Solution and Solid Phase Synthesis of Unusual a-Amino Acids From

Figure 4.1 O
Figure 5.1
Figure 5.2
Figure 5.3
Figure 5.4
Figure 6.1
Figure 6.2
Figure 6.3
Figure 6.4
Possible transition states of the lithium enolate of
Cbz-Glu(0Me) OB0 ester 4.69 ............................ ............................... 1 84
X-Ray Crystal structure of Tr-L-Asp(p-Me)(OMe)OBO ester 5.50 ....... 265
300 MHz 'H-NMR of 2S.3S 5.41 (top) and 2S,3R 5.42 (bottom)
Cbz-L-Asp(p-Me)(OMe)OBO ester .................... .... ........................... 266
Chamberlin's proposed enolate models ................................................. 27 1
A) Chelation convolled mode1 of (E)-lithium enolate of 5.38 B) Non-
Chelation model with (2)-lithium enolate of 5.38 ................................... 274
Possible Functionalization of Solid-Supported $-Hydroxy-a-Amino
Acids ........................... . ........................................................................ 310
MAS 'H-NMR (500 MHz) with spin-echo pulse program of 6.34
(P=Wang) ................................................................................................ 3 14
Experimental setup for Swem Oxidation ............................................. 3 15
MAS "c-NMR (50 MHz) using spin-echo program of 6.37 (P=
@
TentaGe1 PHB resin) ........................................................................... 3 17