Fungiscope - ISHAM

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Introduction The incidence of invasive fungal infections (IFI) is increasing in all parts of the world. The etiology for this ongoing epidemiological development is not completely understood. However, major contributing factors are the increasing number of transplantation procedures undertaken around the world (estimated at 500,000 per year), a widening of the indications for intensive chemotherapy, and the growing number of other clinical conditions requiring immunosuppressive treatment. Therapeutic standards have been developed for the most frequent IFI, i.e. candidiasis, aspergillosis and cryptococcosis. However, the so called “emerging fungi” are also a reason for the increased number of IFIs. Thus, clinicians are now facing infections due to a variety of different fungi without any reliable treatment recommendations and therapeutic decision making is not evidence based. Prevalence of “emerging fungi” is virtually unknown and there is an additional knowledge gap in pathogen biology, since isolates have not been collected systematically. In order to overcome the lack of knowledge on epidemiology, clinical course, biology and pathomechanisms, and finally to develop an evidence based diagnostic-therapeutic integrated approach of IFI caused by “emerging fungi”, A Global Emerging Fungal Infection Registry – <strong>Fungiscope</strong> has been created. <strong>Fungiscope</strong> uses a web-based electronic case form accessible via www.fungiscope.net. For inclusion into the registry patients require cultural, histopathological, serological or molecular evidence of IFI and the associated clinical symptoms and signs. The clinical data on underlying disorder and IFI will be collected and stored in an internet-based database. Additionally, the pathogen strains and samples of infected tissue are collected, examined and stored in a bio-bank – the Fungithek. The clinical and biological data are subsequently evaluated and analysed. Figure 1a and b present the data / sample flow and overall project structure. The clinical database and the bio-bank are connected and accessable to the public via a web-based search engine - FungiQuest (figure 2). In the following report we introduce the most current results and achievements. We also discuss future goals and ongoing developments of the project. Report December 2012 Page 6 of 34
Figure 1a: Project structure Report December 2012 Page 7 of 34
Page 1 and 2: Global Emerging Fungal Infection Re
Page 3 and 4: Study Co-ordinators Clinical ID Mic
Page 5: Clinical ID Microbiology Molecular
Page 9 and 10: Figure 2: FungiQuest database searc
Page 11 and 12: Figure 3: Distribution of 299 patho
Page 13 and 14: Figure 5: Case contributions by cou
Page 15 and 16: Figure 7: Sites of infection for ma
Page 17 and 18: Presentations 2010 - 2012 Achieveme
Page 19 and 20: Initiation of an analysis of combin
Page 21 and 22: Argentina Participating Institution
Page 23 and 24: Laboratoire de santé publique du Q
Page 25 and 26: Hämatologie und Onkologie, Univers
Page 27 and 28: Klinik und Poliklinik für Orthopä
Page 29 and 30: Indonesia Department of Internal Me
Page 31 and 32: Peru Hematology/ BMT Department, Re
Page 33 and 34: Division of Hematology, Dokuz Eylul

Fungiscope - ISHAM

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