Open Access<br />
Jocelyn Kaiser<br />
MEETINGS<br />
Europe Clones U.S. Science Festival<br />
Martin Enserink<br />
PRESIDENTIAL APPOINTMENTS<br />
NSF's Acting Chief Facing Legal Limit on Tenure<br />
Jeffrey Mervis<br />
ACADEMIC LEADERS<br />
Neuroscientist Named MIT President<br />
Andrew Lawler<br />
News Focus<br />
NEUROBIOLOGY<br />
Making Sense of Tourette's<br />
Steve Olson<br />
HIGH-ENERGY ASTROPHYSICS<br />
Telescopes Break New Ground in Quest for Cosmic Rays<br />
Daniel Clery<br />
7TH INTERNATIONAL CONGRESS ON VERTEBRATE<br />
MORPHOLOGY MEETING:<br />
Newly Hatched Dinosaur Babies Hit the Ground Running<br />
Elizabeth Pennisi<br />
7TH INTERNATIONAL CONGRESS ON VERTEBRATE<br />
MORPHOLOGY MEETING:<br />
Tiny Salamanders Show Their Teeth<br />
Elizabeth Pennisi<br />
7TH INTERNATIONAL CONGRESS ON VERTEBRATE<br />
MORPHOLOGY MEETING:<br />
Snake Tartare--Quite a Bodyful<br />
Elizabeth Pennisi<br />
Products<br />
NEW PRODUCTS<br />
NetWatch<br />
FUN: Science Jukebox * DATABASE: Protein Matchmaking *<br />
RESOURCES: Waves of Destruction * RESOURCES: All the Fish in<br />
1383<br />
1385<br />
1386<br />
1386<br />
1387<br />
1389<br />
1389<br />
1390-1392<br />
1393-1395<br />
1396<br />
1396-1397<br />
1397<br />
1477<br />
1381
the Sea<br />
ScienceScope<br />
Japanese Researcher Sues Government Over Detention * California<br />
Acts on Ocean Policy Reports * U.S. Releases Draft Plan for Dealin<br />
With Pandemic Flu * In Settlement, Glaxo Agrees to Publicize Drug<br />
Trial Data<br />
Random Samples<br />
Reef Therapy * Turtle Service * Tibet's Ancient Flood * Georgia<br />
Science Center Closes * Jobs * Nonprofit World * Datapoint * Two<br />
Cultures<br />
<strong>VOL</strong>. <strong>305</strong>, <strong>NO</strong>. 5690, <strong>SEPTEMBER</strong> 10 ; <strong>2004</strong><br />
RESEARCH<br />
This Week in Science<br />
Dendrimeric Diblock Copolymers * Composition of Jupiter's<br />
Atmosphere * Macrocyclic Libraries via DNA * Suddenly Turbulent *<br />
Slippery But Still Wet * Phytoplankton Feel the Heat * Ensuring<br />
Adequate Gas Supplies * Take That Copper * Forming Hearts sans<br />
Fusion * Bacterial Persistence and Antibiotic Resistance * Tracking Iron<br />
Sources of Pathogenic Bacteria * Falling Together * Cdc42: You Are<br />
Being Watched<br />
Editors' Choice: Highlights of the recent literature<br />
ECOLOGY/E<strong>VOL</strong>UTION: Rapid Fin Movement Sleep *<br />
IMMU<strong>NO</strong>LOGY: Inciting Local Reactions * GEOLOGY: Mass<br />
Wasting * CHEMISTRY: A Mercury Bridge * CELL BIOLOGY:<br />
Putting Supplies to Use * BIOCHEMISTRY: A Neatly Pleated Sheet *<br />
PALEOECOLOGY: Turning Over a New Leaf<br />
Brevia<br />
Asymmetric Cochlear Processing Mimics Hemispheric Specialization<br />
Y. S. Sininger and B. Cone-Wesson<br />
Research Article<br />
Jupiter's Atmospheric Composition from the Cassini Thermal Infrared<br />
Spectroscopy Experiment<br />
V. G. Kunde, F. M. Flasar, D. E. Jennings, B. Bézard, D. F. Strobel, B.<br />
J. Conrath, C. A. Nixon, G. L. Bjoraker, P. N. Romani, R. K.<br />
Achterberg, A. A. Simon-Miller, P. Irwin, J. C. Brasunas, J. C. Pearl, M.<br />
D. Smith, G. S. Orton, P. J. Gierasch, L. J. Spilker, R. C. Carlson, A. A.<br />
Mamoutkine, S. B. Calcutt, P. L. Read, F. W. Taylor, T. Fouchet, P.<br />
Parrish, A. Barucci, R. Courtin, A. Coustenis, D. Gautier, E. Lellouch,<br />
A. Marten, R. Prangé, Y. Biraud, C. Ferrari, T. C. Owen, M. M. Abbas,<br />
R. E. Samuelson, F. Raulin, P. Ade, C. J. Césarsky, K. U. Grossman,<br />
and A. Coradini<br />
Mechanism of Ammonia Transport by Amt/MEP/Rh: Structure of<br />
AmtB at 1.35 Å<br />
Shahram Khademi, Joseph O'Connell, III, Jonathan Remis, Yaneth<br />
Robles-Colmenares, Larry J. W. Miercke, and Robert M. Stroud<br />
Reports<br />
1385<br />
1398<br />
1527<br />
1533<br />
1581<br />
1582-1586<br />
1587-1594
Experimental Observation of Nonlinear Traveling Waves in Turbulent<br />
Pipe Flow<br />
Björn Hof, Casimir W. H. van Doorne, Jerry Westerweel, Frans T. M.<br />
Nieuwstadt, Holger Faisst, Bruno Eckhardt, Hakan Wedin, Richard R.<br />
Kerswell, and Fabian Waleffe<br />
Mesophase Structure-Mechanical and Ionic Transport Correlations in<br />
Extended Amphiphilic Dendrons<br />
B.-K. Cho, A. Jain, S. M. Gruner, and U. Wiesner<br />
DNA-Templated Organic Synthesis and Selection of a Library of<br />
Macrocycles<br />
Zev J. Gartner, Brian N. Tse, Rozalina Grubina, Jeffrey B. Doyon,<br />
Thomas M. Snyder, and David R. Liu<br />
Hydrophobic Collapse in Multidomain Protein Folding<br />
Ruhong Zhou, Xuhui Huang, Claudio J. Margulis, and Bruce J. Bern<br />
Climate Impact on Plankton Ecosystems in the Northeast Atlantic<br />
Anthony J. Richardson and David S. Schoeman<br />
Methanobactin, a Copper-Acquisition Compound from Methane-<br />
Oxidizing Bacteria<br />
Hyung J. Kim, David W. Graham, Alan A. DiSpirito, Michail A.<br />
Alterman, Nadezhda Galeva, Cynthia K. Larive, Dan Asunskis, and<br />
Peter M. A. Sherwood<br />
Activation of Endogenous Cdc42 Visualized in Living Cells<br />
Perihan Nalbant, Louis Hodgson, Vadim Kraynov, Alexei Toutchkine,<br />
and Klaus M. Hahn<br />
Advanced Cardiac Morphogenesis Does Not Require Heart Tube Fusion<br />
Shanru Li, Deying Zhou, Min Min Lu, and Edward E. Morrisey<br />
Bacterial Persistence as a Phenotypic Switch<br />
Nathalie Q. Balaban, Jack Merrin, Remy Chait, Lukasz Kowalik, and<br />
Stanislas Leibler<br />
Iron-Source Preference of Staphylococcus aureus Infections<br />
Eric P. Skaar, Munir Humayun, Taeok Bae, Kristin L. DeBord, and Olaf<br />
Schneewind<br />
SOS Response Induction by ß-Lactams and Bacterial Defense Against<br />
Antibiotic Lethality<br />
Christine Miller, Line Elnif Thomsen, Carina Gaggero, Ronen Mosseri,<br />
Hanne Ingmer, and Stanley N. Cohen<br />
Species Coextinctions and the Biodiversity Crisis<br />
Lian Pin Koh, Robert R. Dunn, Navjot S. Sodhi, Robert K. Colwell,<br />
Heather C. Proctor, and Vincent S. Smith<br />
Technical Comments<br />
Comment on "Managing Soil Carbon" (I)<br />
K. Van Oost, G. Govers, T. A. Quine, and G. Heckrath<br />
Comment on "Managing Soil Carbon" (II)<br />
W. H. Renwick, S. V. Smith, R. O. Sleezer, and Robert W. Buddemeier<br />
Response to Comments on "Managing Soil Carbon"<br />
R. Lal, M. Griffin, J. Apt, L. Lave, and G. Morgan<br />
1594-1598<br />
1598-1601<br />
1601-1605<br />
1605-1609<br />
1609-1612<br />
1612-1615<br />
1615-1619<br />
1619-1622<br />
1622-1625<br />
1626-1628<br />
1629-1631<br />
1632-1634<br />
1567<br />
1567<br />
1567
COMMENTARY<br />
Editorial<br />
International Science Meetings<br />
Jane Lubchenco and Goverdhan Mehta<br />
Letters<br />
Extinction Rates and Butterflies Clive Hambler, Martin R. Speight,<br />
Jeremy A. Thomas, and Ralph T. Clarke ; Noguchi's Contributions to<br />
Science Pinghui V. Liu ; Networks by Design: A Revolution in Ecology<br />
Sandy J. Andelman and Michael R. Willig ;<br />
CORRECTIONS AND CLARIFICATIONS<br />
Policy Forum<br />
BIOTECH<strong>NO</strong>LOGY<br />
Japanese Controversies over Transgenic Crop Regulation<br />
Kazuo N. Watanabe, Mohammad Taeb, and Haruko Okusu<br />
Books et al.<br />
TECH<strong>NO</strong>LOGY<br />
The Value of Things to Come<br />
Domenico Grasso<br />
HISTORY OF <strong>SCIENCE</strong>:<br />
Building Circuits of Trust<br />
Sungook Hong<br />
1531<br />
1563<br />
1572<br />
1568-1569<br />
1569-1570<br />
Browsings 1570<br />
Books Received 1570<br />
Perspectives<br />
STRUCTURAL BIOLOGY<br />
1573-1574<br />
The Atomic Architecture of a Gas Channel<br />
Mark A. Knepper and Peter Agre<br />
PHYSICS<br />
Visualizing the Dynamics of the Onset of Turbulence<br />
Friedrich H. Busse<br />
CHEMISTRY<br />
Multidimensional Snapshots of Chemical Dynamics<br />
Albert Stolow and David M. Jonas<br />
MICROBIOLOGY<br />
Enhanced: Pathogenic Bacteria Prefer Heme<br />
Tracey A. Rouault<br />
MICROBIOLOGY<br />
Noninherited Resistance to Antibiotics<br />
Bruce R. Levin<br />
NEWS<br />
News of the Week<br />
STEM CELL POLITICS<br />
California Debates Whether to Become Stem Cell Heavyweight<br />
Gretchen Vogel<br />
AIDS VACCINES:<br />
HIV Dodges One-Two Punch<br />
1574-1575<br />
1575-1577<br />
1577-1578<br />
1578-1579<br />
1544-1545<br />
1545-1547
Jon Cohen<br />
JAPAN BUDGET:<br />
Science Ministry Puts In for Big Increases<br />
Dennis Normile<br />
CLIMATE CHANGE:<br />
Changes in Planktonic Food Web Hint At Major Disruptions in Atlantic<br />
Erik Stokstad<br />
SCIENTIFIC PUBLISHING:<br />
NIH Proposes 6-Month Public Access to Papers<br />
Jocelyn Kaiser<br />
NUCLEAR PROLIFERATION:<br />
South Korea Admits to Laser Enrichment Program<br />
Charles Seife<br />
EUROPEAN UNION:<br />
The Commissioner Who Listened<br />
Martin Enserink<br />
News Focus<br />
<strong>SCIENCE</strong> POLICY:<br />
The Man Behind the Memos<br />
Jocelyn Kaiser<br />
ENDANGERED SPECIES ACT:<br />
Can California Ranchers Save the Tiger Salamander?<br />
Erik Stokstad<br />
BRIAN FAGAN PROFILE:<br />
Archaeologist Leaves an Imprint on His Field--Without Research<br />
Michael Balter<br />
OCEAN ECOLOGY:<br />
Dead Zone Fix Not a Dead Issue<br />
Dan Ferber<br />
AMERICAN CHEMICAL SOCIETY MEETING:<br />
Finding Reactions in a Haystack: Try 'em All, See What Works<br />
Robert F. Service<br />
AMERICAN CHEMICAL SOCIETY MEETING:<br />
Enzyme Deactivates Heart-Friendly HDL<br />
Robert F. Service<br />
AMERICAN CHEMICAL SOCIETY MEETING:<br />
Breaking a Barrier to New Brain Images<br />
Robert F. Service<br />
AMERICAN CHEMICAL SOCIETY MEETING:<br />
Snapshots From the Meeting<br />
Robert F. Service.<br />
Products<br />
NEW PRODUCTS<br />
NetWatch<br />
DATABASE: Down at the Frog Pond * TOOLS: Getting More Out of<br />
Gene Chips * IMAGES: Protozoans on Parade * BIBLIOGRAPHY:<br />
1547<br />
1548-1549<br />
1548<br />
1549<br />
1551<br />
1552-1553<br />
1554<br />
1555<br />
1557<br />
1558<br />
1558-1559<br />
1559<br />
1559<br />
1635<br />
1543
Developing a Gut Reaction * EDUCATION: Dust to Dust<br />
ScienceScope<br />
Big Bucks for Buck Rogers * CITES Withholds Caviar Quotas<br />
Random Samples<br />
Betting on a Wave * Reducing Bird Strikes * Mummy * The Two Faces<br />
of Ginseng * Nanolander * Jobs * Pioneers * Deaths<br />
<strong>VOL</strong>. <strong>305</strong>, <strong>NO</strong>. 5691, <strong>SEPTEMBER</strong> 17 ; <strong>2004</strong><br />
RESEARCH<br />
This Week in Science<br />
Standing CO2 on Its End * Sugar in Two Steps * Disilyne Debut *<br />
Damage-Free Dating * Early Oxygen History * Why the Ice? * Two<br />
Membranes, Two Fusion Mechanisms * Lasting Legacy of Formative<br />
Years * Eosinophil Effects in Mouse Models of Asthma * Dissecting the<br />
Evolution of a Sign Language * How Sweet Is Your Tomato? * Shark<br />
Heavy Chain Structure Revealed * From Gene Expression Patterns to<br />
Function * Moving Forward with Actin<br />
Editors' Choice: Highlights of the recent literature<br />
PLANETARY <strong>SCIENCE</strong>: Paradise Lost? * ECOLOGY/E<strong>VOL</strong>UTION:<br />
Swifter, Higher, Stronger * MATERIALS <strong>SCIENCE</strong>: Fast-Flowing<br />
Filters * BIOCHEMISTRY: One Size Fits Many * MICROBIOLOGY:<br />
Thermophilic Parasite * CHEMISTRY: Rare Frameworks * STKE:<br />
Moving TRPs to the Membrane<br />
Review<br />
Living with the Past: Evolution, Development, and Patterns of Disease<br />
Peter D. Gluckman and Mark A. Hanson<br />
Inflammatory Exposure and Historical Changes in Human Life-Spans<br />
Caleb E. Finch and Eileen M. Crimmins<br />
Brevia<br />
Direct Sub-Angstrom Imaging of a Crystal Lattice<br />
P. D. Nellist, M. F. Chisholm, N. Dellby, O. L. Krivanek, M. F. Murfitt,<br />
Z. S. Szilagyi, A. R. Lupini, A. Borisevich, W. H. Sides, Jr., and S. J.<br />
Pennycook<br />
Research Article<br />
Environmentally Induced Foregut Remodeling by PHA-4/FoxA and<br />
DAF-12/NHR<br />
Wanyuan Ao, Jeb Gaudet, W. James Kent, Srikanth Muttumu, and<br />
Susan E. Mango<br />
Mitochondrial Fusion Intermediates Revealed in Vitro<br />
Shelly Meeusen, J. Michael McCaffery, and Jodi Nunnari<br />
Reports<br />
Two-Step Synthesis of Carbohydrates by Selective Aldol Reactions<br />
Alan B. Northrup and David W. C. MacMillan<br />
A Stable Compound Containing a Silicon-Silicon Triple Bond<br />
Akira Sekiguchi, Rei Kinjo, and Masaaki Ichinohe<br />
A Linear, O-Coordinated 1-CO2 Bound to Uranium<br />
Ingrid Castro-Rodriguez, Hidetaka Nakai, Lev N. Zakharov, Arnold L.<br />
1547<br />
1560<br />
1673<br />
1679<br />
1733-1736<br />
1736-1739<br />
1741<br />
1743-1746<br />
1747-1752<br />
1752-1755<br />
1755-1757<br />
1757-1759
Rheingold, and Karsten Meyer<br />
Age and Timing of the Permian Mass Extinctions: U/Pb Dating of<br />
Closed-System Zircons<br />
Roland Mundil, Kenneth R. Ludwig, Ian Metcalfe, and Paul R. Renne<br />
Molecular Cloud Origin for the Oxygen Isotope Heterogeneity in the<br />
Solar System<br />
Hisayoshi Yurimoto and Kiyoshi Kuramoto<br />
Middle Miocene Southern Ocean Cooling and Antarctic Cryosphere<br />
Expansion<br />
Amelia E. Shevenell, James P. Kennett, and David W. Lea<br />
Crystal Structure of a Shark Single-Domain Antibody V Region in<br />
Complex with Lysozyme<br />
Robyn L. Stanfield, Helen Dooley, Martin F. Flajnik, and Ian A. Wilson<br />
Defining a Link with Asthma in Mice Congenitally Deficient in<br />
Eosinophils<br />
James J. Lee, Dawn Dimina, MiMi P. Macias, Sergei I. Ochkur,<br />
Michael P. McGarry, Katie R. O'Neill, Cheryl Protheroe, Ralph Pero,<br />
Thanh Nguyen, Stephania A. Cormier, Elizabeth Lenkiewicz, Dana<br />
Colbert, Lisa Rinaldi, Steven J. Ackerman, Charles G. Irvin, and Nancy<br />
A. Lee<br />
A Critical Role for Eosinophils in Allergic Airways Remodeling<br />
Alison A. Humbles, Clare M. Lloyd, Sarah J. McMillan, Daniel S.<br />
Friend, Georgina Xanthou, Erin. E. McKenna, Sorina Ghiran, Norma P.<br />
Gerard, Channing Yu, Stuart H. Orkin, and Craig Gerard<br />
Children Creating Core Properties of Language: Evidence from an<br />
Emerging Sign Language in Nicaragua<br />
Ann Senghas, Sotaro Kita, and Asli Özyürek<br />
Two Distinct Actin Networks Drive the Protrusion of Migrating Cells<br />
A. Ponti, M. Machacek, S. L. Gupton, C. M. Waterman-Storer, and G.<br />
Danuser<br />
Zooming In on a Quantitative Trait for Tomato Yield Using<br />
Interspecific Introgressions<br />
Eyal Fridman, Fernando Carrari, Yong-Sheng Liu, Alisdair R. Fernie,<br />
and Dani Zamir<br />
Technical Comments<br />
Comment on "The Early Evolution of the Tetrapod Humerus"<br />
P. E. Ahlberg<br />
Response to Comment on "The Early Evolution of the Tetrapod<br />
Humerus"<br />
Michael I. Coates, Neil H. Shubin, and Edward B. Daeschler<br />
COMMENTARY<br />
Editorial<br />
Talking with North Korea<br />
Norman P. Neureiter<br />
1760-1763<br />
1763-1766<br />
1766-1770<br />
1770-1773<br />
1773-1776<br />
1776-1779<br />
1779-1782<br />
1782-1786<br />
1786-1789<br />
1715<br />
1715<br />
1677<br />
Letters<br />
Hollywood, Climate Change, and the Public Andrew Balmford, Andrea 1713
Manica, Lesley Airey, Linda Birkin, Amy Oliver, and Judith Schleicher<br />
; Evidence for Taming of Cats Tom Rothwell;, J.-D. Vigne, and J.<br />
Guilaine ; Figuring Out What Works in Education Arlene Fink ;<br />
CORRECTIONS AND CLARIFICATIONS<br />
Policy Forum<br />
GENETICS:<br />
Ethical Aspects of ES Cell-Derived Gametes<br />
Giuseppe Testa* and John Harris<br />
Books et al.<br />
ENVIRONMENT:<br />
How Best to Face the Coming Storm<br />
Partha Dasgupta<br />
ANTHROPOLOGY:<br />
Culture and Commerce in a Seafood Bazaar<br />
Stephen Gudeman<br />
1719<br />
1716<br />
1716-1717<br />
Browsings 1717<br />
Books Received 1717<br />
Perspectives<br />
NEURO<strong>SCIENCE</strong>:<br />
1720-1721<br />
Signposts to the Essence of Language<br />
Michael Siegal<br />
CELL BIOLOGY:<br />
Double Membrane Fusion<br />
Nikolaus Pfanner, Nils Wiedemann, and Chris Meisinger<br />
CHEMISTRY:<br />
Japan Bats a Triple<br />
Robert West<br />
CHEMISTRY:<br />
Enhanced: A Dash of Proline Makes Things Sweet<br />
Erik J. Sorensen and Glenn M. Sammis<br />
BIOMEDICINE:<br />
Eosinophils in Asthma: Remodeling a Tangled Tale<br />
Marsha Wills-Karp and Christopher L. Karp<br />
PLANETARY <strong>SCIENCE</strong>:<br />
Predicting the Sun's Oxygen Isotope Composition<br />
Qing-zhu Yin<br />
NEWS<br />
News of the Week<br />
MANAGING <strong>SCIENCE</strong>:<br />
House Votes to Kill Grants, Limit Travel to Meetings<br />
Jocelyn Kaiser<br />
SPACE PROGRAM:<br />
Aiming for the Sun, Crashing to Earth<br />
Richard A. Kerr<br />
<strong>SCIENCE</strong> POLICY:<br />
The Candidates Speak on Science<br />
1723-1724<br />
1724-1725<br />
1725-1726<br />
1726 -1729<br />
1729-1730<br />
1688<br />
1689<br />
1689
MEDICINE<br />
Possible New Role for BRCA2<br />
Jean Marx<br />
DATA SECURITY:<br />
Report Upholds Public Access to Genetic Codes<br />
David Malakoff<br />
WOMEN IN <strong>SCIENCE</strong>:<br />
Harvard Faculty Decry Widening Gender Gap<br />
Yudhijit Bhattacharjee<br />
PALEOCEA<strong>NO</strong>GRAPHY:<br />
Signs of a Warm, Ice-Free Arctic<br />
Richard A. Kerr<br />
DRUG RESEARCH:<br />
Legislators Propose a Registry to Track Clinical Trials From Start to<br />
Finish<br />
Jennifer Couzin<br />
News Focus<br />
<strong>NO</strong>RTH KOREA:<br />
Visiting the Hermit Kingdom<br />
Richard Stone<br />
SCIENTIFIC EXCHANGES:<br />
A Wary Pas de Deux<br />
Richard Stone<br />
SCIENTIFIC EXCHANGES:<br />
Nukes for Windmills: Quixotic or Serious Proposition?<br />
Richard Stone<br />
SCIENTIFIC EXCHANGES:<br />
The Ultimate, Exclusive LAN<br />
Richard Stone<br />
GEOCHEMISTRY:<br />
In Mass Extinction, Timing Is All<br />
Richard A. Kerr<br />
BIOTERRORISM:<br />
Biosecurity Goes Global<br />
David Malakoff<br />
1691<br />
1692<br />
1692<br />
1693<br />
1695<br />
1696<br />
1696-1703<br />
1698-1699<br />
1701<br />
1705<br />
1706-1707<br />
Products<br />
NEW PRODUCTS 1791<br />
NetWatch<br />
EDUCATION: Limulus in the Limelight * IMAGES: Not of This<br />
1687<br />
World * DATABASE: Federal Science Register * IMAGES: Killers in<br />
the Forest * DATABASE: Parsing RNA<br />
ScienceScope<br />
NCI Backs Nano in Cancer War * Panel Recommends Keeping German<br />
Cloning Ban, for Now * Japan Revises Mad Cow Plans * FDA Panel<br />
Approves ADHD Study<br />
Random Samples<br />
1691
Viking Burial Site * Defying Darwin * Magnetic Memories * More<br />
Chimp Charges * Awards * Jobs * Deaths<br />
1709
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