Fungiscope - ISHAM

Global Emerging Fungal Infection Registry 

Initiated in 2003 

Report December 2012 

Working group of the 

Under the auspices of 

Supported by unrestricted grants from Astellas Pharma, Gilead Sciences, Merck and Pfizer

Table of Contents 

Study Co-ordinators ......................................................................... 3 

Introduction .................................................................................... 6 

Current Results ............................................................................... 10 

Achievements and Goals .................................................................. 17 

Presentations 2010-2012 ............................................................... 17 

Publications ................................................................................. 18 

Awards ........................................................................................ 18 

Recent Accomplishments ............................................................... 18 

Goals for 2013 ............................................................................. 19 

Contact Information ......................................................................... 20 

Participating Institutions................................................................... 21 

Report December 2012 Page 2 of 34

Study Co-ordinators 

Clinical ID Microbiology Molecular Biology Pharmacology Pathology 

Austria 

Elisabeth Presterl, MD 

Allgemeines Krankenhaus - 

Universitätskliniken Wien 

Währinger Gürtel 18-20 

1090 Wien 

T +43-1-40400-4440 

F +43-1-4400-4418 

elisabeth.presterl@meduni 

wien.ac.at 

Brazil 

Marcio Nucci, MD 

Hospital Universitário 

Universidade Federal do Rio de 

Janeiro 

Av. Brigadeiro Trompovsky S/N 

21941-590 Rio de Janeiro 

T +55-21-2562-2463 

F +55-21-2562-2460 

mnucci@hucff.ufrj.br 

Czech Republic 

Zdeněk Ráčil, MD 

Dept. of Internal Medicine 

Hemato-Oncology 

University Hospital Brno 

Jihlavska 20 

62500 Brno 

T +420-53223-2830/3642 

F +420-53223-3603 

zracil@fnbrno.cz 

Cornelia Lass-Flörl, MD 

Institute of Hygiene, Microbiology 

and Social Medicine 

Universität Innsbruck 

Fritz-Pregl-Str. 3 

6020 Innsbruck 

T +43-512-9003-70725 

F +43-512-9003-73700 

cornelia.lass-floerl@uibk.ac.at 

Iva Kocmanova, MD 

Dept. of Microbiology 

University Hospital Brno, 

Jihlavska 20 

62500 Brno 

T +420 53223 2974 

ikocmanova@fnbrno.cz 

Walter Buzina, MD 

Institut für Hygiene 

Medizinische Universität 

Universitätsplatz 4 

8010 Graz 

T +43-316-380-7719 

F +43-316-380-9648 

walter.buzina@meduni-graz.at 

Martina Lengerova, MD 

Dept. of Internal Medicine 

Hemato-Oncology 


Jihlavska 20 

62500 Brno 

T +420 53223 3642 

mlengerova@nbrno.cz 

Mojmir Moulis, MD 

Dept. of Pathology 


Jihlavska 20 

62500 Brno 

T +420 53223 1111 

mmoulis@fnbrno.cz 

Ulrich Strasser. MD 

Institut für Pathologie 

Medizinische Universität 

Innsbruck 

Müllerstr. 44 

A-6020 Innsbruck 

T +43-512-9003-71304 

F +43-512-582-088 

ulrich.strasser@i-med.ac.at 

Ludmila Malaskova, MD 

Dept. of Biochemistery 


Jihlavska 20 

62500 Brno 

T. +420 53223 3073 

lmalas@fnbrno.cz 



Germany 

Oliver A. Cornely, MD, FIDSA, 

FACP 

Klinikum der Universität 

Klinik I für Innere Medizin 

50924 Köln 

T +49-221-478-6494 

F +49-221-478-3611 

oliver.cornely@ctuc.de 

India 

Guido Fischer, MS, PhD 

Landesgesundheitsamt Baden- 

Württemberg 

Referat 96 - Arbeitsmedizin, 

umweltbezogener 

Gesundheitsschutz 

Nordbahnhofstraße 135 

70191 Stuttgart 

T +49-711-904-39620 

F +49-711-904-37105 

guido.fischer@rps.bwl.de 

Axel Hamprecht, MD 


Institut f. Mikrobiologie, 

Immunologie u. Hygiene 

Goldenfelsstr. 19-2 

D-50935 Köln 

T +49-221-478 32023 

F +49-(0)221-478-32134 

axel.hamprecht@uk-koeln.de 

Anupma Jyoti Kindo, MD 

Dept. of Microbiology 

Sri Ramachandra Medical 

College/Research Institute 

No.1, Ramachandra Nagar 

Porur, Chennai, 600 116 

T +91-944-523-9196 

F +91 44 2476 5608 

anupmalakra@yahoo.com 

Ralf Bialek, MD 

MVZ Labor Dr. Krause 

Steenbeker Weg 25 

24106 Kiel 

T +49-431-388-252 

bialek@labor-krause.de 

Carsten Müller, MD 


Institut für Pharmakologie 

50924 Köln 

T +49-221-478-5066 

F +49 221 478 7184 

c.mueller@uni-koeln.de 



Israel 

Morad Wattad, MD 

Rabin Medical Center 

Infectious Diseases Unit 

39 Jabotinski St. 

49100 Petah Tikva 

T +972-3-937-7377 

F +972-3-937-6365 

Moradv@clalit.org.il 

Italy 

Livio Pagano, MD 

Dipartimento di Ematologia 

Universita Cattolica del Sacro 

Cuore (Roma) 

Largo Francesco Vito 1 

00168 Roma 

T +39-6-355-03953 

F +39-630-51343 

lpagano@rm.unicatt.it 

Turkey 

Maurizio Sanguinetti, MD 

Istituto di Microbiologia (Roma) 

Università Cattolica del Sacro 

Cuore 

Largo Francesco Vito 1 

00168 Roma 

T +39-06-3015-4964 

F +39-06-3051-152 

msanguinetti@rm.unicatt.it 

Sevtap Arikan-Akdagli, MD 

Mycology Laboratory (Ankara) 

Hacettepe University 

06100 Ankara 

F +90 (312) 3115250 

sevtap.arikan@gmail.com 

Annamaria Tortorano, MD 

Dip. Sanità Pubblica- 

Microbiologia-Virologia Milano 

Università di Milano 

Via Pascal, 36/38 

20133 Milano 

T +39-2-503-15145 

F +39-2-503-15146 

annamaria.tortorano@unimi.it 

Andrea Novelli, MD 

Dipartimento di Farmacologia 

Università degli Studi di Firenze 

Viale Pieraccini, 6 

50139 Firenze 

T +39-055-4271-286 

F +39-055-4271-280 

andrea.novelli@unifi.it 

Gianluigi Vago, MD 

Department of Clinical Sciences 

Luigi Sacco Hospital 

University of Milan 

Via Pascal, 36/38 

20133 Milano 

T +39 0285994869 

F +39 0285994800 

Gianluca.vago@unimi.it 


Introduction 

The incidence of invasive fungal infections (IFI) is increasing in all parts of the world. The 

etiology for this ongoing epidemiological development is not completely understood. 

However, major contributing factors are the increasing number of transplantation procedures 

undertaken around the world (estimated at 500,000 per year), a widening of the indications 

for intensive chemotherapy, and the growing number of other clinical conditions requiring 

immunosuppressive treatment. 

Therapeutic standards have been developed for the most frequent IFI, i.e. candidiasis, 

aspergillosis and cryptococcosis. However, the so called “emerging fungi” are also a reason 

for the increased number of IFIs. Thus, clinicians are now facing infections due to a variety of 

different fungi without any reliable treatment recommendations and therapeutic decision 

making is not evidence based. Prevalence of “emerging fungi” is virtually unknown and there 

is an additional knowledge gap in pathogen biology, since isolates have not been collected 

systematically. 

In order to overcome the lack of knowledge on epidemiology, clinical course, biology and 

pathomechanisms, and finally to develop an evidence based diagnostic-therapeutic integrated 

approach of IFI caused by “emerging fungi”, A Global Emerging Fungal Infection Registry – 

Fungiscope has been created. 

Fungiscope uses a web-based electronic case form accessible via www.fungiscope.net. For 

inclusion into the registry patients require cultural, histopathological, serological or molecular 

evidence of IFI and the associated clinical symptoms and signs. The clinical data on 

underlying disorder and IFI will be collected and stored in an internet-based database. 

Additionally, the pathogen strains and samples of infected tissue are collected, examined and 

stored in a bio-bank – the Fungithek. The clinical and biological data are subsequently 

evaluated and analysed. Figure 1a and b present the data / sample flow and overall project 

structure. The clinical database and the bio-bank are connected and accessable to the public 

via a web-based search engine - FungiQuest (figure 2). 

In the following report we introduce the most current results and achievements. We also 

discuss future goals and ongoing developments of the project. 


Figure 1a: Project structure 


Figure 1b: Material flow 


Figure 2: FungiQuest database search engine 


Current Results 

Until now, 311 cases have been documented and considered valid. The most frequently 

registered pathogens were Mucorales (previously termed Zygomycetes) (n=126; 40.5%), 

Fusarium spp. (n=54; 17.4%), yeasts (n=44; 14.1%), and Dematiaceae (n=34; 10.9%) 

followed by Penicillinum spp. / Paecilomyces spp. (n=15; 4.8%) and Scedosporium spp. 

(n=13; 4.2%) (figure 3). The majority of patients were Caucasian followed by Asian and 

North/South American Indian origins (figure 4). The contribution of cases by country is 

shown in figure 5. 

Sites of infection differ among pathogens, see figure 6. In patients with invasive 

mucormycosis, the lungs were the most commonly involved organs with an incidence of 

67.5%. Other involved sites were the paranasal sinuses (22.2%), deep soft tissues 

(13.5%) and the central nervous system (12.7%). Fusarium spp. infections most 

frequently presented as blood stream infections (51.9%) or skin infections (48.1%). Other 

commonly affected sites were lungs (35.2%) and deep soft tissues (20.4%). Infections 

with Dematiaceae mostly involved the eyes, paranasal sinuses, deep soft tissues, and 

skin (range from 11.8% - 32.4%). By contrast, yeasts were most often diagnosed from 

blood cultures (approximately 64%) followed by pulmonary infections (35.2%). 

The evaluation of risk factors for the development of IFI revealed differences between 

individual pathogens shown in figure 7. The most common risk factors for developing an 

infection with Mucorales and Fusarium spp. were chemotherapy (47.6% and 55.6% 

respectively) or haematopoetic stem cell transplantation (HSCT) (approximately 30%) 

followed by stay at an intensive care unit and diabetes mellitus, with rates of 13.0 – 

18.5%. 

Chemotherapy was also the most common risk factors in patients presenting with yeast 

infections (43.2%). In addition, 34.1% of patients were treated in intensive care units. 

Further risk factors were diabetes mellitus (13.6%) and solid organ transplantation 

(13.6%). 

By contrast, patients with a Dematiaceae infection presented most frequently with 

diabetes mellitus (47.1%) and/or chronic renal disease (17.6%). 

Mortality, attributable mortality and response to treatment differed among individual 

pathogens and are shown in figure 8. The highest overall mortality was observed in 

patients with mucormycosis (57.1%), followed by patients with yeast (52.3%) and 

Fusarium spp. infections (48.1%). In more than 70% of cases the cause of death was the 

fungal infection irrespective of causative species. By contrast, the lowest overall mortality 

was revealed in patients with Dematiaceae, equaling only 5.9%. None of these deaths was 

due to the fungal infection. The highest rates of complete and partial remissions were 

observed in patients with IFI caused by Dematiaceae and Penicillium/Paecilomyces spp 

(73.5 and 73.3% respectively). Patients with a Mucorales infection displayed the lowest 

rate of response to treatment (43.7%). 

In conclusion, the clinical relevance of invasive fungal infections by emerging fungi is 

increasing. In a short time, actual cases from several countries world-wide could be 

documented and showed a broad spectrum of pathogens. Further investigators and 

coordinators are encouraged to contribute to the success of Fungiscope. 


Figure 3: Distribution of 299 pathogens by major groups 


Figure 4: Ethnicities 


Figure 5: Case contributions by country 


Figure 6: Risk factors for major groups 


Figure 7: Sites of infection for major groups 


Figure 8: Outcomes for major group 


Presentations 2010 - 2012 

Achievements and Goals 

October 19-23, 2012 Annual Congress of the German Society for Hematology and 

Oncology (DGHO), Stuttgart, Germany 

September 9-12, 2012 52nd Interscience Conference on Antimicrobial Agents and 

Chemotherapy (ICAAC), San Francisco, CA, USA 

June 23-26, 2012 18th Congress of the International Society for Human and 

Animal Mycology, Berlin, Germany 

April 25-28, 2012 11th Congress of Infectious Diseases and Tropical Medicine, 

Cologne, Germany 

March 31-April 3, 2012 22nd European Congress of Clinical Microbiology and 

Infectious Diseases (ECCMID), London, UK 

January 24-25, 2012 3rd WATL-Congress, Berlin, Germany 

October 2-5, 2011 5th Trends in Medical Mycology (TIMM), Valencia, Spain 

September 30-Oct. 4, 2011 Annual Congress of the German Society for Hematology and 

Oncology (DGHO), Basel, Switzerland 

September 17-21, 2011 51th Interscience Conference on Antimicrobial Agents and 

Chemotherapy (ICAAC), Chicago, USA 

September 1-3, 2011 45th Congress of the German Society for Mycology (DMykG 

e.V.), Kiel, Germany 

May 7-10, 2011 21st ECCMID/27th ICC, Joint Congress of the 

European Society of Clinical Microbiology and Infectious 

Diseases and the International Society of Chemotherapy20th, 

Milan, Italy 

March 31-April 2, 2011 Annual Congress of the German Society for Infectious 

Diseases (DGI), Leipzig, Germany 

October 1-5, 2010 Annual Congress of the German Society for Hematology and 

Oncology (DGHO), Berlin, Germany 

September 12-15, 2010 50th Interscience Conference on Antimicrobial Agents and 

Chemotherapy (ICAAC), MA, Boston, USA 

September 9-11, 2010 44th Congress of the German Society for Mycology (DMykG 

e.V.), Vienna, Austria 

June 23-26, 2010 10th Congress of Infectious Diseases and Tropical Medicine, 

Cologne, Germany 

June 18-19, 2010 MSD Workshop „Infektionen in der Hämatologie“, Munich, 

Germany 

May 7-8, 2010 Paul-Ehrlich-Gesellschaft für Chemotherapie e.V., Spring 

Meeting of the “Sektion Antimykotische Chemotherapie”, 

Bonn, Germany 

April 10-13, 2010 20th European Congress of Clinical Microbiology and 

Infectious Diseases (ECCMID), Vienna, Austria 


Publications 

August 2012 Christopeit M, Lindner A, Surov A, Weber T, Vehreschild MJ, 

Bialek R, Schmoll HJ.Right flank pain and high fever in a 

neutropenic patient with acute lymphoblastic leukaemia. 

Mycoses 2012, Aug 13. Doi: 10.1111/j.1439- 

0507.2012.02231.x. Epub ahead of print 

October 2011 de Hoog GS, Robert V, Lackner M, Vehreschild MJ, 

Vehreschild JJ, Symoens F, Göttlich-Fligg E, Garcia-Hermoso 

D, Harun A, Meyer W, Chen SC, Hamprecht A, Fischer G, 

Buzina W, Cornely OA, Guarro J, Cano J, Horré R 

Making moulds meet. Information retrieval as a basis for 

understanding Pseudallescheria and Scedosporium 

Mycoses. 2011 Oct;54 Suppl 3:1-4 

December 2009 M.J.G.T. Rüping, W.J. Heinz, A.J. Kindo, V. Rickerts, C. Lass- 

Flörl, C. Beisel, R. Herbrecht, Y. Roth, G. Silling, A.J. 

Ullmann, K. Borchert, G. Egerer, J. Maertens, G. 

Maschmeyer, A. Simon, M. Wattad, G. Fischer, J.J. 

Vehreschild, O.A. Cornely 

Forty-one Recent Cases of Invasive Zygomycosis from a 

Global Clinical Registry 

J Antimicrob Chemother. 2010 Feb;65(2):296-302 

July 2008 Rüping M.J.G.T., Albermann N., Ebinger F., Burckhard I., 

Beisel C., Müller C., Vehreschild J.J., Kochanek M., 

Fätkenheuer G., Bangard C., Ullmann A.J., Herr W., Kolbe 

K., Hallek M., Cornely O.A. 

Posaconazole concentrations in the central nervous system. 

J Antimicrob Chemother 2008 Dec;62 (6):1468-70 

Awards 

Young Investigator Award 2010 (Nachwuchsförderpreis) of the German Society for Mycology 

(DMykG e.V.) awarded to Dr. M.J.G.T. Vehreschild for her work on Fungiscope 

Recent Accomplishments 

Initiation of the MSG Phaeohyphomycosis Registry by use of the Fungiscope database 

in October 2012. 

Abstract on the Fusarium spp. Infections joint analysis in cooperation with the Brazilian 

Fusarium spp. Group (Prof. Marcio Nucci, Rio de Janeiro, Brazil) presented as an oral 

presentation at the ICAAC 2012. Manuscript in preparation. 

Newly established cooperation with the Robert Koch Institute in (Dr. Volker Rickerts, 

Berlin, Germany) for extended diagnostics on paraffin embedded specimens of patients 

with suspected emerging invasive fungal infections by use of sequencing plus ribosomal 

RNA FISH 


Initiation of an analysis of combination treatment with liposomal Amphotericin B plus 

posaconazole for mucormycosis infections in co-operation with the SEIFEM study group 

(Prof. Livio Pagano, Rome, Italy) 

Agreement with the ECMM signed to use the Fungiscope clinical database for 

conducting the ECMM TriReg Study on Trichosporon spp. infections 

Database restructuring including: 

o Re-evaluation of all cases with respect to infection vs. colonization 

o Harmonizing different wording used for documentation 

o Structural adjustments facilitating data export and analysis 

Initiation of an epidemiological online survey to monitor trends 

Goals for 2013 

Publication of a subset analysis on rare yeasts, including resistance patterns 

Publication of a comparison between sequencing and morphological results for the first 

100 Fungiscope isolates 

Extending the FungiQuest platform (online since April 2010): 

o Faster inclusion of new cases 

o Inclusion of FungiThek / isolate information 

o Improved search-engine 

Launch of new, improved website 


Chair: 

Oliver A. Cornely, MD, FIDSA, FACP 

oliver.cornely@ctuc.de 

Coordinating Physicians: 

Maria J.G.T. Vehreschild (née Rüping), MD 

maria.vehreschild@ctuc.de 

Kerstin Wahlers, MD 

kerstin.wahlers@ctuc.de 

Contact Information 

Technical advisor, site operator clinicalsurveys.net: 

Jörg J. Vehreschild, MD 

janne.vehreschild@ctuc.de 

Uniklinik Köln 

Infectious Diseases – Clinical Trials Unit II 

BH E15 R64 

Kerpener Strasse 62 

50937 Köln 

Germany 

T +49-221-478-6494 

F +49-221-478-3611 

www.fungiscope.net 


Argentina 

Participating Institutions 

El Centro de Internación de FUNDALEU, Departamento Medico, Buenos Aires, Argentina 

Maria Cecilia 

Dignani 

Instituto Nacional de Enfermedades Infecciosas "Dr. C. G. Malbrán", Buenos Aires, Argentina Susana Cordoba 

Centro de Referencia de Micología Facultad de Ciencias Bioquímicas y Farmacéuticas, 

Universidad Nacional de Rosario, Rosario, Argentina 

Marisa Biasoli 

Centro de Trasplante de Médula Ósea de Rosario (CETRAMOR), Rosario, Argentina. José Anibal Cozzi 

Australia 

Department of Microbiology & Infectious Diseases, Royal Perth Hospital, Perth, Australia Christopher Heath 

Austria 

Abt. f. Anästhesie und Intensivmedizin, Wilhelminenspital Wien, Wien, Austria Peter Wimmer 

Anästhesiologie und Intensivmedizin, Landesklinikum Thermenregion Baden, Baden, Austria Franz Schwameis 

Infektionen und Tropenmedizin, Universitätsklinik I für Innere Medizin, Medizinische 

Universität Wien, Wien, Austria 

Institut für Anästhesie und Intensivmedizin, Landeskrankenhaus Steyr, Steyr, Austria 

Institut für Hygiene, klinische Bakteriologie und Mykologie, Medizinische Universität Graz, 

Graz, Austria 

Institut für Hygiene, Mikrobiologie und Sozialmedizin, Medizinische Universität Innsbruck, 

Innsbruck, Austria 

Christina Kratzer, 

Elisabeth Presterl 

Achim von 

Goedecke 

Walter Buzina 

Cornelia Lass-Flörl, 

Anna Huppert, 

Isabella Schalk 

Institut für Pathologie, Medizinische Universität Innsbruck, Innsbruck, Austria Ulrich Strasser 

Kinder- Herzzentrum Linz, Allgemeines Krankenhaus Linz, Linz, Austria 

Werner 

Moosbauer 

Klinik für Anästhesiologie, Wagner-Jauregg Nervenklinik, Linz, Austria Udo Illievich 

Klinik für Pneumologie, Inselspital, Universitätsspital Bern, Bern, Austria Sebastian Ott 


Krankenhaushygiene, Landeskrankenhaus Klagenfurt, Klagenfurt, Austria Ulrich Zerlauth 

Section of Infectious Diseases, Department of Medicine, Medical University of Graz, Austria Martin Hoenigl 

Universitätsinstitut für Medizinische Mikrobiologie, Hygiene und Infektiologie - SALK Labor 

GmbH, Salzberger Universitätsklinikum, Salzberg, Austria 

Universitätsklinik für Dermatologie, Medizinische Universität Wien, Wien, Austria 

Belgium 

University Hospital Gasthuisberg , Leuven, Belgium 

Brazil 

Hematology and Mycology Laboratory, Hospital Universitário Clementino Fraga, UFRJ, Rio de 

Janeiro, Brazil 

Infection Control Dept., Santa Casa Complexo Hospitalar, Universidade Federal do Rio Grande 

do Sul, Brazil 

Laboratory of Mycology, Hospital das Clinicas, Federal University of Paraná, Curitiba, Brazil 

Serviço de Oncohematologia / TMO, Hospital Univ. Prof. Edgard Santos - UFBA, Salvador, 

Bahia, Brazil 

Markus Hell 

Katharina 

Pfistershammer 

Katrien Lagrou, 

Johan, Maertens, 

Isabel Spriet 

Marcio Nucci 

Alessandro 

Pasqualotto 

Flávio de Queiroz 

Telles 

Marco Aurélio 

Salvino, Monica 

Botura 

Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil Denise Pereira 

Canada 

Department of Medicine, Peter Lougheed Center, Calgary, Canada Andrew Johnson 

Departments of Medicine & Microbiology and Immunology, McGill University, Montreal, 

Canada 

Don Sheppard 

Microbiology and Infectious Diseases, SMBD - Jewish General Hospital, Montreal, Canada Mark Miller 

Service de Maladies Infectieuses, Département de Pédiatrie, McGill University, Montreal, 

Canada 

Philipe Ovetchkine 


Laboratoire de santé publique du Quebec, Secteur Mycologie, Sainte-Anne-de Bellevue 

(Quebec), Canada 

Chile 

Philippe Dufresne 

Facultad de Medicina, Universidad de Valparaíso, Chile Thomas Weitzel 

Unidad de Infectología, Clínica Alemana, Santiago de Chile, Chile Luis Thompson 

China 

Changhai Hospital, Department of Hematology, Shanghai P.R., China Jian-Min Yang 

Institute of Hematology, Peking University People's Hospital, Beijing, China Feng-Rong Wang 

Department of Hematology, Guangdong General Hospital, Guangdong, China Xin Du 

Zhejiang University, School of Medicine, The First Affiliated Hospital, Bone Marrow 

Transplant Center, Hangzhou Zeijiang, China 

Columbia 

Conjunto Residencial Montevideo, Medellin, Columbia 

Croatia 

Division of Haematology, Zagreb University Hospital Centre, Zagreb, Croatia 

Cuba 

Instituto de Hematologia e Imunologia, Habana, Cuba 

Czech Republic 

Dept. of Internal Medicine, Hematology/Oncology, Faculty Hospital Brno, Brno, Czech 

Republic 

He Huang 

Angela Restrepo, 

Angela Tobón 

Nemet Damir, 

Vrohvac Radovan 

Alberto Arencibia 

Núñez 

Zdenek Racil 

Dept. of Microbiology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic Petr Hamal 

Denmark 


Dept. of Hematology, Copenhagen University Hospital, Copenhagen, Denmark 

France 

Département d'Hématologie, Hôpital Saint-Louis, Assistance Publique - Hôpitaux de Paris, 

and Université Denis Diderot, Paris, France 

Hematology and Oncology, University Hospital of Strasbourg Hautepierre Hospital, 

Strasbourg, France 

Germany 

Abteilung für Hämatologie, Onkologie und Rheumatologie, Universitätsklinikum Heidelberg, 

Heidelberg, Germany 

Jannik Helweg- 

Larsen, Emil 

Hermansen 

Emmanuel 

Raffoux, Patricia 

Ribaud 

Raoul Herbrecht 

Johann Wilhelm 

Schier 

Abteilung für Innere Medizin, Hämatologie u.Onkologie, Klinikum Frankfurt, Germany Michael Kiehl 

Abteilung für Kinder- und Jugendmedizin, Marienhospital Witten, Witten, Germany Bahman Gharavi 

Department of Infectious Diseases and Tropical Medicine, Ludwig-Maximilians-Universität 

München, Muenchen, Germany 

Thomas Loescher 

Dermatologie, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany Gesina Hansel 

Division of Clinical Infectious Diseases, Medical Clinic, Research Center Borstel, Borstel, 

Germany 

Gastroenterologie & Infektiologie, St. Josef Hospital, Klinikum der Ruhr-Universität Bochum, 

Bochum, Germany 

Christoph Lange 

Renate 

Schlottmann 

Abt. Hämatologie und Onkologie, Georg-August-Universität, Goettingen, Germany Silke Neumann 

Hämatologie / Internist. Onkologie, Uniklinik Erlangen, Erlangen, Germany Wolf Rösler 

Hämatologie und Onkologie, Klinikum Ernst von Bergmann, Potsdam, Germany 

Hämatologie und Onkologie, Medizinische Klinik I, Kliniken Sindelfingen, Sindelfingen, 

Germany 

Angelika Gerhardt, 

Georg 

Maschmeyer 

Stefan Neuburger 


Hämatologie und Onkologie, Universitätsklinikum Freiburg, Freiburg, Germany 

Hämatologie/Onkologie/Immunologie/Rheumatologie, Klinikum Schwäbisch Gmünd, 

Stauferklinik, Mutlangen, Germany 

HNO-Klinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany 

Hartmut Bertz, 

Werner C. 

Neubauer 

Holger Hebart 

Katrin Gollner, 

Kathrin 

Scheckenbach 

II. Medizinische Klinik, Einheit für Stammzelltransplantation, Klinikum Augsburg, Augsburg Christoph Schmid 

III. Medizinische Klinik, Universitätsklinikum Mannheim , Mannheim, Germany 

Dieter Buchheidt, 

Anne Dietz 

Infektiologikum Frankfurt, Frankfurt, Deutschland Gaby Knecht 

Institut für Infektiologie, Asklepios Klinik St. Georg, Hamburg, Germany M. Sabranski 

Institut für Medizinische Mikrobiologie und Hygiene, Universität Lübeck, Lübeck, Germany Jan Rupp 

Institut für Medizinische Mikrobiologie, Universitätskliniken Göttingen, Göttingen, 

Deutschland 

Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Germany 

Uwe Groß 

Claudia 

Wickenhauser 

Institut für Tropenmedizin, Universitätsklinikum Düsseldorf, Düsseldorf, Germany Stefan Reuter 

Interdisziplinäres Zentrum für Palliativmedizin, Agaplesion Markus Krankenhaus, Frankfurt 

am Main, Germany 

Kinderkardiologie und Pädiatrische Intensivmedizin, Klinikum der Universität München- 

Großhadern, München, Germany 

Sabine Mousset 

Markus Loeff 

Klinik III für Innere Medizin, Uniklinik Ulm, Ulm, Germany Georg Härter 

Klinik f. Hämato-Onkologie, Klinikum Harlaching, Städtisches Klinikum München GmbH, 

München, Germany 

Klinik für Anaesthesiologie und Operative Intensivmedizin, Klinikum Konstanz, Konstanz, 

Germany 

Klinik für Dermatologie, University of Tübingen, Tübingen, Germany 

Meinolf Karthaus, 

Xavier Schiel 

Wolfgang Krüger 

Sybille Schmidt, 

Martin Schaller 


Klinik für Hals-, Nasen- und Ohrenheilkunde, Klinikum der Universität München-Großhadern, 

München, Germany 

Klinik für Hämatologie und Onkologie, Vivantes Krankenhaus, Berlin, Germany 

Klinik für Hämatologie, Onkologie & Palliativmedizin, Städt. Kliniken Bielefeld gem.GmbH, 

Bielefeld, Germany 

Klinik für Hämatologie, Onkologie und Klin. Immunologie, Universitätsklinikum Düsseldorf, 

Düsseldorf, Germany 

Klinik für Hämatologie/Internistische Onkologie und Stammzelltransplantation, Kliniken Essen 

Süd, Essen, Germany 

Robert Guerkov 

Jörg Beyer, Markus 

Müller 

Martin Görner 

Thomas Schröder 

Mohammed 

Wattad 

Klinik für Infektiologie und Tropenmedizin, LMU, München, Germany Thomas Loescher 

Klinik für Innere Medizin IV, Onkologie und Hämatologie, Martin-Luther-University Halle- 

Wittenberg, Halle, Germany 

Maximilian 

Christopeit, Hans- 

Heinrich Wolf 

Klinik für Knochenmarktransplantation, Universitätsklinikum Essen, Essen, Germany Rudolf Trenschel 

Klinik für Neonatologie, Universität zu Bonn, Bonn, Germany Cornelia Graef 

Klinik für Nephrologie, Universitätsklinikum Essen, Essen, Germany Oliver Witzke 

Klinik für Neurochirurgie, Charité-Universitätsmedizin Berlin, Berlin, Germany Olaf Süss 

Klinik für Neurologie, Helios-Klinikum Berlin-Buch, Berlin, Germany Franz-Josef Dieste 

Klinik für Innere Medizin II, Sektion Infektiologie, Universitätsklinikum Jena, Jena, Germany Matthias Pletz 

Klinik I für Innere Medizin, Uniklinik Köln, Köln, Germany 

Klinik und Poliklinik für Innere Medizin C, Hämatologie und Onkologie - 

Transplantationszentrum Universitätsklinikum der Ernst-Moritz-Arndt-Universität Greifswald, 

Greifswald, Germany 

Klinik und Poliklinik für Innere Medizin, Abteilung für Hämatologie und Onkologie, 

Universitätsklinikum Rostock, Rostock, Germany 

Oliver Cornely, 

Fedja Farowski, 

Maria Vehreschild, 

Jörg Janne 

Vehreschild, 

Kerstin Wahlers 

William Krüger, 

Katrin Schulz 

Kersten Borchert, 

Lena Diestel, 

Michael Schmitt 


Klinik und Poliklinik für Orthopädie, Uniklinik Köln, Köln, Germany Rolf Sobottke 

Klinik und Poliklinik für Kinderheilkunde – Pädiatrische Hämatologie/Onkologie - Uniklinik 

Münster, Münster, Germany 

Klinikum Dortmund Nord, Abteilung Pneumologie/Infektiologie, Dortmund, Germany 

Andreas Groll 

Jörg Ritter 

Bernhard Schaaf, 

Stefanie Später, 

Greta Ullrich 

Klinikum Neuperlach, Medizinische Klinik IV, München, Germany Meinolf Karthaus 

Medizinische Klinik 5 – Hämatologie und Internistische Onkologie, Uniklinik Erlangen, 

Erlangen, Germany 

Medizinische Klinik 5 – Hämatologie und Internistische Onkologie, University of 

Witten/Herdecke, Köln, Germany 

Stefan Kallert, 

Stefan Krause 

Stefan Sauerland 

Medizinische Klinik A, KMT-Zentrum, Uniklinik Münster, Münster, Germany Gerda Silling 

Medizinische Klinik I, Klinikum Bremen-Mitte, Bremen, Germany Henrike Thomssen 

Medizinische Klinik III, Klinikum der Universität München-Großhadern, München, Germany 

Helmut Ostermann 

Lisa Peterson 

Medizinische Klinik und Poliklinik I, Uniklinik Dresden, Dresden, Germany Ulrich Schuler 

Medizinische Klinik und Poliklinik II, Charité-Universitätsmedizin Berlin, Berlin, Germany Markus Ruhnke 

Medizinische Klinik und Poliklinik II, Universität Würzburg, Würzburg, Germany 

Werner Heinz, 

Jürgen Löffler, 

Hartwig Klinker, 

Bhanu Sinha, 

Andrew Ullmann 

Medizinische Klinik und Poliklinik II, Universitätsklinikum Schleswig-Holstein, Kiel, Germany Heinz-A. Horst 

Medizinische Klinik und Poliklinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany Gerlinde Egerer 

Medizinische Poliklinik, Klinikum der Universität München-Großhadern, Müuenchen, 

Germany 

Johannes Bogner 

MVZ Labor Dr. Krause und Kollegen, Kiel, Germany Ralf Bialek 

Mykologisches Labor, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany Irina Vennewald 

Onkologikum Frankfurt, Frankfurt, Germany Angelika Böhme 


Pädiatrische Hämatologie und Onkologie Infektiologie, Zentrum der Kinderheilkunde, 

Universität zu Bonn, Bonn, Germany 

Rheumatologische Ambulanz, Sana Rheumazentrum Rheinland-Pfalz AG, Bad Kreuznach, 

Deutschland 

Arne Simon 

Eckhard Weber 

Robert Koch Institut, Abteilung für Infektionskrankheiten,Berlin, Germany Volker Rickerts 

Universitätsklinikum Freiburg, Freiburg, Germany Helmut Lang 

Zentrum für Infektiologie und Reisemedizin, Universitätsklinikum Freiburg, Freiburg, 

Germany 

Zentrum für Kinder- und Jugendmedizin, Klinik III, Klinikum der Johann Wolfgang Goethe- 

Universität, Frankfurt am Main, Germany 

Dirk Wagner 

Thomas 

Lehrnbecher 

Institut für Hygiene, Kliniken der Stadt Köln, Krankenhaus Merheim, Köln, Germany Frauke Mattner 

Institut für Medizinische Mikrobiologie, Universitätsklinikum Essen, Essen, Germany Jörg Steinmann 

Greece 

1st Department of Propaedeutic Medicine, Athens University, Athens, Greece Anna Skiada 

Cystic Fibrosis Department, Aghia Sophia Children´s Hospital, Athens, Greece 

Infectious Diseases and Antimicrobial Chemotherapy Research Laboratory, Athens University, 

Athens, Greece 

Stavros 

Doudounakis 

George L. Petrikkos 

Laboratory for Clinical Microbiology, Attikon University General Hospital, Athens, Greece Joseph Meletiadis 

Hungary 

Department of Microbiology, Faculty of Science and Informatics, University of Szeged, 

Szeged, Hungary 

India 

Department of Medical Microbiology, Postgraduate Institute of Medical Education & 

Research, Chandigarh, India 

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & 

Research, Chandigarh, India 

Dept. of Microbiology, Centre for Basic Sciences, Kasturba Medical College, Manipal 

University, Manipal, India 

Lorant Hatvani 

Arunaloke 

Chakrabarti 

Ritesh Agarwal 

Prakash 

Yegneswaran 


Indonesia 

Department of Internal Medicine University of Indonesia, Faculty of Medicine University of 

Indonesia, Mangunkusumo Hospital, Jakarta, Indonesia 

Ireland 

Erni J Nelwan 

Dept. of Bacteriology, Belfast City Hospital, Belfast, Ireland John E. Moore 

Trinity College, Dublin Saint James Hospital, Dublin, Ireland Thomas Rogers 

Israel 

Department of Otolaryngology – Head & Neck Surgery, Edith Wolfson Medical Center, Holon, 

Israel 

Yehudah Roth 

Hadassah University Medical Center, Jerusalem, Israel Maya Korem 

Infectious Diseases Unit, Rabin Medical Center, Petah Tikva, Israel Morad Wattad 

Sheba Medical Center Israel, Tel Aviv, Israel Nathan Keller 

Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Ronen Ben-Ami 

Italy 

Department of Biomedical Science and Human Oncology — Hygiene Section, University of 

Bari, Bari, Italy 

Maria Teresa 

Montagna 

Dipartimento di Ematologia, Universita Cattolica del Sacro Cuore, Rome, Italy Livio Pagano 

Dipartimento di Farmacologia, Università degli Studi di Firenze, Firenze, Italy Andrea Novelli 

Divisione di Ematologia e Trapianto di Midollo Osseo, Ospedale San Martino, Genova, Italy Andrea Bacigalupo 

Hematology Unit, San Camillo-Forlanini Hospital, Rome, Italy Mariagrazia Garzia 

Istituto di Microbiologia, Universita Cattolica del Sacro Cuore, Rome, Italy 

Laboratorio di Micologia Medica, Sezione Sanità Pubblica, University of Milan, Milan, Italy 

Oncoematologia Pediatrica, Policlinico G.B. Rossi, Verona, ItalyClinica di Oncoematologia 

Pediatrica, Azienda Ospedaliera Padova, Padova, Italy 

Maurizio 

Sanguinetti 

Annamaria 

Tortorano 

Simone Cesaro 

Pathology Unit, Luigi Sacco Hospital, University of Milan, Milan, Italy Gianluigi Vago 


Japan 

Division of Control and Treatment of Infectious Diseases, Chiba University Hospital, Chiba, 

Japan 

Katsuhiko Kamei, 

Akira Watanabe 

Nagasaki University Hospital, Nagasaki, Japan Shigeru Kohno 

Seirei Hamamatsu General Hospital, Shizuoka, Japan Shinichiro Morioka 

Korea 

Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea Joon Seong Park 

Hematology-Oncology Clinic, Hematopoietic Stem Cell Transplantation Center, Center for 

Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Korea 

Kuwait 

Hyeon Seok Eom 

Microbiology Department, Health Sciences Center, Kuwait, Kuwait Eiman Mokaddas 

Lebanon 

American University of Beirut Medical Center, Beirut, Lebanon 

Lithuania 

Souha Kanj- 

Sharara 

Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania Marius Miglinas 

Vilnius University Hospital, Department of Hematology, Vilnius, Lithuania Indre Klimiene 

Mexico 

Hospital Civil de Guadalajara, Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico, 

Hospital General de Culiacán, Sinaloa, Mexico 

IXtlamatia Clinical Research S.A. de C.V, Mexico City, Mexico 

Netherlands 

Eduardo 

Rodriguez-Noriega 

Ramón Rivas 

Llamas 

Miguel Ángel 

Reséndiz 

Department of Medical Microbiology, Canisius-Wilhelmina Hospital, Nijmegen, Netherlands Jacques Meis 

University Medical Center Groningen, Groningen, the Netherlands Jan P. Arends 


Peru 

Hematology/ BMT Department, Rebagliati National Hospital, Lima, Peru 

Portugal 

Eduardo 

Fernandez-Vertiz 

Coimbra University Hospital, Coimbra, Portugal Rui Tome 

Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal Rita Caramalho 

Romania 

Department of Mycology-Mycotoxicology, Universitatea Petre Andrei, Iasi, Romania Mihai Mares 

Russia 

Department of Clinical Mycology, Allergology and Immunology, St. Petersburg Medical 

Academy of Postgraduate Education, St. Petersburg, Russia 

Singapore 

Nikolay Klimko 

Sofya Khostelidi 

Infectious Diseases Care, 03-01 Mount Elizabeth Medical Centre, 228510 Singapore Asok Kurup 

National University Health System, University Medicine Center, Division of Infectious 

Diseases, NUHS Tower Block, Level 10, 119228 Singapore 

National University Health System, University Children\'s Medical Institute, Department of 

Pediatrics, 119228 Singapore, Singapore 

Slovakia 

Chai Louis Yin Ann 

Si Min Chan 

National Cancer Institute, Bratislava, Slovakia Lubos Drgona 

South Africa 

Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa Robert Dunn 

Nelson R. Mandela School of Medicine, Pretoria, South Africa Teke Apalata 

Spain 

Department of Hematology, University Hospital La Fe, Valencia, Spain, Valencia, Spain 

Grupo Andaluz de Leucemias Agudas GALA, Hospital Juan Ramón Jiménez-Huelva, Huelva, 

Spain 

Rebeca Rodriguez 

Veiga 

Eusebio Martín 

Chacón 


Servicio de Hematología de la Unidad de Consejo y Cuidado Oncológico de Sanitas, Hospital 

de la Princesa, Madrid, Spain 

Rafael de la 

Cámara 

Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, Sevilla, Spain Martin-Pena 

Almudena 

Sweden 

Clinical Micrbiological Laboratory, Sunderby Hospital, Luleå, Luleå, Sweden Peter Cettner 

Switzerland 

Abt. für Spitalhygiene und Spitalepidemiologie, Universitätsspital Basel, Basel, Switzerland Andreas Widmer 

Division of Infectious Dieseases & Hospital Epidemiology, Universitätsspital Basel, Basel, 

Switzerland 

U. Flueckiger 

Medizin I Abteilung für Hämatologie, Universitätsspital Basel, Basel, Switzerland Alois Gratwohl 

Institut für Infektionskrankheiten, Bern, Switzerland Stefan Zimmerli 

Universitätsklinik für Pneumologie, Inselspital, Universitätsspital Bern, Bern, Switzerland Sebastian Ott 

University Hospital Lausanne (CHUV), Lausanne, Switzerland Andrej Trampiz 

Taiwan 

Far Eastern Memorial Hospital, Taipei, Taiwan Chiaying Liu 

Tai-Chen Stem Cell Therapy Center, National Taiwan University, Taipeh, Taiwan Jih-Luh Tang 

Division of Infectious Diseases, Department of Internal Medicine, Center For Infection 

Control, National Taiwan University Hospital, Taipei, Taiwan 

Thailand 

Division of Infectious Diseases and Tropical Medicine, Khon Kaen University, Khon Kaen, 

Thailand 

Turkey 

Yee-Chun Chen 

Ploenchan 

Chetchotisakd 

Akdeniz University Medical Faculty, Department of Clinical Microbiology, Antalya, Turkey Dilara Ogunc 

Department of Medicine, Section of Infectious Diseases, Hacettepe University Medical 

School, Ankara, Turkey 

Murat Akova, 

Sevtap Arikan, 

Omrun Uzun 


Division of Hematology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey Fatih Demirkan 

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Baskent 

University, Ankara, Turkey 

Can Boga 

Beyoglu Eye Training and Research Hospital, Istanbul, Turkey Serhat Imamoglu 

Dokuz Eylul University Hospital, Department of Hematology, Izmir, Turkey 

United Kingdom 

Omur Gokmen 

Sevindik 

Department of Infection, St George's University of London, London, United Kingdom Jon Lambourne 

NPHS Microbiology ABM (Swansea and Bridgend), Wales, United Kingdom Nidhika Berry 

Princess Royal University Hospital, South London Healthcare NHS Trust, Farnborough 

Common, Orpington, Kent, United Kingdom 

M. Mansour 

Ceesay 

Southern General Hospital, Glasgow, United Kingdom Nitish Khanna 

USA 

Department of Infectious Diseases, Section of Transplant Infectious Diseases, Medicine 

Institute and Transplant Center, Cleveland Clinic Lerner College of Medicine of Case Western 

University, Cleveland, Ohio, USA 

Sherif Beniameen 

Mossad 

Department of Pathology, University of Colorado, Denver, USA Diane Hutchinson 

Division of Infectious Diseases, University of Washington Office, Washington, USA Philip Coffin 

University of Alabama at Birmingham, Birmingham, USA John Baddley 

University of Texas Southwestern Medical Center at Dallas, Dallas, USA Sanjay Revankar 

Medical Microbiology Division, Department of Pathology, University of Iowa College of 

Medicine, Iowa City, IA, USA 

Linda Boyken 

MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana, USA Patricia Connolly 

Division of Medical Microbiology, Department of Pathology The Johns Hopkins University 

School of Medicine, Baltimore, MD, USA 

Division of Infectious Diseases Director, Microbiology & Infectious Diseases Translational 

Research Center Henry Ford Hospital, Wayne State University School of Medicine, Detroit, MI 

Sean Zhang 

Jose. A Vasquez

Fungiscope - ISHAM

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