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ChangingCottonLandscapeNeilForrester

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The key factors affecting the development of resistance to Bt cotton will be addressed later but it<br />

is clear that Pakistan should be planning now for the introduction of pyramided or stacked gene<br />

products for bollworm control. It is much more difficult for insects to develop resistance to two or<br />

more combined toxins than it is for them to develop resistance to the same toxins presented<br />

individually and sequentially.<br />

This then brings the first of a number of recommendations concerning the adoption of insect<br />

tolerant cottons for the Pakistan cotton industry:-<br />

1) It is strongly recommended that Pakistan introduce Bollgard 2 or 3 (and other stacked<br />

insecticidal transgenes) as soon as possible and that this should be done through a professional<br />

cottonseed industry. Do not delay because of the current high resistance risk to segregating and<br />

mixed single gene Bollgard 1. Stack this with Roundup Ready Flex.<br />

2) Negotiate with Monsanto for either a one-off fee or a per kg based technology fee. Details of<br />

both these pricing models have been communicated separately. The subsidy could be gradually<br />

phased out after, say, 5-10 years. Pricing should be based on parity for the same product sold<br />

in the Indian Punjab. Explore alternative funding sources e.g. US aid funds.<br />

3) Negotiate also with other potential technology providers.<br />

4) As part of the Tech Fee, ask for training in introgression breeding and genetic purity Quality<br />

Assurance. Ideally, a Centre of Excellence for this should be set up in Pakistan.<br />

5) Independently check to verify the efficacy of all potential Bt cottons against a standard<br />

reference technology (e.g. Bollgard 1 for single gene Bts and Bollgard 2 for double gene Bts).<br />

This should be done in side by side replicated field tests, artificially infested if need be.<br />

6) Ask for information on primers for all new Bt technologies to be lodged in all regulatory<br />

applications (Commercial-in-Confidence if required) so that potential future disputes on genetic<br />

integrity of commercial products can be effectively investigated.<br />

7) As a matter of urgency, set up a Bt Resistance Monitoring facility in Pakistan so that any<br />

changes in bollworm susceptibility to Bt toxins can be closely tracked.<br />

8) Improve and develop local Bio-Safety Evaluation capacity so that the relevant Pakistan<br />

authorities are capable of following the world’s best practice in the evaluation of new GM<br />

regulatory applications. This should involve training in such places as the US/Canada and/or<br />

Australia as well as contact with such organizations as the International Society for Bio-Safety<br />

Research (http://www.isbr.info/) and the International Life Sciences Institute<br />

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