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A <strong>CONTRIBUTION</strong> <strong>TO</strong> <strong>THE</strong> <strong>DEBATE</strong> <strong>OVER</strong> <strong>THE</strong> <strong>ORIGIN</strong> <strong>AND</strong> DEVELOPMENT<br />
OF TREPONEMAL DISEASE: A CASE STUDY FROM SOU<strong>THE</strong>RN ILLINOIS<br />
By<br />
Twana Jill Golden<br />
BA, Southern Illinois University Carbondale, 2004<br />
A Thesis<br />
Submitted in Partial Fulfillment<br />
Of the Requirements for the<br />
Master of Arts Degree<br />
Department of Anthropology<br />
In the Graduate School<br />
Southern Illinois University<br />
Carbondale<br />
December 2007
UMI Number: 1450022<br />
UMI Microform 1450022<br />
Copyright 2008 by ProQuest Information and Learning Company.<br />
All rights reserved. This microform edition is protected against<br />
unauthorized copying under Title 17, United States Code.<br />
ProQuest Information and Learning Company<br />
300 North Zeeb Road<br />
P.O. Box 1346<br />
Ann Arbor, MI 48106-1346
<strong>THE</strong>SIS APPROVAL<br />
A <strong>CONTRIBUTION</strong> <strong>TO</strong> <strong>THE</strong> <strong>DEBATE</strong> <strong>OVER</strong> <strong>THE</strong> <strong>ORIGIN</strong> <strong>AND</strong> DEVELOPMENT<br />
OF TREPONEMAL DISEASE: A CASE STUDY FROM SOU<strong>THE</strong>RN ILLINOIS<br />
By<br />
Twana Jill Golden<br />
A Thesis Submitted in Partial<br />
Fulfillment of the Requirements<br />
for the Degree of<br />
Master of Arts<br />
in the field of Anthropology<br />
Approved by:<br />
Susan M. Ford, Chair<br />
Tracy Prowse<br />
Heather Lapham<br />
Graduate School<br />
Southern Illinois University Carbondale<br />
November 2007
AN ABSTRACT OF <strong>THE</strong> <strong>THE</strong>SIS OF<br />
TWANA JILL GOLDEN, for the Master of Arts degree in Anthropology, presented on<br />
May 11, 2007, at Southern Illinois University at Carbondale.<br />
TITLE: A <strong>CONTRIBUTION</strong> <strong>TO</strong> <strong>THE</strong> <strong>DEBATE</strong> <strong>OVER</strong> <strong>THE</strong> <strong>ORIGIN</strong> <strong>AND</strong><br />
DEVELOPMENT OF TREPONEMAL DISEASE: A CASE STUDY FROM<br />
SOU<strong>THE</strong>RN ILLINOIS.<br />
MAJOR PROFESSOR: Dr. Susan M. Ford<br />
There is a long-standing debate over the origin of syphilis, one of the treponemal<br />
diseases. Some researchers believe syphilis originated in the Old World but was<br />
misdiagnosed as such diseases as leprosy or tuberculosis (Baker and Armelagos 1988;<br />
Rothschild & Rothschild 1996). Others believe syphilis originated in the New World and<br />
was brought to the Old World by Columbus’ crew in 1493; still others believe treponemal<br />
disease originated in Africa spreading with humans as they migrated throughout the<br />
world, mutating to form the syndromes: pinta, yaws, bejel and venereal syphilis (Ortner<br />
2003).<br />
This study explores the possible presence of treponemal disease in Pre-Columbian<br />
North America. 54 individuals from the Archaic Period (4000-2900 BC) site of Carrier<br />
Mills in Saline County, Southern Illinois were examined for characteristic signs of<br />
treponemal disease, including 9 infants, 2 adolescents and 43 adults. Analysis suggests<br />
many individuals suffered from some syndrome closely matching the expected effects of<br />
a treponemal disease. Osteitis, periosteal reaction, lesions, joint fusion, and saber shins<br />
i
were among the characteristics found in this population. Therefore, the Black Earth site<br />
of the Carrier Mills Archaeological District in southern Illinois provides strong evidence<br />
of treponemal disease in the New World prior to 1493 AD.<br />
ii
ACKNOWLEDGMENTS<br />
First, I would like to express my deepest sincerities to God and to my family, my<br />
mother Helen, my father Larry, my brother Brad, and my grandmother Mary Jane for all<br />
that they have done for me. For helping me make it through many tough times in<br />
graduate school, for their emotional support, words of encouragement, and for helping<br />
me to become the person I am today. I wouldn’t be where I am today without them!<br />
Special thanks are also due to my wonderful committee members: Dr. Susan M.<br />
Ford (chair) for all of her encouragement and confidence in me, Dr. Heather Lapham for<br />
all of her help and allowing me the space at Stotlar to conduct my research, and Dr. Tracy<br />
Prowse, whose enthusiasm with the “skellies” helped me to find a new appreciation for<br />
my research. I would also like to thank Dr. Robert S. Corruccini for all of his advice,<br />
everyone at the Center for Archaeological Investigations and our wonderful anthropology<br />
secretaries, Tedi Thomas and Becki Bondi, for all of their help and support through<br />
graduate school.<br />
I would like to extend a great round of applause to all of my fabulous friends who<br />
took the time to listen and ask me questions to help me figure out what the bones were<br />
telling me. To Jennifer, Jeff, Mags, Kate, Val, Kim, Jess, and Erica for their support<br />
throughout graduate school when times were so tough. And last but not least, to<br />
everyone in my cohort and the Newman Community. I love you all!<br />
Thanks and God Bless you all!<br />
iii
TABLE OF CONTENTS<br />
Abstract............................................................................................................................. i<br />
Acknowledgements......................................................................................................... iii<br />
Table of Contents............................................................................................................ iv<br />
List of Tables .............................................................................................................. vi<br />
List of Figures ............................................................................................................. vii<br />
Chapter 1 Introduction ......................................................................................................1<br />
Chapter 2 Theories and Etiologies....................................................................................5<br />
2.1 Hypotheses of the Origin of Treponemal Disease .............................................5<br />
2.2 Hypotheses of the Development of Treponemal Disease..................................6<br />
2.3 Syndromes of Treponemal Disease ...................................................................9<br />
2.3.1 Yaws ....................................................................................................10<br />
2.3.2 Endemic Syphilis .................................................................................13<br />
2.3.3 Venereal Syphilis.................................................................................15<br />
2.3.4 Congenital Syphilis..............................................................................17<br />
2.4 Other Studies of Treponematoses ....................................................................19<br />
2.5 Other Similar Diseases.....................................................................................24<br />
2.5.1 Tuberculosis.........................................................................................24<br />
2.5.2 Leprosy ................................................................................................28<br />
2.5.2.1 Lepromatous Leprosy (LL)......................................................29<br />
2.5.2.2 Tuberculoid Leprosy (TT) .......................................................30<br />
2.5.3 Tumors .................................................................................................31<br />
2.5.4 Osteomyelitis .......................................................................................32<br />
2.5.5 Paget’s Disease ....................................................................................34<br />
2.6 Differential Diagnosis......................................................................................35<br />
2.7 Objectives ........................................................................................................38<br />
Chapter 3 Materials and Methods...................................................................................40<br />
3.1 Materials ..........................................................................................................40<br />
3.1.1 The Sample – Carrier Mills Archaeological District ...........................40<br />
3.1.2 Burial Population – Black Earth Site...................................................41<br />
3.2 Methods............................................................................................................44<br />
3.3 Summary..........................................................................................................49<br />
Chapter 4 Results ............................................................................................................55<br />
4.1 Likelihood of Treponemal Disease..................................................................55<br />
4.1.1 Certain..................................................................................................59<br />
iv
4.1.2 Highly Likely.......................................................................................63<br />
4.1.3 Possible ................................................................................................64<br />
4.1.4 None.....................................................................................................66<br />
4.1.5 Differential Diagnosis and Summary...................................................66<br />
4.2 Type of Treponemal Disease ...........................................................................68<br />
4.2.1 Bone Groups ........................................................................................69<br />
4.3 Comparison of Findings...................................................................................71<br />
4.4 Summary..........................................................................................................73<br />
Chapter 5 Discussion and Conclusions.........................................................................109<br />
5.1 Differential Diagnosis of Treponemal Disease..............................................109<br />
5.2 Comparisons to Other Sites ...........................................................................111<br />
5.3 Carrier Mills – Life in the Archaic ................................................................116<br />
5.3.1 General Middle and Late Archaic......................................................117<br />
5.3.2 Inferences of Life at Carrier Mills .....................................................117<br />
5.4 History and Origin of Treponemal Disease ...................................................121<br />
5.5 Conclusions....................................................................................................123<br />
Literature Cited ............................................................................................................125<br />
Appendices....................................................................................................................137<br />
A Differential Diagnosis......................................................................................137<br />
B Summary of Burials .........................................................................................145<br />
Permission Letter to Use Maps............................................................................163<br />
Vita ..............................................................................................................................164<br />
v
LIST OF TABLES<br />
TABLE 3.1 – Total Sample versus sub-sample..............................................................51<br />
TABLE 4.1 – Pathological Markers of Infants...............................................................76<br />
TABLE 4.2 – Pathological Markers of Adolescents ......................................................78<br />
TABLE 4.3 – Pathological Markers of Young Adults ...................................................80<br />
TABLE 4.4 – Pathological Markers of Middle Adults...................................................84<br />
TABLE 4.5 – Pathological Markers of Old Adults ........................................................88<br />
TABLE 4.6 – Summary and Percentages of Possible Treponemal Markers..................90<br />
TABLE 4.7 – Percentages of Possible Treponemal Disease ..........................................94<br />
TABLE 4.8 – Bone Groups of Infants............................................................................95<br />
TABLE 4.9 – Bone Groups of Adolescents....................................................................96<br />
TABLE 4.10 – Bone Groups of Young Adults...............................................................97<br />
TABLE 4.11 – Bone Groups of Middle Adults..............................................................99<br />
TABLE 4.12 – Bone Groups of Old Adults .................................................................101<br />
TABLE 4.13 – Bone Groups of Carrier Mills compared to Confirmed Disease..........102<br />
vi
LIST OF FIGURES<br />
FIGURE 3.1 – Carrier Mills Archaeological District.....................................................52<br />
FIGURE 3.2 – Carrier Mills Archaeological Sites (Areas A, B, C).............................. 53<br />
FIGURE 3.3 – Map of Archaic Period Burials...............................................................54<br />
FIGURE 4.1 – Percentages of Treponemal Markers in Juveniles and Adults..............103<br />
FIGURE 4.2 – Percentages of Treponemal Markers in Males, Females, and<br />
Total Sample .........................................................................................104<br />
FIGURE 4.3 – Likelihood of Treponemal Disease in Individuals at Carrier Mills......105<br />
FIGURE 4.4 – Burial 38 Drawing of skull showing location of lesions ......................106<br />
FIGURE 4.5 – Burial 38 Left 3 rd metacarpal with unifocal bone loss and<br />
woven bone ...........................................................................................107<br />
FIGURE 4.6 – Burial 38 Right tibia posterior midshaft 6 lesions with woven and<br />
sclerotic reaction ...................................................................................107<br />
FIGURE 4.7 – Burial 38 Left fibula lateral close up of cloaca ....................................108<br />
FIGURE 4.8 – Burial 38 Left 1 st metatarsal plantar with woven and sclerotic<br />
reaction..................................................................................................108<br />
vii
CHAPTER 1<br />
INTRODUCTION<br />
“The ‘Great Pox’ spread rapidly, afflicting victims with suppurating sores that ate<br />
away flesh and bone and was followed by deformity, insanity and death” (Pook 2001:1).<br />
This was believed to be the “Wrath of God,” his punishment for decadence and<br />
immorality (Salt 2002). The “Wrath of God” is better known today as syphilis. Syphilis,<br />
or the “Great Pox,” as it was referred to in Medieval times, was for most people a<br />
terrifying disease with many consequences. The biggest question to revolve around the<br />
disease of syphilis is its place of origin: just where did this foul disease originate?<br />
In anthropology today, there is a long-standing debate concerning the origin of<br />
treponemal disease. This debate began near the end of the 19 th century (Ortner 2003) and<br />
includes two major themes: 1) where did the first treponemal disease originate; and 2) is<br />
treponemal disease one syndrome or several different syndromes, known collectively as<br />
treponematoses? Some researchers argue that syphilis originated in the Old World but<br />
was not diagnosed as syphilis until the fifteenth century, due to its similarities to other<br />
diseases such as leprosy and tuberculosis (Holcomb 1934; Crosby 1969; Rothschild and<br />
Rothschild 1996; Bogdan and Weaver 1992). Other scholars argue that syphilis<br />
originated in the New World and was brought to the Old World by Christopher Columbus<br />
and his crew in 1493 AD, following their return from the New World (Baker and<br />
1
Armelagos 1988; Cockburn 1963). Still other theories suggest that syphilis originated in<br />
Africa, spreading as humans migrated throughout the world and becoming the syndromes<br />
of treponemal disease we know today (Hudson 1965; Ortner 2003; Bogdan & Weaver<br />
1992).<br />
In order to study disease in ancient populations, we must turn to the discipline of<br />
paleopathology. Paleopathology is the “study of disease, both human and nonhuman, in<br />
antiquity using a variety of different sources including human mummified and skeletal<br />
remains, ancient documents, illustrations from early books, painting and sculpture from<br />
the past, and analysis of coprolites” (Ortner 2003:8). In studying ancient human remains<br />
we can gain a glimpse of what ancient peoples’ lives might have been like.<br />
Paleopathology is particularly important in the study of archaeological human<br />
remains. In these ancient contexts, written records of health and medical practices are<br />
often missing (Lovell 2000). Paleopathology aims to rebuild the life of diseases<br />
historically and geographically, to shed light on cultural processes and their interaction<br />
with disease, to trace the evolution of diseases through time, and to gain a better<br />
understanding of disease processes and how they affect the growth and development of<br />
bone through the study of human archaeological remains (Ibid.).<br />
The most important step in paleopathological investigation is a clear description<br />
of the changes observed on the bones and the documentation of these changes (Lovell<br />
2000). Part of documenting the changes involves recording any patterns of lesions found<br />
on the bone and also within the individual. If lesions are found on the bones, it is<br />
important to identify the specific bone, the section of bone involved, the aspect of the<br />
bone, and the distribution of the lesions on the bone (Ibid.).<br />
2
When pathological lesions are found on the bones of an individual, we must ask<br />
ourselves 1) if the lesions occur on one side of the body or if they are bilateral when<br />
paired bones are present, 2) if there are similar lesions elsewhere on the skeleton of the<br />
individual, and 3) if there are different types of lesions on the skeleton (Lovell 2000).<br />
These types of questions are crucial in the differential diagnosis of skeletal lesions (Ibid.).<br />
Treponemal disease is but one of many different diseases that affect the human<br />
skeleton. Treponematosis, along with tuberculosis, leprosy, tumors, osteomyelitis, and<br />
Paget’s disease leave destructive lesions on the skeleton. The lesions of these diseases<br />
are so similar that differential diagnosis becomes difficult. Hence, the distribution of<br />
lesions within the skeleton of an individual and within the sample become very important<br />
factors.<br />
The purpose of this research is to contribute to the debate on the origin and<br />
development of treponemal disease. Was treponemal infection present in the New World<br />
prior to 1493 AD? Powell and Cook (2005:4) state that treponemal disease has been<br />
present in North America “at least fifteen centuries before the first voyage of Columbus.”<br />
According to Rothschild (2003; 2005), the oldest known skeletal population in North<br />
America to exhibit treponemal infection inhabited the Windover site in Florida, which<br />
dates to approximately 7900 B.P. Other sites where treponematoses have possibly been<br />
detected in North America include: Carrier Mills in Illinois (ca. 6300 B.P.); the Ward site<br />
in Kentucky (ca. 4300 B.P.); the Lu-25 site in Alabama (ca. 4300 B.P.); the Oconto<br />
County site in Wisconsin (ca. 3250 B.P.); Frontenac Island in New York (ca. 2000 B.P.),<br />
Libben in Ohio (1200-850 B.P.) and Amaknak in Alaska (Rothschild 2003; 2005). Was<br />
treponemal infection found in Illinois prior to 1493 AD and, if so, during what time<br />
3
period did it originate? According to Baker and Armelagos (1988), treponemal disease<br />
has existed in Illinois for the past 3,000 years. Most of the sites discussed are from the<br />
Middle to Late Woodland (1000 BC – AD 1000) and Mississippian (AD 1000 – 1400)<br />
periods; two sites mentioned date to the Late Archaic (3000 – 1000 BC) period, the<br />
Klunk site (920 BC) (Powell et al. 2005) and the Morse site (1500 – 1000 BC) (Baker<br />
and Armelagos 1988). Is there more evidence supporting the presence of a treponemal<br />
infection from the Archaic period in Illinois? This research provides strong evidence<br />
that a treponemal disease did exist within the Archaic period sample of the Carrier Mills<br />
Archaeological District. Further analysis provides confirmation that a non-venereal form<br />
of treponemal disease, similar to yaws, was present in Illinois prior to 1493 AD.<br />
The importance of this research is to help elucidate the place of origin of<br />
treponemal disease so that the disease itself may be better understood. This study is just<br />
one component of this ongoing debate. The many components together will tell us where<br />
treponemal disease originated, so that we can learn how it spread and whether or not it is<br />
one or several different syndromes. Studies of disease in ancient populations provide<br />
insight into the geographical and chronological distribution of disease, responses to<br />
stress, the conditions of a society and its growth and how the society functioned as a<br />
whole (Armelagos 1969). Cultural differences, life patterns and life-span may also be<br />
inferred from the skeletons through examination of burial practices, burial goods, the<br />
determination of age and sex, and overall health of the individuals in the sample. This<br />
research and analysis will use a narrow focus on the paleopathological evidence found in<br />
the Carrier Mills Archaeological District to determine the presence or absence of<br />
treponemal disease and to also attempt to address some of these larger issues.<br />
4
CHAPTER 2<br />
<strong>THE</strong>ORIES <strong>AND</strong> ETIOLOGIES OF DISEASES<br />
2.1 Hypotheses of the Origin of Treponemal Disease<br />
There are two major hypotheses concerning the geographic origin of syphilis.<br />
The first one is the Columbian Hypothesis, based on statements from Columbus’<br />
contemporaries Ulrich von Hutten and Ruy Diaz de Isla that Christopher Columbus and<br />
his crew brought syphilis back to Europe upon their return in 1493 from the New World,<br />
where syphilis supposedly originated (Crosby, Jr 1972; see also: Baker and Armelagos<br />
1988; Bogdan and Weaver 1992; Cook 1993; Rodríguez-Martín 2000). This theory<br />
gained its’ popularity in the sixteenth century and is still used today. Crosby (1969)<br />
states that the “pox” was brought back from the New World to the Old World by<br />
Columbus and his crew in the 1490’s. The evidence he gives is the historical accounts of<br />
the physicians and the historians at the time of the epidemic. The reports that exist were<br />
written after the epidemics, but Crosby (1969) suggests that the reason for this is that the<br />
more prominent people of the times wanted to suppress any and all negative reports about<br />
the New World. Therefore, with the absence of written reports, perhaps lost or buried in<br />
archives until after the epidemics, and with the agreement of the disease being new to<br />
Europe, treponemal disease must have originated in the Americas.<br />
5
The second hypothesis is the Pre-Columbian Hypothesis, which suggests that<br />
syphilis existed in the Old World long before Christopher Columbus’ historic journey to<br />
the New World. Since leprosy already existed in the Old World, researchers from the<br />
1400’s and 1500’s (Francisco Villalobos, John Maynard, Petrus Andraes Matthiolous,<br />
Ruiz Diaz de Isla) believed that syphilis may have been misdiagnosed as leprosy<br />
(Holcomb 1934). In other words, doctors in Medieval times thought the two diseases<br />
were one based upon their similar symptoms and did not realize that a separate disease<br />
even existed other than leprosy (Baker and Armelagos 1988; Bogdan and Weaver 1992;<br />
Rodríguez-Martín 2000). Cockburn (1963:154) states that the original peoples of the<br />
“New World were already infected when they first crossed the Bering land bridge tens of<br />
thousands of years ago.” Humans carried many different parasites with them when they<br />
began migrating to other lands, including some form of treponeme. This means that<br />
treponemal disease was everywhere that humans inhabited before the time of ocean travel<br />
(Cockburn 1963), hence before Christopher Columbus sailed the ocean blue.<br />
2.2 Hypotheses on the Development of Treponemal Disease<br />
In addition to the two major hypotheses regarding the geographic origin of<br />
syphilis, there are three major hypotheses involving the development of the syndromes.<br />
These hypotheses are referred to as the Unitarian Hypothesis, the Non-Unitarian<br />
Hypothesis, and Livingston’s Alternative Hypothesis. The Unitarian Hypothesis suggests<br />
only a single treponematosis was present in both the Old and New Worlds before<br />
Columbus’ journey. This theory, proposed by Hudson (1965), suggests that since there<br />
6
were no specific differences between the bacteria of the four syndromes, the syndromes<br />
should all be classified as strains of one disease known as treponematosis. This<br />
treponemal disease is extremely flexible and evolved with various human populations,<br />
forming the different syndromes that are known today. Hudson (1965) also proposes that<br />
yaws was the first treponematosis and that it probably originated in sub-Saharan Africa,<br />
accompanying humans as they extended their range through migrations to other lands. As<br />
humans migrated, the climate changed, causing yaws to evolve into endemic<br />
treponematosis (Ibid.). Humans became more sedentary and villages emerged. Endemic<br />
treponematosis flourished through children because the barriers of clothing and personal<br />
hygiene had not come into effect yet (Ibid.). Other changes occurred as urban life<br />
emerged, discouraging the spread of endemic treponematosis and encouraging venereal<br />
treponematosis. The sexually transmitted bacteria became more successful within<br />
sedentary villages due to natural selection. The mode of transmission remained the same,<br />
direct contact of an open sore but because humans changed their behaviors, the bacteria<br />
found new ways to invade the host. Treponemal disease then would be a biological<br />
gradient based on each person’s physical and cultural states, presenting itself as different<br />
clinical patterns according to climate and human behaviors such as better hygiene,<br />
wearing more clothing and improved living conditions (Ibid.).<br />
The Non-Unitarian Hypothesis suggests that there are four treponematoses; pinta,<br />
yaws, endemic syphilis, and venereal syphilis, resulting from the mutations of the first<br />
treponemal bacteria (Aufderheide and Rodríguez-Martín 1998; Rodríguez-Martín 2000).<br />
Hackett (1967) proposes that before 20,000 B.C., the first treponemal disease would have<br />
been pinta, which arose from an animal infection. A genetic mutation, which took place<br />
7
about 10,000 B.C., resulted in yaws, a much more invasive disease with tissue<br />
destruction. The next mutation occurred about 7,000 B.C., also the time when a climatic<br />
change occurred in Africa, Asia and Australia, which resulted in endemic syphilis, in<br />
these dry, warmer regions of the world. A third mutation occurred around 3,000 B.C.,<br />
that resulted in a mild form of venereal syphilis. The last mutation occurred in late<br />
fifteenth century in Europe, with a much more serious form of venereal syphilis occurring<br />
as the result (Ibid.). As humans began to cluster in villages and wear more clothing, the<br />
treponemal bacterium had to adapt to its human host in order to survive. The changing<br />
environmental conditions along with the mutations in the bacteria meant that bacteria that<br />
were transmitted through sexual contact were the favored bacteria. The bacteria that<br />
were transmitted through skin-to-skin contact were the bacteria that died out.<br />
The last hypothesis is Livingston’s Alternative Hypothesis. Livingstone (1991)<br />
believes that there is not enough evidence to assume that the treponemal diseases have<br />
adapted in humans throughout human evolution because it is a newer disease, which has<br />
mutated into several different syndromes of treponemal infection, but was introduced to<br />
the New World at the time of Columbus (Ibid.). He suggests that the increase in rates of<br />
the treponemal disease in cases in the Americas is due to an introduction of an extremely<br />
toxic form of treponemal infection from the Old World as a result of increased contact<br />
with Africa (Livingstone 1991; Rodríguez-Martín 2000). This would have been a new<br />
strain of treponemal infection to the Europeans, which would have resulted in a low<br />
immunity to the disease, causing it to spread rapidly through the sexual practices in<br />
Europe at this time, thus increasing the virulence or infectiousness of the disease<br />
(Aufderheide and Rodríguez-Martín 1998; Rodríguez-Martín 2000).<br />
8
Of these hypotheses of origin and development, it is likely that the disease<br />
developed due to a variety of factors. Treponemal disease likely originated with humans,<br />
spreading as humans migrated to new lands. Therefore, treponemal disease would have<br />
existed in both the Old and New Worlds before Columbus’ journey. It is likely that the<br />
syndromes of treponematoses are all different syndromes that have existed independently<br />
in different parts of the world at different times and, in other times coexisting in the same<br />
parts of the world. Now that we have some idea of the hypotheses concerning the origin<br />
and development of treponemal disease, the four syndromes of treponemal disease are<br />
described in detail in the following section.<br />
2.3 Syndromes of Treponemal Disease<br />
They were byles, sharpe, and standynge out, hauynge the<br />
simylitude and quantite of acornes, from which came so foule humours,<br />
and so great stinche, that who so ever ones smelled it, thoughte hym selfe<br />
to be enfecte. The colour of these pusshes [pustules] was derke grene, and<br />
the syghte therof was more grevouse unto the patiente than the peyne it<br />
selfe: and yet their peynes were as thoughe they had lyen in the fyre<br />
(Ulrich von Hutten 1540:2).<br />
This was the first recorded description of syphilis from the 1500’s. Today’s<br />
description is much more scientific, but not significantly different in detail. The first<br />
symptom of syphilis is a painless ulcer or chancre (Lukens 2005). After the chancre<br />
9
develops, various skin eruptions follow which contain mucous patches that ooze<br />
yellowish-greenish pus.<br />
Treponemal disease is a chronic infectious disease caused by the bacterium<br />
Treponema pallidum. These bacteria are known as spirochetes. The disease caused by<br />
Treponema pallidum can be broken down into four different syndromes, with a fifth<br />
syndrome being transmitted congenitally. The syndromes are: Pinta, Yaws, Endemic<br />
Syphilis, Venereal Syphilis and Congenital Syphilis. The differences among the<br />
syndromes mostly depend upon the geographic region in which the infected individual<br />
lives (Larsen 1997; Aufderheide and Rodríguez-Martín 1998; Ortner 2003). Listed<br />
below are the syndromes of syphilis with a brief description of each one, except for Pinta<br />
(Treponema pallidum careteum) which affects only the skin and will not be discussed<br />
here because it cannot be found in the archaeological record. Appendix A is a key of<br />
differential diagnosis between yaws, endemic syphilis, venereal syphilis, congenital<br />
syphilis, tuberculosis, leprosy, tumors, osteomyelitis and Paget’s disease.<br />
2.3.1 Yaws<br />
Yaws (Treponema pallidum pertenue) is a chronic, recurrent, infectious, non-<br />
venereal form of the treponematoses that is usually acquired in childhood through direct<br />
contact of an open sore or indirect contact by flies or other insects. Therefore, yaws is<br />
most often seen in children and adolescents (Ortner 2003; Aufderheide and Rodríguez-<br />
Martín 1998). Transmission may also occur congenitally (Ortner 2003). Congenital<br />
yaws results when a woman acquires yaws later in life, transmitting the bacteria to the<br />
fetus via the bloodstream. This does not mean that a young pregnant woman acquiring<br />
10
yaws cannot pass the pathogen to the fetus, but that if an older pregnant woman acquires<br />
yaws, she is more likely to pass the pathogen to her fetus, since yaws is typically acquired<br />
in childhood. Only the skin and bones are affected by this treponemal disease. Yaws can<br />
occur in three different stages. The first stage is characterized by the “mother yaw,” or<br />
the first lesion. This mother yaw appears at the initial site of infection, usually the legs,<br />
between five to eight weeks after the initial exposure (Powell and Cook 2005). The<br />
mother yaw will become larger or thicker, circular, and begin to itch resulting in a tumor<br />
that will eventually form a lesion. This stage can last for six months and it ends with the<br />
mother yaw healing spontaneously (Powell and Cook 2005; Aufderheide and Rodríguez-<br />
Martín 1998).<br />
After a period of latency, the second stage begins with similar lesions to the<br />
mother yaw. The lesions from this second stage form a general pattern all over the body<br />
(Powell and Cook 2005). These lesions are small and either de-pigmented or hyper-<br />
pigmented. If this stage is not treated, it can last up to five years, alternating between<br />
remissions and relapses (Ibid.). Bone lesions may occur at this stage in the shafts of long<br />
bones, the paranasal maxillae, or the hand phalanges. Plantar lesions may also develop in<br />
the feet causing severe debilitation and resulting in individuals walking on the edges of<br />
their feet (Ibid.).<br />
The final or tertiary stage is the most destructive stage of yaws, occurring after a<br />
period of latency that can last for several years. This is the stage that has the most<br />
extensive skeletal lesions. Although very destructive to skin, mucous tissues and bone,<br />
the central nervous system, cardiovascular system and internal organs are not affected,<br />
which is seen in venereal syphilis (Powell and Cook 2005). The most common bone<br />
11
affected is the tibia, followed by the fibula, clavicle, femur, ulna, radius and bones of the<br />
hands and feet (Aufderheide and Rodríguez-Martín 1998). The most typical or<br />
characteristic feature of this stage is the saber shin, also known as “boomerang leg”<br />
(Roberts and Manchester 1995; Ortner 2003). Saber shin is a remodeling of the anterior<br />
crest of the tibia, followed by bone deposition. Rarely the posterior aspect of the tibia’s<br />
shaft is changed. This remodeling of bone results in a curved appearance similar to that<br />
of a cavalry saber blade, hence the name saber shin (Powell and Cook 2005).<br />
Another feature that characterizes yaws is dactylitis (Aufderheide and Rodríguez-<br />
Martín 1998; Douglas et al.1997). Dactylitis is a bone change occurring in the hands that<br />
leads to enlargement of the phalanges. These bony changes in the hands are more<br />
common in young individuals and are uncommon in venereal syphilis (Aufderheide and<br />
Rodríguez-Martín 1998). Skull lesions are uncommon in yaws, but when they do occur,<br />
they are less severe than cases with venereal syphilis. The frontal or parietals may have<br />
shallow, pitted cortical lesions but the most destructive lesions are more likely to occur in<br />
the nasal-pharyngeal region of the cranium (Powell and Cook 2005). Seven to 8% of<br />
cases with skeletal involvement have extensive destruction of the nasal area and of the<br />
maxilla (Aufderheide and Rodríguez-Martín 1998). This results in the condition known<br />
as gangosa (Roberts and Manchester 1995). Gangosa is the destructive ulceration of the<br />
nasal-palatal region of the face. In 5% of cases with gangosa, perforation of the hard<br />
palate occurs, and it is more severe than in cases found with venereal syphilis<br />
(Aufderheide and Rodríguez-Martín 1998). Nasal-palatal destruction and tibial<br />
involvement are frequently found in yaws.<br />
12
Differential diagnosis between yaws and venereal syphilis can be very<br />
complicated. For this reason, geographic factors play an important role in the diagnosis<br />
of yaws (Aufderheide and Rodríguez-Martín 1998). Yaws is generally found in rural<br />
areas of western and equatorial Africa, Latin America, the Caribbean Islands, Southeast<br />
Asia, North Australia, New Guinea, and the islands of the Southern Pacific Ocean<br />
(Aufderheide and Rodríguez-Martín 1998; Roberts and Manchester 1995). Rothschild<br />
(2003) speculates that yaws may be the treponemal infection that was present in North<br />
America before Columbus’ journey.<br />
2.3.2 Endemic syphilis<br />
Endemic syphilis (Treponema pallidum endemicum) is an acute, infectious<br />
disease that occurs primarily in children between the ages of two and ten years within<br />
rural areas. Transmission of endemic syphilis occurs directly and indirectly through<br />
contact of the infectious lesions of the skin and mucous membranes or through<br />
contaminated linens. The infection may be spread by the shared use of eating and<br />
drinking implements, such as pipes, toothpicks, or cigarettes (Aufderheide and<br />
Rodríguez-Martín 1998; Powell and Cook 2005). The initial lesion is small, painless, and<br />
often unobserved resulting in a cutaneous and mucosal rash with inflammatory<br />
destructive lesions on the skin, bones and the naso-pharyngeal region (Powell and Cook<br />
2005; Aufderheide and Rodríguez-Martín 1998). A latent period can occur for months or<br />
even years, followed by infectious lesions that have a hard irregular center consisting of<br />
dead cells and pus. These lesions affect the skin, nasopharynx and bones (Powell and<br />
13
Cook 2005). Spontaneous healing of the lesions may occur, but the damage they cause<br />
can be debilitating.<br />
The skeletal lesions that occur in endemic syphilis are almost identical to those<br />
occurring in yaws (Aufderheide and Rodríguez-Martín 1998). These skeletal lesions are<br />
also morphologically indistinguishable from the skeletal lesions of venereal syphilis<br />
(description provided below). The differences between yaws and endemic syphilis can<br />
be seen when looking at the population as a whole. In an epidemiological approach,<br />
Rothschild et al. (2000) describe endemic syphilis as having a high population frequency,<br />
occurring in both subadults and adults, affecting few bone groups and very little if any<br />
involvement of the hands and feet, unlike yaws. With endemic syphilis, as with the other<br />
treponematoses, the tibia is the most frequently affected bone, with the typical features<br />
being the deformity of the saber shin (Aufderheide and Rodríguez-Martín 1998; Roberts<br />
and Manchester 1995). Some of the other more commonly involved bones include the<br />
fibula, ulna, radius, clavicle, phalanges and calcaneus (Aufderheide and Rodríguez-<br />
Martín 1998). Nasal-palatal destruction and tibial involvement are frequently found in<br />
this syndrome. Transmission does not occur congenitally, thus endemic syphilis does not<br />
leave any traces on the teeth such as the commonly found Hutchinson’s incisors or<br />
mulberry molars that are found in congenital syphilis, which are discussed below (Ibid.).<br />
Endemic syphilis has a low mortality rate and acts as an endemic disease, limited<br />
to regions of low socioeconomic levels and bad hygiene (Aufderheide and Rodríguez-<br />
Martín 1998). This syndrome is often found in arid and warm climates of the eastern<br />
Mediterranean Sea, southwestern Asia, and sub-Saharan Africa (Ibid.). Rothschild<br />
14
(2003) speculates that not only yaws but also endemic syphilis was present in North<br />
America before Columbus’ journey.<br />
2.3.3 Venereal Syphilis<br />
Venereal syphilis (Treponema pallidum pallidum) is an acute, sub-acute, or<br />
chronic infectious disease that has three different phases and is the most dangerous of the<br />
syndromes (Aufderheide and Rodríguez-Martín 1998; Powell and Cook 2005).<br />
Transmission occurs directly through sexual contact. Indirect transmission can occur<br />
through infected objects such as needles or nonsexual contact of an open sore<br />
(Aufderheide and Rodríguez-Martín 1998).<br />
Venereal syphilis is characterized in its primary stage by a lesion or chancre at the<br />
point of entry (Ortner 2003). A period of incubation occurs for approximately three<br />
weeks. After this period a small, painless chancre appears on the genitals (Powell and<br />
Cook 2005). If the chancre is not treated, the bacteria will rapidly multiply, spreading<br />
throughout the body via the bloodstream (Ortner 2003). This leads to the secondary stage<br />
which includes a variety of lesions appearing on the skin and genitals (Powell and Cook<br />
2005).<br />
In the secondary stage a rash develops, which affects the skin and mucous<br />
membranes (Aufderheide and Rodríguez-Martín 1998). The lesions in this stage are<br />
highly infectious. The bones of the distal limbs are often involved, resulting in periostitis<br />
and osteitis. The various lesions in this phase usually occur in the first year, but they can<br />
last up to four years (Powell and Cook 2005).<br />
15
After a period of latency, the tertiary stage develops. In this third stage the<br />
lesions that occur affect the skin, skeletal, cardiovascular, and central nervous systems in<br />
20 - 50% of cases, if left untreated (Aufderheide and Rodríguez-Martín 1998). This is<br />
why venereal syphilis is the most dangerous syndrome. Seventy percent of all the<br />
skeletal lesions occur on the tibia, cranial vault, and bones of the nasal cavity (Ortner<br />
2003). This syndrome has been nicknamed the “Great Imitator” because the symptoms<br />
of this disease are so variable and many resemble those of other diseases, such as leprosy,<br />
tuberculosis, tumors, osteomyelitis, and Paget’s disease (Aufderheide and Rodríguez-<br />
Martín 1998).<br />
Aufderheide and Rodríguez-Martín (1998) state the most characteristic skeletal<br />
lesions of venereal syphilis are those of the skull, specifically the parietal and the frontal<br />
bones. This characteristic is known as Caries sicca and is manifested as sunken,<br />
destructive areas of bone loss and bone growth forming an irregular surface on the cranial<br />
vault. In other words, the cranial vault contains a series of hills and valleys instead of<br />
being smooth. Other commonly affected bones include the tibia, nasal-palatal region,<br />
sternum, clavicle, vertebrae, femur, fibula, humerus, ulna and radius (Ibid.). Of the<br />
previous bones named, the tibia exhibits syphilitic lesions ten times more often than the<br />
others (Bogdan and Weaver 1992). Ortner (2003) states the spine is rarely involved, but<br />
when it is involved, the cervical vertebrae are most often affected. Nasal-palatal<br />
destruction can be found in a less severe form than seen in yaws, and the most commonly<br />
affected joint is the knee (Aufderheide and Rodríguez-Martín 1998; Roberts and<br />
Manchester 1995).<br />
16
2.3.4 Congenital Syphilis<br />
Venereal syphilis can also be transmitted from the mother to the fetus, which<br />
results in congenital syphilis. This may occur in two ways. First, congenital syphilis<br />
may be transmitted from a mother with venereal syphilis, through the placenta to the<br />
fetus, infecting the fetus with spirochetes (bacteria). The infected fetus will either be<br />
aborted or die soon after birth (Aufderheide and Rodríguez-Martín 1998). The<br />
spirochetes cause a degeneration of the cells that develop into bone. This results in a 50<br />
% fatality rate of affected fetuses, but in the case of a mild infection, infants may live for<br />
many years with a dormant phase of congenital syphilis (Ibid.). The second way that<br />
transmission may occur is during birth as the infant passes through the birth canal of an<br />
infected mother (Powell and Cook 2005).<br />
Congenital syphilis can be divided into two different phases, an early phase and a<br />
late phase. The early phase occurs in infants from birth to four years (Powell and Cook<br />
2005). The most characteristic symptom in newborns is rhinitis, which is an<br />
inflammation of the mucous membranes in the nose (Lukens 2005). This inflammation<br />
causes the formation of the permanent central incisors and first molars to be disrupted,<br />
resulting in the dental stigmata of congenital syphilis described below. A rash develops<br />
on the surfaces of the hands, feet, anus and mouth (Powell and Cook 2005). The skeletal<br />
system becomes involved, leading to osteochondritis (i.e. inflammation of the bone and<br />
cartilage), perichondritis (i.e., an inflammation of the connective tissue membrane that<br />
surrounds the cartilage) and periostitis (i.e., an inflammation of the membrane of<br />
connective tissue that covers all bones). The shafts of the tibiae are the most commonly<br />
involved long bones, but any bone can be involved. Infants who survive this stage will<br />
17
have lesions that heal spontaneously, so much so that there are no traces of the lesions<br />
later in life (Ibid.).<br />
According to Aufderheide and Rodríguez-Martín (1998), osteochondritis of the<br />
metaphysis is found in the majority of the archaeological specimens. Periostitis of the<br />
tibia and the femur can also be found (Ortner 2003). The most frequently involved bones<br />
are the tibia, radius, ulna and the cranium (Aufderheide and Rodríguez-Martín 1998).<br />
The late phase of congenital syphilis occurs in children and adolescents from five<br />
to fifteen years of age (Powell and Cook 2005). This is the phase where disfiguration of<br />
the cranium occurs. Saddle nose may occur which results in the bridge of the nose<br />
collapsing. Other alterations of the skull include Parrot’s sign (prominent frontal bosses),<br />
a high palatal arch, and a disproportionate size of the maxillae and mandible (Ibid.).<br />
Postcranial alterations of the skeleton include flaring scapulae, thickening of the sternum<br />
and clavicles, swelling of the knees, and saber shins. The alterations to the skeleton<br />
discussed here remain with the individual throughout life (Ibid.).<br />
According to Cook (1993) and Aufderheide and Rodríguez-Martín (1998),<br />
characteristics to look for in the teeth of an individual with congenital syphilis are<br />
Hutchinson’s incisors, mulberry molars and Moon’s molars, which may also be<br />
associated with saddle nose. Hutchinson’s incisors are permanent central incisors that<br />
are smaller than normal and exhibit a shallow notch in the middle of the incisal edge, a<br />
screwdriver shape, the presence of a diastema between the incisors, a dirty grey surface,<br />
with the crown surfaces tapering mesially and distally (Shafer et al. 1974; Hillson 1996;<br />
Pindborg 1970; Hillson et al. 1998). Moon’s molars or bud molars are permanent first<br />
molars exhibiting a clinched appearance of the crown, a narrow occlusal area giving the<br />
18
tooth a domed or bud-like appearance, and bulbous crown formation (Colby et al.1971;<br />
Hillson 1996; Hillson et al.1998). Fournier’s or mulberry molars are permanent first<br />
molars with the occlusal surface altered so that it looks like a mulberry and the tooth is<br />
also smaller than the normal first and second molars (Hillson 1996; Pindborg 1970). The<br />
permanent canines, both upper and lower, may also be affected, but these changes are not<br />
as noticeable as with the permanent incisors and molars. A hypoplastic defect occurs on<br />
the canines in the form of a circular groove around the tip of the tooth (Hillson et al.<br />
1998; Jacobi et al. 1992). This circular groove may become a shallow notch due to<br />
attrition. The canine may also be yellowish in color and may have a puckered appearance<br />
(Jacobi et al. 1992).<br />
2.4 Other Studies of Treponematoses<br />
Brothwell (1970) suggested an evolutionary tree for the treponemes which<br />
included extinct forms of the disease. The evolutionary tree began at the base with a non-<br />
human treponeme branching into two forms, one branch for extinct forms and one branch<br />
for pinta. The tree trunk then continues branching to form yaws, then possibly another<br />
branch for more extinct forms, with the trunk continuing until it branches off with<br />
endemic syphilis and then finally branching into venereal syphilis. This tree would<br />
represent various forms of the treponemes advancing to more complicated forms which<br />
would not be ancestral to the varieties of treponemes that occur today (Brothwell 1970).<br />
My point here is that another form of treponematosis could have been present in North<br />
America besides the syndromes of yaws, endemic syphilis, and venereal syphilis we<br />
19
know today. This other form could have existed for thousands of years and then due to<br />
forces of natural selection, it could have become selected against and died, thus becoming<br />
extinct.<br />
In 1995 Rothschild, Hershkovitz, and Rothschild proclaimed the earliest evidence<br />
of treponemal disease came from Homo erectus. They reanalyzed periosteal reaction<br />
patterns of several H. erectus skeletal remains housed at the National Museum of Kenya<br />
in Nairobi. They found involvement of the long bones and upper and lower extremities.<br />
The periosteal reaction distribution pattern most closely resembled that of yaws. Their<br />
study would confirm an African origin for treponemal disease dating to the Middle<br />
Pleistocene (Rothschild et al. 1995).<br />
Another study conducted by Rothschild and Rothschild (1996) resulted in<br />
conclusions about the effects of venereal syphilis, yaws and endemic syphilis on<br />
populations. Venereal syphilis had a low population frequency (5-14%), a median<br />
number of bone groups were affected (2), and saber shins occurred without remodeling,<br />
or no periosteal reaction was evident on the surface of bones. Bone involvement in<br />
children was also rare (Ibid.). For cases with yaws, there was a high population<br />
frequency (21-33%), a median number of bone groups were affected (4), the hands and<br />
feet were affected, bone lesions occurred in subadults, and saber shins exhibited<br />
periosteal reaction (Ibid.). Endemic syphilis occurred with a high population frequency<br />
(25-40%), a median number of bone groups were affected (2), saber shins showed<br />
evidence of periosteal reaction, and the hands and feet were rarely affected (Ibid.).<br />
Rothschild et al. (2000) state that tibial changes are found in 99% of individuals<br />
with treponemal disease and therefore the tibia is critical to diagnosis of treponemal<br />
20
infection. Treponemal disease can be recognized on the basis of periosteal reaction along<br />
with osteitis (Ibid.). Other diagnostic criteria include saber shin, the frequency of hand<br />
and foot involvement, and the number of bone groups affected (Ibid.). “Bone group” is<br />
an artificial construct used by Rothschild et al. (2000):<br />
“to quantitate the extent of skeletal involvement. Involvement of a skeletal<br />
component is treated as 1 bone group, whether that involvement is unilateral or<br />
bilateral. Carpal, tarsal, metacarpal, metatarsal, and phalangeal involvement are<br />
each considered single bone groups, whether ≥ 1 are affected.” (pg. 937).<br />
For example, the tibiae would be considered a bone group, as would the radii. Each<br />
group of bones in the hands and feet are considered a bone group. If one distal phalanx<br />
on the right hand is affected, then the hand phalanges are considered to be affected, no<br />
matter if it is the right or left side.<br />
In the study conducted by Rothschild et al. (2000), venereal syphilis was<br />
identified as affecting few bone groups (1.9), having a low population frequency (14% or<br />
less), unilateral tibial involvement and saber shin associated with periosteal remodeling.<br />
Yaws affected a median number of bone groups (4), had a high population frequency<br />
(more than 20%), affected the hands and feet frequently and produced bone lesions in<br />
subadults. Endemic syphilis affected few bone groups (2), exhibited a high population<br />
frequency (more than 20%), and occurred in subadults as well as adults (Ibid.).<br />
Rothschild et al. (2000) also found that in cases of yaws and endemic syphilis (bejel),<br />
21
subadults and adults were affected at the same frequencies, while in populations with<br />
syphilis, subadults were affected with a 5% or less frequency.<br />
The study conducted by Rothschild et al (2004) found some of the same results as<br />
the study by Rothschild (2005). Both studies found that bone involvement occurred in 2–<br />
13% of individuals with venereal syphilis, while individuals with yaws or endemic<br />
syphilis had bone involvement of 20–40%. Rothschild (2005) states the most critical<br />
skeletal criterion in diagnosing a treponemal disease is the pattern of periosteal reaction,<br />
tibial remodeling and bone destruction. This study also found that in cases of syphilis<br />
less than 5% of children have skeletal involvement. Children with yaws or endemic<br />
syphilis exhibited a rate of 10–20% skeletal involvement (Ibid.). Venereal syphilis rarely<br />
affected the hands and feet and the incisors and first molars were only affected in cases<br />
with venereal syphilis. Finally, the saber shin remodeling that occurs in venereal<br />
syphilis hinders the signs of periosteal reaction, making it difficult to see the actual<br />
reaction (Ibid.).<br />
In a study by Hutchinson and Richman (2006), skeletal samples were examined<br />
from the prehistoric southeastern United States to try to aid in the debate on the origin<br />
and geographic distribution of syphilis. The skeletal samples encompass a broad<br />
geographic and topographic range, including such time periods as the Archaic (8000 –<br />
1000 BC) through the protohistoric (AD 1500 – 1600) periods. Their study assesses the<br />
presence of treponemal disease, venereal and nonvenereal, in an evolutionary context<br />
according to geographic, physiographic, and temporal patterns of treponemal disease.<br />
Hutchinson and Richman (2006) suggest that increases in the frequency of positive cases<br />
are due to an increase in population density and changing human behaviors. In other<br />
22
words, the evolution of treponemal disease was caused by the changing environment and<br />
living conditions of the human host, instead of changes occurring within the pathogen<br />
itself. The bacteria, therefore did not change; genetically treponemal disease is one<br />
species that has adapted to the changing environment of the human host.<br />
Smith (2006) conducted a study on skeletal remains in the Western Tennessee<br />
River Valley consisting of eight sites spanning the Middle (6000-3000 BCE) to Late<br />
(2500-ca. 1000 to 500 BCE) Archaic and Early Woodland (500 BCE-0 CE) periods. Her<br />
study focused on sedentism and the advent of pottery, which she predicts can be<br />
correlated to the appearance of diseases like treponemal disease (Ibid.). The evidence of<br />
pottery at a site means that the community was using the site for long periods of time.<br />
This would mean that villages were beginning to emerge. The emergence of villages and<br />
a larger group of people living closer together would allow the spread of such diseases as<br />
the treponematoses.<br />
Smith (2006) found that out of 581 individuals, 13 (9 adults and 4 sub-adults)<br />
exhibited “periostitis pathognomonic or indicative of treponemal disease” (Smith<br />
2006:207). The syndrome believed to have affected these samples is of a non-venereal<br />
form. This evidence is pre-Columbian with an increase in frequency occurring after 1000<br />
CE. The increase in frequency was attributed to the advent of sedentism and agriculture<br />
(Ibid.).<br />
Levréro et al. (2007) conducted a recent study on a population of gorillas from the<br />
Republic of Congo who exhibited skin lesions indicative of yaws. In this study 17% of<br />
the 377 gorillas exhibited some type of lesion (Ibid.). The locations of the lesions were<br />
mainly on the faces of the gorillas. They found that in some instances the lesions were so<br />
23
deep that they produced debilitating handicaps (Ibid.). It is interesting that yaws affects<br />
gorillas in some of the same ways as it affects humans. Levréro et al. (2007) found that<br />
yaws affected young gorillas, males were affected more than females, unmated adult<br />
males suffered more with lesions, and in non-breeding groups the immature gorillas<br />
suffered more from yaws. With the presence of yaws among non-human primates, this<br />
study and others like it can help us to determine what life might have been like for our<br />
hominid ancestors who suffered from nonvenereal treponemal disease.<br />
2.5 Other Similar Diseases<br />
Treponemal disease produces effects on the bones of an individual that are very<br />
similar to other diseases. In the past others believed that perhaps syphilis was not<br />
recognized as a disease because it was so similar to tuberculosis or leprosy. Hackett<br />
(1967) states that leprosy was used as a blanket term to refer to several different diseases<br />
present in Europe in Medieval times. The Bible and medieval documents are used to<br />
demonstrate the confusion between syphilis and leprosy (Baker and Armelagos 1988).<br />
Here, I will describe the diseases of tuberculosis and leprosy, in order to aid in the<br />
process of differential diagnosis between treponematoses, tuberculosis, and leprosy.<br />
Other diseases that affect the skeleton in similar ways to treponemal disease include<br />
tumors, osteomyelitis and Paget’s disease. These other diseases will also be discussed in<br />
the section below.<br />
2.5.1 Tuberculosis<br />
24
Tuberculosis is an acute and chronic infectious disease caused by the bacterium<br />
Mycobacterium tuberculosis or M. bovis. M. tuberculosis is the most common bacterium<br />
that affects humans. M. bovis can also affect humans, but it is most commonly found in<br />
cattle (Ortner 2003). M. tuberculosis is transmitted from human to human through the air<br />
by inhaling bacteria within moisture droplets that have been spread into the air from the<br />
cough of an infected person (Aufderheide and Rodríguez-Martín 1998). The disease<br />
usually begins in the lungs as a respiratory infection. The bacteria then multiply in the<br />
lungs, spreading to surrounding tissues (Ibid.). The tissues may die, resulting in an area<br />
of scar tissue that may contain live M. tuberculosis bacteria that can remain dormant for<br />
some time. These dormant bacteria can reactivate the disease if other stressors affect the<br />
lung, such as invasion of the lung by cancer or from the person contracting HIV/AIDS<br />
(Powell 1992; Aufderheide and Rodríguez-Martín 1998). This process is known as the<br />
primary infection (Aufderheide and Rodríguez-Martín 1998). The primary infection can<br />
lead to a secondary infection by the dissemination of the bacteria via the blood stream to<br />
any or all of the organs in the body. Thus, the infection reaches the skeletal system via<br />
the bloodstream (Ortner 2003). The most important factor to remember in the destruction<br />
of the skeletal tissue is the “pattern of resorptive lesions with little evidence of<br />
proliferative, reactive changes” (Aufderheide and Rodríguez-Martín 1998:134). In other<br />
words, tuberculosis causes a resorption of bone with very little bone growth or evidence<br />
of a reaction occurring.<br />
Skeletal tuberculosis is most often found in areas of trabecular bone (Aufderheide<br />
and Rodríguez-Martín 1998). For this reason, the spine is involved in more than 40% of<br />
the skeletal lesions. The most common area of involvement in the vertebrae is the<br />
25
anterior surface of the thoracic or lumbar vertebral body, which occurs in approximately<br />
80% of cases (Ibid.). Erosion occurs producing an abscess that extends into the<br />
intervertebral space. Herniation of the intervertebral disk occurs, causing the spread of<br />
the abscess through the cartilaginous defect and into the vertebral body. This produces a<br />
“narrowing of the affected intervertebral disk space” (Aufderheide and Rodríguez-Martín<br />
1998:122). The abscess then progresses in a vertical fashion to an adjacent vertebral<br />
body, where the process occurs again. Posterior involvement of the vertebral body only<br />
occurs in approximately 20% of the cases of skeletal tuberculosis, with the same type of<br />
process occurring as in anterior vertebral body involvement. Occasionally the vertebral<br />
neural arch, processes or articular elements are directly involved (Ibid.). A progressive<br />
destruction of the vertebral body often leads to the collapse of the vertebral body. This<br />
collapse causes shortening of the trunk of the individual and anterior bending of the spine<br />
above the collapsed area, which is known as kyphosis. In kyphosis, usually two or three<br />
thoracic vertebrae are involved, but it may involve as many as six or more vertebrae<br />
(Ibid.). Only 10% of cases result in paraplegia, due to the compression of the spinal cord<br />
and nerves (Ibid.).<br />
Other sites of tuberculosis in the skeletal system involve the joints. Bacilli are<br />
disseminated to the trabecular bone of long bones, which resides in the metaphysis. Most<br />
often the hip and knee are involved (Aufderheide and Rodríguez-Martín 1998).<br />
Involvement of the hip occurs in 20% of cases, this being the second most frequent site of<br />
skeletal lesions (Ibid.). It is most common in children between the ages of three and ten<br />
(Ibid.). Most frequently bone destruction occurs in the acetabulum, but the femoral head,<br />
neck and trochanter may be affected. Dislocation of the hip may occur if there is<br />
26
extensive destruction of the area through exposure of the bone by ulceration of the<br />
cartilage (Ibid.). Exposure of the bone will result in bone-on-bone contact causing<br />
eburnation. Eburnation may cause the femur neck to crumble, thus dislocating the hip<br />
(Ibid.). Only 16% of cases of skeletal tuberculosis involve the knee, resulting in<br />
deforming lesions on the surface of the knee, and upper extremity joints are involved<br />
much less frequently (Ibid.).<br />
The ribs, flat pelvic bones, sternum, and sometimes the cranium in adults are<br />
involved (Aufderheide and Rodríguez-Martín 1998). Rib lesions occur in 9% of<br />
individuals with pulmonary tuberculosis (Ibid.). The internal surfaces of the ribs are<br />
affected by a mild to moderate periostitis. This usually involves several adjacent ribs<br />
with ribs four to eight being the most common ones involved. Sometimes the central<br />
portion of the rib body is involved, but rarely are the costal head and neck affected. Rib<br />
lesions are more common on the left side of the thorax (Ibid.). The cranium is rarely<br />
involved in tuberculosis, but when it does occur, it affects young adults almost<br />
exclusively. The most common area of involvement is the cranial vault. Here,<br />
tuberculosis appears as “small numerous areas of destruction, less than 2 cm in diameter,<br />
with poorly defined margins and some surrounding reactive sclerosis” (Aufderheide and<br />
Rodríguez-Martín 1998:140). The lesions often cross the sutures of the cranium, and the<br />
destruction starts on the outside and moves to the inside of the skull. The facial bones,<br />
mandible and cranial base may be involved, but it is rare (Ibid.).<br />
Since tubercular skeletal lesions that occur in areas other than spine are almost<br />
indistinguishable from other diseases, it is important to study the lesions and their<br />
distribution not only within the skeleton, but also within the population being examined.<br />
27
Only about 1% of all patients with tuberculosis have exhibited skeletal lesions<br />
(Aufderheide and Rodríguez-Martín 1998). The main difference between tuberculosis<br />
and treponemal disease is that tuberculosis destroys already existing bone tissue, while in<br />
treponemal disease there is a proliferation of new bone (Powell 1992). Tuberculosis does<br />
not produce new bone, it only destroys bone.<br />
2.5.2 Leprosy<br />
True leprosy was not known until after 300 BC (Baker and Armelagos 1988). In<br />
Medieval times leprosy was the term used for disfiguring, depigmenting diseases often<br />
spread by sexual contact, heredity, and breastfeeding. The transmission of leprosy in<br />
Medieval times was thought to be from sexual intercourse (Ibid.). Since leprosy is not<br />
transmitted sexually, nor is it hereditary, this gives reason to believe that venereal<br />
syphilis was confused as leprosy (Ibid.). On the other hand, Crane-Kramer (2002)<br />
disagrees that there was any confusion between leprosy and syphilis and provides an<br />
analysis of skeletal material (600 individuals) that suggests a diagnostic confusion<br />
between leprosy and syphilis did not exist in Medieval times.<br />
Leprosy, or Hansen’s disease, as it is sometimes referred to, is a chronic<br />
infectious disease caused by the bacterium Mycobacterium leprae. In humans it affects<br />
the skin, nasal tissues, peripheral nerves, and the skeleton (Aufderheide and Rodríguez-<br />
Martín 1998). Leprosy has a worldwide distribution, but it is more commonly found in<br />
tropical and subtropical areas of Asia, Africa, and the Americas (Ortner 2003). This<br />
disease is found more commonly in rural areas as opposed to urban ones (Aufderheide<br />
and Rodríguez-Martín 1998). Transmission occurs by the inhalation of the M. leprae<br />
28
acteria through moisture droplets in the air. Direct skin-to-skin contact may also<br />
transmit the bacterium from person-to-person through an ulcerated, infected lesion<br />
(Ibid.). The ratio of infected males to females is 2:1 (Ortner 2003). Bones are only<br />
directly involved in approximately 5% of all patients with leprosy (Ibid.). In leprosy,<br />
more commonly there is a resorption of bone, whereas bone lesions are less frequent.<br />
This resorption occurs in the nasal spine (Buckley and Tayles 2003). Leprosy has two<br />
main clinical forms: lepromatous leprosy (LL) and tuberculoid leprosy (TT) (Aufderheide<br />
and Rodríguez-Martín 1998). Both of these forms of leprosy are discussed below.<br />
2.5.2.1 Lepromatous Leprosy (LL). This form of leprosy creates alterations to the<br />
anterior face (Steyn and Henneberg 1995). It begins as a chronic “inflammation of the<br />
nasal mucous membrane” (Lukens 2005:1278), known as rhinitis. The nasal membrane<br />
forms lesions, becomes encrusted, and may bleed, which produces a perforation of the<br />
inner wall of the nose (Aufderheide and Rodríguez-Martín 1998). This infection may<br />
spread to the superior surface of the hard palate, to the nasal bone, nasal spine and the<br />
central maxilla. Erosion of these areas can lead to collapse of the bridge of the nose,<br />
resulting in the feature known as saddle nose, which is unique to lepromatous leprosy<br />
(Ibid.).<br />
If the lepromatous rhinitis spreads to the maxilla, it will erode the maxillary bone<br />
beginning in the midline and extending to the palate (Aufderheide and Rodríguez-Martín<br />
1998). This results in the loss of the upper central incisors and may even extend to the<br />
canines. The mandible is not affected. All of the facial changes discussed above are<br />
together known as facies leprosa, which can be seen in archaeological specimens (Ibid.).<br />
29
Postcranially the long bones of the extremities are sometimes affected, beginning<br />
with the metaphysis and possibly spreading to the epiphysis or medullary canal<br />
(Aufderheide and Rodríguez-Martín 1998). Involvement occurs more commonly in the<br />
hands and feet. In the hands, the most common area of involvement is the phalanges.<br />
Complete destruction of the distal phalanges may occur, which results in shortening of<br />
the fingers (Ibid.). In the feet, the metatarsals are the most commonly affected bones, as<br />
well as the talus and the calcaneus. This may result in club-shaped stumps for the feet<br />
(Ibid.). The bones of the hands and feet are very badly disfigured through the destruction<br />
that occurs from leprosy (Manchester and Roberts 1989).<br />
2.5.2.2 Tuberculoid Leprosy (TT). In tuberculoid leprosy the number of bacteria in the<br />
skin lesions are greatly reduced, which means that this form of leprosy is much less<br />
infectious (Aufderheide and Rodríguez-Martín 1998). The characteristic changes of<br />
facies leprosa present in lepromatous leprosy are absent in tuberculoid leprosy (Ibid.).<br />
Skin lesions are fewer in number, usually a single lesion occurs, but the lesions that do<br />
occur extend to much deeper levels. Similar effects on the bones are seen in lepromatous<br />
leprosy and tuberculoid leprosy, but the effects of tuberculoid leprosy on bones occur<br />
much earlier and more intensively than does lepromatous leprosy (Ibid.).<br />
Leprosy has been found to affect the tibia and fibula (Aufderheide and Rodríguez-<br />
Martín 1998). Here it produces pitting and longitudinally striated subperiosteal bone<br />
deposits. The lateral surface of the tibia also exhibits vascular grooves. The fibula is not<br />
as affected as the tibia. These changes often occur bilaterally and symmetrically in the<br />
tibia and fibula and are more prominent in the distal third portion of the bones (Ibid.).<br />
30
2.5.3 Tumors<br />
Treponemal disease can be very similar to many types of tumors also seen within<br />
the bones of an individual. The different tumors discussed here are osteosarcoma,<br />
meningioma, metastatic carcinoma, and multiple myeloma. Osteosarcoma is a malignant<br />
tumor that develops from the connective tissue of bone. In ancient remains they are most<br />
commonly found in individuals under the age of 30 and males are affected more often<br />
than females (Aufderheide and Rodríguez-Martín 1998; Ortner 2003). This tumor is<br />
found in long bones, most commonly the proximal femur and the head of the humerus.<br />
Osteosarcoma may also affect individuals over the age of 30. In this group, the tumor<br />
affects the flat bones and the skull, with the mandible frequently affected (Aufderheide<br />
and Rodríguez-Martín 1998). New bone formation may occur sometimes resulting in the<br />
appearance of an “onion skin.” Bone spicules that lie perpendicular to the affected bone<br />
surface may also occur. This characteristic is known as a ‘sunburst effect’ (Ibid.).<br />
Meningioma is a soft tissue tumor that affects the membranes of the brain and<br />
spinal cord. The skeletal evidence for these tumors can be found in the spine, but most<br />
are found inside the cranium. This tumor more commonly affects older individuals with<br />
the average age being 45 years (Aufderheide and Rodríguez-Martín 1998). Most of these<br />
lesions are found on the interior of the skull vault with hyperostosis occurring on the<br />
exterior above the lesion. The hyperostosis may be so pronounced that it causes a<br />
thickening of the skull. A spiculated appearance may result from these changes (Ibid.).<br />
Metastatic carcinoma is a malignant tumor occurring most commonly in<br />
individuals over the age of 40. The vertebrae, pelvis, ribs, major long bones, sternum and<br />
31
skull are the most commonly affected bones found in individuals suffering from this type<br />
of tumor (Aufderheide and Rodríguez-Martín 1998). Characteristics to look for in the<br />
archaeological record are pathologic fractures and vertebral collapse with multiple bone<br />
lesions (Ibid.).<br />
Multiple myeloma is a malignant tumor usually occurring in individuals over the<br />
age of 40 and more often in males than females (Ortner 2003). The lesions of this tumor<br />
are strictly lytic, restricted to a particular area, small and round, resorbing bone instead of<br />
producing new bone and having a scalloped edge (Aufderheide and Rodríguez-Martín<br />
1998; Ortner 2003). Most often the lesions are seen in the flat bones, particularly the<br />
skull. In the skull, the lesions can occur internally, externally or both. Eventually the<br />
inner and outer table of the skull is penetrated, resulting in a punched-out appearance. In<br />
the later stages of the disease, the lesions may affect the long bone metaphyses, especially<br />
in the femur and humerus, and collapse of the vertebral body may occur (Aufderheide<br />
and Rodríguez-Martín 1998; Ortner 2003). The most commonly affected bones are the<br />
vertebrae, ribs, skull, pelvis, femur, clavicle, and scapula (Aufderheide and Rodríguez-<br />
Martín 1998).<br />
2.5.4 Osteomyelitis<br />
Osteomyelitis is an infection within bone and bone marrow caused by bacteria<br />
that commonly produce pus (Aufderheide and Rodríguez-Martín 1998). It is<br />
distinguished from periostitis by the involvement of the marrow cavity. The most<br />
commonly affected areas are those of the knee, distal tibia, proximal femur, and<br />
sometimes the humerus is affected (Ibid.). All age groups and any part of the skeleton<br />
32
can suffer from osteomyelitis (Ortner 2003). In children, usually the proximal and distal<br />
ends of the bone are affected, the areas where growth occurs. In adults the ends of the<br />
bones as well as the shafts are affected (Aufderheide and Rodríguez-Martín 1998).<br />
Osteomyelitis usually only affects one bone, although multiple bones can be involved.<br />
The bones become enlarged and deformed through the processes of destruction of the<br />
bone and bone formation. Osteomyelitis is characterized by an area of dead bone that is<br />
surrounded by new bone and has a cloaca (hole) that allows pus to drain from the infected<br />
area. The dead bone is known as a sequestrum, while the new bone is an involucrum.<br />
Healing may occur, but some pitting and cavities will remain in the affected bone (Ibid.).<br />
Osteomyelitis is not commonly found in the bones of the hands and feet. If it<br />
does occur, an expanded involucrum will result which resembles changes found in<br />
congenital syphilis and tuberculosis found in children. In adults the foot phalanges are<br />
more apt to be involved (Ortner 2003). Osteomyelitis is not commonly found in the<br />
vertebrae. If it does occur, adults are affected more often than children, and usually only<br />
one vertebra is involved. The cervical vertebrae are most commonly involved with the<br />
sites of infection in the neural arch and spinous processes (Ibid.). It is also rare to find<br />
osteomyelitis in the skull. When it does occur, the most common area is that of the<br />
frontal bone. The infection will cross sutures, spreading throughout the cranial vault and<br />
into the parietals, but the occipital is rarely involved. The outer table is usually affected<br />
more than the inner table (Ibid.). Middle ear infections can result in osteomyelitis<br />
affecting the mastoid, temporal, and petrous bone, and the mandible and maxilla can also<br />
be affected (Ibid.). No matter what bone is affected, osteomyelitis is characterized by the<br />
presence of a sequestrum and an involucrum.<br />
33
2.5.5 Paget’s Disease<br />
The cause of this disease is unknown. Paget’s disease is characterized by both<br />
bone resorption and new bone formation that occurs simultaneously. The most common<br />
age group affected is those individuals over the age of 60, and males are more commonly<br />
affected than females (Aufderheide and Rodríguez-Martín 1998; Ortner 2003). Bones<br />
that are affected most commonly are the pelvis, femur, skull, tibia, vertebral column,<br />
clavicles and ribs. The fibula and the bones of the hands and feet are usually not<br />
involved (Ortner 2003). In the skull, both the inner and outer tables are thinned. In later<br />
stages of progression, new bone is produced on the inner and outer tables and also within<br />
the diploë. This phase may last for many years, producing a thickening of the cranium 2-<br />
3 cm in depth (Aufderheide and Rodríguez-Martín 1998). The infection usually crosses<br />
over the suture lines (Ortner 2003). The facial bones generally are not affected, but when<br />
they are, severe deformity is the result (Aufderheide and Rodríguez-Martín 1998; Ortner<br />
2003).<br />
Paget’s disease affects all areas of the vertebrae, mostly the lumbar, but the most<br />
noticeable changes occur on the vertebral body (Aufderheide and Rodríguez-Martín<br />
1998). The center of the vertebral body may become depressed, fusion of adjacent<br />
vertebral bodies may occur, and the outer edges may also become widened and dense<br />
(Ibid.).<br />
The long bones may also be affected by Paget’s disease. A thickening of the<br />
cortex occurs, but the medullary cavity is left intact, although it may become narrowed<br />
(Ortner 2003). Bowing occurs from the deposition of new bone on the femur<br />
34
anterolaterally and on the tibia laterally. Fractures can also be seen with the most<br />
common being fissure-like stress fractures (Aufderheide and Rodríguez-Martín 1998).<br />
2.6 Differential Diagnosis<br />
To summarize, these diseases are best differentiated by the profile of effects<br />
outlined in Appendix A. Treponemal disease most often affects the skull, hands, tibiae,<br />
fibulae, and feet of an infected individual. Tuberculosis most often affects the spine or<br />
vertebral column, causing collapse of the vertebral body(s) of an individual.<br />
Tuberculosis can also affect the skull, but unlike treponemal disease, there is usually only<br />
a single lesion affecting both the inner and outer tables with very little, if any, bony<br />
reaction and irregular margins that are destructive in nature (Mitchell 2003).<br />
Tuberculosis destroys bone while treponematosis produces new bone. Treponemal<br />
disease produces a general increased swelling of the diaphyses in long bones, whereas<br />
tuberculosis does not (Steinbock 1976). Treponemal disease produces multiple lesions, a<br />
larger area of involvement in the long bone shafts, an altered medullary cavity, an uneven<br />
cortex with bone formation and destruction unlike the changes seen in tuberculosis<br />
(Steinbock 1976).<br />
Leprosy affects the maxillary bone, palate, hands and feet of an individual<br />
through the resorption of bone. In treponemal disease there is a remodeling and<br />
formation of bone, whereas in tuberculosis and leprosy there is a resorption of bone.<br />
Treponemal disease can also affect the spine, but it affects the cervical vertebrae more<br />
35
commonly, whereas tuberculosis more commonly affects the thoracic and lumbar<br />
vertebrae.<br />
Other things to consider for a differential diagnosis between treponemal disease<br />
and tuberculosis or leprosy are the distribution of lesions within the population.<br />
Tuberculosis skeletal lesions are found in 1% of the population (Aufderheide and<br />
Rodríguez-Martín 1998), while periosteal reaction greater than 2% of the population is<br />
considered to be treponemal disease (Rothschild et al. 2004). Proliferative lesions are not<br />
as common in leprosy because of the resorption of bone and leprosy only affects 5% of<br />
the skeleton (Ortner 2003). A higher frequency of skeletal involvement should indicate a<br />
treponemal disease. Nonvenereal treponemal disease has the highest population<br />
frequency (20-40%) that involves periosteal reaction (Rothschild 2000). No other disease<br />
has a population frequency this high involving periosteal reaction. Venereal syphilis has<br />
a low population frequency (14% or less) and because of this reason it is harder to<br />
differentiate from other diseases when considering lesions within the skeleton of an<br />
individual (Ibid.).<br />
Osteosarcoma involves only one bone, while treponemal disease occurs bilaterally<br />
in long bones and in older individuals (Aufderheide and Rodríguez-Martín 1998;<br />
Steinbock 1976). Meningioma affects the skull, never the postcranial skeleton<br />
(Aufderheide and Rodríguez-Martín 1998). Meningioma produces a thickening of the<br />
inner and outer tables of the skull and also a widening of the diploë, unlike treponemal<br />
disease (Steinbock 1976). Metastatic carcinoma lesions are usually small, not necrotic<br />
and regeneration of the bone does not occur. Unlike treponemal disease these lesions are<br />
widely scattered and the lesions do not coalesce (Steinbock 1976). Treponemal disease<br />
36
forms new bone growth surrounding the lesions and treponemal disease also exhibits<br />
postcranial lesions (Kelley 1980). The lesions occurring in multiple myeloma are lytic<br />
lesions and they are smaller than the lesions occurring in treponemal disease<br />
(Aufderheide and Rodríguez-Martín 1998). Steinbock (1976) states that the lesions<br />
occurring in multiple myeloma are smaller, not necrotic, do not regenerate the bone and<br />
are widely scattered lesions that do not coalesce, which is unlike those lesions seen in<br />
treponemal disease. Kelley (1980) adds that in treponemal disease there is a formation of<br />
new bone that surrounds the lesions and that the lesions of treponemal disease also occur<br />
in the postcranial skeleton.<br />
Pyogenic (pus-producing) osteomyelitis usually involves fewer bones than<br />
treponemal disease. Osteomyelitis also produces the characteristic sequestrum,<br />
involucrum, and cloaca in the postcranial skeleton, whereas in treponemal disease these<br />
pathologic changes are rarely observed (Aufderheide and Rodríguez-Martín 1998;<br />
Steinbock 1976). Osteomyelitis usually does not involve the cranium, whereas<br />
treponemal disease does (Steinbock 1976). Kelley (1980) states that osteomyelitis is<br />
more destructive than treponemal disease, involving joints more often.<br />
Paget’s disease produces massive thickening of the skull vault, while in<br />
treponemal disease there is bone formation and bone loss that produces hills and valleys,<br />
not an extreme expansion of the diploë (Aufderheide and Rodríguez-Martín 1998).<br />
Histologic examination of the bones also reveals the mosaic pattern of Paget’s disease<br />
that is not found in treponemal disease (Steinbock 1976). Kelley (1980) states that<br />
Paget’s disease and treponemal disease differ in the age of onset and that Paget’s disease<br />
is a localized infection that lacks cloacae, whereas treponemal disease is widespread and<br />
37
may occasionally possess cloacae in the postcranial skeleton. Paget’s disease can<br />
produce periosteal reaction but the frequency is never greater than 1% in individuals<br />
under the age of 40 years (Rothschild 2005). In Paget’s disease, cortical thickening of<br />
the tibia occurs on the posterior portion, while in treponemal disease, cortical thickening<br />
occurs on the anterior portion of the tibia (Ibid.).<br />
2.7 Objectives<br />
In summary, there are several hypotheses revolving around the geographic origins<br />
and development of treponemal disease. Did it originate in the New World or the Old<br />
World? Was Columbus’ voyage responsible for bringing it to Europe, where it became<br />
more virulent? Has it always been present in the genus Homo and migrated with humans<br />
as they moved to new lands? Is it one disease that transforms depending upon the<br />
environment and social factors of the human host or is it several different organisms that<br />
are very similar?<br />
Treponemal disease leaves markers on the bones that may be similar to other<br />
diseases. These other diseases are tuberculosis, leprosy, tumors, osteomyelitis, and<br />
Paget’s disease. Looking at the distribution of lesions within a skeleton and the<br />
prevalence of lesions at the population level helps to differentiate between the different<br />
diseases that affect the bones.<br />
In the pages to come, through the study of an early (Archaic) prehistoric<br />
population in North America, the Carrier Mills sample from Southern Illinois, these<br />
questions will be addressed; 1) Is there a treponemal disease within this sample?; 2) If<br />
38
there is a treponemal disease, then which one is it?; 3) What does this study tell us about<br />
the lifestyle of this population?; and 4) What does this mean in terms of the history and<br />
origin of treponematoses?<br />
39
CHAPTER 3<br />
MATERIAL <strong>AND</strong> METHODS<br />
3.1 Materials<br />
3.1.1 The Sample – Carrier Mills Archaeological District<br />
The focus of my research was on the human skeletal remains recovered from the<br />
Carrier Mills Archaeological District, which is located in southern Illinois, in Saline<br />
County, 2.5 km south of the village of Carrier Mills and north of the South Fork of the<br />
Saline River (see Figure 3.1) (Jefferies and Morrow 1982). Excavation of the site was<br />
performed in 1978 and 1979 by the Center for Archaeological Investigations at Southern<br />
Illinois University, Carbondale (Jefferies and Morrow 1982). There are three major sites;<br />
11SA86, 11SA87, 11SA88, and several smaller sites within the 57 hectares of the district.<br />
The Black Earth site (11SA87) is the largest and most complex site (Jefferies and<br />
Morrow 1982) and it is the site that contains the human skeletal remains examined in this<br />
research. There are three main areas within the Black Earth site: A, B, and C (see Figure<br />
3.2). The skeletons examined in this study are from Area A, which produced the most<br />
burials, with 201 burial features containing 223 individuals (Jefferies 1982b). Some of<br />
the burials were located in the plow zone and were severely disturbed, while the majority<br />
of the burials were recovered from the midden zone, which was undisturbed and located<br />
in the central portion of Area A. Most burials date from the Middle Archaic (4500-3000<br />
40
BC) to Late Archaic (3000-1000 BC) periods, but a few have been identified as<br />
Woodland period burials (1000 BC – AD 1000) (Jefferies and Morrow 1982).<br />
Skeletal preservation for both the Archaic and Woodland period groups is good to<br />
excellent as a result of the soil having a high pH level and a good drainage system. The<br />
soil also contained high carbonate concentrations that slowed deterioration of the bone,<br />
but left hard deposits on the surfaces of the bones (Bassett 1982). These deposits<br />
hindered both the initial analysis conducted by Bassett (1982) and the research conducted<br />
here.<br />
3.1.2 Burial Sample<br />
The burial sample of the Black Earth site (11SA87) has been dated using<br />
radiocarbon dating techniques. Eight charcoal samples were analyzed from undisturbed<br />
features within the Area A midden. The samples were collected based on their specific<br />
vertical positions, so that midden deposition rates could be calculated (Bassett 1982).<br />
These charcoal samples produced dates ranging from 3955 to 2910 B.C. (Jefferies<br />
1982a). It is believed that the inhabitants occupied this area from approximately 4000<br />
B.C. to 2900 B.C., due to the dates revealed from the radiocarbon dating (Bassett 1982).<br />
The inhabitants were hunter-gatherers who were becoming more accustomed to a<br />
sedentary lifestyle, which implies that there was also a gradual increase in the population<br />
over time. An increase in population also results in an increase in plant and animal<br />
species found in archaeological sites. For these reasons, the Archaic period has been<br />
characterized as having an “increasing regional specialization and adaptation marked by<br />
the appearance of large, intensively occupied sites” (Jefferies and Morrow 1982;19), and<br />
41
it is also a time when specialized tool forms begin to appear. There is evidence within<br />
this Archaic period site of multiseasonal occupation, meaning that this site was probably<br />
occupied year-round instead of being a seasonal camp that depended upon the<br />
environment and availability of foods (Jefferies and Morrow 1982). The increase in<br />
population size along with multiseasonal occupation also suggests that since people were<br />
staying in one place for long periods of time, they had to have a place to bury their dead.<br />
Therefore, the Archaic period is also the time in which we begin to see archaeological<br />
evidence for an increase in the use of cemeteries.<br />
Everett J. Bassett (1982) performed the original osteological analysis on all of the<br />
Carrier Mills burials (approximately 500 burials). This analysis took place between the<br />
years of 1980 and 1982. The general descriptions of the burials as described by Bassett<br />
(1982) can be found in Appendix F of The Carrier Mills Archaeological Project: Human<br />
Adaptation in the Saline Valley, Illinois, Volume 2. This appendix includes the burial<br />
number, cultural affiliation, sex, age group category, estimated age of the individual,<br />
preservation/completeness evaluation of the remains, osteitis evaluation, and any other<br />
pathological information that was observed by Bassett (1982).<br />
Area A contains 237 individuals with 157 dating to the Archaic (4000 – 2900<br />
B.C.) period, 35 from the Woodland (1000 B.C. – A.D. 1000) period, and 45 are of<br />
undetermined date (but either Archaic or Woodland). Of the total Archaic period sample,<br />
there are 51 juveniles, 54 males, 47 females and 5 individuals that are of undetermined<br />
sex. Within the juvenile sample, there are 46 infants (birth to 3 yrs), 4 children (3 to 12<br />
yrs), and 1 adolescent (12 to 20 yrs). There are an additional 6 adolescents (12 to 20 yrs)<br />
whose skeletal remains were complete enough to determine sex and are included in the<br />
42
data for males and females instead of juveniles. Of the adult sample, there are 45 young<br />
adults (20 to 35 yrs), 49 middle adults (35 to 50 yrs) and 6 old adults (>50+ yrs) within<br />
this sample. Males outnumber females in a ratio of 1.5:1.<br />
A “treponemal-like” infection has been identified within this skeletal sample<br />
(Bassett 1982). Individuals in the sample exhibit some characteristics that are associated<br />
with treponemal disease, but these traits may also be associated with other diseases,<br />
particularly tuberculosis (Bassett 1982). Bassett (1982) found periosteal involvement,<br />
lytic lesions, and saber-shins throughout this sample. The most common bones affected<br />
were the long bones and the cranium, but the ribs, vertebrae, scapulae, clavicles, and<br />
bones of the hands and feet were also affected. He used osteitis as a general term to<br />
describe all bone inflammation, but because it was so widespread, he developed a rating<br />
system of slight, moderate and severe to help in the analysis (Bassett 1982).<br />
Osteitis indicates that an infection was present at the time of death. In Bassett’s<br />
(1982) terminology and analysis, ‘slight’ osteitis meant that the infection is present on the<br />
anterior portion of the tibiae; it may also be present on the fibulae, posterior tibiae and the<br />
anterior femora with slight periosteal remodeling distinguishable. Bassett’s (1982)<br />
category of ‘moderate’ osteitis meant that the infection is also present on the posterior<br />
femora, the humeri, radii, ulnae, clavicles, metatarsals, metacarpals, and maybe even the<br />
ribs, with saber-shin (an anterior bowing of the tibiae) being noticeable. Bassett’s (1982)<br />
category of ‘severe’ osteitis indicated obvious saber-shin, deep lesions visible on the<br />
tibiae, other long bones and the cranium.<br />
Previous research of the human skeletal remains from the Carrier Mills<br />
Archaeological District includes: Miller (1981) on postcranial nonmetric traits, Larsen<br />
43
(1981) on the relationships between the stress indicators of Harris lines and dental<br />
asymmetry, Brandon (1986) on dietary inferences through dental analysis, Anderson<br />
(1998) on measuring stress through tibial growth patterns in juveniles, Van Arsdale<br />
(1998) on the sexual division of labor through the patterns of vertebral osteoarthritis, and<br />
Clapper (2006) on activities based on musculoskeletal stress markers. This research will<br />
explore the tentatively identified treponemal disease within the Archaic period group.<br />
3.2 Methods<br />
This study was conducted in 2006-2007 at the Center for Archaeological<br />
Investigations curation facility in Carbondale, Illinois, where the sample from Area A of<br />
the Black Earth site of the Carrier Mills Archaeological District is housed. The entire<br />
sample of Area A individuals was sorted according to cultural affiliation (e.g. Woodland<br />
[1000 BC – AD 1000] or Archaic [4000 – 2900 BC] periods). The Archaic period<br />
sample of 157 individuals was then sorted numerically according to burial number. The<br />
sub-sample (54 individuals) that was visually examined were the first 54 individuals<br />
excavated from the Archaic period. Table 3.1 gives the categories (e.g. infants, young<br />
adults, males, females, etc.) and the percentages of the individuals in the total sample<br />
(157) versus the percentages of individuals from the sub-sample (54). Also compared<br />
from the total sample and the sub-sample in this Table are the numbers of males, females,<br />
and juveniles, the numbers of individuals diagnosed by Bassett (1982) as having slight,<br />
moderate, severe, and no osteitis, and the number of burials that were considered to be<br />
complete based on a rating of 1, 2, and 3 with 1 being the least complete and 3 being the<br />
44
most complete. As can be seen from Table 3.1, the percentages of males, females,<br />
juveniles, and undetermined from the sub-sample are nearly equivalent to those of the<br />
entire sample. The percentage that is lacking the most is that of the juveniles.<br />
Figure 3.3 is a map of the Archaic period burials. This map indicates that the<br />
burials were widely distributed throughout the entire Stratum 1 area of the site, the core<br />
area. The central and western portions of the Stratum 1 layer of Area A contain the most<br />
burials. This map contains all but five individuals from the sub-sample (54) used in this<br />
study. On the original map of all of the Archaic burials, there were a few outliers to the<br />
North, South and West along the trenches for this site. This map has been cropped to<br />
show a closer view of the densest concentration of burials, or the core area of the site.<br />
Another reason why the map lacks the total number of Archaic burials (157) is that some<br />
burials were left out of the initial analysis by Lynch (1982) due to preservation issues.<br />
Only 124 burials were analyzed and plotted on the map. It is apparent that by sampling<br />
the first 54 individuals, the subsample included individuals widely distributed across the<br />
site except in the southeast quandrant. There was nothing distinct or different about the<br />
site preservation, burial context, or mixture of individuals in that quadrant (Brian Butler,<br />
personal communication).<br />
Bassett’s (1982) age assessment for the juveniles was based on five criteria:<br />
dental calcification, occipital development, long bone length, dental eruption, and the<br />
union of epiphyses. Each individual was also assigned an approximate error factor<br />
depending on the estimated age of the individual (Bassett 1982). Sex determination was<br />
not attempted for the juveniles.<br />
45
Adult age estimation, as assessed by Bassett (1982), was based on five criteria of<br />
progressive changes in the human skeleton. These changes occur in areas of the auricular<br />
surface, pubic symphysis, cranial suture closure, functional dental wear, and involution of<br />
the cortical and trabecular bone of the proximal femur. The most useful indicators were<br />
the auricular surface, because it has the most variation and is preserved more frequently<br />
in the Carrier Mills sample, followed by the pubic symphysis, the second most preserved<br />
indicator in the sample (Bassett 1982). Adults missing all of the aging indicators due to<br />
poor preservation were separated into 3 different age categories: 18-35 years, 35+ years,<br />
and 18+ years depending on the amount of skeletal degeneration related to age. Each<br />
individual was also assigned an approximate error factor depending on the estimated age<br />
of the individual (Ibid.).<br />
Sex indicators utilized by Bassett (1982) for the adults were the characteristics of<br />
the pelvis, skull, and postcranial robusticity. The most useful indicators are those of the<br />
pelvis. Three non-metric methods were used for the pelvis: “1) the ventral arc of the<br />
pubis, the subpubic concavity, and the medial aspect of the ischiopubic ramus, 2) the<br />
sciatic notch, and 3) the feminine preauricular sulcus” (Bassett 1982:1039). The<br />
characteristics of the skull utilized to indicate the sex of the individuals were:<br />
“1) development of the nuchal ridges, 2) presence or absence of the external<br />
occipital protuberance, 3) mastoid size, 4) robusticity of the mandible, and 5)<br />
presence and size of the supraorbital ridges” (Bassett 1982:1039).<br />
46
Individuals with ambiguous, contradictory, incomplete, or poorly preserved<br />
characteristics were assigned Male (?), Female (?), or just a simple (?).<br />
A sub-sample of 54 individuals from the Archaic (4000 – 2900 B.C.) period<br />
sample was examined, in this study. Of the 54 individuals, nine are infants (birth to 3<br />
yrs), two are adolescents (12 to 20 yrs), nineteen are young adults (20 to 35 yrs), twenty<br />
are middle adults (35 to 50 yrs), and four are old adults (>50+ yrs). These age categories<br />
follow the standard age categories as described by Buikstra and Ubelaker (1994). There<br />
are twenty-six males: 1 adolescent, 12 young adults, 12 middle adults, and 1 old adult;<br />
seventeen females: 1 adolescent, 6 young adults, 7 middle adults, 3 old adults; nine<br />
juveniles, and two individuals of undetermined sex: 1 young adult and 1 middle adult,<br />
which results in the same ratio of 1.5 males to 1 female as that seen in the entire sample.<br />
Here, Bassett’s (1982) determination of sex and age were used as a reference<br />
point for the specimens and initial estimate. However, Bassett’s work was not tightly<br />
focused, due to his research being broad, including determining such factors as sex, age,<br />
disease, demography, growth, stature, dating techniques and a general description of the<br />
burials from the entire Carrier Mills Archaeological District, which consists of nearly 500<br />
skeletons. Therefore, his sex determination and age estimates were reevaluated, resulting<br />
in some changes during this analysis.<br />
Of the 54 individuals in this research, the sex determination for five of them was<br />
changed. Burials 45, 66, 84, 86, and 89 were originally identified as male, but were<br />
reclassified as female based upon wide sciatic notches, small mastoids, and complete<br />
perforation of the olecranon fossa of the humerus. Age categories were also changed for<br />
eight of the 54 individuals. Burials 29, 45, and 94, originally categorized as young<br />
47
adults, were changed to middle adults. Burial 50 was originally a middle adult and was<br />
changed to a young adult. Burials 66, 100, and 114, originally adolescents, were changed<br />
to young adults. Burial 103, a middle adult in Bassett's analysis, was reclassified as an<br />
old adult. These changes were not due to altered estimates of absolute age but to<br />
reconsiderations of the age ranges in each category. For example, Burial 29 was<br />
originally classified as a young adult (20-35), but upon examination of the age of the<br />
individual, which was determined to be approximately 44 years of age, this individual<br />
was reclassified as a middle adult (35-50).<br />
During the examination, data were entered into an Excel database using the<br />
skeletal code key, following the Standards For Data Collection manual (Buikstra and<br />
Ubelaker 1994). The following information was recorded in the Data Collection<br />
Worksheet: burial number, skeletal element, side, section, aspect, pathology, lesion<br />
location and lesion type. Also noted in the database are additional observations on<br />
diagrams, sketches of where the lesions occur if any, photographs taken of the<br />
pathological changes, and any comments regarding the examination.<br />
The teeth of the nine infants were visually examined, particularly the permanent<br />
incisors and permanent first molars, for the characteristic changes of congenital syphilis,<br />
including Hutchinson’s incisors, Mulberry molars and Moon’s molars. The canines were<br />
examined for evidence of hypoplasias as well. The teeth of the adults were also<br />
examined for pathological changes.<br />
Any abnormal shape in bone, size and formation, and bone loss specific to<br />
treponemal infection was recorded. All bones presenting these features were set aside,<br />
labeled and photographed. Photographs were taken throughout the data collection and at<br />
48
the conclusion of the analysis. A Nikon Coolpix 7600 digital camera was used,<br />
uploading images into a computer with each image assigned a number, and the number<br />
recorded in the database.<br />
3.3 Summary<br />
In summary, one third of the Archaic period skeletal sample of the Carrier Mills<br />
Archaeological District was examined, specifically those of the Black Earth site, for<br />
evidence of treponemal disease. These data were then used to address the following two<br />
questions: 1) Is there evidence of a treponemal disease within this sample? and 2) If there<br />
is a treponemal disease, which one is it?<br />
To determine if there is a treponemal disease in the Carrier Mills skeletal sample,<br />
twenty-eight different pathological features were first examined. After determining the<br />
presence and absence of these features, it was decided that five primary features should<br />
be used to determine the likelihood of treponemal disease within this sample. The five<br />
primary traits/markers were decided upon after consulting Ortner (2003) and Bogdan and<br />
Weaver’s (1992) diagram showing the distribution of the most frequent sites of skeletal<br />
lesions due to treponematoses. These five primary markers are 1) cranial 2) hand 3) tibial<br />
4) fibular and 5) foot involvement.<br />
To answer the question of which treponemal disease is present in this sample, a<br />
differential diagnosis based on a profile of the effect of treponematoses on populations<br />
used by Rothschild et al. (2000) was utilized. This profile highlights the differences<br />
between yaws, endemic syphilis, and venereal syphilis through the comparison of cases<br />
49
with confirmed disease. The differences include: hand and foot involvement, adult<br />
versus juvenile, and the average number of bone groups affected. In order to examine<br />
these questions, the data were summarized based on presence of periosteal and other<br />
lesions by: age group, sex, bones included, and uni- or bilaterality. The results of this<br />
study are presented in the following chapters.<br />
50
Category<br />
Table 3.1. Carrier Mills Archaic Burials Statistics<br />
Total Sample<br />
(157)<br />
Sub-Sample<br />
(54)<br />
Total % of total Total<br />
% of<br />
total<br />
Infants 46 29% 9 17%<br />
Children 4 3% 0 0%<br />
Adolescents 7 4% 2 4%<br />
Young Adults 45 29% 19 35%<br />
Middle Adults 49 31% 20 37%<br />
Old Adults 6 4% 4 7%<br />
Total Adults 100 64% 43 80%<br />
Total Juveniles 57 36% 11 20%<br />
Males 54 34% 26 48%<br />
Females 47 30% 17 31%<br />
Juveniles, unsexed 51 32% 9 17% if rest of sample<br />
Undetermined 5 3% 2 4% with no osteitis*:<br />
Slight Osteitis 49 31% 23 43% 23/157 15%<br />
Moderate Osteitis 7 4% 7 13% 7/157 4%<br />
Severe Osteitis 1 1% 1 1% 1/157 1%<br />
No Osteitis 100 64% 23 43% 123/157 78%<br />
Complete 1 (least) 27 17% 5 9%<br />
Complete 2 60 38% 15 28%<br />
Complete 3 (most) 70 45% 34 63%<br />
Total sample % of total = t/157*100<br />
Sub-sample % of total = t/54*100<br />
Total juveniles = Infants + Children + Adolescents<br />
Total adults = young adults + middle adults + old adults<br />
Males = all the males in the sample (adults and determined adolescents)<br />
Females = all the females in the sample (adults and determined adolescents)<br />
Juveniles = infants + children + undetermined adolescents<br />
* This is just an example of what the results of the study would be if the rest of the<br />
Carrier Mills Archaic burial sample were not infected with osteitis. This demonstrates<br />
that the percentage of osteitis found in this sample is still high (20%).<br />
51
Figure 3.1 Location of Carrier Mills Archaeological District in southern Illinois.<br />
Image adapted from Jefferies & Morrow 1982.<br />
52
Figure 3.2. Location of Carrier Mills Archaeological District Sites (SA86, SA87,<br />
SA88). Image adapted from Jefferies & Morrow 1982.<br />
53
Figure 3.3. Locations of Archaic burials by sex determination.<br />
Shaded burials indicate burials in this study. Adapted from Lynch 1982.<br />
54
CHAPTER 4<br />
RESULTS<br />
Appendix B provides a summary of the Burials exhibiting skeletal lesions that are<br />
possible treponemal characteristics for each of the 54 Carrier Mills Archaic individuals<br />
that were examined. The appendix contains the burial number, age/sex category of the<br />
individual, completeness of the skeleton, and degree of osteitis that the skeletal remains<br />
exhibit. Also contained in this appendix are the notes pertaining to the coding of the<br />
human skeletal remains as designated during this analysis.<br />
Of the total number of Archaic period skeletons, Bassett (1982) diagnosed 49<br />
with slight osteitis, seven with moderate osteitis, and one male with severe osteitis. Of<br />
the subsample of 54 individuals that were examined in this study, Bassett (1982)<br />
diagnosed 23 of them with slight osteitis (12 males, 10 females and 1 of undetermined<br />
sex), 7 with moderate osteitis (5 males and 2 females), 1 male with severe osteitis, and 23<br />
without any signs of osteitis. While the results presented here are similar in scope of<br />
affected individuals, there are some differences and a more detailed understanding of the<br />
pattern of affected bones.<br />
4.1 Likelihood of Treponemal Disease<br />
55
Determination of the presence or absence of a treponemal disease and which<br />
syndrome is present is based on the presence or absence of osteitis/periostitis changes in<br />
different bones and bone groups, by age, sex, and uni- or bilaterality. Tables 4.1 – 4.5<br />
provide an initial summary of the presence of osteitis or other pathological feature of<br />
each burial, by bone/bone group, and sex for each age group in the Carrier Mills Archaic<br />
sample. All the tables contain the burial number, estimated age in years of the individual,<br />
sex of the individual, and the presence, absence, or observability of the 28 different<br />
pathological markers used in this study. Markers falling into the five primary sets of<br />
features for distinguishing treponemal disease from other diseases are numbered and in<br />
bold. These five primary marker sets are: 1) cranial involvement; 2) hand involvement;<br />
3) tibial involvement; 4) fibular involvement; and 5) foot involvement. The tables also<br />
contain the number of pathological markers associated with each burial and the number<br />
of bone groups affected in each burial. Table 4.1 contains the information for the infants,<br />
Table 4.2 contains the adolescents, Table 4.3 consists of the young adults, Table 4.4 is the<br />
middle adults, and finally the old adults are in Table 4.5.<br />
By looking at Tables 4.1 – 4.5, it is immediately apparent that osteitis and related<br />
pathological lesions were widespread in this sample. The Totals column is the total<br />
number of individuals affected for each pathological marker. In Table 4.1 (Infants), of<br />
the 28 pathological markers, 17 are found on individual infants, while 11 are not. Of the<br />
17 markers found, 10 markers occur on four or more affected individuals. Table 4.2<br />
(Adolescents) shows that 17 of the 28 pathological markers are exhibited on individual<br />
juveniles. Table 4.3 (Young Adults) shows that 23 of the 28 pathological markers are<br />
exhibited on young adult skeletons; 6 of the pathological markers occur on 10 or more<br />
56
affected individuals. From Table 4.4 (Middle Adults), it is clear that 24 of the 28<br />
pathological markers occur on one or more of these skeletons, and 8 of the pathological<br />
markers are found on 10 or more affected individuals. Table 4.5 (Old Adults) shows that<br />
out of the 28 pathological markers, 18 affect old adult skeletons, with 13 of those<br />
affecting 2 or more individuals. This demonstrates that the skeletal remains for this sub-<br />
sample have a high frequency of bone infection.<br />
Table 4.6 contains a summary and the percentages of occurrence for these 28<br />
possible pathological markers (either osteitis on a bone/group or other feature) found<br />
within the sample. The data are broken down into the numbers of infants, adolescents,<br />
young adults, middle adults, and old adults possessing each marker, but since treponemal<br />
disease also affects males more than females, the numbers of males, females, and<br />
unknown (adults of undetermined sex) exhibiting each marker are also included.<br />
Percentages were calculated based on the number of individuals affected for the juveniles<br />
(infants + adolescents), adults, males and females relative to the number preserving that<br />
bone for this sample.<br />
The adults are affected considerably more than juveniles in this study (see Table<br />
4.6 and Figure 4.1). Focusing on the five primary markers, the cranium is affected far<br />
more in the adults (67%) than in the juveniles (36%). The hands are affected far more in<br />
the adult (72%) sample than in the juvenile (18%) sample. The bilateral tibiae are more<br />
affected in the adult (93%) versus the juvenile (100%) sample. The bilateral fibulae are<br />
affected in almost all individuals in which both are present, including 80% of the adults<br />
and 67% of the juveniles. Involvement of the feet is also seen considerably more in the<br />
adults (78%) than in the juveniles (43%).<br />
57
The results in Table 4.6 indicate that males are generally affected more in this<br />
sample than are females (see also Fig. 4.2). Although the frontal/parietal region is<br />
affected in fewer males (37%) than females (54%), nasal/palatal involvement was seen in<br />
38% of males, but no females. The hands are also affected more in males (75%) than in<br />
females (63%). Bilateral tibiae are affected in almost equal frequency in males (95%)<br />
and females (92%). Saber shin, however, is found in 29% of males, but no females.<br />
Bilateral fibulae involvement is again about the same in males (78%) than in females<br />
(77%). But the feet are affected far more in males (87%) than in females (67%). It is<br />
interesting that the male sample is affected more in the hands, feet and saber shin tibia<br />
deformity. This could be due to the absence of some of the skeletal elements or to<br />
observer error, but as reviewed earlier, treponemal disease generally affects males more<br />
than females (Aufderheide and Rodríguez-Martín 1998).<br />
The considerable differences in the adult versus the juvenile sample could be due<br />
to the frequent absence of hand and foot bones, tibiae, and fibulae in the juvenile sample.<br />
Table 4.6 further demonstrates the high level of occurrence of many pathological markers<br />
indicative of a treponemal infection, in addition to the five primary markers (in bold),<br />
although some (particularly dental features) are conspicuously lacking. While the<br />
absence of dental markers could be due to missing permanent incisors and first molars or<br />
to attrition in some cases, it may also be indicative that this infection could be<br />
nonvenereal in nature. Nonvenereal treponemal disease does not affect the teeth.<br />
Table 4.7 is a summary of the likelihood of the Carrier Mills Archaic burial sub-<br />
sample suffering from treponemal disease. Listed are the numbers of burials with a<br />
rating system as follows: ‘none’, ‘possible’, ‘highly likely’ and ‘certain’ for suffering<br />
58
from treponemal disease. The ratings are based on the five primary markers of cranial,<br />
hands, tibiae, fibulae, and feet involvement. Thus, if a burial did not exhibit<br />
osteitis/pathology for any of these five primary areas, the individual was scored not to<br />
have a treponemal disease (“None”). If a burial had involvement in one, two or three of<br />
these areas, the individual was considered to have “Possible” treponemal disease. If a<br />
burial exhibited involvement in four or five of these areas, then it was considered to be<br />
“Highly Likely” that the individual had a treponemal disease. A “Certain” for<br />
treponemal disease was coded if the individual possessed all five of the markers, had<br />
lesions that perforated the cortex, and had the saber shin deformity. If an individual had<br />
fewer than five of the primary markers, but exhibited the saber shin deformity, that<br />
individual was also considered ‘certain’ for treponemal disease. As has been noted, most<br />
of the individuals in this study exhibited infection of the bone on at least one or more<br />
elements. Almost all of the 11% of individuals categorized as ‘none’ had at least one<br />
bone with osteitis , but since none of the primary marker elements were affected, they<br />
were placed in the category of ‘none’. A visual summary of the likelihood of treponemal<br />
disease in the Carrier Mills individuals is shown in Figure 4.3. Below is a discussion of<br />
the individuals included in each of the likelihood categories based on the five primary<br />
marker sets. In discussing individual burials, they will be abbreviated as Burial = B +<br />
number (Burial 38 = B38).<br />
4.1.1 Certain<br />
Six individuals (11% of the sample) were diagnosed as ‘certain’ for treponemal<br />
disease, and all of these were males. The most severe case exhibited all 5 characteristic<br />
59
markers on the skeleton, had lesions perforating the cortex, and had saber shin tibiae.<br />
B38 is a middle adult male approximately 40 years old, previously diagnosed as severe<br />
osteitis (Bassett 1982). This unfortunate individual had lesions on his entire skeleton. Of<br />
the five primary markers used for diagnosis of the skeletons, this individual possessed<br />
pathological lesions in all 5 areas of the skeleton: crania, hands, tibiae, fibulae, and feet<br />
involvement. This individual also exhibited saber shin deformity of the tibia, which was<br />
a bilateral phenomenon.<br />
The cranium of B38 exhibits lesions on the frontal, left parietal, left maxilla, left<br />
and right mandible, right nasal, left and right lacrimal, and occipital bones. The frontal<br />
contains 8 lytic lesions ranging in size from
also affected. These were all in the forms of lesions. Figure 4.5 is the left third<br />
metacarpal showing one lesion surrounded by woven bone.<br />
The tibiae of B38 exhibit bilateral lesions. The right tibia has approximately 10<br />
lesions on the surface that perforate the cortex. They range in size from ~0.5 cm to 1.5<br />
cm wide. Eight of them are surrounded by woven and sclerotic reaction. This tibia also<br />
exhibits the most prominent marker of treponemal disease, the saber shin. Figure 4.6<br />
shows the right tibia, posterior midshaft with six lesions surrounded by woven and<br />
sclerotic reaction. The left tibia also has approximately 10 lesions on the surface that<br />
perforate the cortex. They range in size from 1 to 1.5 cm long. Woven and sclerotic<br />
reaction also surrounds eight of them, and it also has the saber shin characteristic.<br />
The fibulae of B38 both exhibit lesions, woven bone, and a sclerotic reaction.<br />
The right fibula is bowed medio-laterally and it has five lesions, which are all<br />
approximately 1.5 cm long. The left fibula has one long lesion (~11 cm in length) that is<br />
best described as a cloaca that is surrounded by sclerotic reaction. Figure 4.7 is a closeup<br />
of the lateral left fibula showing the cloacae and the surrounding sclerotic reaction.<br />
The feet of B38 are severely infected. Of the tarsals, the right side is affected.<br />
The calcaneus has lesions and osteophytes. All the metatarsals of both feet are affected.<br />
The right metatarsals have lesions and woven bone. The first metatarsal is fused with the<br />
first phalanges. The left metatarsals are swollen with woven bone and sclerotic reaction,<br />
trabecular coarsening and cortical thinning. Figure 4.8 shows the plantar surface of the<br />
first left metatarsal showing woven and sclerotic reaction.<br />
The other five burials are not as severely affected as B38. These five burials are<br />
B104, B25, B48, B33 and B65. B104 is a middle adult male of 46 years exhibiting<br />
61
involvement of all of the five primary markers and the characteristic saber shin<br />
deformity. In the hands, the metacarpals exhibit bone loss, woven bone and deposition of<br />
bone. The hand phalanges also exhibit deposition of bone and bone loss. The carpals<br />
exhibit bone loss as well. The tibiae have woven bone and sclerotic response anteriorly<br />
as well as striations medially. The left tibia has two lesions on the lateral surface at the<br />
proximal end and the saber shin deformity. The right tibia has one lesion proximal<br />
laterally and also has the saber shin deformity. The fibulae also exhibit woven bone and<br />
sclerotic response along with striations on the entire shafts. The foot phalanges have bone<br />
deposition and loss.<br />
B25, a young adult male of 33 years, shows involvement of the hands, tibiae, and<br />
fibulae. The hands have woven bone on the phalanges along with bony growths. The<br />
metacarpals are misshapen, like they have been twisted. The right tibia has a<br />
concentration of woven bone on the anterior midshaft along with the saber shin<br />
deformity. The left tibia has striations, osteitis, and the saber shin deformity.<br />
B48 is a young adult male, aged 20-35 years, possessing markers on the tibiae,<br />
fibulae, and feet. The right tibia exhibits striations on the shaft medially and the saber<br />
shin deformity. The left tibia has striations medially on the shaft and has a patch of<br />
woven bone on the distal 1/3 of the shaft along the postero-medial surface, as well as the<br />
saber shin deformity. Both fibulae exhibit striations along the entire shaft. In the feet,<br />
the tarsals have bone loss and the fifth intermediate and distal phalanges are fused on one<br />
foot (side unclear).<br />
B33 is a middle adult male, 35 years of age. This particular individual has<br />
involvement of the palate, hands, tibiae, fibulae, and feet. There is pitting on the palate.<br />
62
Three hand phalanges exhibit unifocal bone loss. The right tibia exhibits a slight saber<br />
shin, with both tibiae having striations on the medial shaft but no apparent thick spongy<br />
growth on either tibia. The fibulae have striations on the shaft and are flattened, while<br />
the right fibula has sclerotic reaction on the medial surface of the distal shaft. The<br />
metatarsals have bone loss and woven bone present. Both ulnae are bowed at the distal<br />
end.<br />
B65 is a middle adult male of 49 years who exhibits involvement of the hands,<br />
tibiae, fibulae, and feet. The intermediate and proximal hand phalanges look swollen and<br />
have spicules along the shafts. The right tibia has the saber shin deformity, a thick<br />
spongy patch of bone on the medial surface of the proximal end, and striations on the<br />
medial shaft. The left tibia is missing. The fibula is not smooth, but exhibits osteitis that<br />
is bubbly in appearance. The metatarsals have bone loss, woven and sclerotic reaction on<br />
the shafts. Both ulnae and radii are bowed on the distal end.<br />
4.1.2 Highly Likely<br />
Out of the 54 individuals examined, 15 (28%) were scored as ‘highly likely’ for<br />
displaying pathological lesions consistent with treponemal disease. One of the infants fit<br />
into this category with four of the primary markers. B32 (age 0.8 yrs) had cranial, tibial,<br />
fibular, and foot involvement. On the cranium, the left orbit exhibits extensive woven<br />
bone, while the left temporal also has extensive woven bone present. The tibiae from<br />
B32 exhibit woven bone, as well as the fibulae. One of the adolescents, B89 (female, 16<br />
years), had four of the five primary markers, including involvement of the hands, tibiae,<br />
fibulae, and feet.<br />
63
Of the young adults, three were ranked as ‘highly likely’ for having treponemal<br />
disease, with each having four of the five primary markers. These three burials are B35,<br />
B82, and B84. B35 (male, 21 years) had involvement of the crania, hands, tibiae, and<br />
feet. B82 (undetermined sex, 25 years) had involvement of the hands, tibiae, fibulae, and<br />
feet. B84 (female, 29 years) had involvement of the crania, hand, tibiae, and fibulae.<br />
Six of the middle adults were ‘highly likely’ to have been affected by treponemal<br />
disease. Four of these burials had four primary markers, B7, B91, B99, and B110. B7<br />
(female, 47 years) exhibited involvement of the crania, hands, tibiae, and feet. B99<br />
(female, 35 years), and B110 (male, 36 years) both exhibited involvement of the hands,<br />
tibiae, fibulae, and feet. B91 (male, 42 years) had involvement of the crania, hands,<br />
tibiae, and fibulae. The other two burials had five of the primary markers, B86 (female,<br />
35 years), and B93 (male, 42 years). Although B86 and B93 possessed all five traits,<br />
they were not categorized as certain for having a treponemal disease because neither of<br />
them showed signs of saber tibia.<br />
All four of the old adults were categorized as ‘highly likely’ for suffering from<br />
treponemal disease. B1 (female, 56 years), and B4 (female, 58 years) possessed all five<br />
primary markers, but again they were not categorized as ‘certain’ for having a treponemal<br />
disease because neither of them showed signs of saber tibia. The other two burials, B51<br />
(male, 51 years), and B103 (female, 53 years), both had involvement of four of the<br />
primary markers: hands, tibiae, fibulae, and feet.<br />
4.1.3 Possible<br />
64
The majority of the individuals in this study were considered ‘possible’ for<br />
treponemal disease (28 out of 54, or 52%). Individuals with one, two or three of the five<br />
primary marker sets were categorized as ‘possible’ for having suffered from treponemal<br />
disease. Of the infants examined, five were scored as ‘possible’ cases for treponemal<br />
disease. B77 (1.3 years) had hand involvement, while B30 (0.2 years) and B40 (0.6<br />
years) both had cranial involvement. B62 (0.4 years) had cranial and tibial involvement,<br />
while B87 (0.8 years) had tibial and fibular involvement. One of the two adolescents was<br />
scored as ‘possible’ for suffering from treponemal disease. B116 is a male of<br />
approximately 16 years of age. He possessed two of the primary markers; involvement<br />
of the fibulae and feet.<br />
Twelve of the young adults were scored as ‘possible’ for suffering from<br />
treponemal disease. Three young adults all exhibited only one of the primary marker<br />
sets. B39 (male, 22 years) and B109 (female, 21 years) both had hand involvement. B83<br />
(female, 20 years) had tibial involvement. B69 (male, 29 years) possessed two of the<br />
primary markers, involvement of the hands and feet. The other eight of the young adults<br />
all possessed three of the five primary markers. B66 (female, 21 years) had cranial,<br />
tibial, and fibular involvement. B105 (male, 27 years) had involvement of the hands,<br />
fibulae, and feet. B50 (male, 34 years), B95 (male, 34 years), and B100 (male, 20+<br />
years), B111 (female, 22 years), B113 (male, 26 years), and B114 (male, 20 years) all<br />
possessed markers on the tibiae, fibulae, and feet.<br />
Ten of the middle adults were scored as ‘possible’ cases of treponemal disease.<br />
Four of these ten possessed two of the primary markers. B29 (male, 44 years) had cranial<br />
and tibiae involvement. B85 (female, 40 years) had involvement of the fibulae and feet.<br />
65
B94 (undetermined sex, 44 years) had involvement of the hand and foot. B121 (male, 39<br />
years) had cranial and hand involvement. The other six individuals all had three of the<br />
five primary markers. B17 (female, 50 years) exhibited involvement of the tibiae,<br />
fibulae, and feet. B45 (female, 37 years), B49 (male, 46 years), and B72 (male, 38 years)<br />
all suffered from hand, tibiae, and fibulae involvement. B106 (female, 47 years) had<br />
cranial, tibiae, and fibulae involvement, while B124 (male, 42 years) exhibited<br />
involvement of the hands, tibiae, and feet.<br />
4.1.4 None<br />
Of the 54 individuals examined, 5 (9%) were scored as having no signs of<br />
treponemal disease, although these individuals did exhibit infection. Of the infants<br />
examined, B21 (1.7 years), B46 (0.1 years), and B63 (0.4 years) did not contain any of<br />
the five primary markers and therefore were scored as ‘none’ for having treponemal<br />
disease. Two of the young adults were scored as ‘none’ for suffering from treponemal<br />
disease. B3 (male, 27 years) and B41 (female, 18-35 years) did not have any of the five<br />
primary markers.<br />
4.1.5 Differential Diagnosis and Summary<br />
There are five other diseases that have often been difficult to differentiate from<br />
treponemal disease in prehistoric populations: tuberculosis, leprosy, tumors,<br />
osteomyelitis, and Paget’s disease (see Chapter 2 for specific descriptions).<br />
As reviewed above, tuberculosis affects the spine of individuals; more than 40%<br />
of the skeletal lesions are seen in the spine (Aufderheide and Rodríguez-Martín 1998).<br />
66
Most commonly the thoracic and lumbar vertebrae are affected. Collapse of the vertebral<br />
column may occur, usually involving, but not limited to, two or three vertebrae. The hip,<br />
knee and ribs may also be affected (Ibid.). In this study, some of the cervical, thoracic<br />
and lumbar vertebrae are affected in all of the age categories. The vertebrae that are<br />
affected do not have abscesses that progress horizontally to cause collapse of the<br />
vertebral body. Most of the vertebrae exhibit signs of degenerative arthritis and, in some<br />
cases, Schmorl’s nodes. Cranial involvement is generally characteristic of treponemal<br />
disease and not tuberculosis. In tuberculosis a single lesion that affects the inner and<br />
outer tables is often seen. This lesion is not accompanied by any bony reaction. In the<br />
cranial lesions observed in this study, there are multiple lesions affecting the outer table<br />
and they are accompanied by bony reaction.<br />
Leprosy (Lepromatous) most often affects the face in individuals (see Chapter 2).<br />
It causes a resorption of bone in the nasal spine. Leprosy also causes erosion of the<br />
maxillary bone and the palate, and it also affects the hands and feet. In this study, none<br />
of the individuals exhibited resorption of the nasal spine or of the vertebral column. The<br />
hands and feet of the individuals in this study were affected, but resorption of the distal<br />
phalanges of the hands was not seen, nor was the diagnostic club-shaped foot of leprosy<br />
recognizable in the feet of the individuals in the Carrier Mills sample.<br />
The lesions occurring in the individuals of this study also do not fit the profile<br />
outlined above (Chapter 2) for various tumors. Osteosarcoma involves only one bone,<br />
meningioma never affects the postcranial skeleton, metastatic carcinoma and multiple<br />
myeloma produce small lesions without regeneration of bone and the lesions are not<br />
necrotic. The individuals in this study have lesions that are large, surrounded by<br />
67
egeneration of bone with some necrosis, and the lesions are multiple affecting the cranial<br />
and postcranial skeleton.<br />
Osteomyelitis produces sequestra, involucra, and cloaca in the postcranial<br />
skeleton and does not usually affect the cranium. In this study no sequestra or involucra<br />
were observed, and the cranium is affected in some individuals. Paget’s disease produces<br />
massive expansion of the skull vault and is a localized infection that may cause periosteal<br />
reaction, but this percentage is never greater than 1%. In this study no extreme expansion<br />
of the skull vault was observed. The infection in this study is widespread and affects far<br />
more than 1% of the sample.<br />
Thus it appears overwhelmingly likely that the Carrier Mills sample suffered from<br />
some type of treponemal disease. Eighty–nine percent of this sample possessed between<br />
one to five of the primary markers for treponemal disease. Some form of periosteal<br />
involvement was observed in all but one individual from this study, and this individual<br />
(Burial 41) was not complete. Now that it has been determined that a treponemal disease<br />
did exist in the Carrier Mills Archaeological District sample, the differential diagnosis of<br />
which syndrome of treponemal disease existed at Carrier Mills will be examined and<br />
determined.<br />
4.2 Type of Treponemal Disease<br />
Distinguishing between the different syndromes of treponemal disease is a very<br />
hard task. Many of the bony alterations that occur in one syndrome also occur in the<br />
other syndromes. The saber shin deformity of the tibiae can be found in all of the<br />
68
treponematoses that affect the skeleton. Deformity of the nasal-palatal region may also<br />
be seen as well as lesions affecting any bone of the body. The lesions are<br />
morphologically indistinguishable between the different syndromes. Caries sicca is one<br />
characteristic that is not seen in all of the treponematoses. This is the destruction of the<br />
cranium produced by venereal syphilis in the tertiary stage. According to Rothschild et<br />
al. (2004:64), “periosteal reaction diffusely affecting multiple bones of more than 2% of<br />
the population is basically a manifestation of treponemal disease.” A frequency of 2-14%<br />
indicates the presence of syphilis, while frequencies of 20-40% indicate the presence of<br />
either yaws or endemic syphilis (Rothschild et al. 2004).<br />
Rothschild et al. (2000) developed a rubric and summary table of differential<br />
diagnosis, relying on the frequency of occurrence in a sample, the ages affected, and the<br />
bone groups involved, using a specific set of bone groups. This study will draw on that<br />
table to determine which treponemal disease existed in this sample.<br />
4.2.1 Bone Groups<br />
Tables 4.8- 4.12 contain data on the different bone groups affected within the<br />
sample. The tables are divided into the five different age categories; Table 4.8 is infants,<br />
Table 4.9 is adolescents, Table 4.10 consists of young adults, Table 4.11 is middle<br />
adults, and Table 4.12 contains old adults. Each table consists of the burial numbers for<br />
that age group, estimated age in years, sex of the individual, and then a listing of the bone<br />
groups showing osteitis or dental changes characteristic of treponemal disease. The<br />
different bone groups included are the nine defined and used by Rothschild et al. (2000):<br />
tibiae, fibulae, femora, humeri, radii, ulnae, hand bones, foot bones, clavicles, cranial,<br />
69
plus one additional group added for this study, teeth. The “teeth" group includes only the<br />
incisors and the molars. This group is important for distinguishing the different<br />
treponemal syndromes; thus it is included in this study. If any bone in a particular bone<br />
group is affected, then it is indicated as present with an X. Multiple X’s are used for the<br />
hands and feet because the carpals, tarsals, metacarpals, metatarsals, hand and foot<br />
phalanges are each considered separate bone groups (following Rothschild et al. 2000).<br />
If no member of the bone group is affected, it is indicated with an N. If the bone group<br />
was not observable or missing, there is an O on these tables. The number of bone groups<br />
affected (marked with an X) for each burial is then totaled.<br />
The data presented in Tables 4.8 – 4.12 indicate that there are many bone groups<br />
affected in most members of this sample instead of just a few bone groups. This sample<br />
is thus polyostotic, meaning that when looking at the bone groups, an average number<br />
greater than three are affected (Rothschild et al. 2000).<br />
Table 4.13 is a comparison of the numbers of bone groups affected within the<br />
Carrier Mills Archaic burial sample and the numbers found in individuals with confirmed<br />
cases of syphilis, yaws and endemic syphilis summarized by Rothschild et al. (2000).<br />
The numbers of adults and juveniles evaluated are totaled and the percent affected is also<br />
shown. The Carrier Mills sample has unilateral tibial involvement, but it also has<br />
bilateral tibial involvement, which was not taken into account in the Rothschild et al.<br />
(2000) study because two of their five populations were from ossuaries, hindering the<br />
assessment of a disease process involving bilaterality of the tibia. Also shown in this<br />
table are the age (years before present), of the different sites/samples, average numbers of<br />
bone groups affected, whether or not the hands/feet are affected in greater than 5% of the<br />
70
cases, and the distribution or number of individuals affected according to the different<br />
bone groups.<br />
It is clear from this comparison that the disease process which affected the<br />
individuals at Carrier Mills was not venereal syphilis. In fact, it is most like the pattern<br />
of involvement seen in yaws, but with far greater expression in terms of both numbers of<br />
individuals and average numbers of bone groups affected (see discussion in Chapter 5).<br />
4.3 Comparison of Findings<br />
Bassett (1982) found that the most common sites of localized infection for the<br />
skeletons of the Carrier Mills sample were the temporal area, the shoulder region, and the<br />
tibiae. His findings were consistent for both males and females. The fingers and the os<br />
coxae were also affected in males. Bassett (1982) also found widespread infection<br />
throughout the skeletal sample, no matter the age or sex of the individuals. This infection<br />
consisted of periosteal involvement, lesions, and saber shins of the tibiae. Out of the<br />
nearly 500 individuals from the Middle Archaic (4500 – 3000 BC) to the Woodland<br />
(1000 BC – AD 1000) periods, Bassett (1982) diagnosed 122 cases of slight osteitis,<br />
characterized by slight periosteal involvement of the anterior and posterior tibiae, the<br />
fibulae, anterior femora, and slight remodeling of the periosteum. There were 35 cases of<br />
moderate osteitis, in which he included periosteal involvement of these same bones but<br />
also the posterior femora, humeri, radii, ulnae, clavicles, metatarsals, metacarpals, and in<br />
some instances the ribs. A diagnosis of moderate osteitis also included a thick spongy<br />
growth on the tibiae and noticeable saber shins (Bassett 1982). The individuals affected<br />
71
the most were classified as having severe osteitis; there were 8 cases of these. This<br />
includes all the affected bones from the two previous classifications with the addition of<br />
deep lesions on the tibiae, other long bones, and crania. The saber shin became very<br />
obvious in these cases as well. Bassett (1982) suggested this infection was non-venereal<br />
due to symptoms occurring in young individuals as well as older individuals.<br />
The results of the present study mostly agree with the results of Bassett’s (1982)<br />
study. There is widespread infection present in all groups of this burial sample. Bassett<br />
(1982) diagnosed all infants in this study as having no osteitis. I would disagree. Of the<br />
nine infants examined here, 4 have cranial involvement, 3 have tibial involvement, 8 have<br />
involvement of the thoracic or lumbar vertebrae, and all 9 have involvement of at least<br />
one long bone. This disagreement could be due to difficulties in assessing the normal<br />
patterns of bone growth and development in infants.<br />
Another area of disagreement centers on the diagnosis of saber shins on some<br />
individuals. Bassett (1982) diagnosed Burials 1, 25, 33, 48, 65, 103, and 104 as having<br />
moderate osteitis. His diagnosis also included thick spongy growth on the tibiae and<br />
noticeable saber shins of these individuals. I did not categorize the disease process on<br />
these individuals in precisely the same way. Burial 1 has medial striations on both tibiae,<br />
and saber shin was not observed for either tibia. The left tibia did not have thick spongy<br />
growth although the right tibia did have spongy growth on the lateral surface of the shaft.<br />
Burial 25 does exhibit saber shin tibiae. The right tibia also has a concentration of woven<br />
bone at the midshaft that extends from the anterior to medial surface. Burial 33 has a<br />
slight saber shin of the right tibia. No thick spongy growth was observed on either tibia.<br />
Burial 48 exhibits saber shin on both tibiae. The tibiae both have striations on the shafts<br />
72
medially, but there is not thick spongy growth visible on the right tibia. The left tibia has<br />
a patch of thicker spongy growth medial to posterior on the distal third of the shaft that is<br />
barely noticeable. Burial 65 has saber shin on the right tibia. There are striations on the<br />
medial shaft and a thick spongy patch of bone on the proximal third of the shaft medial.<br />
The left tibia is missing. Burial 103 may have slight bowing of the tibiae, but it is so<br />
slight that this burial is considered not to have saber shin tibiae. Both tibiae do have<br />
striations medially on the shafts, but there is not any thick spongy growth on either tibia.<br />
Burial 104 exhibits saber shin on both tibiae. There are striations on the shafts of both<br />
tibia medially, there is spongy bone on both anterior shafts, and both have lesions on the<br />
proximal shafts lateral, the left has two lesions, while the right has one lesion. Bassett<br />
(1982) diagnosed eight individuals with saber shin tibiae and the present study diagnosed<br />
six individuals with saber shin tibiae, including Burial 38.<br />
Most of the findings in Bassett’s (1982) original study of the Carrier Mills<br />
skeletal sample that pertain to the individuals in this sample were confirmed. There are<br />
differences pertaining to the infants and to the individuals diagnosed as having saber shin<br />
tibiae. These differences can be attributed to observer error (given the large amount of<br />
analysis undertaken at once by Bassett) and to the many new advances in paleopathology<br />
since 1982.<br />
4.4 Summary<br />
Treponemal disease was determined to be present in this sub-sample based on the<br />
presence of osteitis/periostitis changes in different bones/groups by age, sex, and uni- or<br />
73
ilaterality of the extremities. Five primary marker sets (cranial, hand, tibial, fibular, and<br />
foot) were used to determine the likelihood of a treponemal disease within this sub-<br />
sample. Thirty-nine percent of the sub-sample were categorized as highly likely - to -<br />
certain for having treponemal disease, 52% were possible for exhibiting treponemal<br />
disease, and 9% had indications of a general infection, but were classified as not having<br />
had a clear indication of treponemal infection.<br />
Rothschild et al. (2004) concluded that 2% or more of a population with periosteal<br />
reaction is indicative of a treponemal disease. They also state that a frequency of 20-40%<br />
indicates either yaws or endemic syphilis in a population. The results of this study show<br />
that 91% of the sub-sample display some kind of periosteal reaction, which is a<br />
considerably greater amount than the 2% necessary to indicate treponemal disease. The<br />
present study also found that 39% of the individuals were categorized as highly likely - to<br />
-certain for treponemal disease. This would fall into the range of the 20-40% (at least)<br />
that is indicative of a nonvenereal treponemal infection, like yaws.<br />
From the comparison in Table 4.13, the profile of age and bone group<br />
involvement make it clear that the Carrier Mills Archaeological District suffered from a<br />
syndrome of treponemal disease most like yaws. When Carrier Mills is compared to the<br />
confirmed cases of yaws summarized by Rothschild et al. (2004), the number of<br />
individuals affected are higher in frequency, with much greater than 5% (in fact 99%) of<br />
the Carrier Mills sample affected as a whole (only one individual without evidence of<br />
bone disease), and the hands and feet are also affected with a much higher prevalence rate<br />
than 5%. Sixty percent of the individuals in this study had involvement of the hands,<br />
while 73% had involvement of the feet (see Table 4.6). This is a significant amount, too<br />
74
high of a percentage to be considered venereal syphilis or endemic syphilis. What do<br />
these figures tell us about the Carrier Mills sample? In the Discussion and Conclusions<br />
Chapter, I will examine more closely: 1) the differential diagnosis of treponemal disease,<br />
2) what life might have been like for the Archaic peoples of Carrier Mills, Illinois, and 3)<br />
what this study means in terms of the history and origin of treponemal disease.<br />
75
Table 4.1. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS<br />
Infants (n=9, age = birth to 3 years)<br />
Burial Number B21 B30 B32 B40 B46 B62 B63 B77 B87 <strong>TO</strong>TALS<br />
Estimated Age (years) 1.7 0.2 0.8 0.6 0.1 0.4 0.4 1.3 0.8 -<br />
Sex of individual Juv Juv Juv Juv Juv Juv Juv Juv Juv -<br />
1 Frontal/Parietal Involvement A P P P A P A A A 4<br />
1 Nasal/Palatal Involvement<br />
A A A A A A A A A 0<br />
Hutchinson's Incisors<br />
A A A A A A A A A 0<br />
Moon's Molars A A A A A A A A A 0<br />
Mulberry Molars A A A A A A A A A 0<br />
Clavicle Involvement A P P P P P P P P 8<br />
Bilateral Humerus Involvement P P P P P P P P P 9<br />
Unilateral Humerus Involvement<br />
A A A A A A A A A 0<br />
Bilateral Radius Involvement - A P P P A A P A 4<br />
Unilateral Radius Involvement<br />
- P A A A P P A P 4<br />
Bowed Radius - A A A A A A A A 0<br />
Bilateral Ulna Involvement - A P A P P A P P 5<br />
Unilateral Ulna Involvement<br />
- P A P A A P A A 3<br />
Bowed Ulna - A A A A A A A A 0<br />
2 Hand Involvement<br />
A A A A A A A P A 1<br />
Rib Involvement A P P P P P P P P 8<br />
Cervical Vertebrae Involvement A A A A A A A A A 0<br />
Thoracic Vertebrae Involvement A A P P P P P P A 6<br />
Lumbar Vertebrae Involvement P A P P P P A P P 7<br />
Periarticular Resorptive Foci (V)<br />
A A A A A A A A A 0<br />
Bilateral Femur Involvement A A P P A P A P P 5<br />
Unilateral Femur Involvement A P A A P A A A A 2<br />
3 Bilateral Tibia Involvement - - P - - - - - P 2<br />
3 Unilateral Tibia Involvement - A A - - P - - A 1<br />
3 Saber Shin Tibia - A A - - A - - A 0<br />
76
Table 4.1. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS,<br />
continued.<br />
Infants (n=9, age = birth to 3 years)<br />
Burial Number B21 B30 B32 B40 B46 B62 B63 B77 B87 <strong>TO</strong>TALS<br />
Estimated Age (years) 1.7 0.2 0.8 0.6 0.1 0.4 0.4 1.3 0.8 -<br />
Sex of individual Juv Juv Juv Juv Juv Juv Juv Juv Juv -<br />
4 Bilateral Fibula Involvement - - P - - - - - P 2<br />
4 Unilateral Fibula Involvement<br />
- - A - - - - - A 0<br />
5 Foot Involvement A A P - A - - - A 1<br />
Number of Pathological Features 2 7 12 9 8 10 6 9 9 72<br />
Number of Bone Groups Affected<br />
1 5 8 5 5 6 4 6 7 -<br />
The five primary markers are numbered and indicated in bold.<br />
P = present A = absent - = not observable<br />
77
Table 4.2. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS<br />
Adolescents (n=2, age = 12 to 20 years)<br />
Burial Number B89 B116 <strong>TO</strong>TALS<br />
Estimated Age (years) 16.5 16.3<br />
-<br />
Sex of individual F M -<br />
1 Frontal/Parietal Involvement A A 0<br />
1 Nasal/Palatal Involvement<br />
A A 0<br />
Hutchinson's Incisors<br />
A A 0<br />
Moon's Molars A A 0<br />
Mulberry Molars A A 0<br />
Clavicle Involvement P P 2<br />
Bilateral Humerus Involvement - P 1<br />
Unilateral Humerus Involvement<br />
P A 1<br />
Bilateral Radius Involvement A A 0<br />
Unilateral Radius Involvement<br />
P P 2<br />
Bowed Radius A A 0<br />
Bilateral Ulna Involvement A P 1<br />
Unilateral Ulna Involvement<br />
P A 1<br />
Bowed Ulna A A 0<br />
2 Hand Involvement<br />
P A 1<br />
Rib Involvement P P 2<br />
Cervical Vertebrae Involvement P A 1<br />
Thoracic Vertebrae Involvement<br />
P P 2<br />
Lumbar Vertebrae Involvement P P 2<br />
Periarticular Resorptive Foci (V)<br />
A A 0<br />
Bilateral Femur Involvement P - 1<br />
Unilateral Femur Involvement P - 1<br />
3 Bilateral Tibia Involvement P - 1<br />
3 Unilateral Tibia Involvement P - 1<br />
3 Saber Shin Tibia A - 0<br />
78
Table 4.2. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS,<br />
continued.<br />
Adolescents (n=2, age = 12 to 20 years)<br />
Burial Number B89 B116 <strong>TO</strong>TALS<br />
Estimated Age (years) 16.5 16.3<br />
-<br />
Sex of individual F M -<br />
4 Bilateral Fibula Involvement A - 0<br />
4 Unilateral Fibula Involvement<br />
P P 2<br />
5 Foot Involvement P P 2<br />
Number of Pathological Features 15 9 24<br />
Number of Bone Groups Affected<br />
12 6 -<br />
The five primary markers are numbered and indicated in bold.<br />
P = present A = absent - = not observable<br />
79
Table 4.3. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS<br />
Young Adults (n=19, age = 20 to 35 years)<br />
Burial Number B3 B25 B35 B39 B41 B48 B50 B66 B69 B82<br />
Estimated Age (years) 27 33 21 22 20-35 20-35 34 21 29 25<br />
Sex of individual M M M M F M? M F M ?<br />
1 Frontal/Parietal Involvement A P P A - - - P A A<br />
1 Nasal/Palatal Involvement<br />
A P A - - - - A A A<br />
Hutchinson's Incisors<br />
A A A - - - - A A A<br />
Moon's Molars A A A - - - - A A A<br />
Mulberry Molars A A A - - - - A A A<br />
Clavicle Involvement A P P - A - - P P P<br />
Bilateral Humerus Involvement A A A - - - - P A P<br />
Unilateral Humerus Involvement<br />
A A A A A - P A A P<br />
Bilateral Radius Involvement A A A - - - A P A A<br />
Unilateral Radius Involvement<br />
A P A A A - A A P P<br />
Bowed Radius A A A A A - A A A A<br />
Bilateral Ulna Involvement A P A A - - A A A A<br />
Unilateral Ulna Involvement<br />
A A P A A - A P A P<br />
Bowed Ulna A A A A A - A P A P<br />
2 Hand Involvement<br />
A P P P - - A A P P<br />
Rib Involvement A A A A - - A P A P<br />
Cervical Vertebrae Involvement A A P - - - - A A A<br />
Thoracic Vertebrae Involvement<br />
P P P P A A - P P P<br />
Lumbar Vertebrae Involvement P P P P - - P P P P<br />
Periarticular Resorptive Foci (V)<br />
P A A A A - A P P A<br />
Bilateral Femur Involvement P P P P - - P P - P<br />
Unilateral Femur Involvement A A A A A - A P A P<br />
3 Bilateral Tibia Involvement - P P - - P P - - P<br />
3 Unilateral Tibia Involvement - P P - A A A P - A<br />
3 Saber Shin Tibia - P A - A P A A - A<br />
80
Table 4.3. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS,<br />
continued.<br />
Young Adults (n=19, age = 20 to 35 years)<br />
Burial Number B3 B25 B35 B39 B41 B48 B50 B66 B69 B82<br />
Estimated Age (years) 27 33 21 22 20-35 20-35 34 21 29 25<br />
Sex of individual M M M M F M? M F M ?<br />
4 Bilateral Fibula Involvement - P A - - P P - - P<br />
4 Unilateral Fibula Involvement<br />
- A A - A A A P - P<br />
5 Foot Involvement - A P - A P P - P P<br />
Num. of Pathological Features 4 13 11 4 0 4 6 14 7 16<br />
Num. of Bone Groups Affected<br />
1 8 7 3 - 4 7 7 4 10<br />
The five primary markers are numbered and indicated in bold.<br />
P = present A = absent - = not observable<br />
81
Table 4.3. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS, cont.<br />
Young Adults (n=19, age = 20 to 35 years)<br />
Burial Number B83 B84 B95 B100 B105 B109 B111 B113 B114 <strong>TO</strong>TALS<br />
Estimated Age (years) 20 29 34 20+ 27 21 22 26 20 -<br />
Sex of individual F F M M? M F F M M -<br />
1 Frontal/Parietal Involvement A P - - - A A A A 4<br />
1 Nasal/Palatal Involvement<br />
- A - - - A A A A 1<br />
Hutchinson's Incisors<br />
A A - - - A A A - 0<br />
Moon's Molars A A - - - A A A A 0<br />
Mulberry Molars A A - - - A A A A 0<br />
Clavicle Involvement A P - - - A A A A 6<br />
Bilateral Humerus Involvement P P - - - A A - P 5<br />
Unilateral Humerus Involvement<br />
A A - - - P A A A 3<br />
Bilateral Radius Involvement A A - - - P A - A 2<br />
Unilateral Radius Involvement<br />
A A - - A A A A A 3<br />
Bowed Radius A A - - A A A A A 0<br />
Bilateral Ulna Involvement A A - - - P A - A 2<br />
Unilateral Ulna Involvement<br />
A A - - A A A A A 3<br />
Bowed Ulna A A - - A A A A A 2<br />
2 Hand Involvement<br />
A P - - P P A A A 8<br />
Rib Involvement A P - - - P A A A 4<br />
Cervical Vertebrae Involvement P P - - - - A - A 3<br />
Thoracic Vertebrae Involvement<br />
P P - - - P P - P 12<br />
Lumbar Vertebrae Involvement P P A - - P P - P 13<br />
Periarticular Resorptive Foci (V)<br />
A A A - - A P - A 4<br />
Bilateral Femur Involvement P P - A - P P P P 13<br />
Unilateral Femur Involvement P P P P P A A A A 7<br />
3 Bilateral Tibia Involvement P P P P A - P P P 12<br />
3 Unilateral Tibia Involvement A A P A A - A A A 4<br />
3 Saber Shin Tibia A A A A A - A A A 2<br />
82
Table 4.3. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS, cont.<br />
Young Adults (n=19, age = 20 to 35 years)<br />
Burial Number B83 B84 B95 B100 B105 B109 B111 B113 B114 <strong>TO</strong>TALS<br />
Estimated Age (years) 20 29 34 20+ 27 21 22 26 20 -<br />
Sex of individual F F M M? M F F M M -<br />
4 Bilateral Fibula Involvement A P - P P - P P P 10<br />
4 Unilateral Fibula Involvement<br />
A A P A A - A P A 4<br />
5 Foot Involvement A A P P P - P P P 11<br />
Num. of Pathological Features 7 12 5 4 4 8 7 5 7 138<br />
Num. of Bone Groups Affected<br />
3 7 5 5 6 6 3 4 6 -<br />
The five primary markers are numbered and indicated in bold.<br />
P = present A = absent - = not observable<br />
83
Table 4.4. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS<br />
Middle Adults (n=20, age = 35 to 50 years)<br />
Burial Number B7 B17 B29 B33 B38 B45 B49 B65 B72 B85<br />
Estimated Age (years) 47 50 44 35 40 37 46 49 38 40<br />
Sex of individual F F M M M F M M M F<br />
1 Frontal/Parietal Involvement P - P A P A - P A -<br />
1 Nasal/Palatal Involvement<br />
A - - P P A - P - -<br />
Hutchinson's Incisors<br />
- - - A A A - A - -<br />
Moon's Molars - - - A A - - A - -<br />
Mulberry Molars - - - A A - - A - -<br />
Clavicle Involvement A P - P P P - P - A<br />
Bilateral Humerus Involvement A P - A P P - A A -<br />
Unilateral Humerus Involvement<br />
P A - A P A P P A P<br />
Bilateral Radius Involvement A A - A P A P A A -<br />
Unilateral Radius Involvement<br />
P A - A P A A A P -<br />
Bowed Radius A A - A A A A P A -<br />
Bilateral Ulna Involvement A A - A A A A A A A<br />
Unilateral Ulna Involvement<br />
P A - A P A A A A A<br />
Bowed Ulna A A - P P A A P P A<br />
2 Hand Involvement<br />
P A A P P P P P P A<br />
Rib Involvement A A - A P P A A A P<br />
Cervical Vertebrae Involvement P - - P P P P A A P<br />
Thoracic Vertebrae Involvement P A - P P P P P P P<br />
Lumbar Vertebrae Involvement P P - P P P P P P P<br />
Periarticular Resorptive Foci (V)<br />
P P - P P P P P A P<br />
Bilateral Femur Involvement A A A P P P P A P P<br />
Unilateral Femur Involvement A A A A A A P P A A<br />
3 Bilateral Tibia Involvement P - P P P P P - - -<br />
3 Unilateral Tibia Involvement P P A A A A A P - -<br />
3 Saber Shin Tibia A A A P P A A P - -<br />
84
Table 4.4. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS,<br />
continued.<br />
Middle Adults (n=20, age = 35 to 50 years)<br />
Burial Number B7 B17 B29 B33 B38 B45 B49 B65 B72 B85<br />
Estimated Age (years) 47 50 44 35 40 37 46 49 38 40<br />
Sex of individual F F M M M F M M M F<br />
4 Bilateral Fibula Involvement A P A P P P P - - -<br />
4 Unilateral Fibula Involvement<br />
A A A P P A A P - P<br />
5 Foot Involvement P P P P P A A P - P<br />
Number of Pathological Features 12 7 3 14 21 11 11 15 6 9<br />
Number of Bone Groups Affected<br />
7 4 3 7 13 8 6 7 5 5<br />
The five primary markers are numbered and indicated in bold.<br />
P = present A = absent - = not observable<br />
85
Table 4.4. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS, cont.<br />
Middle Adults (n=20, age = 35 to 50 years)<br />
Burial Number B86 B91 B93 B94 B99 B104 B106 B110 B121 B124 <strong>TO</strong>TALS<br />
Estimated Age (years) 35 42 42 44 35 46 47 36 39 42 -<br />
Sex of individual F M M ? F M F M M M -<br />
1 Frontal/Parietal Involvement P A P A A P P A A - 8<br />
1 Nasal/Palatal Involvement<br />
A P A A A A A A P - 5<br />
Hutchinson's Incisors<br />
A A A A A - A A A A 0<br />
Moon's Molars A A A A A - A A A A 0<br />
Mulberry Molars A A A A A - A A A A 0<br />
Clavicle Involvement A A P P A P A P P A 10<br />
Bilateral Humerus Involvement A P A P A A P P P - 8<br />
Unilateral Humerus Involvement<br />
A A P - A A A A A P 7<br />
Bilateral Radius Involvement P P A A A A A P P - 6<br />
Unilateral Radius Involvement<br />
A A P P P A A A A P 7<br />
Bowed Radius P A A A A A A A A A 1<br />
Bilateral Ulna Involvement A P A - A A A A A A 1<br />
Unilateral Ulna Involvement<br />
A A A P P P A A A P 6<br />
Bowed Ulna A A A A A P A A P A 5<br />
2 Hand Involvement<br />
P P P P P P A P P P 16<br />
Rib Involvement A P A P P P A A P P 9<br />
Cervical Vertebrae Involvement A A A P A A A A P P 9<br />
Thoracic Vertebrae Involvement P P P P P P A P P P 17<br />
Lumbar Vertebrae Involvement P P P P P A P P P - 17<br />
Periarticular Resorptive Foci (V)<br />
A A P A A A P P P P 13<br />
Bilateral Femur Involvement A P A - P A P P P P 12<br />
Unilateral Femur Involvement P A A - A P A A P A 5<br />
3 Bilateral Tibia Involvement A P P - P P P P - - 12<br />
3 Unilateral Tibia Involvement P A P - P A A A - P 8<br />
3 Saber Shin Tibia A A A - A P A A - A 4<br />
86
87<br />
Table 4.4. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS, cont.<br />
Middle Adults (n=20, age = 35 to 50 years)<br />
Burial Number B86 B91 B93 B94 B99 B104 B106 B110 B121 B124 <strong>TO</strong>TALS<br />
Estimated Age (years) 35 42 42 44 35 46 47 36 39 42 -<br />
Sex of individual F M M ? F M F M M M -<br />
4 Bilateral Fibula Involvement P P P - P P P A - - 11<br />
4 Unilateral Fibula Involvement<br />
A A A - A P A P - A 7<br />
5 Foot Involvement P A P P P P A P - P 14<br />
Number of Pathological Features 10 11 12 10 11 13 7 11 13 11 218<br />
Number of Bone Groups Affected<br />
8 8 10 9 9 9 4 9 7 8 -<br />
The five primary markers are numbered and indicated in bold.<br />
P = present A = absent - = not observable
Table 4.5. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS<br />
Old Adults (n=4, age = >50+ years)<br />
Burial Number B1 B4 B51 B103 <strong>TO</strong>TALS<br />
Estimated Age (years) 56 58 51 53<br />
-<br />
Sex of individual F F M F<br />
-<br />
1 Frontal/Parietal Involvement P P - - 2<br />
1 Nasal/Palatal Involvement<br />
A A - - 0<br />
Hutchinson's Incisors<br />
A A - - 0<br />
Moon's Molars<br />
A A - - 0<br />
Mulberry Molars<br />
A A - -<br />
0<br />
Clavicle Involvement A A A P 1<br />
Bilateral Humerus Involvement A P - P 2<br />
Unilateral Humerus Involvement P A P A 2<br />
Bilateral Radius Involvement A A A P 1<br />
Unilateral Radius Involvement A A A A 0<br />
Bowed Radius A A A A 0<br />
Bilateral Ulna Involvement A P P A 2<br />
Unilateral Ulna Involvement A A A A 0<br />
Bowed Ulna A A A P 1<br />
2 Hand involvement P P P P 4<br />
Rib Involvement A A A P 1<br />
Cervical Vertebrae Involvement A A - A 0<br />
Thoracic Vertebrae Involvement P A P P 3<br />
Lumbar Vertebrae Involvement P A P A 2<br />
Periarticular Resorptive Foci (V) P P A A 2<br />
Bilateral Femur Involvement P P - P 3<br />
Unilateral Femur Involvement P A P A 2<br />
3 Bilateral Tibia Involvement P P P P 4<br />
3 Unilateral Tibia Involvement A P A A 1<br />
3 Saber Shin Tibia A A A A 0<br />
88
Table 4.5. PATHOLOGICAL MARKERS ASSOCIATED WITH <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE INDIVIDUALS,<br />
continued.<br />
Old Adults (n=4, age = >50+ years)<br />
Burial Number B1 B4 B51 B103 <strong>TO</strong>TALS<br />
Estimated Age (years) 56 58 51 53 -<br />
Sex of individual F F M F -<br />
4 Bilateral Fibula Involvement P P A P 3<br />
4 Unilateral Fibula Involvement A A P A 1<br />
5 Foot Involvement P P P P 4<br />
Number of Pathological Features 11 10 9 11 37<br />
Number of Bone Groups Affected 7 9 8 8 -<br />
The five primary markers are numbered and indicated in bold.<br />
P = present A = absent - = not observable<br />
89
Table 4.6. SUMMARY & PERCENTAGES OF POSSIBLE TREPONEMAL MARKERS FOUND IN CARRIER MILLS<br />
# of # of % of # of # of # of % of % of<br />
Infants Adol Juv Y Adults M Adults O Adults Adults Total<br />
Markers (n=9) (n=2) (n=11) (n=19) (n=20) (n=4) (n=43) (t=54)<br />
1 Frontal/Parietal Involvement 4/9 0/2 36% 4/13 8/16 2/2 45% 43%<br />
1 Nasal/Palatal Involvement 0/9 0/2 0 1/11 5/14 0/2 22% 16%<br />
Hutchinson's Incisors 0/9 0/2 0 0/11 0/13 0/2 0 0<br />
Moon's Molars 0/9 0/2 0 0/12 0/12 0/2 0 0<br />
Mulberry Molars 0/9 0/2 0 0/12 0/12 0/2 0 0<br />
Clavicle Involvement 8/9 2/2 91% 6/13 10/17 1/4 50% 60%<br />
Bilateral Humerus Involvement 9/9 1/1 100% 5/11 8/16 2/3 50% 63%<br />
Unilateral Humerus Involvement 0/9 1/2 9% 3/15 7/18 2/4 32% 27%<br />
Bilateral Radius Involvement 4/8 0/2 40% 2/12 6/17 1/4 27% 30%<br />
Unilateral Radius Involvement 4/8 2/2 60% 3/15 7/18 0/4 27% 34%<br />
Bowed Radius 0/8 0/2 0 0/16 2/18 0/4 5% 4%<br />
Bilateral Ulna Involvement 5/8 1/2 60% 2/13 1/18 2/4 14% 24%<br />
Unilateral Ulna Involvement 3/8 1/2 40% 3/16 6/19 0/4 23% 27%<br />
Bowed Ulna 0/8 0/2 0 2/16 6/19 1/4 23% 18%<br />
2 Hand Involvement 1/9 1/2 18% 8/15 16/20 4/4 72% 60%<br />
Rib Involvement 8/9 2/2 91% 4/14 9/19 1/4 38% 50%<br />
Cervical Vertebrae Involvement 0/9 1/2 9% 3/10 9/18 0/3 39% 31%<br />
Thoracic Vertebrae Involvement 6/9 2/2 73% 12/14 17/19 3/4 86% 83%<br />
Lumbar Vertebrae Involvement 7/9 2/2 82% 13/14 17/18 2/4 89% 87%<br />
Periarticular Resorptive Foci (Vert.) 0/9 0/2 0 4/15 13/19 2/4 50% 39%<br />
Bilateral Femur Involvement 5/9 1/1 60% 13/14 12/19 3/3 78% 74%<br />
Unilateral Femur Involvement 2/9 1/1 30% 7/18 5/19 2/4 34% 33%<br />
3 Bilateral Tibia Involvement 2/2 1/1 100% 12/13 12/13 4/4 93% 94%<br />
3 Unilateral Tibia Involvement 1/4 1/1 40% 4/15 7/16 1/4 34% 35%<br />
3 Saber Shin Tibia 0/4 0/1 0 2/15 4/16 0/4 17% 15%<br />
90
Table 4.6. SUMMARY & PERCENTAGES OF POSSIBLE TREPONEMAL MARKERS FOUND IN CARRIER MILLS, cont.<br />
# of # of % of # of # of # of % of % of<br />
Infants Adol Juv Y Adults M Adults O Adults Adults Total<br />
Markers (n=9) (n=2) (n=11) (n=19) (n=20) (n=4) (n=43) (t=54)<br />
4 Bilateral Fibula Involvement 2/2 0/1 67% 10/12 11/14 3/4 80% 79%<br />
4 Unilateral Fibula Involvement 0/2 2/2 50% 4/15 6/17 1/4 31% 33%<br />
5 Foot Involvement 1/5 2/2 43% 11/15 14/18 4/4 78% 73%<br />
The five primary markers are numbered and indicated in bold.<br />
n = number of individuals in age category<br />
t = total number of individuals in the sample<br />
% of juveniles = infants + adolescents/observable # X100<br />
% of adults = young + middle + old adults/observable # X100<br />
% of total = juveniles + adults/observable # X100<br />
% of males = number of males affected/observable # X100<br />
% of females = number of females affected/observable # X100<br />
91
Table 4.6. SUMMARY & PERCENTAGES OF POSSIBLE TREPONEMAL MARKERS FOUND IN CARRIER MILLS, cont.<br />
# of % of # of % of<br />
Males M Females F<br />
Markers (n=26) (t=26) (n=17) (t=17)<br />
1 Frontal/Parietal Involvement 7/19 37% 7/13 54%<br />
1 Nasal/Palatal Involvement 6/16 38% 0/12 0<br />
Hutchinson's Incisors 0/15 0 0/12 0<br />
Moon's Molars 0/16 0 0/11 0<br />
Mulberry Molars 0/16 0 0/11 0<br />
Clavicle Involvement 12/18 67% 6/17 35%<br />
Bilateral Humerus Involvement 7/16 44% 8/14 57%<br />
Unilateral Humerus Involvement 8/22 36% 5/17 29%<br />
Bilateral Radius Involvement 5/19 26% 4/15 27%<br />
Unilateral Radius Involvement 8/23 35% 3/16 19%<br />
Bowed Radius 1/23 4% 1/16 6%<br />
Bilateral Ulna Involvement 4/21 19% 2/16 13%<br />
Unilateral Ulna Involvement 5/23 22% 4/17 24%<br />
Bowed Ulna 7/23 30% 2/17 12%<br />
2 Hand Involvement 18/24 75% 10/16 63%<br />
Rib Involvement 7/22 32% 8/16 50%<br />
Cervical Vertebrae Involvement 6/18 33% 6/14 43%<br />
Thoracic Vertebrae Involvement 20/21 95% 13/17 76%<br />
Lumbar Vertebrae Involvement 19/21 90% 14/16 88%<br />
Periarticular Resorptive Foci (Vert.) 10/22 45% 9/17 53%<br />
Bilateral Femur Involvement 16/21 76% 13/16 81%<br />
Unilateral Femur Involvement 9/25 36% 6/17 35%<br />
3 Bilateral Tibia Involvement 18/19 95% 11/12 92%<br />
3 Unilateral Tibia Involvement 6/21 29% 7/15 47%<br />
3 Saber Shin Tibia 6/21 29% 0/15 0<br />
92
Table 4.6. SUMMARY & PERCENTAGES OF POSSIBLE TREPONEMAL MARKERS FOUND IN CARRIER MILLS, cont.<br />
# of % of # of % of<br />
Males M Females F<br />
Markers (n=26) (t=26) (n=17) (t=17)<br />
4 Bilateral Fibula Involvement 14/18 78% 10/13 77%<br />
4 Unilateral Fibula Involvement 10/22 45% 3/16 19%<br />
5 Foot Involvement 20/23 87% 10/15 67%<br />
The five primary markers are numbered and indicated in bold.<br />
n = number of individuals in age category<br />
t = total number of individuals in the sample<br />
% of juveniles = infants + adolescents/observable # X100<br />
% of adults = young + middle + old adults/observable # X100<br />
% of total = juveniles + adults/observable # X100<br />
% of males = number of males affected/observable # X100<br />
% of females = number of females affected/observable # X100<br />
93
Table 4.7. PERCENTAGES OF POSSIBLE TREPONEMAL DISEASE<br />
Likeli- None Possible Highly Certain<br />
hood - - Likely -<br />
# Markers 0 Markers 1-3 Markers 4-5 markers 5 + markers<br />
Burials 5/54 28/54 15/54 6/54<br />
Percent 9% 52% 28% 11%<br />
Note: Based on cranial, hands, tibiae, fibulae, and feet, and involvement.<br />
Please see text for descriptions.<br />
94
Table 4.8. BONE GROUPS AFFECTED IN <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
Infants (n=9, age = birth to 3 years)<br />
Burial Numbers B21 B30 B32 B40 B46 B62 B63 B77 B87 <strong>TO</strong>TALS<br />
Estimated Age (years) 1.7 0.2 0.8 0.6 0.1 0.4 0.4 1.3 0.8 -<br />
Sex of Individual Juv Juv Juv Juv Juv Juv Juv Juv Juv -<br />
Bone Group - - - - - - - - - -<br />
Tibia O N X O O X O O X 3<br />
Fibula O O X O O O O O X 2<br />
Femora N X X X X X N X X 7<br />
Humerus X X X X X X X X X 9<br />
Radius O X X X X X X X X 8<br />
Ulna O X X X X X X X X 8<br />
Hand Bones N N N N N N N X N 1<br />
Foot Bones N N X O N O O O N 1<br />
Clavicle N X X X X X X X X 8<br />
Cranial N X X X N X N N N 4<br />
Teeth N N N N N N N N N 0<br />
<strong>TO</strong>TALS 1 6 9 6 5 7 4 6 7 51<br />
X = affected bone group, N = non-affected bone group, O = not observable<br />
95
Table 4.9. BONE GROUPS AFFECTED IN <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
Adolescents (n = 2, age = 12 to 20 years)<br />
Burial Numbers B89 B116 <strong>TO</strong>TALS<br />
Estimated Age (years) 16.5 16.3 -<br />
Sex of Individual F M -<br />
Bone Group - - -<br />
Tibia X O 1<br />
Fibula X X 2<br />
Femora X O 1<br />
Humerus X X 2<br />
Radius X X 2<br />
Ulna X X 2<br />
Hand Bones XX N 2<br />
Foot Bones XXX X 4<br />
Clavicle X X 2<br />
Cranial N N 0<br />
Teeth (incisors, molars) N N 0<br />
<strong>TO</strong>TALS 12 6 18<br />
X = affected bone group,N = non-affected bone group, O = not observable<br />
96
Table 4.10. BONE GROUPS AFFECTED IN <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
Young Adults (n = 19, age = 20 to 35 years)<br />
Burial Numbers B3 B25 B35 B39 B41 B48 B50 B66 B69 B82<br />
Estimated Age (years) 27 33 21 22 20-35 20-35 34 21 29 25<br />
Sex of Individual M M M M F M? M F M ?<br />
Bone Group - - - - - - - - - -<br />
Tibia O X X O N X X X O X<br />
Fibula O X N O N X X X O X<br />
Femora X X X X N O X X N X<br />
Humerus N N N N N O X X N X<br />
Radius N X N N N O N X X X<br />
Ulna N X X N N O N X N X<br />
Hand Bones N XX X XX O O N N X X<br />
Foot Bones O N XX O N XX XXX O X XX<br />
Clavicle N X X O N O O X X X<br />
Cranial N X X N O O O X N N<br />
Teeth (incisors, molars) N N N O O O O N N N<br />
<strong>TO</strong>TALS 1 9 8 3 0 4 7 8 4 10<br />
X = affected bone group, N = non-affected bone group, O = not observable<br />
97
Table 4.10. BONE GROUPS AFFECTED IN <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE,<br />
continued.<br />
Young Adults (n = 19, age = 20 to 35 years)<br />
Burial Numbers B83 B84 B95 B100 B105 B109 B111 B113 B114 <strong>TO</strong>TALS<br />
Estimated Age (years) 20 29 34 20+ 27 21 22 26 20 -<br />
Sex of Individual F F M M? M F F M M -<br />
Bone Group - - - - - - - - - -<br />
Tibia X X X X N O X X X 13<br />
Fibula N X X X X O X X X 12<br />
Femora X X X X X X X X X 16<br />
Humerus X X O O O X N N X 7<br />
Radius N N O O N X N N N 5<br />
Ulna N N O O N X N N N 5<br />
Hand Bones N XX O O XX XX N N N 13<br />
Foot Bones N N XX XX XX O X X XX 20<br />
Clavicle N X O O O N N N N 6<br />
Cranial N X O O O N N N N 4<br />
Teeth (incisors, molars) N N O O O N N N N 0<br />
<strong>TO</strong>TALS 3 8 5 5 6 6 4 4 6 54<br />
X = affected bone group, N = non-affected bone group, O = not observable<br />
98
Table 4.11. BONE GROUPS AFFECTED IN <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
Middle Adults (n = 20, age = 35 to 50 years)<br />
Burial Numbers B7 B17 B29 B33 B38 B45 B49 B65 B72 B85<br />
Estimated Age (years) 47 50 44 35 40 37 46 49 38 40<br />
Sex of Individual F F M M M F M M M F<br />
Bone Group - - - - - - - - - -<br />
Tibia X X X X X X X X O O<br />
Fibula N X N X X X X X O X<br />
Femora N N N X X X X X X X<br />
Humerus X X O N X X X X N X<br />
Radius X N O N X N X X X O<br />
Ulna X N O X X N N X X N<br />
Hand Bones X N N X XXX XXX XX X X N<br />
Foot Bones XX X XX XX XXX N N X O XX<br />
Clavicle N X O X X X O X O N<br />
Cranial X O X X X N O X N O<br />
Teeth (incisors, molars) O O O N N O O N O O<br />
<strong>TO</strong>TALS 8 5 4 9 14 8 7 10 4 5<br />
X = affected bone group, N = non-affected bone group, O = not observable<br />
99
Table 4.11. BONE GROUPS AFFECTED IN <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE, continued.<br />
Middle Adults (n = 20, age = 35 to 50 years)<br />
Burial Numbers B86 B91 B93 B94 B99 B104 B106 B110 B121 B124 <strong>TO</strong>TALS<br />
Estimated Age (years) 35 42 42 44 35 46 47 36 39 42 -<br />
Sex of Individual F M M ? F M F M M M -<br />
Bone Group - - - - - - - - - - -<br />
Tibia X X X O X X X X O X 17<br />
Fibula X X X O X X X X O N 15<br />
Femora X X N O X X X X X X 15<br />
Humerus N X X X N N X X X X 14<br />
Radius X X X X X N N X X X 13<br />
Ulna N X N X X X N N X X 10<br />
Hand Bones X XX XXX XXX XX XXX N X XXX X 31<br />
Foot Bones XXX N XX XX XX X N XXX O XX 28<br />
Clavicle N N X X N X N X X N 10<br />
Cranial X X X N N X X N X O 11<br />
Teeth (incisors, molars) N N N N N O N N N N 0<br />
<strong>TO</strong>TALS 9 9 11 9 9 10 5 10 9 8 74<br />
X = affected bone group, N = non-affected bone group, O = not observable<br />
100
Table 4.12. BONE GROUPS AFFECTED IN <strong>THE</strong> CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
Old Adults (n = 4, age = >50+ years)<br />
Burial Numbers B1 B4 B51 B103 <strong>TO</strong>TALS<br />
Estimated Age (years) 56 58 51 53 -<br />
Sex of Individual F F M F -<br />
Bone Group - - - - -<br />
Tibia X X X X 4<br />
Fibula X X X X 4<br />
Femora X X X X 4<br />
Humerus X X X X 4<br />
Radius N N N X 1<br />
Ulna N X X X 3<br />
Hand Bones X XX XX X 6<br />
Foot Bones XX XX X XX 7<br />
Clavicle N N N X 1<br />
Cranial X X O O 2<br />
Teeth (incisors, molars) N N O O 0<br />
<strong>TO</strong>TALS 8 10 8 10 36<br />
X = affected bone group, N = non-affected bone group, O = not observable<br />
101
Table 4.13. NUMBERS OF BONE GROUPS AFFECTED IN CARRIER MILLS SAMPLE<br />
COMPARED <strong>TO</strong> CONFIRMED DISEASE<br />
Carrier<br />
Confirmed Disease*<br />
Parameter<br />
Mills Syphilis Yaws Bejel<br />
Date, years before present<br />
Adults<br />
> 3000 60-90 500 50-200<br />
No. evaluated 43 2906 214 40<br />
No. (%) affected<br />
Juveniles<br />
42(98%) 145(5%) 71(33%) 10(25%)<br />
No. evaluated 11 50 60 10<br />
No. (%) affected 11(100%) 0(0%) 8(14%) 1(10%)<br />
>5% affected Yes No Yes Yes<br />
Bilateral tibial involvement Yes - - -<br />
Unilateral tibial involvement Yes Yes No No<br />
Saber shin without surface reaction No Yes No No<br />
Average no. of bone groups affected 6.3 1.9 4.0 2.0<br />
Average no. of bone groups > 3 Yes No Yes No<br />
Hands/Feet >5%<br />
Distribution, no. affected<br />
Yes No Yes No<br />
Tibia 67 96 35 14<br />
Fibula 58 41 20 3<br />
Femora 77 41 31 3<br />
Humerus 59 16 10 0<br />
Radius 42 8 13 1<br />
Ulna 36 6 15 0<br />
Hand Bones 122 2 9 0<br />
Foot Bones 128 0 12 0<br />
Clavicle 43 4 3 0<br />
Cranial 22 38 7 1<br />
Teeth (incisors, molars) 0 - - -<br />
* Adapted from Rothschild et al. 2000, and Rothschild and Rothschild 1994,<br />
based on 3280 skeletons of known treponemal pathology.<br />
102
Percentages<br />
100<br />
90<br />
80<br />
70<br />
60<br />
50<br />
40<br />
30<br />
20<br />
10<br />
0<br />
Figure 4.1. Percentages of Treponemal Markers in Juveniles and Adults<br />
Juveniles<br />
Adults<br />
Fron/Par Nas/Pal Hand Bi Tib Uni Tib Saber Tib Bi Fib Uni Fib Foot<br />
103
Percentages<br />
100<br />
90<br />
80<br />
70<br />
60<br />
50<br />
40<br />
30<br />
20<br />
10<br />
0<br />
Figure 4.2. Percentages of Treponemal Markers in Males, Females, and Total Sample<br />
Fron/Par Nas/Pal Hand Bi Tib Uni Tib Saber Tib Bi Fib Uni Fib Foot<br />
Males<br />
Females<br />
Totals<br />
104
Likelihood %<br />
60%<br />
50%<br />
40%<br />
30%<br />
20%<br />
10%<br />
0%<br />
Figure 4.3. Likelihood of Treponemal Disease in Individuals at Carrier Mills<br />
None<br />
Possible<br />
Highly Likely<br />
Certain<br />
105
106
Figure 4.4. Cranium of Burial 38 showing location and size of lesions.<br />
106
Figure 4.5. Burial 38 Left 3 rd metacarpal with unifocal bone loss and woven bone.<br />
Figure 4.6. Burial 38 Right tibia posterior midshaft 6 lesions with woven and sclerotic<br />
reaction.<br />
107
Figure 4.7. Burial 38 Left fibula lateral close up of cloaca.<br />
Figure 4.8. Burial 38 Left 1 st metatarsal plantar with woven and sclerotic reaction.<br />
108
CHAPTER 5<br />
DISCUSSION <strong>AND</strong> CONCLUSIONS<br />
5.1 Differential Diagnosis of Treponemal Disease<br />
The distribution of pathological alterations in the skeletons from Carrier Mills is<br />
almost certainly indicative of an endemic treponemal infection and not of leprosy,<br />
tuberculosis, or some other disease. Differentiating between the three syndromes of<br />
treponemal disease affecting the human skeletal system can be very challenging. The<br />
syndromes yaws, endemic syphilis, and venereal syphilis leave similar periosteal changes<br />
on the same bones, for the most part. Rothschild et al. (2000) suggest that an<br />
epidemiological approach can discriminate between the different syndromes of<br />
treponematoses. This chapter provides an epidemiological approach to discriminating<br />
between the different treponematoses as applied to the human skeletal remains from the<br />
Carrier Mills Archaeological District.<br />
Venereal syphilis was not the syndrome of treponemal disease affecting the<br />
Carrier Mills sample. This was concluded from comparing the confirmed cases of<br />
venereal syphilis in samples from the Rothschild et al. (2000) study to the present study<br />
(see Table 4.13). In the confirmed cases of venereal syphilis, prevalence in the<br />
population is small: very few adults have affected bone groups (5%), while none of the<br />
juveniles are affected. In the Carrier Mills sample, 98% of the adults have affected bone<br />
109
groups, and 100% of the juveniles are affected. (Note that this comparison is based on<br />
the nine bone groups of Rothschild et al. plus teeth, not the five "primary markers" used<br />
earlier to indicate any evidence of a treponemal infection). The hands and feet are only<br />
affected in fewer than 5% of the sample of the confirmed cases of venereal syphilis. For<br />
the Carrier Mills sample, more than 5% of the hands and feet are involved. The average<br />
number of bone groups affected in the confirmed cases of venereal syphilis is few, at 1.9<br />
(Rothschild et al. 2000). The average number of bone groups for the Carrier Mills study<br />
is much higher at 6.3. On the basis of both adults and juveniles affected, more than 5%<br />
of the hands and feet being affected, and the average number of bone groups being<br />
greater than 3, the Carrier Mills Archaic sample could not have suffered from venereal<br />
syphilis.<br />
By comparing the Carrier Mills sample to that of the confirmed cases of endemic<br />
syphilis (bejel), it is concluded that endemic syphilis was not the treponemal disease<br />
affecting this sample either. In the confirmed cases of endemic syphilis, 25% of the<br />
adults are affected and 10% of the juveniles are affected (see Table 4.13). In the Carrier<br />
Mills sample, 98% of the adults are affected, while 100% of the juveniles are affected.<br />
While it is true that greater than 5% of the juveniles are affected in the confirmed cases of<br />
endemic syphilis, it is still a very small percentage compared to ubiquity seen in the<br />
Carrier Mills juveniles. The hands and feet are affected in fewer than 5% of individuals<br />
of the confirmed cases of endemic syphilis (see Table 4.13). In the Carrier Mills study,<br />
the hands and feet are affected greater than 5%. The average number of bone groups<br />
affected in the Carrier Mills sample is 6.3, while the average number of bone groups in<br />
the confirmed cases of endemic syphilis is much smaller, at 2.0. Based on these figures,<br />
110
endemic syphilis is not the treponemal disease affecting the Carrier Mills Archaic<br />
sample.<br />
The comparison of the confirmed cases of yaws to that of the Carrier Mills study<br />
strongly supports that the Carrier Mills Archaic sample suffered from a treponemal<br />
disease most like that of yaws, among known modern treponemal syndromes. In yaws,<br />
greater than 5% of the individuals have involvement of the hands and feet, there is a<br />
greater frequency of adults and juveniles affected, and the average number of bone<br />
groups affected is greater than three (see Table 4.13). This is the pattern seen in the<br />
Carrier Mills sample. It is overwhelmingly apparent that a treponemal disease<br />
resembling that of yaws affected the Carrier Mills Archaic sample. So what does this tell<br />
us about the life of the Carrier Mills Archaic people as compared to other<br />
contemporaneous North American sites located nearby and what does it mean in the<br />
context of the debate on the origin of treponemal disease?<br />
5.2 Comparisons to Other Sites<br />
The findings of this research can now be compared to other nearby or Archaic<br />
sites. The first two sites are those of Moundville and Irene Mound. Powell (1991) found<br />
similar pathological evidence of nonvenereal treponemal disease at both of these sites.<br />
Moundville is a Mississippian (AD 1050-1550) period occupation site located in west<br />
central Alabama. The total number of excavated burials from this site is 1500; of these<br />
Powell (1991) selected 564 for her study. Irene Mound is also a Mississippian (AD<br />
1110-1400) site located near the mouth of the Savannah River on the Atlantic Coast.<br />
111
Two hundred and sixty-five individuals were selected from this site for analysis. Both of<br />
these samples revealed extensive periostitis on the long bone shafts of the tibia, fibula,<br />
radius, and ulna, along with saber shin deformity (Ibid.). In the Moundville sample,<br />
small, circular depressions were found on the cranial vaults. Skeletons from Irene<br />
Mound, on the other hand, exhibited evidence of gangosa. A young adult female from<br />
Irene Mound exhibited lesions of the frontal, palate, maxilla and extensive remodeling of<br />
the nasal aperture (Ibid.).<br />
When Carrier Mills is compared to Moundville and Irene Mound, there are clear<br />
similarities. Numerous foci of periostitis along the long bone shafts of the tibiae and<br />
fibulae, as well as saber shin deformity are found in the skeletons from all three sites.<br />
The Irene Mound skeletons display evidence of gangosa, while those from Carrier Mills<br />
do not, although at both Irene Mound (IM) and Carrier Mills (CM) there are lesions on<br />
the frontal bones of two individuals (a young adult female (IM) and a middle adult male<br />
(CM)). The differences in the disease profile between these sites could be attributed to<br />
the time span between the sites; Irene Mound and Moundville are both Mississippian,<br />
while Carrier Mills is Archaic.<br />
Pete Klunk Mounds in west central Illinois is a Late Archaic (900 BC) site (Cook<br />
2002; Powell et al. 2005). This site only produced 22 individuals, with one of these, a<br />
young adult male 18-25 years, exhibiting evidence of treponemal disease. The<br />
characteristics of this individual include: thickened and rounded margins of the nasal<br />
aperture; small nasal spurs; the floor of the nasal cavity, the bony palate and the lacrimal<br />
canals displaying reactive new bone formation; the palate thickened with a small<br />
perforation; the anterior nasal spine somewhat resorbed, broad and irregular; and the<br />
112
midline crest irregular, porous and raised (Cook 2002). All of these characteristics can be<br />
found in the gangosa deformity of yaws (Ibid.).<br />
Pete Klunk Mounds and Carrier Mills do not seem to have many similarities,<br />
except for the fact that the most severe case at both sites is male. Cook (2002) concluded<br />
that the characteristics found in the young adult male at Pete Klunk were those of<br />
gangosa from yaws. None of the individuals examined at Carrier Mills had the gangosa<br />
deformity. It is possible that the characteristics visible in the Carrier Mills site belong to<br />
a different syndrome of treponemal disease. Perhaps this syndrome is an earlier form of<br />
yaws that did not have advanced gangosa deformity.<br />
Eva II is a late Middle Archaic (5000-3000 BC) site in western Tennessee with<br />
approximately 71 adults and adolescents recovered from the site (Powell et al. 2005).<br />
Two burials exhibit characteristics of treponemal disease. Burial 11 is a middle adult<br />
male that exhibits the following characteristics: surface pitting, round depressions with<br />
radiating striae, and raised areas of bone with multiple shallow round depressions on the<br />
frontal and parietals; the palate is perforated; there is periostitis on the ribs, left humerus,<br />
left radius, left fibula, right clavicle, both femora, and both tibiae (Ibid.). The second is<br />
Burial 36, an adult of indeterminate age and sex, although Powell et al. (2005) state that<br />
this was probably a male. This adult exhibits several characteristics: the frontal and right<br />
posterior parietal have thickened cortical bone with circular depressions; there are also<br />
stellate scars, circumvallate lesions and areas of porosity on the cranium; 6 rib fragments<br />
have lesions on the dorsal surface which are circular depressions with woven bone; the<br />
left tibia and both femora exhibit nodular cavitation; the left clavicle has lesions that are<br />
113
coalescing and penetrating; the distal metaphysis of the left humerus is thickened; and the<br />
midshaft of the right radius has reactive bone and superficial cavitation (Ibid.).<br />
Eva II (EII) and Carrier Mills (CM) have many similarities. All three burials with<br />
major symptoms appear to be males (EII 11, 36, and CM 38). The frontal and parietals<br />
have multiple shallow round depressions and surface pitting, and periostitis is seen in<br />
multiple long bones including the femora, tibiae, fibulae, and radii. The frontal lesions of<br />
CM Burial 38 show focal superficial cavitation. Powell et al. (2005) conclude that this is<br />
a non-venereal treponemal disease due to the fact that there is no evidence found for<br />
congenital cases or the characteristic dental stigmata of congenital syphilis.<br />
The Barrett site is in the Green River Valley of McLean County, Kentucky. This<br />
site includes 412 individuals: 237 adults, 41 children, 101 infants, and 33 individuals of<br />
undetermined age. The Archaic site dates to 5620 BP or 4520 BP according to new<br />
radiocarbon dates (Powell et al. 2005). Pathological changes in this sample include a<br />
high frequency of lesions involving the nasal cavity, palate and face that are resorptive in<br />
nature (Ibid.). The palates display pitting and a large incisive foramen. The crania<br />
exhibit lesions of the vault that include clustered pits, radial scars, circumvallate<br />
cavitation, and confluent clustered pits (Ibid.). The postcranial skeleton exhibits diffuse<br />
pitting, linear striations, periosteal plaques, remodeled and active lesions of which the<br />
tibia and fibula are the most affected (Ibid.).<br />
The skeletal materials from Barrett and Carrier Mills have a few similarities.<br />
Again they differ in the characteristics involving the face. The Barrett skeletal collection<br />
has many characteristics of the gangosa deformity, while Carrier Mills does not. Carrier<br />
Mills Burial 38 exhibits focal superficial cavitation and clustered pits on the cranium,<br />
114
similar to what is seen at Barrett. Both Barrett and Carrier Mills individuals exhibit<br />
linear striations, periosteal plaques, and remodeled lesions of the tibiae, fibulae, and<br />
femora.<br />
The last site is that of Indian Knoll from the Archaic (3352-2013 BC) period<br />
located along the Green River in western Ohio County, Kentucky (Cassidy 1972; Powell<br />
et al. 2005). This site includes 1234 skeletons (Cassidy 1972). The original analysis of<br />
this site was performed by Snow (1948), who concluded that syphilis was present in this<br />
population based on 4 affected individuals. Burial 9 is that of a young woman with<br />
palatine and maxillae involvement; Burial 13 is that of a young woman whose nasal<br />
aperture exhibits scarred, rounded over borders; Burial 508 is that of a young man who<br />
has similar characteristics to those of Burial 9; and Burial 490, the most affected<br />
individual, has lesions on the frontal, maxillae, hard palate, humerus and radii (Ibid.).<br />
The humerus includes sinus formation and drainage, while the radii exhibit “lace-like<br />
fenestration” of bone (Snow 1948:506).<br />
Cassidy (1972) examined 285 individuals from Indian Knoll; 70 of those were<br />
affected in some way, and she diagnosed the characteristics as those of endemic<br />
treponematosis. The analysis revealed that 2.4 % of the Indian Knoll individuals were<br />
affected from all age groups (see Cassidy 1972 for a complete chart of the individuals<br />
affected). The characteristics found include: thickening of the periosteal surface, raised<br />
discolored vascular plaques, thickened cortexes, narrow longitudinal striations, smooth<br />
billowed areas, and swollen bones perforated by sinuses and bowed (Ibid.). The bones<br />
affected include the tibia, fibula, femur, ulna, radius, humerus, clavicle, ribs, zygomatics,<br />
and frontal (Ibid.).<br />
115
Kelley (1980) conducted a study of 813 individuals from Indian Knoll. Twenty-<br />
eight (3.4%) of these individuals were diagnosed as having characteristics of treponemal<br />
disease. Eight adults, 4 males and 4 females, between the ages of 20-35 years and 20<br />
juveniles between the ages of 1-3 years exhibited destructive lesions of the nasal, palatal<br />
and calvarial bones, bowing and swelling of long bone shafts in children and infants, and<br />
saber tibiae (Ibid.). No dental stigmata were found, which the author concluded was<br />
indicative of nonvenereal treponemal disease (Ibid.). For a complete list of burials and<br />
their characteristics, see Kelley (1980).<br />
Indian Knoll and Carrier Mills also share similarities. Both have raised,<br />
discolored, vascular plaques, narrow longitudinal striations, swollen bones, bowed bones,<br />
sinus formation and saber shin tibiae. Neither site produced any evidence of dental<br />
stigmata.<br />
In comparing Carrier Mills to these other sites, there are many similarities and<br />
there are some differences. The biggest difference is the absence of nasal resorption or<br />
the characteristics of the gangosa deformity in Carrier Mills. Perhaps the Carrier Mills<br />
individuals suffered from another form of nonvenereal treponemal disease similar to<br />
yaws / endemic syphilis suggested for the other sites, but not quite the same. What is<br />
clear is that there was a nonvenereal form of treponematosis present and in fact<br />
widespread in this sub-sample from Carrier Mills.<br />
5.3 Carrier Mills – Life in the Archaic Period<br />
116
The majority of the burials from the Black Earth site of the Carrier Mills<br />
Archaeological District are dated to 4000 – 2900 BC, the Middle to Late Archaic periods.<br />
Before inferences can be made about life at Carrier Mills during the Archaic period, it is<br />
pertinent to give a general description of the Middle to Late Archaic periods. This<br />
description will aid in the understanding of life during the Archaic time period.<br />
5.3.1 General Middle and Late Archaic Period<br />
Muller (1986) characterizes the Middle Archaic in the Lower Ohio River Valley<br />
as a time of increased sedentism, an increased use of a wider variety of plants, the<br />
exploitation of small game, and the cultivation of seeds, all occurring during a much drier<br />
and warmer climate than today.<br />
The Late Archaic period, according to Muller (1986), was a time when a more<br />
complex social and economic organization began to develop but without social<br />
distinction between people, and domesticated plants were utilized to a much greater<br />
degree. Long-distance exchange systems also began to develop. Evidence of these<br />
exchange systems is seen through the presences of such materials as conch shell and<br />
copper objects found at Carrier Mills. The Late Archaic was also a period when we<br />
begin to see the first archaeological evidence of cemeteries and perhaps (also indicative<br />
of increased sedentism), in some areas, the emergence of achieved status (Muller 1986).<br />
5.3.2 Inferences of Life at Carrier Mills<br />
Life of the Carrier Mills Archaic peoples must have been very harsh. There were<br />
many changes occurring in the environment. People were accessing new resources and<br />
117
learning how to better utilize older ones; small game animals, plants, and nuts. They<br />
were discovering that a sedentary lifestyle had fewer benefits than a hunter-gatherer<br />
lifestyle. Living in settled groups provided more protection from enemies, and better<br />
hunting strategies, but the availability of a broad range of foods decreased. People were<br />
forced to rely on certain crops and if these crops failed, malnutrition became a serious<br />
problem.<br />
Examining the paleopathological evidence from Carrier Mills, it can be concluded<br />
that this sample suffered from an endemic treponemal disease, very similar to yaws. This<br />
disease affected both juveniles and adults. In this study, the adults appeared to exhibit<br />
considerably more advanced stages of the disease than the juveniles, but in the overall<br />
skeletal sample of Carrier Mills there is evidence of a high infant mortality rate, with<br />
27% of the population dying within the first year of life (Bassett 1982). It must be<br />
remembered that 100% of those dying as juveniles had some expression of bony effects<br />
from the disease (or other infection).<br />
Yaws is acquired in childhood and is seen more commonly in children and<br />
adolescents. In this study, there were not any children (aged 4-11 years) included and<br />
there were only two adolescents. Of the 9 infants that were examined, some of them<br />
were missing their hands, tibiae, fibulae, and foot bones. These factors could be the<br />
reasons why the adults show a considerably higher amount of infection than the juveniles<br />
– an artifact of preservation, sampling strategy, and overall illness of the population.<br />
Yaws would have been a major stressor in this population. In a study of the<br />
juvenile tibial growth patterns of the Carrier Mills sample, Anderson (1998) found that<br />
the growth patterns in the Carrier Mills juveniles closely resembled the tibial growth<br />
118
patterns of children from South America suffering from chronic malnourishment. This<br />
form of stress then would be chronic, and not episodic, resulting in no recovery period<br />
from the stressor. Yaws would have infected this population for long periods of time.<br />
Thus, if a juvenile contracted the disease and lived into adulthood, the individual would<br />
have suffered through the three different phases of the disease. The individual would<br />
have had many lesions on the skin, with some of the lesions excreting pus. Since the<br />
disease affected the individual throughout his/her lifetime, there would not be time for<br />
periods of recovery from other stressors.<br />
In the study of the wild gorillas by Levréro et al. (2007), the third stage of yaws<br />
caused deep lesions to occur that cause necrosis of the surrounding tissues. The lesions<br />
found in the gorilla population were mainly located on their faces. These deep lesions<br />
produced gangosa, which results in death of the tissues of the nose and lips. Some<br />
deformities of the jaws were also recorded (Ibid.). Most (70%) of the gorillas suffered<br />
from type A lesions which are pinkish, smooth lesions with oozing surfaces (Ibid.). Only<br />
19% of the affected gorillas suffered from type C lesions, which are deep, mutilating<br />
lesions. The gorillas with type C lesions exhibited difficulties in chewing, due to the<br />
absence of lips, or in some cases deformities of the jaws (Ibid.). Locomotion was also<br />
hindered for some of the individuals due to their inability to rest their limbs on the ground<br />
because of the lesions.<br />
If we look back at this study of Carrier Mills, there are only six individuals with<br />
nasal/palatal involvement; 1 is a young adult and five are middle adults. This<br />
demonstrates that the individuals would have had the disease for a length of time because<br />
these characteristics are occurring in older individuals. Usually it is in the third stage that<br />
119
we see destructive lesions, although in the Carrier Mills study, no extreme cases of<br />
gangosa were found. If the individuals were suffering from fleshy lesions on or around<br />
the nose and lips, this would hinder their sense of smell and their ability to eat, therefore<br />
resulting in chronic malnourishment. If the women were pregnant, suffering from the<br />
complications of eating, they would have been malnourished but their babies would have<br />
also been malnourished. Maybe this is one of the reasons for the chronic malnourishment<br />
found in Anderson’s (1998) study of the Carrier Mills individuals, although the level of<br />
oral infection was not high.<br />
Van Arsdale’s (1998), study of vertebral osteoarthritis at Carrier Mills found that<br />
adult males suffered harsher lifestyles than adult females. In this study, adult males are<br />
affected far more than adult females, but both sexes would have suffered consequences in<br />
providing for their families. The adult male life in the Archaic period must have been<br />
laden with disease, complicated by the stresses of hunting and other activities while<br />
dealing with the complications of a treponemal disease similar to yaws. Individuals<br />
whose hands and feet were affected would have had complications in walking, picking up<br />
tools, making tools, and the many different tasks associated with hunting such as<br />
preparing the kill for the journey back to the village. For women, the complications<br />
would involve problems with gathering berries, caring for the young, not being able to<br />
walk and difficulties in preparing food. Fishing may have also been an important activity<br />
for both sexes at Carrier Mills, one made more difficult for the many individuals with<br />
infected hands.<br />
Other complications that might arise would be with communication. Severe<br />
destruction of the face could result in a harsh voice (Powell and Cook 2005). Loss of<br />
120
teeth and the hard palate would result in difficulty in speaking and eating. Nonetheless,<br />
the skeletons of most adults overall are those of robust and strong individuals (Bassett<br />
1982; Clapper 2006). Levréro et al. (2007) state that yaws is rarely lethal. In their study<br />
of the gorilla population, only one female gorilla disappeared from the population being<br />
studied. Other gorillas survived as long as the two years and eight months of the study<br />
with serious handicaps (Ibid.). Perhaps then death resulted from general infection or<br />
maybe death was the result of chronic malnourishment.<br />
5.4 History and Origin of Treponemal Disease<br />
This study of the Carrier Mills skeletal sample contributes to the hypothesis that a<br />
non-venereal form of treponemal disease existed in North America at least 3000 years<br />
before the present. The majority of the burials from the Black Earth site of Area A are<br />
dated to the Middle to Late Archaic, spanning a time period of 4000 – 2900 BC. This<br />
means that the most conservative date for the presence of a yaws type of infection in<br />
North America would be 4900 years before present, and the earliest date could be 6000<br />
years before present. Therefore, a yaws-like treponematosis was likely in North America<br />
long before Columbus and his crew arrived in 1492 AD.<br />
Recently Rothschild (2003) suggested that the earliest evidence for treponemal<br />
infection similar to yaws was at the Windover site in Florida, 7900 years BP. However,<br />
the Windover site has not yet been confirmed as the oldest site in North America<br />
exhibiting treponemal disease by any detailed pathological analysis of the skeletal<br />
collection. Walker et al. (2005) propose that collections from the Santa Barbara Channel<br />
121
Area of Southern California (4000 – 5000 years ago) are some of the oldest remains<br />
exhibiting evidence for treponemal disease in the Western Hemisphere.<br />
The presence of a yaws-like treponemal infection at Carrier Mills provides the<br />
earliest evidence for treponematosis in Illinois at 6000 – 4900 BP, and perhaps the oldest<br />
well-documented evidence in the Western Hemisphere. The second oldest site discussed<br />
in Illinois is the Pete Klunk site, which dates to 2900 BP (Powell et al. 2005). Other sites<br />
from Illinois include Morton Mounds, Fisher, Parker Heights, Rose Mounds, Gibson, J<br />
Gay, L Gay, Ledders, and Yokem all dating from 1000 BC to AD 1000 (Powell et al.<br />
2005).<br />
As discussed in Chapter 2, the first hypothesis concerning the origin of syphilis is<br />
the “Columbian theory” whose supporters believe that Columbus and his crew brought<br />
venereal syphilis back to Europe from the Americas. The Carrier Mills study does not<br />
support this hypothesis, as it was a non-venereal form of treponemal disease that existed<br />
in this sample, namely yaws. Thus, unless yaws transformed to venereal syphilis in the<br />
ships crossing the Atlantic Ocean, Columbus and his crew could not have brought back<br />
venereal syphilis from North America to Europe.<br />
The second hypothesis, the “Pre-Columbian theory”, suggests that venereal<br />
syphilis existed in Europe long before Columbus’ journey to the New World and that<br />
Columbus brought the disease to the Americas. As detailed above, this study proves that<br />
a non-venereal form of treponemal disease, most like yaws, did exist in North America<br />
before Columbus’ journey. The Pre-Columbian theory can only be true if we include the<br />
evidence of non-venereal treponemal disease as evidence of the existence of the<br />
122
treponematoses, which could include venereal syphilis, in North America before<br />
Columbus’ journey.<br />
The other three hypotheses; Livingston’s Alternative Hypothesis, the Unitarian<br />
and the Non-Unitarian hypotheses, are all hypotheses suggesting early presence of<br />
treponemal disease in the Old World. Was there only a single treponematosis existing in<br />
both the Old and New Worlds before Columbus’ journey that evolved into the other<br />
syndromes following the evolution of humans through time? Alternatively, was there<br />
one treponematosis that began as an animal infection, eventually infecting humans and<br />
evolving into the different syndromes of treponemal disease as a result of the pathogen<br />
adapting to different environmental circumstances? This study alone does not attempt to<br />
answer these questions. Perhaps if we examine a broad range of studies involving<br />
treponemal disease, these types of questions can be answered. Therefore, further<br />
research into the theories of development of treponemal disease needs to be undertaken.<br />
5.5 Conclusions<br />
This study found that a treponemal disease likely did affect the Carrier Mills<br />
sample. This syndrome was most similar to that of yaws, but not precisely identical to<br />
the pattern of symptoms seen in modern yaws. Other researchers believe that it is<br />
possible that another form of treponematosis did exist thousands of years ago (Baker and<br />
Armelagos 1988), with many evolutionary changes having occurred since then. We<br />
know that gradual change does occur over time within plants, animals and even in<br />
bacteria, so it is possible that another form of treponematosis did exist thousands of years<br />
123
ago. This would account for the many similarities found in the Carrier Mills individuals<br />
to the treponemal disease of yaws. The treponemal disease in this study is most like<br />
yaws, but it is more widespread, occurring in the population far more frequently. It is<br />
almost as if this treponemal disease was a “super-" or a "hyper-yaws”.<br />
Life in the Archaic of Carrier Mills must have been harsh, with a yaws-like<br />
treponematosis affecting all age groups, possibly causing high infant mortality rates but<br />
also affecting people throughout their lifetimes. As for the debate on the origin of<br />
treponemal disease, this research strongly favors the hypothesis that a non-venereal form<br />
of treponematoses existed in North America before Columbus’ historic journey.<br />
Therefore, Columbus most likely did not return to Europe with venereal syphilis<br />
contracted from the peoples of the Americas. However, it could be possible that<br />
Columbus and his crew returned to Europe with a non-venereal form of treponematosis<br />
from the Americas, but this would not explain the epidemic of venereal syphilis in 16 th<br />
century Europe.<br />
124
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136
APPENDICES
APPENDIX A. DIFFERENTIAL DIAGNOSIS OF DISEASES IN THIS STUDY<br />
Names of Yaws Bejel Venereal<br />
Diseases Syphilis<br />
Parameters<br />
% of Population 20-40% 20-40% 2-14%<br />
Age Groups Primarily Primarily Subadults<br />
Child, Adol; Child 2-10; & Adults<br />
Adults Subadults; of sexual<br />
Adults maturity<br />
Bone Groups Median Few Few<br />
Skeletal Involvement 5-15%<br />
Common Bones Affected Tibia 99% Tibia 99% Parietal &<br />
Frontal;<br />
Tibia 99%<br />
Bones Affected<br />
Skull X - X<br />
Tibia X X X<br />
Fibula X X X<br />
Clavicle X X X<br />
Femur X - X<br />
Ulna X X X<br />
Radius X X X<br />
Hands X X -<br />
Feet X X -<br />
Humerus - - X<br />
Sternum - - X<br />
Vertebrae - - X (Cervical)<br />
Nasal/Palatal X X X<br />
Nasal Bones X X X<br />
Other Changes<br />
Joints Affected - - Knee, Elbow,<br />
Shoulder<br />
Cranial Changes - - Outer surface<br />
sutures not crossed<br />
Periosteal Reaction X X X<br />
Osteitis X X X<br />
Congenital Transmission Possible No Yes<br />
137
APPENDIX A. DIFFERENTIAL DIAGNOSIS OF DISEASES IN THIS STUDY, continued.<br />
Names of Yaws Bejel Venereal<br />
Diseases<br />
Characteristic Features<br />
Syphilis<br />
Symmetrical Dacty- Nasal-Palatal Nasal-Palatal<br />
destruction -<br />
litis, Gangosa, destruction - rare, empty<br />
nasal cavity,<br />
Periostitis, joint Periostitis of short<br />
bones of hand &<br />
smooth<br />
swelling, Fibula<br />
feet, lateral walls,<br />
tunnel-like<br />
rarely deformed, Fusiform enlarge- passageradius/ulna<br />
bowed ment way, Caries sicca<br />
Angulation of fingers bone deposition, Cardiovascular &<br />
Shortened fingers Little medullary central nervous<br />
systems,<br />
Saber shin tibia changes,<br />
unilateral<br />
Saber shin tibia tibial involvement<br />
Saber shin tibia<br />
Geographic<br />
Locations<br />
X = affected<br />
- = not sure if<br />
affected<br />
138<br />
Africa, Latin America E Mediterranean Worldwide<br />
Carribean SW Asia but more<br />
SE Asia Sub-Saharan in Urban areas<br />
N Australia Africa<br />
New Guinea North America<br />
North America (rural areas)<br />
(rural areas)<br />
Sources: Ortner 2003, Hackett 1976, Rothschild et al. 2000, Aufderheide & Rodriguez-<br />
Martin 1998, Rothschild et al.<br />
2004
APPENDIX A. DIFFERENTIAL DIAGNOSIS OF DISEASES IN THIS STUDY, cont.<br />
Names of Congenital Tuberculosis Leprosy<br />
Diseases Syphilis<br />
Parameters<br />
% of Population<br />
Age Groups Primarily All ages; All ages;<br />
Fetus & 2:1 ratio of 2:1 ratio of<br />
Neonate; males to males to<br />
Infant females females<br />
Bone Groups - - -<br />
Skeletal Involvement - 3% 5%<br />
Common Bones Affected Spine; areas of Skull,<br />
cancellous bone; Hands & Feet<br />
long bones -<br />
metaphysis &<br />
epiphysis; cranial<br />
vault<br />
Bones Affected<br />
Skull X X X<br />
Tibia X - X<br />
Fibula - - X<br />
Clavicle - - -<br />
Femur X - -<br />
Ulna X - -<br />
Radius X - -<br />
Hands - X X<br />
Feet - X X<br />
Humerus - - -<br />
Sternum - X -<br />
Vertebrae - X (Thoracic,Lumbar) -<br />
Nasal/Palatal - - X<br />
Nasal Bones - X X<br />
Other Changes<br />
Joints Affected - Sacro-iliac, knee, -<br />
Ankle, shoulder<br />
elbow<br />
Cranial Changes - Inner surface -<br />
Periosteal Reaction X - -<br />
Osteitis X - -<br />
Congenital Transmission Solely No No<br />
139
APPENDIX A. DIFFERENTIAL DIAGNOSIS OF DISEASES IN THIS STUDY, cont.<br />
Names of Congenital Tuberculosis Leprosy<br />
Diseases<br />
Characteristic Features<br />
Syphilis<br />
Osteochondritis, Bony ankylosis, Facies Leprosa,<br />
vertebral TB - pitting &<br />
Metaphysis,<br />
L1,<br />
vertebral<br />
perforation<br />
Periostitis,<br />
collapse, of palate & nasal<br />
septum,<br />
Hutchinson's incisor Spina ventosa, absorption<br />
Mulberry molars Desctruction of<br />
mandibular<br />
of anterior nasal<br />
Moon's molars<br />
angle spine, ascending<br />
absorption of<br />
max.<br />
alveolus, loosing<br />
& shedding of<br />
incisors &<br />
canines<br />
Geographic<br />
Locations<br />
X = affected<br />
- = not sure if<br />
affected<br />
140<br />
Worldwide<br />
Worldwide except for Arctic<br />
regions<br />
Rural areas<br />
Sources: Ortner 2003, Hackett 1976, Rothschild et al. 2000, Aufderheide & Rodriguez-<br />
Martin 1998, Rothschild et al.<br />
2004
APPENDIX A. DIFFERENTIAL DIAGNOSIS OF DISEASES IN THIS STUDY, cont.<br />
Names of Osteosarcoma Meningioma Metastatic<br />
Diseases<br />
Parameters<br />
% of Population<br />
Older<br />
Carcinoma<br />
Age Groups Ancient populations individuals Most commonly<br />
under age 30<br />
males affected<br />
Average age 45 individuals over<br />
more<br />
than females<br />
age of 40<br />
Bone Groups - - -<br />
Skeletal Involvement - - -<br />
vertebrae,<br />
Common Bones Affected More common Spine, Cranium, pelvis,<br />
in longbones; Skull vault ribs, major long<br />
also affected flat bones, sternum,<br />
Bones Affected<br />
bones, skull with<br />
mandible most<br />
affected<br />
skull<br />
Skull X X X<br />
Tibia X - X<br />
Fibula X - -<br />
Clavicle - - -<br />
Femur X - X<br />
Ulna X - -<br />
Radius X - -<br />
Hands - - -<br />
Feet - - -<br />
Humerus X - X<br />
Sternum - - X<br />
Vertebrae - X X<br />
Nasal/Palatal - - -<br />
Nasal Bones<br />
Other Changes<br />
- - -<br />
Joints Affected Prox femur<br />
Head of humerus<br />
- -<br />
Cranial Changes - Inner surface -<br />
Periosteal Reaction - - -<br />
Osteitis - - -<br />
Congenital Transmission - - -<br />
141
APPENDIX A. DIFFERENTIAL DIAGNOSIS OF DISEASES IN THIS STUDY, cont.<br />
Names<br />
of Osteosarcoma Meningioma Metastatic<br />
Diseases Carcinoma<br />
Characteristic Features<br />
Onion Skin Hyperostosis,<br />
thickening of<br />
pathologic<br />
fractures,<br />
appearance,<br />
the<br />
skull,<br />
vertebral collapse<br />
bone spicules per-<br />
spiculated with multiple<br />
pendicular to surface<br />
Sunburst Effect<br />
appearance bone lesions<br />
Sources: Ortner 2003, Hackett 1976, Rothschild et al. 2000, Aufderheide & Rodriguez-<br />
Martin 1998, Rothschild et al. 2004<br />
142
APPENDIX A. DIFFERENTIAL DIAGNOSIS OF DISEASES IN THIS STUDY, cont.<br />
Names of Multiple Osteomyelitis Paget's Disease<br />
Diseases<br />
Parameters<br />
% of Population<br />
Myeloma<br />
Most common<br />
Age Groups Most commonly All age groups<br />
age<br />
individuals over group - individuals<br />
age of 40, males over 60, males<br />
more than<br />
more than<br />
females<br />
females<br />
Bone Groups - - -<br />
Skeletal Involvement<br />
Common Bones<br />
- - -<br />
Affected flat bones, skull, any bone, pelvis, femur,<br />
long bone meta- knee, distal tibia, skull, tibia,<br />
prox<br />
vertebrae,<br />
physes, femur, femur,humerus, clavicles,<br />
humerus, pelvis, uncommonly: ribs<br />
collapse of cervical vertebrae,<br />
Bones Affected<br />
vertebral body,<br />
ribs, scapula<br />
skull - frontal<br />
Skull X X Frontal X<br />
Tibia - X X<br />
Fibula - - -<br />
Clavicle X - X<br />
Femur X X X<br />
Ulna - - -<br />
Radius - - -<br />
Hands - - -<br />
Feet - - -<br />
Humerus X X -<br />
Sternum - - -<br />
Vertebrae X X Cervical X Lumbar<br />
Nasal/Palatal - - -<br />
Nasal Bones<br />
Other Changes<br />
- - -<br />
Joints Affected - knee -<br />
Cranial Changes internal & outer table inner & outer<br />
external tables, diploe<br />
Periosteal Reaction - - -<br />
Osteitis - - -<br />
Congenital<br />
Transmission - - -<br />
143
APPENDIX A. DIFFERENTIAL DIAGNOSIS OF DISEASES IN THIS STUDY, cont.<br />
Names<br />
of Multiple Osteomyelitis Paget's Disease<br />
Diseases Myeloma<br />
Characteristic Features<br />
lytic lesions re- usually affects longbones =<br />
stricted to particular only 1 bone, thickening of cortex<br />
area, small, round, sequestrum, medullary cavity in<br />
tact,bone<br />
resorbing bone, involucrum<br />
resorption,<br />
scalloped edges,<br />
new bone<br />
formation,<br />
punched out thickening of<br />
appearance cranium, fissure-like<br />
stress fractures<br />
Sources: Ortner 2003, Hackett 1976, Rothschild et al. 2000, Aufderheide & Rodriguez-<br />
Martin 1998, Rothschild et al. 2004<br />
144
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness * * Notes<br />
1 Old Adult >50% but Moderate Parietal - 3-5 foci inside skull; 1st meta-<br />
56 yrs
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS,<br />
continued.<br />
Degree<br />
Burial Age/Sex Complete- of<br />
Osteitis<br />
Num Category ness * * Notes<br />
humerus - unifocal bone loss, osteitis; right<br />
femur - striations, osteitis; thoracic<br />
vertebrae - multifocal bone loss, compression;<br />
lumbar vertebrae - multifocal<br />
bone<br />
loss, schmorl's nodes on 2, compression<br />
Clavicle - both swollen, left has woven<br />
103 Old Adult >50% but Moderate bone;<br />
53 yrs 50% but None Calcaneus - woven bone; unilateral tibia -<br />
50 yrs
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness * * Notes<br />
bodies, sacrum<br />
29 Mid Adult >50% but Slight Frontal - multifocal bone loss; calcaneus -<br />
44 yrs
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness *<br />
cranium<br />
* Notes<br />
unifocal, multifocal bone loss, deposition<br />
of woven bone, sclerotic reaction;<br />
unilateral<br />
other long bone - right humerus - osteitis,<br />
woven bone, multifocal bone loss, right<br />
radius - woven & sclerotic reaction,<br />
right ulna - sclerotic reaction, left ulna -<br />
woven bone; cervical - multifocal bone<br />
loss;<br />
thoracic - multifocal bone loss anterior<br />
body of 1; lumbar - sclerotic reaction<br />
anterior bodies of 2; periarticular resorptive<br />
foci - cervical -inferior superior bodies,<br />
thoracic - inferior bodies & 1 facet, lumbar<br />
-<br />
superior (4) & inferior (1) bodies<br />
45 Mid Adult comp. Slight Clavicle - osteitis on both, right - unifocal<br />
37 yrs 90% post- bone loss; ribs - 1st ribs - woven bone;<br />
cranial<br />
carpals - multifocal bone loss,<br />
Female comp.<br />
cranium<br />
metacarpalswoven<br />
bone, osteitis, hand phalanges -<br />
multifocal bone loss, osteitis;<br />
bilateral tibia - woven bone, striations;<br />
bilateral fibula - striations; bilateral<br />
other long bone - humerus - woven bone,<br />
femur - woven & sclerotic reaction,<br />
striations; cervical - compression; thoracicunifocal<br />
bone loss,<br />
compression, woven bone; lumbar -<br />
unifocal<br />
bone loss, compression, woven bone; periarticular<br />
resorptive foci -<br />
cervical bodies & facets, thoracic bodies &<br />
facets, lumbar bodies & facets, sacrum -<br />
1st vertebrae<br />
49 Mid Adult comp. Slight Metacarpals - unifocal bone loss, hand<br />
46 yrs 90% postcranial<br />
phalanges - unifocal bone loss; bilateral<br />
Male comp. tibia - woven bone, bowed<br />
medial lateral, striations, osteitis; bilateral<br />
fibula - striations, osteitis,sclerotic reaction;<br />
148
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness *<br />
cranium<br />
* Notes<br />
bilateral other long<br />
bone - radius - woven & sclerotic reaction,<br />
woven bone, femur - woven bone, sclerotic<br />
reaction; thoracic - fusion, compression,<br />
multifocal bone loss; lumbar -compression,<br />
multifocal bone loss; periarticular<br />
resorptive<br />
foci - cervical bodies & facets, thoracic<br />
bodies & facets, lumbar bodies, sacrum<br />
1st vertebrae<br />
65 Mid Adult comp. Moderate Clavicle - left - woven bone; intermediate<br />
49 yrs 90% postcranial<br />
phalanges swelled; metatarsals - multifocal<br />
Male comp. bone loss, woven & sclerotic reaction,<br />
unifocal bone loss, osteitis; unilateral tibiaright<br />
- woven bone, striations; unilateral<br />
fibula - don't know which side - osteitis;<br />
unilateral other long bone - right humerus -<br />
woven bone - smudge-like, right femur -<br />
woven bone, left femur -<br />
striations;thoracicfusion,<br />
compression, multifocal bone loss;<br />
lumbar - compression, multifocal bone<br />
loss; periarticular resorptive foci - thoracicsuperior<br />
& inferior bodies, lumbar -<br />
superior & inferior bodies, sacrum - 1st<br />
vertebrae<br />
72 Mid Adult >50% but None Metacarpals - unifocal bone loss; unilateral<br />
38 yrs
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness * * Notes<br />
85 Mid Adult >50% but None Ribs - woven bone posterior & anterior of<br />
40 yrs 50% but Slight Nasal/palatal - porosity & coalescence of<br />
42 yrs
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness *<br />
cranial<br />
* Notes<br />
Male comp. carpals, hand phalanges - sclerotic<br />
reaction; tarsals, metatarsals - sclerotic<br />
reaction, metatarsals - unifocal bone loss;<br />
bilateral tibia - striations; unilateral tibia -<br />
right - sclerotic reaction; bilateral fibula -<br />
striations, sclerotic reaction;unilateral other<br />
long bone - right radius - swollen, striations,<br />
left radius - woven bone, deposit of woven<br />
bone, right humerus - unifocal bone loss;<br />
thoracic - T8-9 fused, unifocal multifocal<br />
bone loss; lumbar -fusion -L4-5, sacrum,<br />
coccyx, L2-3 - fused, L2 compression;<br />
periarticular resorptive foci - thoracic -<br />
articular surfaces of 6 affected -<br />
mostly inferior, cervical - bodies & facet<br />
94 Mid Adult >50% but None Clavicle - both woven & sclerotic reaction,<br />
44 yrs
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness * * Notes<br />
bilateral tibia - striations; unilateral tibia -<br />
right - bowed medial-lateral, unifocal bone<br />
loss; bilateral fibula - striations; bilateral<br />
other long bone - femur -unifocal bone loss,<br />
striations; unilateral other long bone -<br />
right radius - unifocal bone loss, swollen,<br />
left ulna - unifocal bone loss; thoracic -<br />
unifocal bone loss; lumbar - schmorl's<br />
nodes<br />
104 Mid Adult >50% but Moderate Parietal - unifocal multifocal bone loss;<br />
46 yrs
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness *<br />
cranial<br />
* Notes<br />
Male comp.<br />
cranium<br />
loss, metatarsals - sclerotic reaction,<br />
unifocal multifocal bone loss, woven bone,<br />
cloacae, circumscription, foot phalanges -<br />
unifocal bone loss, abnormal shape, woven<br />
bone; bilateral tibia - striations, sclerotic<br />
reaction; unilateral fibula - radius - flared/<br />
swollen, femur - striations; thoracic - some<br />
bodies are angled to the left, unifocal bone<br />
loss; lumbar - unifocal multifocal bone loss;<br />
periarticular resorptive foci - thoracic -<br />
transverse processes of 4<br />
121 Mid Adult comp. None Palatal - porosity, bump of bone; clavicle -<br />
39 yrs 90% post- both - deposition of woven bone; ribs -<br />
cranial<br />
woven bone some anterior<br />
Male comp.<br />
shafts,deposition<br />
of woven bone on 12th rib; carpals - multifocal<br />
bone loss, hand phalanges - woven<br />
bone, metacarpals - abnormal shape;<br />
bilateral other long bone - humerus -<br />
sclerotic reaction, radius - swollen radial<br />
tuberosities, femur - striations; unilateral<br />
other long bone - left femur - deposition of<br />
woven bone; cervical - compression;<br />
thoracic - unifocal bone loss 9 bodies,<br />
compression; lumbar - compression,<br />
deposition of bone on spinous processes;<br />
periarticular resorptive foci - cervical -<br />
bodies & facets, thoracic - facets<br />
124 Mid Adult >50% but Slight Ribs - woven bone on some anterior, 1<br />
42 yrs
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness * * Notes<br />
- unifocal bone loss;periarticular resorptive<br />
foci - cervical - bodies superior & inferior,<br />
thoracic - inferior facets of 6, superior<br />
facets 2<br />
Yng cranium<br />
Bilateral other long bone - femur -<br />
3 Adult comp. None striations;<br />
27 yrs 90% postcranial<br />
thoracic - schmorl's nodes 1 body, com-<br />
Male comp. pressed; lumbar - schmorl's nodes<br />
3 bodies; periarticular resorptive foci -<br />
cervical - superior 4 bodies<br />
Yng cranium<br />
25 Adult comp. Moderate Clavicle - left acromial end is larger than<br />
33 yrs 90% postcranial<br />
right; metacarpals - abnormal shape - wide,<br />
Male comp. twisted, hand phalanges - woven bone,<br />
bony growths; bilateral tibia - striations;<br />
unilateral tibia - right - concentration of<br />
woven bone; bilateral fibula - striations,<br />
pin pricks; bilateral other long bone - ulna -<br />
multifocal bone loss, femur - woven bone,<br />
striations; unilateral other long bone - left<br />
radius - woven bone; thoracic - unifocal<br />
multifocal bone loss 12 bodies; lumbar -<br />
unifocal multifocal bone loss 5 bodies<br />
Yng cranium<br />
35 Adult comp. None Parietal - unifocal bone loss near sagittal<br />
21 yrs 90% postcranial<br />
suture; clavicle - multifocal bone loss<br />
Male comp. sternal end - groove w/several smaller<br />
holes; carpals - unifocal bone loss; metatarsals<br />
- unifocal bone loss, foot phalangesunifocal<br />
bone loss; bilateral tibia -<br />
striations, multifocal bone loss; unilateral<br />
tibia - left - unifocal bone loss; bilateral<br />
other long bone - femur - woven bone,<br />
striations; unilateral other long bone - right<br />
ulna - unifocal bone loss; cervical -<br />
unifocal bone loss 6 bodies; thoracic -<br />
unifocal multifocal bone loss 8 bodies;<br />
lumbar - unifocal multifocal bone loss<br />
4 bodies<br />
154
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category<br />
Yng<br />
ness * * Notes<br />
39 Adult >50% but None Carpals - multifocal bone loss, hand<br />
22 yrs
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness * * Notes<br />
focal bone loss 7 bodies multifocal bone<br />
loss on all, compression; lumbar - unifocal<br />
bone loss 5 bodies, multifocal bone loss<br />
on all, compression; periarticular resorptive<br />
foci - thoracic - 5 inferior facets<br />
Yng cranium<br />
69 Adult comp. None Clavicle - both - woven & sclerotic reaction<br />
29 yrs 90% postcranial<br />
acromial ends, sternal ends swollen;carpal<br />
Male comp. woven bone; metatarsals - woven bone on<br />
all 5 present; unilateral other long bone -<br />
left radius - woven bone; thoracic - T12 -<br />
multifocal bone loss on inferior body, 2<br />
facets larger, T11 - schmorl's nodes, 2<br />
larger facets, compression, T9(?) - deep<br />
lesion superior body, schmorl's node inferior<br />
body, sclerotic reaction on some; lumbar-<br />
L1 -schmorl's node inferior body, L2 -large<br />
lesion posterior body inferior, schmorl's<br />
node superior body, L4, L5 - schmorl's<br />
node inferior body, some compression;<br />
periarticular resorptive foci - cervical - 2<br />
inferior facets, thoracic - T10 & 11<br />
posterior bodies<br />
Yng cranium<br />
82 Adult comp. Slight Clavicle- left -woven bone; ribs- deposition<br />
25 yrs 90% postcranial<br />
of woven bone on shafts; metacarpals -<br />
Unde- comp. woven bone on shafts of 2; calcaneus -<br />
termined woven bone, 1st metatarsals - woven bone;<br />
bilateral tibia - woven bone, striations,<br />
osteitis; bilateral fibula - woven &<br />
sclerotic reaction; unilateral fibula - left -<br />
unifocal bone loss; bilateral other long bone<br />
humerus - osteitis, femur - striations,<br />
osteitis; unilateral other long bone - right<br />
radius - unifocal bone loss, woven bone,<br />
left ulna - concentration of woven bone,<br />
right femur - woven bone; thoracic - multifocal<br />
bone loss, woven bone anterior<br />
bodies of 2; lumbar - multifocal bone loss,<br />
compression<br />
156
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category<br />
Yng<br />
ness * * Notes<br />
83 Adult >50% but Slight Bilateral tibia -striations; bilateral other long<br />
bone - humerus -woven bone, femur -<br />
20 yrs
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness * * Notes<br />
18 + yrs unifocal bone loss, talus - sequestrum;<br />
Male<br />
Yng<br />
bilateral tibia - woven bone, striations;<br />
bilateral fibula -sclerotic reaction, striations;<br />
unilateral other long bone - femur -not sure<br />
which side - striations<br />
105 Adult
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness * * Notes<br />
20 yrs 90% postcranial<br />
metatarsals - woven bone; bilateral tibia -<br />
Male comp. striations, woven bone; bilateral fibula -<br />
woven & sclerotic reaction, multifocal bone<br />
loss; bilateral other long bone - humerus -<br />
woven bone, femur - striations, woven<br />
bone; thoracic -unifocal multifocal bone<br />
lossschmorl's node on 1 inferior body;<br />
lumbar - unifocal bone loss horizontal<br />
lesions across 4 bodies<br />
cranium<br />
Clavicle -both have woven bone; ribs -<br />
89 Adol comp. Slight woven<br />
16 yrs 90% postcranial<br />
bone sternal ends; metacarpals - woven<br />
Female comp.<br />
cranium<br />
bone, hand phalanges - woven bone;<br />
calcaneus - woven bone, metatarsals -<br />
woven bone, foot phalanges - woven bone;<br />
bilateral tibia - striations, woven bone;<br />
unilateral tibia - right - unifocal bone loss;<br />
unilateral fibula - not sure which side -<br />
striations, woven bone; bilateral other long<br />
bone - femur - striations, woven bone; unilateral<br />
other long bone - left femur - unifocal<br />
bone loss, radius - not sure which side -<br />
swollen, unifocal bone loss, woven bone,<br />
ulna - not sure which side - striations,<br />
humerus - not sure which side -woven<br />
bone;<br />
cervical - unifocal multifocal bone loss;<br />
thoracic - unifocal multifocal bone loss,<br />
compression; lumbar - unifocal multifocal<br />
bone loss<br />
116 Adol comp. None Clavicle - both woven bone; ribs - woven<br />
bone on several anterior; calcaneus -<br />
16 yrs 90% postcranial<br />
woven<br />
Male comp. bone; unilateral fibula - right - woven bone;<br />
bilateral other long bone - humerus - woven<br />
bone, ulna - woven bone; unilateral other<br />
long bone - right radius - woven bone;<br />
thoracic - unifocal multifocal bone loss,<br />
schmorl's nodes on 3 bodies, compression;<br />
159
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness *<br />
cranium<br />
* Notes<br />
lumbar - L1-5 - woven & sclerotic reaction,<br />
schmorl's nodes L1,2,3 superior & inferior<br />
bodies, compression, L4 - unifocal<br />
bone loss - horizontal lesion<br />
21 Infant comp. None Bilateral other long bone - humerus - woven<br />
1.7 90% postcranial<br />
bone, swollen/flared; lumbar - unifocal bone<br />
UJ comp.<br />
cranium<br />
loss<br />
30 Infant comp. None Frontal or parietal? - woven bone inside<br />
0.2 90% postcranial<br />
w/grooves, frontal - woven bone above &<br />
UJ comp.<br />
cranium<br />
inside orbits; clavicle - don't know which<br />
side - woven bone around sternal end; ribswoven<br />
bone anterior & posterior & at both<br />
ends of some; bilateral other long bone -<br />
humerus - woven bone over most of shaftsworse<br />
at ends; unilateral other long bone -<br />
right radius - woven bone, right ulna -<br />
woven<br />
bone, right femur - woven bone<br />
32 Infant comp. None Frontal -woven bone inside orbits -extensive<br />
0.8 90% post- & other parts of frontal; clavicle - both -<br />
cranial<br />
woven bone around ends; ribs - woven<br />
UJ comp.<br />
cranium<br />
bone<br />
at ends & anterior shaft of some; metatarsals<br />
- woven bone on 1; bilateral tibia -<br />
woven bone; bilateral fibula - woven bone;<br />
bilateral other long bone - humerus - woven<br />
bone, radius - woven bone, ulna - woven<br />
bone, femur - woven bone; thoracic -<br />
unifocal<br />
bone loss; lumbar - unifocal bone loss<br />
40 Infant comp. None Frontal or parietal? - woven bone inside;<br />
0.6 90% postcranial<br />
clavicle - both - woven bone on both ends;<br />
UJ comp. ribs - woven bone on 1; bilateral other<br />
long bone - humerus - woven bone, radius -<br />
woven bone, femur - woven bone; uni-<br />
160
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness *<br />
cranium<br />
* Notes<br />
lateral other long bone -left ulna -woven<br />
bone; thoracic - unifocal bone loss;<br />
lumbar - unifocal bone loss<br />
46 Infant comp. None Clavicle - both - woven bone; ribs - woven<br />
0.1 90% postcranial<br />
bone, sternal ends appear to be swollen;<br />
UJ comp.<br />
cranium<br />
bilateral other long bone - humerus - woven<br />
bone radius - woven bone, ulna - woven<br />
bone; unilateral other long bone - left femurwoven<br />
bone; thoracic - unifocal bone loss;<br />
lumbar - unifocal bone loss<br />
62 Infant comp. None Frontal or parietal? - woven bone superior,<br />
0.4 90% postcranial<br />
frontal - woven bone inside the orbits;<br />
UJ comp.<br />
cranium<br />
clavicle - both - woven bone; ribs - woven<br />
bone, sternal ends appear to be swollen;<br />
unilateral tibia - not sure what side - woven<br />
bone; bilateral other long bone - humerus -<br />
woven bone, ulna - woven bone, femur -<br />
woven bone; unilateral other long bone -<br />
right radius - woven bone; thoracic -unifocal<br />
multifocal bone loss; lumbar -unifocal<br />
multifocal bone loss<br />
63 Infant comp. None Clavicle - not sure which side - woven bone;<br />
0.4 90% postcranial<br />
rib - woven bone anterior shafts & ends of<br />
UJ comp. some; bilateral other long bone - humerus -<br />
woven bone; unilateral other long bone -<br />
radius - not sure which side - woven bone,<br />
right ulna - woven bone; thoracic -<br />
multifocal bone loss<br />
77 Infant >50% but None Clavicle - both - woven bone at ends; ribs -<br />
1.3
APPENDIX B. SUMMARY OF CARRIER MILLS ARCHAIC BURIAL SAMPLE<br />
INDIVIDUALS SHOWING POSSIBLE TREPONEMAL CHARACTERISTICS, cont.<br />
Burial Age/Sex Complete-<br />
Degree<br />
of<br />
Osteitis<br />
Num Category ness *<br />
cranium<br />
* Notes<br />
multifocal bone loss; lumbar - multifocal<br />
bone loss<br />
87 Infant comp. None Clavicle - both - woven bone at ends; ribs -<br />
0.8 90% postcranial<br />
woven bone at ends; bilateral tibia - woven<br />
UJ comp. bone; bilateral fibula - woven bone;<br />
bilateral other long bone - humerus - woven<br />
bone, unifocal bone loss, ulna -woven bone,<br />
femur - woven bone; unilateral other long<br />
bone - radius - not sure which side - woven<br />
bone; lumbar - multifocal bone loss<br />
* Taken from Bassett (1982)<br />
162
Twana Jill Golden<br />
PO Box 2382<br />
Carbondale, IL 62902<br />
October 29, 2007<br />
Center For Archaeological Investigations<br />
Southern Illinois University<br />
Carbondale, IL 62901<br />
Dear Dr. Butler:<br />
This letter will confirm our recent telephone conversation. I am completing a masters<br />
thesis at Southern Illinois University entitled “A Contribution to the Debate Over the<br />
Origin and Development of Treponemal Disease: A Case Study from Southern Illinois.”<br />
I would like your permission to reprint in my thesis maps from the following:<br />
Jefferies RW, Butler BM, editors. 1982. The Carrier Mills Archaeological<br />
Project: Human Adaptation in the Saline Valley, Illinois Volume 1. Southern<br />
Illinois University at Carbondale: Center for Archaeological Investigations,<br />
Research Paper No 33.<br />
The maps to be reproduced are:<br />
Figure 1. Location of the Carrier Mills Archaeological District in Southern<br />
Illinois. Page 4 of the volume.<br />
Figure 3. Locations of Sites in the District. Page 6 of the volume.<br />
The requested permission extends to any future revisions and editions of my thesis,<br />
including non-exclusive world rights in all languages, and to the prospective publication<br />
of my thesis. These rights will in no way restrict publication of the material in any other<br />
form by you or by others authorized by you. Your signing of this letter will also confirm<br />
that the Center for Archaeological Investigations owns the copyright to the abovedescribed<br />
material.<br />
If these arrangements meet with your approval, please sign this letter where indicated<br />
below and return it to me. Thank you very much.<br />
Sincerely,<br />
Twana Jill Golden<br />
PERMISSION GRANTED FOR <strong>THE</strong><br />
USE REQUESTED ABOVE:<br />
_________________________ Date:_______________<br />
Dr. Brian M. Butler<br />
163
VITA<br />
Graduate School<br />
Southern Illinois University<br />
Twana Jill Golden Date of Birth: January 28, 1972<br />
P.O. Box 2382, Carbondale, Illinois 62902<br />
Southeastern Illinois College at Harrisburg<br />
Associate In Applied Science, Electronic Data Processing, May 1993<br />
Southern Illinois University at Carbondale<br />
Bachelor of Arts, Anthropology, May 2004<br />
Special Honors and Awards:<br />
Scholastic Honors Award, College of Liberal Arts, Southern Illinois University<br />
Carbondale, 2003<br />
Scholastic Honors Award, College of Liberal Arts, Southern Illinois University<br />
Carbondale, 2004<br />
Excellence in Anthropology, Southern Illinois University Carbondale, 2004<br />
Thesis Title:<br />
A Contribution to the Debate Over the Origin and Development of Treponemal<br />
Disease: A Case Study from Southern Illinois<br />
Major Professor: Susan M. Ford<br />
164